{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:21:00Z","timestamp":1793830860632,"version":"4.6.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Mega-Project for Infectious Disease","award":["2018ZX10301408"],"award-info":[{"award-number":["2018ZX10301408"]}]},{"name":"The National Key Research and Development program of China","award":["2016YFD0500307"],"award-info":[{"award-number":["2016YFD0500307"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772205"],"award-info":[{"award-number":["81772205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAMS innovation fund for Medical Sciences","award":["2016-I2M-2-002"],"award-info":[{"award-number":["2016-I2M-2-002"]}]},{"name":"CAMS innovation fund for Medical Sciences","award":["2018-I2M-3-004"],"award-info":[{"award-number":["2018-I2M-3-004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-1777-7","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T09:02:51Z","timestamp":1548061371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers"],"prefix":"10.1186","volume":"17","author":[{"given":"Jiwei","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"1777_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fimmu.2013.00058","volume":"4","author":"N Imami","year":"2013","unstructured":"Imami N, Westrop SJ, Grageda N, Herasimtschuk AA. Long-term non-progression and broad HIV-1-specific proliferative T-cell responses. Front Immunol. 2013;4:58.","journal-title":"Front Immunol"},{"issue":"4","key":"1777_CR2","first-page":"195","volume":"9","author":"NK Saksena","year":"2007","unstructured":"Saksena NK, Rodes B, Wang B, Soriano V. Elite HIV controllers: myth or reality? AIDS Rev. 2007;9(4):195\u2013207.","journal-title":"AIDS Rev"},{"issue":"9","key":"1777_CR3","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1097\/QAD.0b013e32832b44c8","volume":"23","author":"S Grabar","year":"2009","unstructured":"Grabar S, Selinger-Leneman H, Abgrall S, Pialoux G, Weiss L, Costagliola D. Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV. Aids. 2009;23(9):1163\u20139.","journal-title":"Aids."},{"issue":"2","key":"1777_CR4","first-page":"245","volume":"90","author":"E Gonzalo-Gil","year":"2017","unstructured":"Gonzalo-Gil E, Ikediobi U, Sutton RE. Mechanisms of virologic control and clinical characteristics of HIV+\u2009elite\/viremic controllers. Yale J Biol Med. 2017;90(2):245\u201359.","journal-title":"Yale J Biol Med"},{"issue":"5","key":"1777_CR5","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1128\/JVI.02165-06","volume":"81","author":"JN Blankson","year":"2007","unstructured":"Blankson JN, Bailey JR, Thayil S, Yang HC, Lassen K, Lai J, et al. Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J Virol. 2007;81(5):2508\u201318.","journal-title":"J Virol"},{"issue":"2","key":"1777_CR6","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1006\/viro.2002.1706","volume":"304","author":"B Wang","year":"2002","unstructured":"Wang B, Dyer WB, Zaunders JJ, Mikhail M, Sullivan JS, Williams L, et al. Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infection. Virology. 2002;304(2):246\u201364.","journal-title":"Virology"},{"issue":"10","key":"1777_CR7","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1172\/JCI16233","volume":"111","author":"JJ Lum","year":"2003","unstructured":"Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, et al. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Investig. 2003;111(10):1547\u201354.","journal-title":"J Clin Investig"},{"issue":"5","key":"1777_CR8","first-page":"1021","volume":"145","author":"T Yamada","year":"2000","unstructured":"Yamada T, Iwamoto A. Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection. Adv Virol. 2000;145(5):1021\u20137.","journal-title":"Adv Virol"},{"key":"1777_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1742-4690-5-67","volume":"5","author":"L Caly","year":"2008","unstructured":"Caly L, Saksena NK, Piller SC, Jans DA. Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor. Retrovirology. 2008;5:67.","journal-title":"Retrovirology."},{"issue":"4","key":"1777_CR10","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1056\/NEJM199501263320405","volume":"332","author":"F Kirchhoff","year":"1995","unstructured":"Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med. 1995;332(4):228\u201332.","journal-title":"N Engl J Med"},{"issue":"5","key":"1777_CR11","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/JVI.72.5.3646-3657.1998","volume":"72","author":"R Salvi","year":"1998","unstructured":"Salvi R, Garbuglia AR, Di Caro A, Pulciani S, Montella F, Benedetto A. Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor. J Virol. 1998;72(5):3646\u201357.","journal-title":"J Virol"},{"issue":"7","key":"1777_CR12","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1128\/JVI.01959-09","volume":"84","author":"R Pushker","year":"2010","unstructured":"Pushker R, Jacque JM, Shields DC. Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression. J Virol. 2010;84(7):3644\u201353.","journal-title":"J Virol"},{"issue":"2","key":"1777_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1006\/viro.1999.9783","volume":"259","author":"A Brambilla","year":"1999","unstructured":"Brambilla A, Turchetto L, Gatti A, Bovolenta C, Veglia F, Santagostino E, et al. Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection. Virology. 1999;259(2):349\u201368.","journal-title":"Virology"},{"issue":"11","key":"1777_CR14","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1128\/JVI.69.11.6758-6769.1995","volume":"69","author":"NL Michael","year":"1995","unstructured":"Michael NL, Chang G, d\u2019Arcy LA, Tseng CJ, Birx DL, Sheppard HW. Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression. J Virol. 1995;69(11):6758\u201369.","journal-title":"J Virol"},{"issue":"17","key":"1777_CR15","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1089\/088922299309865","volume":"15","author":"DV Mourich","year":"1999","unstructured":"Mourich DV, Lee S, Reyes-Teran G, Mackewicz CE, Levy JA. Lack of differences in nef alleles among HIV-infected asymptomatic long-term survivors and those who progressed to disease. AIDS Res Hum Retroviruses. 1999;15(17):1573\u20135.","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"2","key":"1777_CR16","doi-asserted-by":"publisher","first-page":"e31928","DOI":"10.1371\/journal.pone.0031928","volume":"7","author":"M Pernas","year":"2012","unstructured":"Pernas M, Casado C, Arcones C, Llano A, Sanchez-Merino V, Mothe B, et al. Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller. PLoS ONE. 2012;7(2):e31928.","journal-title":"PLoS ONE"},{"issue":"5","key":"1777_CR17","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1128\/jvi.76.5.2298-2305.2002","volume":"76","author":"BH Edwards","year":"2002","unstructured":"Edwards BH, Bansal A, Sabbaj S, Bakari J, Mulligan MJ, Goepfert PA. Magnitude of functional CD8+\u2009T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol. 2002;76(5):2298\u2013305.","journal-title":"J Virol"},{"issue":"6","key":"1777_CR18","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1084\/jem.20090365","volume":"206","author":"N Goonetilleke","year":"2009","unstructured":"Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, et al. The first T cell response to transmitted\/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med. 2009;206(6):1253\u201372.","journal-title":"J Exp Med"},{"issue":"18","key":"1777_CR19","doi-asserted-by":"publisher","first-page":"9334","DOI":"10.1128\/JVI.00460-11","volume":"85","author":"CT Berger","year":"2011","unstructured":"Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, et al. High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. J Virol. 2011;85(18):9334\u201345.","journal-title":"J Virol"},{"issue":"7","key":"1777_CR20","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1128\/JVI.07034-11","volume":"86","author":"S Ferrando-Martinez","year":"2012","unstructured":"Ferrando-Martinez S, Casazza JP, Leal M, Machmach K, Munoz-Fernandez MA, Viciana P, et al. Differential Gag-specific polyfunctional T cell maturation patterns in HIV-1 elite controllers. J Virol. 2012;86(7):3667\u201374.","journal-title":"J Virol"},{"issue":"6","key":"1777_CR21","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.immuni.2008.12.002","volume":"29","author":"JN Blankson","year":"2008","unstructured":"Blankson JN, Siliciano RF. Elite suppression of HIV-1 replication. Immunity. 2008;29(6):845\u20137.","journal-title":"Immunity"},{"issue":"12","key":"1777_CR22","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1182\/blood-2005-12-4818","volume":"107","author":"MR Betts","year":"2006","unstructured":"Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+\u2009T cells. Blood. 2006;107(12):4781\u20139.","journal-title":"Blood"},{"issue":"17","key":"1777_CR23","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.1182\/blood-2008-10-182709","volume":"113","author":"AL Ferre","year":"2009","unstructured":"Ferre AL, Hunt PW, Critchfield JW, Young DH, Morris MM, Garcia JC, et al. Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood. 2009;113(17):3978\u201389.","journal-title":"Blood"},{"issue":"10","key":"1777_CR24","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1084\/jem.20070784","volume":"204","author":"JR Almeida","year":"2007","unstructured":"Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, et al. Superior control of HIV-1 replication by CD8+\u2009T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med. 2007;204(10):2473\u201385.","journal-title":"J Exp Med"},{"issue":"7","key":"1777_CR25","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nri3478","volume":"13","author":"BD Walker","year":"2013","unstructured":"Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13(7):487\u201398.","journal-title":"Nat Rev Immunol"},{"issue":"22","key":"1777_CR26","doi-asserted-by":"publisher","first-page":"14169","DOI":"10.1128\/JVI.79.22.14169-14178.2005","volume":"79","author":"B Emu","year":"2005","unstructured":"Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, et al. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol. 2005;79(22):14169\u201378.","journal-title":"J Virol"},{"issue":"2","key":"1777_CR27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.clim.2011.02.008","volume":"139","author":"M Salgado","year":"2011","unstructured":"Salgado M, Rallon NI, Rodes B, Lopez M, Soriano V, Benito JM. Long-term non-progressors display a greater number of Th17 cells than HIV-infected typical progressors. Clinical immunology. 2011;139(2):110\u20134.","journal-title":"Clinical immunology."},{"key":"1777_CR28","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ebiom.2017.05.029","volume":"21","author":"A Rouers","year":"2017","unstructured":"Rouers A, Klingler J, Su B, Samri A, Laumond G, Even S, et al. HIV-specific B cell frequency correlates with neutralization breadth in patients naturally controlling HIV-infection. EBioMedicine. 2017;21:158\u201369.","journal-title":"EBioMedicine."},{"issue":"2","key":"1777_CR29","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.virol.2012.10.026","volume":"435","author":"JQ Wu","year":"2013","unstructured":"Wu JQ, Sasse TR, Wolkenstein G, Conceicao V, Saksena MM, Soedjono M, et al. Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology. 2013;435(2):308\u201319.","journal-title":"Virology"},{"issue":"3","key":"1777_CR30","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clim.2007.05.016","volume":"124","author":"GM O\u2019Connor","year":"2007","unstructured":"O\u2019Connor GM, Holmes A, Mulcahy F, Gardiner CM. Natural Killer cells from long-term non-progressor HIV patients are characterized by altered phenotype and function. Clin Immunol. 2007;124(3):277\u201383.","journal-title":"Clin Immunol"},{"issue":"6","key":"1777_CR31","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.chom.2014.05.011","volume":"15","author":"J Leng","year":"2014","unstructured":"Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, et al. A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers. Cell Host Microbe. 2014;15(6):717\u201328.","journal-title":"Cell Host Microbe"},{"issue":"6","key":"1777_CR32","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/QAD.0000000000001022","volume":"30","author":"EM Leitman","year":"2016","unstructured":"Leitman EM, Willberg CB, De Burgh-Thomas A, Streeck H, Goulder PJ, Matthews PC. Subdominant Gag-specific anti-HIV efficacy in an HLA-B*57-positive elite controller. Aids. 2016;30(6):972\u20134.","journal-title":"Aids."},{"issue":"1","key":"1777_CR33","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12879-018-2961-8","volume":"18","author":"Y Moosa","year":"2018","unstructured":"Moosa Y, Tanko RF, Ramsuran V, Singh R, Madzivhandila M, Yende-Zuma N, et al. Case report: mechanisms of HIV elite control in two African women. BMC Infect Dis. 2018;18(1):54.","journal-title":"BMC Infect Dis"},{"issue":"3","key":"1777_CR34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood.V93.3.936","volume":"93","author":"M Magierowska","year":"1999","unstructured":"Magierowska M, Theodorou I, Debre P, Sanson F, Autran B, Riviere Y, et al. Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood. 1999;93(3):936\u201341.","journal-title":"Blood"},{"issue":"10","key":"1777_CR35","doi-asserted-by":"publisher","first-page":"7406","DOI":"10.4049\/jimmunol.177.10.7406","volume":"177","author":"H Horton","year":"2006","unstructured":"Horton H, Frank I, Baydo R, Jalbert E, Penn J, Wilson S, et al. Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection. J Immunol. 2006;177(10):7406\u201315.","journal-title":"J Immunol"},{"issue":"4","key":"1777_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ng934","volume":"31","author":"MP Martin","year":"2002","unstructured":"Martin MP, Gao X, Lee JH, Nelson GW, Detels R, Goedert JJ, et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002;31(4):429\u201334.","journal-title":"Nat Genet"},{"issue":"6","key":"1777_CR37","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ng2035","volume":"39","author":"MP Martin","year":"2007","unstructured":"Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet. 2007;39(6):733\u201340.","journal-title":"Nat Genet"},{"issue":"5","key":"1777_CR38","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1093\/infdis\/jir833","volume":"205","author":"J Guergnon","year":"2012","unstructured":"Guergnon J, Dalmasso C, Broet P, Meyer L, Westrop SJ, Imami N, et al. Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection. J Infect Dis. 2012;205(5):718\u201324.","journal-title":"J Infect Dis"},{"issue":"6010","key":"1777_CR39","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1126\/science.1195271","volume":"330","author":"F Pereyra","year":"2010","unstructured":"International HIVCS, Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010;330(6010):1551\u20137.","journal-title":"Science."},{"issue":"9","key":"1777_CR40","doi-asserted-by":"publisher","first-page":"e184","DOI":"10.1371\/journal.pmed.0050184","volume":"5","author":"A Ramasamy","year":"2008","unstructured":"Ramasamy A, Mondry A, Holmes CC, Altman DG. Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS Med. 2008;5(9):e184.","journal-title":"PLoS Med"},{"issue":"19","key":"1777_CR41","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1093\/bioinformatics\/bts485","volume":"28","author":"X Wang","year":"2012","unstructured":"Wang X, Kang DD, Shen K, Song C, Lu S, Chang LC, et al. An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection. Bioinformatics. 2012;28(19):2534\u20136.","journal-title":"Bioinformatics"},{"issue":"43","key":"1777_CR42","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545\u201350.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1777_CR43","first-page":"17","volume":"4","author":"B Zhang","year":"2005","unstructured":"Zhang B, Horvath S. A general framework for weighted gene co-expression network analysis. Stati Appl Genet Mol Biol. 2005;4:17.","journal-title":"Stati Appl Genet Mol Biol"},{"key":"1777_CR44","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 2008;9:559.","journal-title":"BMC Bioinform"},{"issue":"1","key":"1777_CR45","doi-asserted-by":"publisher","first-page":"8067","DOI":"10.1038\/s41598-018-26318-3","volume":"8","author":"L Ma","year":"2018","unstructured":"Ma L, Zhang Z, Liu Z, Pan Q, Wang J, Li X, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8(1):8067.","journal-title":"Sci Rep."},{"key":"1777_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/v9050105","volume":"9","author":"J Ding","year":"2017","unstructured":"Ding J, Zhao J, Yang Z, Ma L, Mi Z, Wu Y, et al. Microbial natural product alternariol 5-O-methyl ether inhibits HIV-1 integration by blocking nuclear import of the pre-integration complex. Viruses. 2017;9:5.","journal-title":"Viruses."},{"issue":"7422","key":"1777_CR47","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nature11433","volume":"491","author":"M Li","year":"2012","unstructured":"Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012;491(7422):125\u20138.","journal-title":"Nature"},{"issue":"3","key":"1777_CR48","doi-asserted-by":"publisher","first-page":"e58768","DOI":"10.1371\/journal.pone.0058768","volume":"8","author":"C Brombin","year":"2013","unstructured":"Brombin C, Diomede L, Tudor D, Drillet AS, Pastori C, Poli E, et al. A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients. PLoS ONE. 2013;8(3):e58768.","journal-title":"PLoS ONE"},{"key":"1777_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2016.02.014","volume":"493","author":"Z Liang","year":"2016","unstructured":"Liang Z, Liu R, Zhang H, Zhang S, Hu X, Tan J, et al. GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. Virology. 2016;493:1\u201311.","journal-title":"Virology"},{"issue":"6","key":"1777_CR50","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1172\/JCI45235","volume":"121","author":"M Rotger","year":"2011","unstructured":"Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger SE, Martinez R, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Investig. 2011;121(6):2391\u2013400.","journal-title":"J Clin Investig"},{"issue":"28","key":"1777_CR51","doi-asserted-by":"publisher","first-page":"9860","DOI":"10.1073\/pnas.0503463102","volume":"102","author":"S Sankaran","year":"2005","unstructured":"Sankaran S, Guadalupe M, Reay E, George MD, Flamm J, Prindiville T, et al. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc Natl Acad Sci USA. 2005;102(28):9860\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1777_CR52","doi-asserted-by":"publisher","first-page":"e1000781","DOI":"10.1371\/journal.ppat.1000781","volume":"6","author":"M Rotger","year":"2010","unstructured":"Rotger M, Dang KK, Fellay J, Heinzen EL, Feng S, Descombes P, et al. Genome-wide mRNA expression correlates of viral control in CD4+\u2009T-cells from HIV-1-infected individuals. PLoS Pathog. 2010;6(2):e1000781.","journal-title":"PLoS Pathog"},{"issue":"7","key":"1777_CR53","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrmicro3449","volume":"13","author":"T Doyle","year":"2015","unstructured":"Doyle T, Goujon C, Malim MH. HIV-1 and interferons: who\u2019s interfering with whom? Nat Rev Microbiol. 2015;13(7):403\u201313.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"1777_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11904-014-0244-6","volume":"12","author":"SE Bosinger","year":"2015","unstructured":"Bosinger SE, Utay NS. Type I interferon: understanding its role in HIV pathogenesis and therapy. Current HIV\/AIDS reports. 2015;12(1):41\u201353.","journal-title":"Current HIV\/AIDS reports."},{"key":"1777_CR55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1172\/jci.insight.94366","volume":"2","author":"L Cheng","year":"2017","unstructured":"Cheng L, Yu H, Li G, Li F, Ma J, Li J, et al. Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection. JCI Insight. 2017;2:12.","journal-title":"JCI Insight."},{"key":"1777_CR56","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00575-18","author":"LL Boeijen","year":"2018","unstructured":"Boeijen LL, Hou J, de Groen RA, Verbon A, Boonstra A. Persistent replication of HIV, HCV and HBV results in distinct gene expression profiles by human NK cells. J Virol. 2018. \n                    https:\/\/doi.org\/10.1128\/JVI.00575-18\n                    \n                  .","journal-title":"J Virol."}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1777-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-1777-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1777-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T19:05:29Z","timestamp":1579547129000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-1777-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1777"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-1777-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]},"assertion":[{"value":"3 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"35"}}