{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:13:07Z","timestamp":1790435587316,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011260","name":"FP7 Research infrastructures","doi-asserted-by":"publisher","award":["295097"],"award-info":[{"award-number":["295097"]}],"id":[{"id":"10.13039\/100011260","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tunisian ministry of public health","award":["PEC-4-TUN"],"award-info":[{"award-number":["PEC-4-TUN"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12967-018-1504-9","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T10:01:44Z","timestamp":1528365704000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases"],"prefix":"10.1186","volume":"16","author":[{"name":"the PEC Consortium","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-1834","authenticated-orcid":false,"given":"Yosr","family":"Hamdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroua","family":"Boujemaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Ben Rekaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherif","family":"Ben Hamda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najah","family":"Mighri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"El Benna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Mejri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Labidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouha","family":"Daoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chokri","family":"Naouali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Messaoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Chargui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kais","family":"Ghedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Samir","family":"Boubaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Mrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamouda","family":"Boussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Abdelhak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"issue":"4","key":"1504_CR1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/GRF.0000000000000239","volume":"59","author":"K Rojas","year":"2016","unstructured":"Rojas K, Stuckey A. Breast cancer epidemiology and risk factors. Clin Obstet Gynecol. 2016;59(4):651\u201372.","journal-title":"Clin Obstet Gynecol"},{"issue":"6","key":"1504_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/bcr3591","volume":"15","author":"KN Maxwell","year":"2013","unstructured":"Maxwell KN, Nathanson KL. Common breast cancer risk variants in the post-COGS era: a comprehensive review. Breast Cancer Res. 2013;15(6):212.","journal-title":"Breast Cancer Res"},{"issue":"3","key":"1504_CR3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.15288\/jsad.2017.78.442","volume":"78","author":"JJ Li","year":"2017","unstructured":"Li JJ, et al. Polygenic risk, personality dimensions, and adolescent alcohol use problems: a longitudinal study. J Stud Alcohol Drugs. 2017;78(3):442\u201351.","journal-title":"J Stud Alcohol Drugs"},{"issue":"5","key":"1504_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrg1325","volume":"5","author":"J Shendure","year":"2004","unstructured":"Shendure J, et al. Advanced sequencing technologies: methods and goals. Nat Rev Genet. 2004;5(5):335.","journal-title":"Nat Rev Genet"},{"issue":"10","key":"1504_CR5","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/nbt1486","volume":"26","author":"J Shendure","year":"2008","unstructured":"Shendure J, Ji H. Next-generation DNA sequencing. Nat Biotechnol. 2008;26(10):1135.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"1504_CR6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.canlet.2015.09.014","volume":"369","author":"AP Sokolenko","year":"2015","unstructured":"Sokolenko AP, et al. Identification of novel hereditary cancer genes by whole exome sequencing. Cancer Lett. 2015;369(2):274\u201388.","journal-title":"Cancer Lett"},{"issue":"9","key":"1504_CR7","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/humu.23017","volume":"37","author":"MR Chandler","year":"2016","unstructured":"Chandler MR, Bilgili EP, Merner ND. A review of whole-exome sequencing efforts toward hereditary breast cancer susceptibility gene discovery. Hum Mutat. 2016;37(9):835\u201346.","journal-title":"Hum Mutat"},{"issue":"1","key":"1504_CR8","doi-asserted-by":"publisher","first-page":"e0167581","DOI":"10.1371\/journal.pone.0167581","volume":"12","author":"YC Kim","year":"2017","unstructured":"Kim YC, et al. Unique features of germline variation in five Egyptian familial breast cancer families revealed by exome sequencing. PLoS ONE. 2017;12(1):e0167581.","journal-title":"PLoS ONE"},{"issue":"4","key":"1504_CR9","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.ajhg.2012.02.027","volume":"90","author":"D Park","year":"2012","unstructured":"Park D, et al. Rare mutations in XRCC2 increase the risk of breast cancer. Am J Hum Genet. 2012;90(4):734\u20139.","journal-title":"Am J Hum Genet"},{"issue":"2","key":"1504_CR10","doi-asserted-by":"publisher","first-page":"e55681","DOI":"10.1371\/journal.pone.0055681","volume":"8","author":"FJ Gracia-Aznarez","year":"2013","unstructured":"Gracia-Aznarez FJ, et al. Whole exome sequencing suggests much of non-BRCA1\/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles. PLoS ONE. 2013;8(2):e55681.","journal-title":"PLoS ONE"},{"issue":"42","key":"1504_CR11","doi-asserted-by":"publisher","first-page":"15172","DOI":"10.1073\/pnas.1407909111","volume":"111","author":"JI Kiiski","year":"2014","unstructured":"Kiiski JI, et al. Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer. Proc Natl Acad Sci. 2014;111(42):15172\u20137.","journal-title":"Proc Natl Acad Sci"},{"issue":"7","key":"1504_CR12","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1158\/2159-8290.CD-14-0212","volume":"4","author":"DJ Park","year":"2014","unstructured":"Park DJ, et al. Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome\u2014spectrum cancers. Cancer Discov. 2014;4(7):804\u201315.","journal-title":"Cancer Discov"},{"issue":"6","key":"1504_CR13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/ng.3284","volume":"47","author":"C Cybulski","year":"2015","unstructured":"Cybulski C, et al. Germline RECQL mutations are associated with breast cancer susceptibility. Nat Genet. 2015;47(6):643.","journal-title":"Nat Genet"},{"issue":"9","key":"1504_CR14","doi-asserted-by":"publisher","first-page":"e1002894","DOI":"10.1371\/journal.pgen.1002894","volume":"8","author":"ER Thompson","year":"2012","unstructured":"Thompson ER, et al. Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles. PLoS Genet. 2012;8(9):e1002894.","journal-title":"PLoS Genet"},{"issue":"1","key":"1504_CR15","first-page":"16","volume":"94","author":"K Dimassi","year":"2016","unstructured":"Dimassi K, et al. Cancer mortality among reproductive age women in Tunisia. Tunis Med. 2016;94(1):16\u201322.","journal-title":"Tunis Med"},{"issue":"10","key":"1504_CR16","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1016\/j.ejca.2014.03.016","volume":"50","author":"M Corbex","year":"2014","unstructured":"Corbex M, Bouzbid S, Boffetta P. Features of breast cancer in developing countries, examples from North-Africa. Eur J Cancer. 2014;50(10):1808\u201318.","journal-title":"Eur J Cancer"},{"issue":"4","key":"1504_CR17","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/07357907.2017.1289217","volume":"35","author":"LN Al-Eitan","year":"2017","unstructured":"Al-Eitan LN, Jamous RI, Khasawneh RH. Candidate gene analysis of breast cancer in the Jordanian population of arab descent: a case-control study. Cancer Invest. 2017;35(4):256\u201370.","journal-title":"Cancer Invest"},{"issue":"3","key":"1504_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/tbj.12392","volume":"21","author":"S Bayraktar","year":"2015","unstructured":"Bayraktar S, et al. Genotype\u2013phenotype correlations by ethnicity and mutation location in BRCA mutation carriers. Breast J. 2015;21(3):260\u20137.","journal-title":"Breast J"},{"issue":"1","key":"1504_CR19","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/1471-2407-14-470","volume":"14","author":"H Wen","year":"2014","unstructured":"Wen H, et al. Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer. BMC cancer. 2014;14(1):470.","journal-title":"BMC cancer"},{"issue":"5","key":"1504_CR20","first-page":"520","volume":"19","author":"H Lynch","year":"2013","unstructured":"Lynch H, et al. Can unknown predisposition in familial breast cancer be family-specific? Breast J. 2013;19(5):520\u20138.","journal-title":"Breast J"},{"issue":"2","key":"1504_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3857\/roj.2015.33.2.149","volume":"33","author":"JM Noh","year":"2015","unstructured":"Noh JM, et al. Exome sequencing in a breast cancer family without BRCA mutation. Radiat Oncol J. 2015;33(2):149.","journal-title":"Radiat Oncol J"},{"issue":"7616","key":"1504_CR22","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","volume":"536","author":"M Lek","year":"2016","unstructured":"Lek M, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016;536(7616):285.","journal-title":"Nature"},{"issue":"7571","key":"1504_CR23","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"Consortium, G.P.","year":"2015","unstructured":"Consortium, G.P. A global reference for human genetic variation. Nature. 2015;526(7571):68.","journal-title":"Nature"},{"issue":"11","key":"1504_CR24","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/humu.20892","volume":"29","author":"SV Tavtigian","year":"2008","unstructured":"Tavtigian SV, et al. In silico analysis of missense substitutions using sequence-alignment based methods. Hum Mutat. 2008;29(11):1327\u201336.","journal-title":"Hum Mutat"},{"issue":"1","key":"1504_CR25","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","volume":"14","author":"EY Chen","year":"2013","unstructured":"Chen EY, et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform. 2013;14(1):128.","journal-title":"BMC Bioinform"},{"issue":"1","key":"1504_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000;25(1):25.","journal-title":"Nat Genet"},{"issue":"D1","key":"1504_CR27","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2014","unstructured":"Szklarczyk D, et al. STRING v10: protein\u2013protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2014;43(D1):D447\u201352.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1504_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/bioinformatics\/btr625","volume":"28","author":"EY Chen","year":"2011","unstructured":"Chen EY, et al. Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers. Bioinformatics. 2011;28(1):105\u201311.","journal-title":"Bioinformatics"},{"issue":"11","key":"1504_CR29","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"26","key":"1504_CR30","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1056\/NEJMsa0708739","volume":"358","author":"PD Pharoah","year":"2008","unstructured":"Pharoah PD, et al. Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med. 2008;358(26):2796\u2013803.","journal-title":"N Engl J Med"},{"issue":"38","key":"1504_CR31","doi-asserted-by":"publisher","first-page":"61845","DOI":"10.18632\/oncotarget.11259","volume":"7","author":"MZ Enyedi","year":"2016","unstructured":"Enyedi MZ, et al. Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples. Oncotarget. 2016;7(38):61845.","journal-title":"Oncotarget"},{"issue":"3","key":"1504_CR32","doi-asserted-by":"publisher","first-page":"e1003284","DOI":"10.1371\/journal.pgen.1003284","volume":"9","author":"S Nickels","year":"2013","unstructured":"Nickels S, et al. Evidence of gene\u2013environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet. 2013;9(3):e1003284.","journal-title":"PLoS Genet"},{"issue":"9","key":"1504_CR33","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/hmg\/ddm050","volume":"16","author":"N Johnson","year":"2007","unstructured":"Johnson N, et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. Hum Mol Genet. 2007;16(9):1051\u20137.","journal-title":"Hum Mol Genet"},{"issue":"11","key":"1504_CR34","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1054\/bjoc.2001.2131","volume":"85","author":"S Denic","year":"2001","unstructured":"Denic S, Bener A. Consanguinity decreases risk of breast cancer\u2014cervical cancer unaffected. Br J Cancer. 2001;85(11):1675.","journal-title":"Br J Cancer"},{"issue":"4_suppl","key":"1504_CR35","doi-asserted-by":"publisher","first-page":"8S","DOI":"10.1177\/1010539513497220","volume":"25","author":"H Liu","year":"2013","unstructured":"Liu H, et al. A cross-sectional study of associations between nonsynonymous mutations of the BARD1 gene and breast cancer in Han Chinese women. Asia Pac J Public Health. 2013;25(4_suppl):8S\u201314S.","journal-title":"Asia Pac J Public Health."},{"issue":"18","key":"1504_CR36","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1158\/1078-0432.CCR-08-0429","volume":"14","author":"P Chen","year":"2008","unstructured":"Chen P, et al. Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin Cancer Res. 2008;14(18):5931\u20137.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"1504_CR37","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.1007\/s11033-011-1410-1","volume":"39","author":"H Gu","year":"2012","unstructured":"Gu H, et al. Variant allele of CHEK2 is associated with a decreased risk of esophageal cancer lymph node metastasis in a Chinese population. Mol Biol Rep. 2012;39(5):5977\u201384.","journal-title":"Mol Biol Rep"},{"key":"1504_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mrfmmm.2014.02.007","volume":"762","author":"P Gresner","year":"2014","unstructured":"Gresner P, et al. Rad51C: a novel suppressor gene modulates the risk of head and neck cancer. Mutat Res Fundam Mol Mech Mutagen. 2014;762:47\u201354.","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"issue":"5","key":"1504_CR39","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.1007\/s11033-011-1381-2","volume":"39","author":"L Shen","year":"2012","unstructured":"Shen L, et al. Association between ATM polymorphisms and cancer risk: a meta-analysis. Mol Biol Rep. 2012;39(5):5719\u201325.","journal-title":"Mol Biol Rep"},{"issue":"6282","key":"1504_CR40","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/346362a0","volume":"346","author":"SC Hyde","year":"1990","unstructured":"Hyde SC, et al. Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature. 1990;346(6282):362.","journal-title":"Nature"},{"issue":"6282","key":"1504_CR41","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/346366a0","volume":"346","author":"GR Cutting","year":"1990","unstructured":"Cutting GR, et al. A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein. Nature. 1990;346(6282):366.","journal-title":"Nature"},{"issue":"1","key":"1504_CR42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.lungcan.2010.01.005","volume":"70","author":"Y Li","year":"2010","unstructured":"Li Y, et al. Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk. Lung Cancer. 2010;70(1):14\u201321.","journal-title":"Lung Cancer"},{"issue":"5","key":"1504_CR43","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/(SICI)1097-0215(19981023)79:5<487::AID-IJC7>3.0.CO;2-X","volume":"79","author":"MC Southey","year":"1998","unstructured":"Southey MC, et al. CFTR \u0394F508 carrier status, risk of breast cancer before the age of 40 and histological grading in a population-based case-control study. Int J Cancer. 1998;79(5):487\u20139.","journal-title":"Int J Cancer"},{"issue":"3","key":"1504_CR44","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10815-016-0654-z","volume":"33","author":"S Ozturk","year":"2016","unstructured":"Ozturk S, et al. The poly (A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. J Assist Reprod Genet. 2016;33(3):335\u201348.","journal-title":"J Assist Reprod Genet"},{"issue":"10","key":"1504_CR45","doi-asserted-by":"publisher","first-page":"T19","DOI":"10.1530\/ERC-16-0221","volume":"23","author":"Y Katsuki","year":"2016","unstructured":"Katsuki Y, Takata M. Defects in homologous recombination repair behind the human diseases: FA and HBOC. Endocr Relat Cancer. 2016;23(10):T19\u201337.","journal-title":"Endocr Relat Cancer"},{"issue":"8","key":"1504_CR46","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.dnarep.2006.05.007","volume":"5","author":"MD Hatfield","year":"2006","unstructured":"Hatfield MD, et al. Identification of MMS19 domains with distinct functions in NER and transcription. DNA Repair. 2006;5(8):914\u201324.","journal-title":"DNA Repair"},{"issue":"26","key":"1504_CR47","doi-asserted-by":"publisher","first-page":"23962","DOI":"10.1074\/jbc.M101041200","volume":"276","author":"X Wu","year":"2001","unstructured":"Wu X, Li H, Chen JD. The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor. J Biol Chem. 2001;276(26):23962\u20138.","journal-title":"J Biol Chem"},{"issue":"4","key":"1504_CR48","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molcel.2007.01.018","volume":"25","author":"S Lone","year":"2007","unstructured":"Lone S, et al. Human DNA polymerase \u03ba encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell. 2007;25(4):601\u201314.","journal-title":"Mol Cell"},{"issue":"6","key":"1504_CR49","doi-asserted-by":"publisher","first-page":"e0178450","DOI":"10.1371\/journal.pone.0178450","volume":"12","author":"JL Stafford","year":"2017","unstructured":"Stafford JL, et al. Reanalysis of BRCA1\/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability. PLoS ONE. 2017;12(6):e0178450.","journal-title":"PLoS ONE"},{"issue":"40","key":"1504_CR50","doi-asserted-by":"publisher","first-page":"28528","DOI":"10.1074\/jbc.274.40.28528","volume":"274","author":"N Champagne","year":"1999","unstructured":"Champagne N, et al. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. J Biol Chem. 1999;274(40):28528\u201336.","journal-title":"J Biol Chem"},{"key":"1504_CR51","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.lungcan.2017.10.001","volume":"113","author":"T Ichikawa","year":"2017","unstructured":"Ichikawa T, et al. Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia. Lung Cancer. 2017;113:134\u20139.","journal-title":"Lung Cancer"},{"issue":"3","key":"1504_CR52","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s10549-014-2908-8","volume":"145","author":"LJ McIver","year":"2014","unstructured":"McIver LJ, et al. Microsatellite genotyping reveals a signature in breast cancer exomes. Breast Cancer Res Treat. 2014;145(3):791\u20138.","journal-title":"Breast Cancer Res Treat"},{"issue":"16","key":"1504_CR53","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1093\/bioinformatics\/btv164","volume":"31","author":"C Suo","year":"2015","unstructured":"Suo C, et al. Integration of somatic mutation, expression and functional data reveals potential driver genes predictive of breast cancer survival. Bioinformatics. 2015;31(16):2607\u201313.","journal-title":"Bioinformatics"},{"issue":"12","key":"1504_CR54","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1111\/j.1600-0854.2007.00646.x","volume":"8","author":"B Wickstead","year":"2007","unstructured":"Wickstead B, Gull K. Dyneins across eukaryotes: a comparative genomic analysis. Traffic. 2007;8(12):1708\u201321.","journal-title":"Traffic"},{"issue":"3","key":"1504_CR55","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/bcr3434","volume":"15","author":"MC Southey","year":"2013","unstructured":"Southey MC, et al. COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 2013;15(3):402.","journal-title":"Breast Cancer Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-018-1504-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-018-1504-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-018-1504-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T19:09:48Z","timestamp":1559848188000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-018-1504-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,7]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1504"],"URL":"https:\/\/doi.org\/10.1186\/s12967-018-1504-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,7]]},"assertion":[{"value":"2 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"158"}}