{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:27:58Z","timestamp":1790270878466,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"National Science and Technology Major Project","award":["2016ZX10002008"],"award-info":[{"award-number":["2016ZX10002008"]}]},{"name":"National Science and Technology Major Project","award":["2016ZX10002009"],"award-info":[{"award-number":["2016ZX10002009"]}]},{"name":"National Science and Technology Major Project","award":["2012ZX10002004"],"award-info":[{"award-number":["2012ZX10002004"]}]},{"name":"Guangzhou Science and Technology Project","award":["1561000155"],"award-info":[{"award-number":["1561000155"]}]},{"name":"the 111 Project","award":["B12003"],"award-info":[{"award-number":["B12003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273142"],"award-info":[{"award-number":["81273142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Major Project","award":["2016ZX10002010"],"award-info":[{"award-number":["2016ZX10002010"]}]},{"name":"Natural Science Fund of Guangdong province","award":["2016A030313250"],"award-info":[{"award-number":["2016A030313250"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672701"],"award-info":[{"award-number":["81672701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12967-017-1167-y","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T04:11:56Z","timestamp":1491883916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis"],"prefix":"10.1186","volume":"15","author":[{"given":"Xiaoyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"issue":"9573","key":"1167_CR1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(07)60723-5","volume":"369","author":"J Liu","year":"2007","unstructured":"Liu J, Fan D. Hepatitis B in China. Lancet. 2007;369(9573):1582\u20133.","journal-title":"Lancet"},{"issue":"8","key":"1167_CR2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","volume":"7","author":"SL Friedman","year":"2010","unstructured":"Friedman SL. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 2010;7(8):425\u201336.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"42","key":"1167_CR3","doi-asserted-by":"crossref","first-page":"11887","DOI":"10.3748\/wjg.v21.i42.11887","volume":"21","author":"CC Hsieh","year":"2015","unstructured":"Hsieh CC, et al. Hepatic immune tolerance induced by hepatic stellate cells. World J Gastroenterol. 2015;21(42):11887\u201392.","journal-title":"World J Gastroenterol"},{"key":"1167_CR4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1479-5876-12-60","volume":"12","author":"M Zhang","year":"2014","unstructured":"Zhang M, et al. Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure. J Transl Med. 2014;12:60.","journal-title":"J Transl Med"},{"key":"1167_CR5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12967-014-0308-9","volume":"12","author":"M Zhang","year":"2014","unstructured":"Zhang M, et al. Liver myofibroblasts from hepatitis B related liver failure patients may regulate natural killer cell function via PGE2. J Transl Med. 2014;12:308.","journal-title":"J Transl Med"},{"issue":"1","key":"1167_CR6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3892\/etm.2012.767","volume":"5","author":"M Zhang","year":"2013","unstructured":"Zhang M, et al. Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Exp Ther Med. 2013;5(1):143\u20139.","journal-title":"Exp Ther Med"},{"issue":"11","key":"1167_CR7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","volume":"6","author":"LE Harrington","year":"2005","unstructured":"Harrington LE, et al. Interleukin 17-producing CD4+\u00a0effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6(11):1123\u201332.","journal-title":"Nat Immunol"},{"issue":"11","key":"1167_CR8","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","volume":"6","author":"H Park","year":"2005","unstructured":"Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11):1133\u201341.","journal-title":"Nat Immunol"},{"issue":"3","key":"1167_CR9","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","author":"S Sakaguchi","year":"1995","unstructured":"Sakaguchi S, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155(3):1151\u201364.","journal-title":"J Immunol"},{"issue":"2","key":"1167_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm.2077","volume":"16","author":"X Liu","year":"2010","unstructured":"Liu X, et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med. 2010;16(2):191\u20137.","journal-title":"Nat Med"},{"issue":"7","key":"1167_CR11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ncpneuro0832","volume":"4","author":"AL Zozulya","year":"2008","unstructured":"Zozulya AL, Wiendl H. The role of regulatory T cells in multiple sclerosis. Nat Clin Pract Neurol. 2008;4(7):384\u201398.","journal-title":"Nat Clin Pract Neurol"},{"issue":"6","key":"1167_CR12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cell.2010.02.021","volume":"140","author":"DR Littman","year":"2010","unstructured":"Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010;140(6):845\u201358.","journal-title":"Cell"},{"issue":"6","key":"1167_CR13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10875-008-9251-y","volume":"28","author":"YY Wan","year":"2008","unstructured":"Wan YY, Flavell RA. TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol. 2008;28(6):647\u201359.","journal-title":"J Clin Immunol"},{"issue":"6","key":"1167_CR14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1365-2893.2011.01561.x","volume":"19","author":"HQ Sun","year":"2012","unstructured":"Sun HQ, et al. Increased Th17 cells contribute to disease progression in patients with HBV-associated liver cirrhosis. J Viral Hepat. 2012;19(6):396\u2013403.","journal-title":"J Viral Hepat"},{"issue":"4","key":"1167_CR15","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.1203013","volume":"191","author":"Z Tan","year":"2013","unstructured":"Tan Z, et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol. 2013;191(4):1835\u201344.","journal-title":"J Immunol"},{"issue":"1","key":"1167_CR16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaut.2008.11.001","volume":"32","author":"RY Lan","year":"2009","unstructured":"Lan RY, et al. Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun. 2009;32(1):43\u201351.","journal-title":"J Autoimmun"},{"issue":"6","key":"1167_CR17","doi-asserted-by":"crossref","first-page":"e39307","DOI":"10.1371\/journal.pone.0039307","volume":"7","author":"J Li","year":"2012","unstructured":"Li J, et al. Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis. PLoS ONE. 2012;7(6):e39307.","journal-title":"PLoS ONE"},{"issue":"2","key":"1167_CR18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jhep.2013.04.011","volume":"59","author":"B Langhans","year":"2013","unstructured":"Langhans B, et al. Intrahepatic IL-8 producing Foxp3(+)CD4(+) regulatory T cells and fibrogenesis in chronic hepatitis C. J Hepatol. 2013;59(2):229\u201335.","journal-title":"J Hepatol"},{"issue":"5","key":"1167_CR19","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jhep.2008.12.033","volume":"50","author":"JP Zhang","year":"2009","unstructured":"Zhang JP, et al. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol. 2009;50(5):980\u20139.","journal-title":"J Hepatol"},{"key":"1167_CR20","doi-asserted-by":"crossref","first-page":"35056","DOI":"10.1038\/srep35056","volume":"6","author":"JF Tu","year":"2016","unstructured":"Tu JF, et al. Regulatory T cells, especially ICOS\u00a0+\u00a0FOXP3\u00a0+\u00a0regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival. Sci Rep. 2016;6:35056.","journal-title":"Sci Rep"},{"issue":"7","key":"1167_CR21","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1053\/j.gastro.2007.03.102","volume":"132","author":"J Fu","year":"2007","unstructured":"Fu J, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology. 2007;132(7):2328\u201339.","journal-title":"Gastroenterology"},{"issue":"6","key":"1167_CR22","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.20082173","volume":"206","author":"DM Kuang","year":"2009","unstructured":"Kuang DM, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med. 2009;206(6):1327\u201337.","journal-title":"J Exp Med"},{"key":"1167_CR23","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","volume":"383","author":"EA Tsochatzis","year":"2014","unstructured":"Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383:1749\u201361.","journal-title":"Lancet"},{"issue":"10","key":"1167_CR24","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/eci.12669","volume":"46","author":"X Li","year":"2016","unstructured":"Li X, et al. Intrahepatic NK cells function suppressed in advanced liver fibrosis. Eur J Clin Invest. 2016;46(10):864\u201372.","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"1167_CR25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","volume":"121","author":"A Orimo","year":"2005","unstructured":"Orimo A, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion. Cell. 2005;121(3):335\u201348.","journal-title":"Cell"},{"key":"1167_CR26","doi-asserted-by":"crossref","first-page":"d808","DOI":"10.2741\/reeves","volume":"7","author":"HL Reeves","year":"2002","unstructured":"Reeves HL, Friedman SL. Activation of hepatic stellate cells\u2014a key issue in liver fibrosis. Front Biosci. 2002;7:d808\u201326.","journal-title":"Front Biosci"},{"issue":"12","key":"1167_CR27","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1158\/0008-5472.CAN-05-0141","volume":"65","author":"S Sharma","year":"2005","unstructured":"Sharma S, et al. Tumor cyclooxygenase-2\/prostaglandin E2-dependent promotion of FOXP3 expression and CD4\u00a0+\u00a0CD25\u00a0+\u00a0T regulatory cell activities in lung cancer. Cancer Res. 2005;65(12):5211\u201320.","journal-title":"Cancer Res"},{"issue":"3","key":"1167_CR28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20082293","volume":"206","author":"K Boniface","year":"2009","unstructured":"Boniface K, et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2\/EP4 receptor signaling. J Exp Med. 2009;206(3):535\u201348.","journal-title":"J Exp Med"},{"issue":"Suppl 1","key":"1167_CR29","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","volume":"38","author":"SL Friedman","year":"2003","unstructured":"Friedman SL. Liver fibrosis from bench to bedside. J Hepatol. 2003;38(Suppl 1):S38\u201353.","journal-title":"J Hepatol"},{"issue":"1","key":"1167_CR30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00262-013-1468-9","volume":"63","author":"M Baniyash","year":"2014","unstructured":"Baniyash M, Sade-Feldman M, Kanterman J. Chronic inflammation and cancer: suppressing the suppressors. Cancer Immunol Immunother. 2014;63(1):11\u201320.","journal-title":"Cancer Immunol Immunother"},{"issue":"2","key":"1167_CR31","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","volume":"49","author":"A Lemmers","year":"2009","unstructured":"Lemmers A, et al. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology. 2009;49(2):646\u201357.","journal-title":"Hepatology"},{"issue":"9","key":"1167_CR32","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.4049\/jimmunol.175.9.6177","volume":"175","author":"M Numasaki","year":"2005","unstructured":"Numasaki M, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175(9):6177\u201389.","journal-title":"J Immunol"},{"issue":"15","key":"1167_CR33","first-page":"3698","volume":"59","author":"E Tartour","year":"1999","unstructured":"Tartour E, et al. Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. 1999;59(15):3698\u2013704.","journal-title":"Cancer Res"},{"issue":"12","key":"1167_CR34","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1164\/rccm.200812-1936OC","volume":"179","author":"I Kotsianidis","year":"2009","unstructured":"Kotsianidis I, et al. Global impairment of CD4+\u00a0CD25+\u00a0FOXP3+\u00a0regulatory T cells in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2009;179(12):1121\u201330.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1167_CR35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1182\/blood-2007-11-120998","volume":"112","author":"P Muranski","year":"2008","unstructured":"Muranski P, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112(2):362\u201373.","journal-title":"Blood"},{"issue":"11","key":"1167_CR36","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.193.11.1303","volume":"193","author":"D Dieckmann","year":"2001","unstructured":"Dieckmann D, et al. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med. 2001;193(11):1303\u201310.","journal-title":"J Exp Med"},{"issue":"3","key":"1167_CR37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/eji.200323701","volume":"33","author":"K Wing","year":"2003","unstructured":"Wing K, et al. CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+\u00a0T cells. Eur J Immunol. 2003;33(3):579\u201387.","journal-title":"Eur J Immunol"},{"issue":"4","key":"1167_CR38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ni1180","volume":"6","author":"H Boehmer von","year":"2005","unstructured":"von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005;6(4):338\u201344.","journal-title":"Nat Immunol"},{"issue":"15","key":"1167_CR39","first-page":"4516","volume":"63","author":"T Azuma","year":"2003","unstructured":"Azuma T, et al. Human CD4+\u00a0CD25+\u00a0regulatory T cells suppress NKT cell functions. Cancer Res. 2003;63(15):4516\u201320.","journal-title":"Cancer Res"},{"issue":"3","key":"1167_CR40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.clim.2004.04.003","volume":"112","author":"P Trzonkowski","year":"2004","unstructured":"Trzonkowski P, et al. CD4+\u00a0CD25+\u00a0T regulatory cells inhibit cytotoxic activity of T CD8+\u00a0and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol. 2004;112(3):258\u201367.","journal-title":"Clin Immunol"},{"issue":"2","key":"1167_CR41","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jhep.2006.01.036","volume":"45","author":"XH Yang","year":"2006","unstructured":"Yang XH, et al. Increase of CD4+\u00a0CD25+\u00a0regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol. 2006;45(2):254\u201362.","journal-title":"J Hepatol"},{"issue":"4","key":"1167_CR42","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.25429","volume":"127","author":"H Nishikawa","year":"2010","unstructured":"Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010;127(4):759\u201367.","journal-title":"Int J Cancer"},{"issue":"2","key":"1167_CR43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2014.08.038","volume":"62","author":"B Langhans","year":"2015","unstructured":"Langhans B, et al. Regulatory CD4+\u00a0T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type. J Hepatol. 2015;62(2):398\u2013404.","journal-title":"J Hepatol"},{"issue":"3","key":"1167_CR44","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2008.07.025","volume":"134","author":"MO Li","year":"2008","unstructured":"Li MO, Flavell RA. TGF-beta: a master of all T cell trades. Cell. 2008;134(3):392\u2013404.","journal-title":"Cell"},{"issue":"1","key":"1167_CR45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1074\/jbc.273.1.302","volume":"273","author":"SC Wang","year":"1998","unstructured":"Wang SC, et al. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem. 1998;273(1):302\u20138.","journal-title":"J Biol Chem"},{"issue":"20","key":"1167_CR46","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1073\/pnas.94.20.10663","volume":"94","author":"Z Shi","year":"1997","unstructured":"Shi Z, Wakil AE, Rockey DC. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA. 1997;94(20):10663\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"1167_CR47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/hep.26013","volume":"57","author":"A Pedroza-Gonzalez","year":"2013","unstructured":"Pedroza-Gonzalez A, et al. Activated tumor-infiltrating CD4+\u00a0regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer. Hepatology. 2013;57(1):183\u201394.","journal-title":"Hepatology"},{"key":"1167_CR48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-1536-3-18","volume":"3","author":"G Trujillo","year":"2010","unstructured":"Trujillo G, Hartigan AJ, Hogaboam CM. T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7-\/- mice. Fibrogenesis Tissue Repair. 2010;3:18.","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"5","key":"1167_CR49","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0006-291X(02)02301-X","volume":"297","author":"J Cheng","year":"2002","unstructured":"Cheng J, et al. Inhibition of the expression of alpha-smooth muscle actin in human hepatic stellate cell line, LI90, by a selective cyclooxygenase 2 inhibitor, NS-398. Biochem Biophys Res Commun. 2002;297(5):1128\u201334.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1167_CR50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2012.05.049","volume":"143","author":"F Meng","year":"2012","unstructured":"Meng F, et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012;143(3):765\u201376.","journal-title":"Gastroenterology"},{"issue":"6","key":"1167_CR51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.1968","volume":"15","author":"C Yao","year":"2009","unstructured":"Yao C, et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med. 2009;15(6):633\u201340.","journal-title":"Nat Med"},{"issue":"5","key":"1167_CR52","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/intimm\/dxp023","volume":"21","author":"RE Cone","year":"2009","unstructured":"Cone RE, et al. T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+\u00a0regulatory T cells induced via the injection of antigen into the anterior chamber. Int Immunol. 2009;21(5):567\u201374.","journal-title":"Int Immunol"},{"issue":"5","key":"1167_CR53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1084\/jem.20040685","volume":"201","author":"L Fahlen","year":"2005","unstructured":"Fahlen L, et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2005;201(5):737\u201346.","journal-title":"J Exp Med"},{"issue":"33","key":"1167_CR54","doi-asserted-by":"crossref","first-page":"E3458","DOI":"10.1073\/pnas.1412489111","volume":"111","author":"D Gate","year":"2014","unstructured":"Gate D, et al. T-cell TGF-beta signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci USA. 2014;111(33):E3458\u201366.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"17","key":"1167_CR55","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1073\/pnas.1304498110","volume":"110","author":"H Ishigame","year":"2013","unstructured":"Ishigame H, et al. Excessive Th1 responses due to the absence of TGF-beta signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci USA. 2013;110(17):6961\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"1167_CR56","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.4049\/jimmunol.178.11.6730","volume":"178","author":"I Kryczek","year":"2007","unstructured":"Kryczek I, et al. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol. 2007;178(11):6730\u20133.","journal-title":"J Immunol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-017-1167-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T14:24:10Z","timestamp":1719152650000},"score":1,"resource":{"primary":{"URL":"http:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-017-1167-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1167"],"URL":"https:\/\/doi.org\/10.1186\/s12967-017-1167-y","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]},"article-number":"75"}}