{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:25:11Z","timestamp":1790904311523,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["Z171100001017076"],"award-info":[{"award-number":["Z171100001017076"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Fund for Basic Scientific Research of Central Public Research Institutes","award":["2018CZ-8"],"award-info":[{"award-number":["2018CZ-8"]}]},{"name":"Special Fund for Basic Scientific Research of Central Public Research Institutes","award":["2016CZ-1"],"award-info":[{"award-number":["2016CZ-1"]}]},{"name":"Special Fund for Basic Scientific Research of Central Public Research Institutes","award":["2018CZ-1"],"award-info":[{"award-number":["2018CZ-1"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870979"],"award-info":[{"award-number":["81870979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Science and Technology Major Project","award":["D161100002816004"],"award-info":[{"award-number":["D161100002816004"]}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special","doi-asserted-by":"publisher","award":["2018-1-6011"],"award-info":[{"award-number":["2018-1-6011"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12967-018-1735-9","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T06:44:23Z","timestamp":1544683463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury"],"prefix":"10.1186","volume":"16","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjie","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"1735_CR1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1093\/brain\/awv375","volume":"139","author":"B Brommer","year":"2016","unstructured":"Brommer B, Engel O, Kopp MA, Watzlawick R, M\u00fcller S, Pr\u00fcss H, et al. Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level. Brain. 2016;139:692\u2013707.","journal-title":"Brain"},{"key":"1735_CR2","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrn1765","volume":"6","author":"C Meisel","year":"2005","unstructured":"Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005;6:775\u201386.","journal-title":"Nat Rev Neurosci"},{"key":"1735_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0079-6123(05)52017-X","volume":"152","author":"AG Rabchevsky","year":"2006","unstructured":"Rabchevsky AG. Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury. Prog Brain Res. 2006;152:265\u201374.","journal-title":"Prog Brain Res"},{"key":"1735_CR4","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/nn.4289","volume":"19","author":"M Ueno","year":"2016","unstructured":"Ueno M, Ueno-Nakamura Y, Niehaus J, Popovich PG, Yoshida Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat Neurosci. 2016;19:784\u20137.","journal-title":"Nat Neurosci"},{"key":"1735_CR5","doi-asserted-by":"publisher","first-page":"12970","DOI":"10.1523\/JNEUROSCI.1974-13.2013","volume":"33","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar-Colucci S, Huang K, et al. Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J Neurosci. 2013;33:12970\u201381.","journal-title":"J Neurosci"},{"key":"1735_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.autneu.2013.12.003","volume":"182","author":"AL Cervi","year":"2014","unstructured":"Cervi AL, Lukewich MK, Lomax AE. Neural regulation of gastrointestinal inflammation: role of the sympathetic nervous system. Auton Neurosci. 2014;182:83\u20138.","journal-title":"Auton Neurosci."},{"key":"1735_CR7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","volume":"52","author":"IJ Elenkov","year":"2000","unstructured":"Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000;52:595\u2013638.","journal-title":"Pharmacol Rev"},{"issue":"3","key":"1735_CR8","doi-asserted-by":"publisher","first-page":"528","DOI":"10.5535\/arm.2016.40.3.528","volume":"40","author":"BI Koo","year":"2016","unstructured":"Koo BI, Bang TS, Kim SY, Ko SH, Kim W, Ko HY. Anorectal manometric and urodynamic parameters according to the spinal cord injury lesion. Ann Rehabil Med. 2016;40(3):528\u201333.","journal-title":"Ann Rehabil Med."},{"issue":"10","key":"1735_CR9","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1016\/j.apmr.2016.03.019","volume":"97","author":"DG Tate","year":"2016","unstructured":"Tate DG, Forchheimer M, Rodriguez G, Chiodo A, Cameron A, Meade M, et al. Risk factors associated with neurogenic bowel complications and dysfunction in spinal cord injury. Arch Phys Med Rehabil. 2016;97(10):1679\u201386.","journal-title":"Arch Phys Med Rehabil"},{"issue":"7","key":"1735_CR10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.4103\/1673-5374.160112","volume":"10","author":"Z Ozisler","year":"2015","unstructured":"Ozisler Z, Koklu K, Ozel S, Unsal-Delialioglu S. Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction. Neural Regen Res. 2015;10(7):1153\u20138.","journal-title":"Neural Regen Res."},{"issue":"3","key":"1735_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF02554543","volume":"32","author":"WE Longo","year":"1989","unstructured":"Longo WE, Ballantyne GH, Modlin IM. The colon, anorectum and spinal cord patient. A review of the functional alternations of the denervated hindgut. Dis Colon Rectum. 1989;32(3):261\u20137.","journal-title":"Dis Colon Rectum."},{"key":"1735_CR12","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/S0140-6736(96)91487-7","volume":"347","author":"S Glickman","year":"1996","unstructured":"Glickman S, Kamm MA. Bowel dysfunction in spinal-cord-injury patients. Lancet. 1996;347:1651\u20133.","journal-title":"Lancet"},{"issue":"6","key":"1735_CR13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ptj\/82.6.601","volume":"82","author":"BT Benevento","year":"2002","unstructured":"Benevento BT, Sipski ML. Neurogenic bladder, neurogenic bowel, and sexual dysfunction in people with spinal cord injury. Phys Ther. 2002;82(6):601\u201312.","journal-title":"Phys Ther."},{"issue":"8","key":"1735_CR14","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1007\/s10350-005-0061-5","volume":"48","author":"C Ng","year":"2005","unstructured":"Ng C, Prott G, Rutkwski S, Li Y, Hansen R, Kellow J, et al. Gastrointestinal symptoms in spinal cord injury: relationships with level of injury and psychologic factors. Dis Colon Rectum. 2005;48(8):1562\u20138.","journal-title":"Dis Colon Rectum"},{"key":"1735_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/sj.sc.3101076","volume":"38","author":"AC Lynch","year":"2000","unstructured":"Lynch AC, Anthony A, Dobbs BR, Frizelle FA. Anorectal physiology following spinal cord injury. Spinal Cord. 2000;38:573\u201380.","journal-title":"Spinal Cord."},{"issue":"7164","key":"1735_CR16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nature06245","volume":"449","author":"L Dethlefsen","year":"2007","unstructured":"Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human microbe mutualism and disease. Nature. 2007;449(7164):811\u20138.","journal-title":"Nature"},{"key":"1735_CR17","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1126\/science.1223490","volume":"336","author":"LV Hooper","year":"2012","unstructured":"Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012;336:1268\u201373.","journal-title":"Science"},{"issue":"2","key":"1735_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","volume":"161","author":"JM Yano","year":"2015","unstructured":"Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264\u201376.","journal-title":"Cell"},{"issue":"2","key":"1735_CR19","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1053\/j.gastro.2007.11.059","volume":"134","author":"RB Sartor","year":"2008","unstructured":"Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134(2):577\u201394.","journal-title":"Gastroenterology"},{"key":"1735_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000268126","volume":"27","author":"S Collins","year":"2009","unstructured":"Collins S, Verdu E, Denou E, Bercik P. The role of pathogenic microbes and commensal bacteria in irritable bowel syndrome. Dig Dis. 2009;27:85\u20139.","journal-title":"Dig Dis"},{"key":"1735_CR21","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1017\/S0007114512005235","volume":"109","author":"V Robles Alonso","year":"2013","unstructured":"Robles Alonso V, Guarner F. Linking the gut microbiota to human health. Br J Nutr. 2013;109:S21\u20136.","journal-title":"Br J Nutr"},{"key":"1735_CR22","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1146\/annurev-immunol-030409-101330","volume":"28","author":"DA Hill","year":"2010","unstructured":"Hill DA, Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol. 2010;28:623\u201367.","journal-title":"Annu Rev Immunol"},{"key":"1735_CR23","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.clinthera.2015.03.002","volume":"37","author":"S Aidy El","year":"2015","unstructured":"El Aidy S, Dinan TG, Cryan JF. Gut microbiota: the conductor in the orchestra of immune-neuroendocrine communication. Clin Ther. 2015;37:954\u201367.","journal-title":"Clin Ther"},{"key":"1735_CR24","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1440-1746.2007.04933.x","volume":"22","author":"S Balzan","year":"2007","unstructured":"Balzan S, de Almeida Quadros C, de Cleva R, Zilberstein B, Cecconello I. Bacterial translocation: overview of mechanisms and clinical impact. J Gastroenterol Hepatol. 2007;22:464\u201371.","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"1735_CR25","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","volume":"15","author":"A Khosravi","year":"2014","unstructured":"Khosravi A, Y\u00e1\u00f1ez A, Price JG, Chow A, Merad M, Goodridge HS, et al. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe. 2014;15(3):374\u201381.","journal-title":"Cell Host Microbe"},{"issue":"10","key":"1735_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.it.2011.06.011","volume":"32","author":"IB Mazo","year":"2011","unstructured":"Mazo IB, Massberg S, von Andrian UH. Hematopoietic stem and progenitor cell trafficking. Trends Immunol. 2011;32(10):493\u2013503.","journal-title":"Trends Immunol"},{"issue":"1","key":"1735_CR27","doi-asserted-by":"publisher","first-page":"e0145878","DOI":"10.1371\/journal.pone.0145878","volume":"11","author":"B Gungor","year":"2016","unstructured":"Gungor B, Adiguzel E, Gursel I, Yilmaz B, Gursel M. Intestinal microbiota in patients with spinal cord injury. PLoS ONE. 2016;11(1):e0145878.","journal-title":"PLoS ONE"},{"issue":"12","key":"1735_CR28","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1084\/jem.20151345","volume":"213","author":"KA Kigerl","year":"2016","unstructured":"Kigerl KA, Hall JC, Wang L, Mo X, Yu Z, Popovich PG. Gut dysbiosis impairs recovery after spinal cord injury. J Exp Med. 2016;213(12):2603\u201320.","journal-title":"J Exp Med"},{"issue":"1","key":"1735_CR29","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s13311-017-0583-2","volume":"15","author":"KA Kigerl","year":"2018","unstructured":"Kigerl KA, Mostacada K, Popovich PG. Gut microbiota are disease-modifying factors after traumatic spinal cord injury. Neurotherapeutics. 2018;15(1):60\u20137.","journal-title":"Neurotherapeutics."},{"key":"1735_CR30","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/sj.sc.3101958","volume":"44","author":"M DeVivo","year":"2006","unstructured":"DeVivo M, Biering-S F, Charlifue S, et al. International spinal cord iniury core data set. Spinal Cord. 2006;44:535\u201340.","journal-title":"Spinal Cord"},{"issue":"3","key":"1735_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/sc.2008.102","volume":"47","author":"K Krogh","year":"2009","unstructured":"Krogh K, Perkash I, Stiens SA, Biering-Srensen F. International bowel function basic spinal cord injury data set. Spinal Cord. 2009;47(3):230\u20134.","journal-title":"Spinal Cord."},{"issue":"3","key":"1735_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/sc.2008.103","volume":"47","author":"K Krogh","year":"2009","unstructured":"Krogh K, Perkash I, Stiens SA, Biering-Srensen F. International bowel function extended spinal cord injury data set. Spinal Cord. 2009;47(3):235\u201341.","journal-title":"Spinal Cord"},{"issue":"9","key":"1735_CR33","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nbt.2676","volume":"31","author":"MG Langille","year":"2013","unstructured":"Langille MG, Zaneveld J, Caporaso JG, McDonald D, Knights D, Reyes JA, et al. Predictive functional profling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol. 2013;31(9):814\u201321.","journal-title":"Nat Biotechnol"},{"issue":"21","key":"1735_CR34","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","volume":"30","author":"DH Parks","year":"2014","unstructured":"Parks DH, Tyson GW, Hugenholtz P, Beiko RG. STAMP: statistical analysis of taxonomic and functional profles. Bioinformatics. 2014;30(21):3123\u20134.","journal-title":"Bioinformatics"},{"issue":"4","key":"1735_CR35","doi-asserted-by":"publisher","first-page":"e1000352","DOI":"10.1371\/journal.pcbi.1000352","volume":"5","author":"JR White","year":"2009","unstructured":"White JR, Nagarajan N, Pop M. Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol. 2009;5(4):e1000352.","journal-title":"PLoS Comput Biol"},{"key":"1735_CR36","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/sc.2011.8","volume":"49","author":"J Li","year":"2011","unstructured":"Li J, Liu G, Zheng Y, Hao C, Zhang Y, Wei B, et al. The epidemiological survey of acute traumatic spinal cord injury (ATSCI) of 2002 in Beijing municipality. Spinal Cord. 2011;49:777\u201382.","journal-title":"Spinal Cord."},{"issue":"9","key":"1735_CR37","doi-asserted-by":"publisher","first-page":"E555","DOI":"10.1097\/BRS.0000000000001896","volume":"42","author":"R Yang","year":"2016","unstructured":"Yang R, Guo L, Huang L, Wang P, Tang Y, Wang W, et al. Epidemiologieal characteristics of traumatic spinal cord injury in Guangdong, China. Spine. 2016;42(9):E555.","journal-title":"Spine."},{"key":"1735_CR38","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2340\/16501977-1074","volume":"45","author":"JP Engkasan","year":"2013","unstructured":"Engkasan JP, Sudin SS. Neurogenic bowel management after spinal cord injury: malaysian experience. J Rehabil Med. 2013;45:141\u20134.","journal-title":"J Rehabil Med"},{"key":"1735_CR39","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/sc.2010.46","volume":"48","author":"R Yasmeen","year":"2010","unstructured":"Yasmeen R, Rathore FA, Ashraf K, Butt AW. How do patients with chronic spinal injury manage their bowels? A cross-sectional survey of 50 patients. Spinal Cord. 2010;48:872\u20135.","journal-title":"Spinal Cord."},{"key":"1735_CR40","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/sj.sc.3100616","volume":"36","author":"TR Han","year":"1998","unstructured":"Han TR, Kim JH, Kwon BS. Chronic gastrointestinal problems and bowel dysfunction in patients with spinal cord injury. Spinal Cord. 1998;36:485\u201390.","journal-title":"Spinal Cord."},{"key":"1735_CR41","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0003-9993(98)90201-5","volume":"79","author":"SC Kirshblum","year":"1998","unstructured":"Kirshblum SC, Gulati M, O\u2019Connor KC, Voorman SJ. Bowel care practices in chronic spinal cord injury patients. Arch Phys Med Rehabil. 1998;79:20\u20133.","journal-title":"Arch Phys Med Rehabil"},{"key":"1735_CR42","first-page":"1114","volume":"85","author":"JM Stone","year":"1990","unstructured":"Stone JM, Nino-Murcia M, Wolfe VA, Perkash I. Chronic gastrointestinal problems in spinal cord injury patients: a prospective analysis. Am J Gastroenterol. 1990;85:1114\u20139.","journal-title":"Am J Gastroenterol"},{"key":"1735_CR43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/sj.sc.3101119","volume":"39","author":"AC Lynch","year":"2001","unstructured":"Lynch AC, Antony A, Dobbs BR, Frizelle FA. Bowel dysfunction following spinal cord injury. Spinal Cord. 2001;39:193\u2013203.","journal-title":"Spinal Cord."},{"key":"1735_CR44","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1089\/neu.2004.21.1371","volume":"21","author":"KD Anderson","year":"2004","unstructured":"Anderson KD. Targeting recovery: priorities of the spinal cord injured population. J Neurotrauma. 2004;21:1371\u201383.","journal-title":"J Neurotrauma"},{"key":"1735_CR45","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1089\/neu.2011.2226","volume":"29","author":"LA Simpson","year":"2012","unstructured":"Simpson LA, Eng JJ, Hsieh JT, Wolfe DL, the SCIRE Research Team. The health and life priorities of individuals with spinal cord injury: a systematic review. J Neurotraum. 2012;29:1548\u201355.","journal-title":"J Neurotraum."},{"key":"1735_CR46","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/1574-6976.12075","volume":"38","author":"M Rajili\u0107-Stojanovi\u0107","year":"2014","unstructured":"Rajili\u0107-Stojanovi\u0107 M, Vos WM. The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiol Rev. 2014;38:996\u20131047.","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"1735_CR47","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/PHM.0b013e31802f0247","volume":"86","author":"J Myers","year":"2007","unstructured":"Myers J, Lee M, Kiratli J. Cardiovascular disease in spinal cord injury: an overview of prevalence, risk, evaluation, and management. Am J Phys Med Rehabil. 2007;86(2):142\u201352.","journal-title":"Am J Phys Med Rehabil"},{"key":"1735_CR48","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/s41598-017-17851-8","volume":"8","author":"M Liao","year":"2018","unstructured":"Liao M, Xie YL, Mao Y, Lu Z, Tan A, Wu CL, et al. Comparative analyses of fecal microbiota in Chinese isolated Yao population, minority Zhuang and rural Han by 16sRNA sequencing. Sci Rep. 2018;8:1142.","journal-title":"Sci Rep."},{"key":"1735_CR49","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1053\/j.gastro.2011.06.072","volume":"141","author":"DM Saulnier","year":"2011","unstructured":"Saulnier DM, Riehle K, Mistretta TA, Diaz MA, Mandal D, Raza S, et al. Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology. 2011;141:1782\u201391.","journal-title":"Gastroenterology"},{"key":"1735_CR50","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.3945\/jn.109.108191","volume":"139","author":"F Li","year":"2009","unstructured":"Li F, Hullar MA, Schwarz Y, Lampe JW. Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet. J Nutr. 2009;139:1685\u201391.","journal-title":"J Nutr"},{"key":"1735_CR51","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"LA David","year":"2014","unstructured":"David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505:559\u201363.","journal-title":"Nature"},{"key":"1735_CR52","first-page":"1","volume":"7","author":"A O\u2019Callaghan","year":"2016","unstructured":"O\u2019Callaghan A, van Sinderen D. Bifdobacteria and their role as members of the human gut microbiota. Front Microbiol. 2016;7:1\u201323.","journal-title":"Front Microbiol."},{"key":"1735_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2016.01204","volume":"7","author":"S Arboleya","year":"2016","unstructured":"Arboleya S, Watkins C, Stanton C, Ross RP. Gut bifdobacteria populations in human health and aging. Front Microbiol. 2016;7:1\u20139.","journal-title":"Front Microbiol."},{"key":"1735_CR54","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","volume":"9","author":"HJ Flint","year":"2012","unstructured":"Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol. 2012;9:577\u201389.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"1735_CR55","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1136\/gutjnl-2015-309990","volume":"65","author":"JR Marchesi","year":"2016","unstructured":"Marchesi JR, Adams DH, Fava F, Hermes GDA, Hirschfield GM, Hold G, et al. The gut microbiota and host health: a new clinical frontier. Gut. 2016;65:330\u20139.","journal-title":"Gut"},{"key":"1735_CR56","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.celrep.2015.03.049","volume":"11","author":"I Mart\u00ednez","year":"2015","unstructured":"Mart\u00ednez I, Stegen JC, Maldonado-G\u00f3mez MX, Eren AM, Siba PM, Greenhill AR, et al. The gut microbiota of rural papua new guineans: composition, diversity patterns, and ecological processes. Cell Rep. 2015;11:527\u201338.","journal-title":"Cell Rep."},{"key":"1735_CR57","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.1208344","volume":"334","author":"GD Wu","year":"2011","unstructured":"Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105\u20138.","journal-title":"Science"},{"issue":"6","key":"1735_CR58","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","volume":"22","author":"P Kovatcheva-Datchary","year":"2015","unstructured":"Kovatcheva-Datchary P, Nilsson A, Akrami R, ShiuanLee Y, Vadder FD, Arora T, et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of prevotella. Cell Metab. 2015;22(6):971\u201382.","journal-title":"Cell Metab"},{"issue":"1","key":"1735_CR59","first-page":"5","volume":"12","author":"U Hofer","year":"2014","unstructured":"Hofer U. Microbiome: pro-infammatory prevotella? Nat Rev Microbiol. 2014;12(1):5.","journal-title":"Nat Rev Microbiol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-018-1735-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-018-1735-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-018-1735-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:17:13Z","timestamp":1775305033000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-018-1735-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1735"],"URL":"https:\/\/doi.org\/10.1186\/s12967-018-1735-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/417709","asserted-by":"object"}]},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"25 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"353"}}