{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:25:46Z","timestamp":1790832346584,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12967-017-1186-8","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T02:23:16Z","timestamp":1493173396000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-2330","authenticated-orcid":false,"given":"Gianluca","family":"Di Monta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Carac\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Marone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Vanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Festino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Palla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mozzillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Antonio","family":"Ascierto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"issue":"1","key":"1186_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejso.2013.09.002","volume":"40","author":"G Monta Di","year":"2014","unstructured":"Di Monta G, Carac\u00f2 C, Benedetto L, et al. Electrochemotherapy as \u201cnew standard of care\u201d treatment for cutaneous Kaposi\u2019s sarcoma. Eur J Surg Oncol. 2014;40(1):61\u20136.","journal-title":"Eur J Surg Oncol"},{"key":"1186_CR2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0304-4157(82)90007-7","volume":"694","author":"U Zimmerman","year":"1982","unstructured":"Zimmerman U. Electric field-mediated fusion and related electrical phenomena. Biochim Biophys Acta. 1982;694:227\u201377.","journal-title":"Biochim Biophys Acta"},{"key":"1186_CR3","first-page":"1319","volume":"78","author":"M Okino","year":"1987","unstructured":"Okino M, Mohri H. Effects of a high voltage electric impulse and anticancer drug on \u2018\u2018in vivo\u2019\u2019 growing tumors. Jpn J Cancer Res. 1987;78:1319\u201321.","journal-title":"Jpn J Cancer Res"},{"key":"1186_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0014-4827(88)90251-0","volume":"175","author":"LM Mir","year":"1988","unstructured":"Mir LM, Banoun H, Paoletti C. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp Cell Res. 1988;175:15\u201325.","journal-title":"Exp Cell Res"},{"key":"1186_CR5","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.1016\/0006-2952(88)90344-9","volume":"37","author":"S Orlowski","year":"1988","unstructured":"Orlowski S, Belehradek J, Paoletti C, et al. Transient electropermeabilization of cells in culture: increase of the cytotoxicityof anticancer drugs. Biochem Pharmacol. 1988;37:4727\u201333.","journal-title":"Biochem Pharmacol"},{"key":"1186_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0277-5379(91)90065-L","volume":"27","author":"J Belehradek Jr","year":"1991","unstructured":"Belehradek J Jr, Orlowski S, Poddevin B, et al. Electrochemotherapy of spontaneous mammary tumours in mice. Eur J Cancer. 1991;27:73\u20136.","journal-title":"Eur J Cancer"},{"issue":"2336\u201342","key":"1186_CR7","first-page":"10","volume":"77","author":"LM Mir","year":"1998","unstructured":"Mir LM, Glass LF, Sersa G, et al. Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer. 1998;77(2336\u201342):10.","journal-title":"Br J Cancer"},{"key":"1186_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejcsup.2006.08.002","volume":"4","author":"M Marty","year":"2006","unstructured":"Marty M, Sersa G, Garbay JR, et al. Electrochemotherapy\u2014an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl. 2006;4:3\u201313.","journal-title":"Eur J Cancer Suppl"},{"issue":"6","key":"1186_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/00008390-200012000-00011","volume":"10","author":"J Gehl","year":"2000","unstructured":"Gehl J, Geertsen PF. Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res. 2000;10(6):585\u20139.","journal-title":"Melanoma Res"},{"issue":"5","key":"1186_CR10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1586\/era.10.43","volume":"10","author":"T Jarm","year":"2010","unstructured":"Jarm T, Cemazar M, Miklavcic D, Sersa G. Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases. Expert Rev Anticancer Ther. 2010;10(5):729\u201346.","journal-title":"Expert Rev Anticancer Ther"},{"key":"1186_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejcsup.2006.08.003","volume":"4","author":"LM Mir","year":"2006","unstructured":"Mir LM, Gehl J, Sersa G, et al. Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or noninvasive electrodes. Eur J Cancer Suppl. 2006;4:14\u201325.","journal-title":"Eur J Cancer Suppl"},{"key":"1186_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1245\/s10434-008-0204-8","volume":"16","author":"LG Campana","year":"2009","unstructured":"Campana LG, Mocellin S, Basso M, et al. Bleomycin-based electrochemotherapy: clinical outcome from a single institution\u2019s experience with 52 patients. Ann Surg Oncol. 2009;16:191\u20139.","journal-title":"Ann Surg Oncol"},{"key":"1186_CR13","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauera","year":"2009","unstructured":"Eisenhauera EA, Therasseb P, Bogaertsc J, Schwartzd LH, Sargente D, Fordf R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228\u201347.","journal-title":"Eur J Cancer"},{"key":"1186_CR14","first-page":"863","volume":"6","author":"G Sersa","year":"2000","unstructured":"Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients. Clin Cancer Res. 2000;6:863\u20137.","journal-title":"Clin Cancer Res"},{"issue":"1213\u20138","key":"1186_CR15","first-page":"18","volume":"34","author":"G Sersa","year":"1998","unstructured":"Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients. Eur J Cancer. 1998;34(1213\u20138):18.","journal-title":"Eur J Cancer"},{"issue":"52\u20136","key":"1186_CR16","first-page":"19","volume":"111","author":"JP Allegretti","year":"2001","unstructured":"Allegretti JP, Panje WR. Electroporation therapy for head and neck cancer including carotid artery involvement. Laryngoscope. 2001;111(52\u20136):19.","journal-title":"Laryngoscope"},{"key":"1186_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0190-9622(96)90838-5","volume":"34","author":"LF Glass","year":"1996","unstructured":"Glass LF, Fenske NA, Jaroszeski M, et al. Bleomycin mediated electrochemotherapy of basal cell carcinoma. J Am Acad Dermatol. 1996;34:82\u20136.","journal-title":"J Am Acad Dermatol"},{"key":"1186_CR18","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.ejso.2016.06.399","volume":"31","author":"LG Campana","year":"2016","unstructured":"Campana LG, Testori A, Curatolo P, Quaglino P, Mocellin S, Framarini M, Borgognoni L, Ascierto PA, Mozzillo N, Guida M, Bucher S, Rotunno R, Marenco F, De Salvo GL, De Paoli A, Rossi CR, Bonadies A. Treatment efficacy with electrochemotherapy: a multi institutional prospective observational study on 376 patients with superficial tumors. Eur J Surg Oncol. 2016;31:1914\u201323.","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"1186_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2478\/raon-2013-0002","volume":"47","author":"B Mali","year":"2013","unstructured":"Mali B, Miklavcic D, Campana LG, Cemazar M, Sersa G, Snoj M, Jarm T. Tumor size and effectiveness of electrochemotherapy. Radiol Oncol. 2013;47(1):32\u201341. doi: 10.2478\/raon-2013-0002 .","journal-title":"Radiol Oncol"},{"issue":"12","key":"1186_CR20","first-page":"3694","volume":"72","author":"M Belehradek","year":"1993","unstructured":"Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek J Jr, Mir LM. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer. 1993;72(12):3694\u2013700.","journal-title":"First clinical phase I-II trial. Cancer."},{"issue":"2","key":"1186_CR21","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/00016480310001114","volume":"123","author":"M Burian","year":"2003","unstructured":"Burian M, Formanek M, Regele H. Electroporation therapy in head and neck cancer. Acta Otolaryngol. 2003;123(2):264\u20138.","journal-title":"Acta Otolaryngol"},{"issue":"9","key":"1186_CR22","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.ejso.2005.04.007","volume":"31","author":"DC Bloom","year":"2005","unstructured":"Bloom DC, Goldfarb PM. The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck. Eur J Surg Oncol. 2005;31(9):1029\u201335.","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"1186_CR23","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3109\/0284186X.2011.573626","volume":"50","author":"LW Matthiessen","year":"2011","unstructured":"Matthiessen LW, Chalmers RL, Sainsbury DC, Veeramani S, Kessell G, Humphreys AC, Bond JE, Muir T, Gehl J. Management of cutaneous metastases using electrochemotherapy. Acta Oncol. 2011;50(5):621\u20139.","journal-title":"Acta Oncol."},{"issue":"6","key":"1186_CR24","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3109\/00016489.2010.541937","volume":"131","author":"FJ Landstr\u00f6m","year":"2011","unstructured":"Landstr\u00f6m FJ, Nilsson CO, Reizenstein JA, Nordqvist K, Adamsson GB, L\u00f6fgren AL. Electroporation therapy for T1 and T2 oral tongue cancer. Acta Otolaryngol. 2011;131(6):660\u20134.","journal-title":"Acta Otolaryngol."},{"issue":"2","key":"1186_CR25","first-page":"265","volume":"25","author":"I Skarlatos","year":"2011","unstructured":"Skarlatos I, Kyrgias G, Mosa E, Provatopoulou X, Spyrou M, Theodorou K, et al. Electrochemotherapy in cancer patients: first clinical trial in Greece. In Vivo. 2011;25(2):265\u201374.","journal-title":"Vivo."},{"issue":"6","key":"1186_CR26","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1097\/SLA.0b013e31824f68b2","volume":"255","author":"M Gargiulo","year":"2012","unstructured":"Gargiulo M, Papa A, Capasso P, Moio M, Cubicciotti E, Parascandolo S. Electrochemotherapy for non-melanoma head and neck cancers: clinical outcomes in 25 patients. Ann Surg. 2012;255(6):1158\u201364.","journal-title":"Ann Surg"},{"key":"1186_CR27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/030089161209800305","volume":"98","author":"N Mevio","year":"2012","unstructured":"Mevio N, Bertino G, Occhini A, Scelsi D, Tagliabue M, Mura Fand Benazzo M. Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary results. Tumori. 2012;98:308\u201313.","journal-title":"Tumori."},{"issue":"Suppl 1","key":"1186_CR28","doi-asserted-by":"crossref","first-page":"A5","DOI":"10.1186\/1471-2482-13-S1-A5","volume":"13","author":"R Benevento","year":"2013","unstructured":"Benevento R, Vicidomini A, Padovano Sorrentino V, Renzulli M, Di Nardo D, Canonico S, Santoriello A. Electrochemotherapy of head and neck cancer in elderly patients: a preliminary report. BMC Surg. 2013;13(Suppl 1):A5.","journal-title":"BMC Surg."},{"issue":"3","key":"1186_CR29","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/jso.23481","volume":"109","author":"N Solari","year":"2014","unstructured":"Solari N, Spagnolo F, Ponte E, Quaglia A, Lillini R, Battista M, Queirolo P, Cafiero F. Electrochemotherapy for the management of cutaneous and subcutaneous metastasis: a series of 39 patients treated with palliative intent. J Surg Oncol. 2014;109(3):270\u20134.","journal-title":"J Surg Oncol."},{"key":"1186_CR30","first-page":"967","volume":"34","author":"V Seccia","year":"2014","unstructured":"Seccia V, Muscatello L, Dallan I, Bajraktari A, Briganti T, Ursino S, Galli L, Falcone A and Sellari-Franceschini S. Electrochemotherapy and its controversial results in patients with head and neck cancer. Anticancer Res. 2014;34:967\u201372.","journal-title":"Anticancer Res."},{"issue":"10","key":"1186_CR31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.bjoms.2014.08.004","volume":"52","author":"LG Campana","year":"2014","unstructured":"Campana LG, Mali B, Sersa G, Valpione S, Giorgi CA, Strojan P, Miklavcic D, Rossi CR. Electrochemotherapy in non-melanoma head and neck cancers: a retrospective analysis of the treated cases. Br J Oral Maxillofac Surg. 2014;52(10):957\u201364.","journal-title":"Br J Oral Maxillofac Surg."},{"key":"1186_CR32","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3109\/00016489.2014.947655","volume":"135","author":"FJ Landstrom","year":"2015","unstructured":"Landstrom FJ, Reinsenstein J, Adamsson GB, Moller C. Electrochemotherapy \u2013 possible benefits and limitations to its use in the head and neck region. Acta Otolaryngol. 2015;135:90\u20135.","journal-title":"Acta Otolaryngol."},{"issue":"10","key":"1186_CR33","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.3109\/00016489.2015.1049663","volume":"135","author":"FJ Landstrom","year":"2015","unstructured":"Landstrom FJ, Reinsenstein J, Adamsson GB, Beckerath MV, Moller C. Long-term follow-up in patients treated with curative electrochemotherapy for cancer in oral cavity and oropharynx. Acta Otolaryngol. 135(10):1070\u20138.","journal-title":"Acta Otolaryngol."},{"key":"1186_CR34","first-page":"1185","volume":"9","author":"R Domanico","year":"2015","unstructured":"Domanico R, Trapasso S, Santoro M, Pingitore D, Allegra E. Electrochemotherapy in combination with chemoradiotherapy in the treatment of oral carcinomas in advanced stages of disease: efficacy, safety, and clinical outcomes in a small number of selected cases. Drug Des Devel Ther. 2015;9:1185\u201391.","journal-title":"Drug Des Devel Ther."},{"issue":"6","key":"1186_CR35","first-page":"610","volume":"151","author":"R Rotunno","year":"2016","unstructured":"Rotunno R, Marenco F, Ribero S, Calvieri S, Amerio P, Curatolo P, Quaglino P. Electrochemotherapy in non-melanoma head and neck skin cancers: a three-center experience and review of the literature. G Ital Dermatol Venereol. 2016;151(6):610\u20138.","journal-title":"G Ital Dermatol Venereol."},{"key":"1186_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejca.2016.05.001","volume":"63","author":"G Bertino","year":"2016","unstructured":"Bertino G, Sersa G, De Terlizzi F, Occhini A, Plaschke CC, Groselj A, Langdon C, Grau JJ, et al. European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: results of the treatment of skin cancer. Eur J Cancer. 2016;63:41\u201352.","journal-title":"Eur J Cancer"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-017-1186-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T07:29:05Z","timestamp":1601969345000},"score":1,"resource":{"primary":{"URL":"http:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-017-1186-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1186"],"URL":"https:\/\/doi.org\/10.1186\/s12967-017-1186-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,26]]},"article-number":"82"}}