{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:54:09Z","timestamp":1790258049654,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zurich Center for Integrative Human Physiology"},{"name":"Heartbay Foundation","award":["None"],"award-info":[{"award-number":["None"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-1843-1","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T14:04:34Z","timestamp":1552917874000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hyperoxia-induced lung structure\u2013function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model"],"prefix":"10.1186","volume":"17","author":[{"given":"Francesco","family":"Greco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Wiegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Wellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-160X","authenticated-orcid":false,"given":"Vincenzo","family":"Cannizzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"issue":"3","key":"1843_CR1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/175114371401500303","volume":"15","author":"N Ridler","year":"2014","unstructured":"Ridler N, Plumb J, Grocott M. Oxygen therapy in critical illness: friend or foe? A review of oxygen therapy in selected acute illnesses. J Intens Care Soc. 2014;15(3):190\u20138.","journal-title":"J Intens Care Soc"},{"issue":"12\u201328","key":"1843_CR2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jpeds.2017.01.002","volume":"181","author":"SH Abman","year":"2017","unstructured":"Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Nelin LD. Interdisciplinary care of children with severe bronchopulmonary dysplasia. J Pediatr. 2017;181(12\u201328):e1.","journal-title":"J Pediatr"},{"issue":"9","key":"1843_CR3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jama.289.9.1124","volume":"289","author":"B Schmidt","year":"2003","unstructured":"Schmidt B. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18\u00a0months: results from the trial of indomethacin prophylaxis in preterms. JAMA. 2003;289(9):1124.","journal-title":"JAMA"},{"issue":"1","key":"1843_CR4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1469-8749.2007.02011.x","volume":"50","author":"S-F Jeng","year":"2008","unstructured":"Jeng S-F, Hsu C-H, Tsao P-N, Chou H-C, Lee W-T, Kao H-A, Hung H-Y, Chang J-H, Chiu N-C, Hsieh W-S. Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very-low-birthweight infants. Dev Med Child Neurol. 2008;50(1):51\u20137.","journal-title":"Dev Med Child Neurol"},{"issue":"6","key":"1843_CR5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.siny.2009.08.002","volume":"14","author":"MM Laughon","year":"2009","unstructured":"Laughon MM, Brian Smith P, Bose C. Prevention of bronchopulmonary dysplasia. Semin Fetal Neonat Med. 2009;14(6):374\u201382.","journal-title":"Semin Fetal Neonat Med"},{"issue":"6","key":"1843_CR6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3345\/kjp.2010.53.6.688","volume":"53","author":"GB Kim","year":"2010","unstructured":"Kim GB. Pulmonary hypertension in infants with bronchopulmonary dysplasia. Korean J Pediatr. 2010;53(6):688.","journal-title":"Korean J Pediatr"},{"issue":"1","key":"1843_CR7","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2016-209729","volume":"72","author":"BR O\u2019Driscoll","year":"2017","unstructured":"O\u2019Driscoll BR, Howard LS, Earis J, Mak V. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017;72(1):ii1\u201390.","journal-title":"Thorax"},{"key":"1843_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2834956","volume":"2017","author":"J-L Vincent","year":"2017","unstructured":"Vincent J-L, Taccone FS, He X. Harmful effects of hyperoxia in postcardiac arrest, sepsis, traumatic brain injury, or stroke: the importance of individualized oxygen therapy in critically ill patients. Can Respir J Hindawi Ltd. 2017;2017:1\u20137.","journal-title":"Can Respir J Hindawi Ltd"},{"issue":"12","key":"1843_CR9","first-page":"L948","volume":"307","author":"M O\u2019Reilly","year":"2014","unstructured":"O\u2019Reilly M, Th\u00e9baud B. Animal models of bronchopulmonary dysplasia. The term rat models. Am J Physiol. 2014;307(12):L948\u201358.","journal-title":"Am J Physiol"},{"issue":"10","key":"1843_CR10","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1164\/rccm.200909-1361OC","volume":"182","author":"YP Visser de","year":"2010","unstructured":"de Visser YP, Walther FJ, Laghmani EH, van der Laarse A, Wagenaar GTM. Apelin attenuates hyperoxic lung and heart injury in neonatal rats. Am J Respir Crit Care Med. 2010;182(10):1239\u201350.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"1843_CR11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000092868","volume":"89","author":"PH Burri","year":"2006","unstructured":"Burri PH. Structural aspects of postnatal lung development\u2014alveolar formation and growth. Neonatology. 2006;89(4):313\u201322.","journal-title":"Neonatology"},{"issue":"4","key":"1843_CR12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.siny.2010.03.009","volume":"15","author":"V Bhandari","year":"2010","unstructured":"Bhandari V. Hyperoxia-derived lung damage in preterm infants. Semin Fetal Neonat Med. 2010;15(4):223\u20139.","journal-title":"Semin Fetal Neonat Med"},{"key":"1843_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/497841","volume":"2011","author":"C Zaragoza","year":"2011","unstructured":"Zaragoza C, Gomez-Guerrero C, Martin-Ventura JL, Blanco-Colio L, Lavin B, Mallavia B, Tarin C, Mas S, Ortiz A, Egido J. Animal models of cardiovascular diseases. J Biomed Biotechnol. 2011;2011:1\u201313.","journal-title":"J Biomed Biotechnol"},{"issue":"5","key":"1843_CR14","first-page":"L924","volume":"311","author":"N Ambalavanan","year":"2016","unstructured":"Ambalavanan N, Morty RE. Searching for better animal models of BPD: a perspective. Am J Physiol. 2016;311(5):L924\u20137.","journal-title":"Am J Physiol"},{"issue":"3","key":"1843_CR15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00441-016-2534-3","volume":"367","author":"C Nardiello","year":"2016","unstructured":"Nardiello C, Mi\u017e\u00edkov\u00e1 I, Morty RE. Looking ahead: where to next for animal models of bronchopulmonary dysplasia? Cell Tissue Res. 2016;367(3):457\u201368.","journal-title":"Cell Tissue Res"},{"issue":"1","key":"1843_CR16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12931-015-0233-3","volume":"16","author":"L Taguchi","year":"2015","unstructured":"Taguchi L, Pinheiro NM, Olivo CR, Choqueta-Toledo A, Grecco SS, Lopes FD, Caperuto LC, Martins MA, Tiberio IF, C\u00e2mara NO, Lago JHG, Prado CM. A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-\u03baB, oxidative stress and metalloproteinases. Respir Res. 2015;16(1):79.","journal-title":"Respir Res"},{"issue":"1","key":"1843_CR17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.expneurol.2012.03.002","volume":"235","author":"T Schmitz","year":"2012","unstructured":"Schmitz T, Endesfelder S, Reinert M-C, Klinker F, M\u00fcller S, B\u00fchrer C, Liebetanz D. Adolescent hyperactivity and impaired coordination after neonatal hyperoxia. Exp Neurol. 2012;235(1):374\u20139.","journal-title":"Exp Neurol"},{"issue":"3","key":"1843_CR18","first-page":"L263","volume":"262","author":"MB Hershenson","year":"1992","unstructured":"Hershenson MB, Aghili S, Punjabi N, Hernandez C, Ray DW, Garland A, Glagov S, Solway J. Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats. Am J Physiol. 1992;262(3):L263\u20139.","journal-title":"Am J Physiol"},{"issue":"2","key":"1843_CR19","first-page":"L227","volume":"269","author":"JL Szarek","year":"1995","unstructured":"Szarek JL, Ramsay HL, Andringa A, Miller ML. Time course of airway hyperresponsiveness and remodeling induced by hyperoxia in rats. Am J Physiol. 1995;269(2):L227\u201333.","journal-title":"Am J Physiol"},{"issue":"1","key":"1843_CR20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","volume":"1148","author":"R Jankord","year":"2008","unstructured":"Jankord R, Herman JP. Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress. Ann N Y Acad Sci. 2008;1148(1):64\u201373.","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"1843_CR21","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3390\/ijms17101776","volume":"17","author":"J Jim\u00e9nez","year":"2016","unstructured":"Jim\u00e9nez J, Richter J, Nagatomo T, Salaets T, Quarck R, Wagennar A, Wan H, Vanoirbeek J, Deprest J, Toelen J. Progressive vascular functional and structural damage in a bronchopulmonary dysplasia model in preterm rabbits exposed to hyperoxia. Int J Mol Sci. 2016;17(10):1776.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1843_CR22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/pr.2013.58","volume":"74","author":"CW Choi","year":"2013","unstructured":"Choi CW, Kim BI, Mason SN, Potts-Kant EN, Brahmajothi MV, Auten RL. Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats. Pediatr Res. 2013;74(1):11\u20138.","journal-title":"Pediatr Res"},{"issue":"3","key":"1843_CR23","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1152\/jappl.2000.89.3.908","volume":"89","author":"RFM Gomes","year":"2000","unstructured":"Gomes RFM, Shen X, Ramchandani R, Tepper RS, Bates JHT. Comparative respiratory system mechanics in rodents. J Appl Physiol. 2000;89(3):908\u201316.","journal-title":"J Appl Physiol"},{"issue":"4","key":"1843_CR24","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/jrr\/rrt234","volume":"55","author":"Z-Y Hong","year":"2014","unstructured":"Hong Z-Y, Eun SH, Park K, Choi WH, Lee JI, Lee EJ, Lee JM, Story MD, Cho J. Development of a small animal model to simulate clinical stereotactic body radiotherapy-induced central and peripheral lung injuries. J Rad Res. 2014;55(4):648\u201357.","journal-title":"J Rad Res"},{"key":"1843_CR25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-62703-496-8_16","volume":"1032","author":"JM Hartney","year":"2013","unstructured":"Hartney JM, Robichaud A. Assessment of airway hyperresponsiveness in mouse models of allergic lung disease using detailed measurements of respiratory mechanics. Mouse Models Allerg Dis. 2013;1032:205\u201317.","journal-title":"Mouse Models Allerg Dis"},{"key":"1843_CR26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2013.03.012","volume":"61","author":"J Ni","year":"2013","unstructured":"Ni J, Dong Z, Han W, Kondrikov D, Su Y. The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis. Free Radical Biol Med. 2013;61:26\u201339.","journal-title":"Free Radical Biol Med"},{"issue":"24","key":"1843_CR27","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1074\/jbc.M114.558130","volume":"289","author":"LRK Penke","year":"2014","unstructured":"Penke LRK, Huang SK, White ES, Peters-Golden M. Prostaglandin E2 inhibits \u03b1-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A. J Biol Chem. 2014;289(24):17151\u201362.","journal-title":"J Biol Chem"},{"issue":"2","key":"1843_CR28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1152\/jappl.2001.91.2.737","volume":"91","author":"H Sakai","year":"2001","unstructured":"Sakai H, Ingenito EP, Mora R, Abbay S, Cavalcante FSA, Lutchen KR, Suki B. Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities. J Appl Physiol. 2001;91(2):737\u201347.","journal-title":"J Appl Physiol"},{"issue":"5","key":"1843_CR29","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1152\/jappl.1996.80.5.1696","volume":"80","author":"KR Lutchen","year":"1996","unstructured":"Lutchen KR, Greenstein JL, Suki B. How inhomogeneities and airway walls affect frequency dependence and separation of airway and tissue properties. J Appl Physiol. 1996;80(5):1696\u2013707.","journal-title":"J Appl Physiol"},{"issue":"5","key":"1843_CR30","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1152\/jappl.1997.82.5.1616","volume":"82","author":"CW Thorpe","year":"1997","unstructured":"Thorpe CW, Bates JHT. Effect of stochastic heterogeneity on lung impedance during acute bronchoconstriction: a model analysis. J Appl Physiol. 1997;82(5):1616\u201325.","journal-title":"J Appl Physiol"},{"issue":"3","key":"1843_CR31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s10439-005-9056-6","volume":"34","author":"JHT Bates","year":"2006","unstructured":"Bates JHT, Allen GB. The estimation of lung mechanics parameters in the presence of pathology: a theoretical analysis. Ann Biomed Eng. 2006;34(3):384\u201392.","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"1843_CR32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1152\/japplphysiol.00270.2003","volume":"96","author":"G Allen","year":"2004","unstructured":"Allen G, Bates JHT. Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury. J Appl Physiol. 2004;96(1):293\u2013300.","journal-title":"J Appl Physiol"},{"issue":"3","key":"1843_CR33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1165\/rcmb.2010-0473OC","volume":"45","author":"H Hamakawa","year":"2011","unstructured":"Hamakawa H, Bartol\u00e1k-Suki E, Parameswaran H, Majumdar A, Lutchen KR, Suki B. Structure\u2013function relations in an elastase-induced mouse model of emphysema. Am J Respir Cell Mol Biol. 2011;45(3):517\u201324.","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"1843_CR34","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1152\/japplphysiol.00587.2011","volume":"112","author":"J Tolnai","year":"2012","unstructured":"Tolnai J, Szabari MV, Albu G, Ma\u00e1r BA, Parameswaran H, Bartol\u00e1k-Suki E, Hantos Z. Functional and morphological assessment of early impairment of airway function in a rat model of emphysema. J Appl Physiol. 2012;112(11):1932\u20139.","journal-title":"J Appl Physiol"},{"issue":"6","key":"1843_CR35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1165\/rcmb.2014-0422OC","volume":"53","author":"J Jagarapu","year":"2015","unstructured":"Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, Wu S. Efficacy of leukadherin-1 in the prevention of hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol. 2015;53(6):793\u2013801.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1843_CR36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fmed.2016.00021","volume":"3","author":"CM Alvira","year":"2016","unstructured":"Alvira CM. Aberrant pulmonary vascular growth and remodeling in bronchopulmonary dysplasia. Front Med. 2016;3:21.","journal-title":"Front Med"},{"issue":"6","key":"1843_CR37","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/pr.2016.164","volume":"80","author":"S Wedgwood","year":"2016","unstructured":"Wedgwood S, Warford C, Agvateesiri SC, Thai P, Berkelhamer SK, Perez M, Underwood MA, Steinhorn RH. Postnatal growth restriction augments oxygen-induced pulmonary hypertension in a neonatal rat model of bronchopulmonary dysplasia. Pediatr Res. 2016;80(6):894\u2013902.","journal-title":"Pediatr Res"},{"issue":"1","key":"1843_CR38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1089\/ped.2013.0323","volume":"27","author":"CD Baker","year":"2014","unstructured":"Baker CD, Abman SH, Mourani PM. Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Pediatr Allerg Immunol Pulmonol. 2014;27(1):8\u201316.","journal-title":"Pediatr Allerg Immunol Pulmonol"},{"issue":"4","key":"1843_CR39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000438979","volume":"108","author":"P Baumann","year":"2015","unstructured":"Baumann P, Fouzas S, Pramana I, Grass B, Niesse O, B\u00fchrer C, Spanaus K, Wellmann S. Plasma proendothelin-1 as an early marker of bronchopulmonary dysplasia. Neonatology. 2015;108(4):293\u20136.","journal-title":"Neonatology."}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1843-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-1843-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1843-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:19:38Z","timestamp":1584404378000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-1843-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1843"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-1843-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]},"assertion":[{"value":"18 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"91"}}