{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:12:42Z","timestamp":1790651562730,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-2-0036"],"award-info":[{"award-number":["W81XWH-16-2-0036"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-1877-4","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T08:06:34Z","timestamp":1555488394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production"],"prefix":"10.1186","volume":"17","author":[{"given":"Alpa","family":"Trivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Gibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Valanoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Vivona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximillian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mars","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawyer","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibani","family":"Pati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"key":"1877_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/1741-7015-11-146","volume":"11","author":"G Siegel","year":"2013","unstructured":"Siegel G, Kluba T, Hermanutz-Klein U, Bieback K, Northoff H, Schafer R. Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells. BMC Med. 2013;11:146.","journal-title":"BMC Med"},{"issue":"4","key":"1877_CR2","first-page":"393","volume":"3","author":"AJ Friedenstein","year":"1970","unstructured":"Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3(4):393\u2013403.","journal-title":"Cell Tissue Kinet"},{"issue":"2","key":"1877_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5966\/sctm.2012-0099","volume":"2","author":"DL Deskins","year":"2013","unstructured":"Deskins DL, Bastakoty D, Saraswati S, Shinar A, Holt GE, Young PP. Human mesenchymal stromal cells: identifying assays to predict potency for therapeutic selection. Stem Cells Transl Med. 2013;2(2):151\u20138.","journal-title":"Stem Cells Transl Med"},{"issue":"6","key":"1877_CR4","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","volume":"22","author":"J Galipeau","year":"2018","unstructured":"Galipeau J, Sensebe L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824\u201333.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"1877_CR5","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1111\/trf.14597","volume":"58","author":"AL Russell","year":"2018","unstructured":"Russell AL, Lefavor R, Durand N, Glover L, Zubair AC. Modifiers of mesenchymal stem cell quantity and quality. Transfusion. 2018;58(6):1434\u201340.","journal-title":"Transfusion"},{"issue":"3","key":"1877_CR6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/(SICI)1097-4644(19991201)75:3<424::AID-JCB8>3.0.CO;2-8","volume":"75","author":"DG Phinney","year":"1999","unstructured":"Phinney DG, Kopen G, Righter W, Webster S, Tremain N, Prockop DJ. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem. 1999;75(3):424\u201336.","journal-title":"J Cell Biochem"},{"issue":"26","key":"1877_CR7","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1056\/NEJMcp052699","volume":"353","author":"LB Ware","year":"2005","unstructured":"Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N Engl J Med. 2005;353(26):2788\u201396.","journal-title":"N Engl J Med"},{"issue":"8","key":"1877_CR8","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1111\/j.1582-4934.2011.01455.x","volume":"16","author":"WA Noort","year":"2012","unstructured":"Noort WA, Oerlemans MI, Rozemuller H, Feyen D, Jaksani S, Stecher D, et al. Human versus porcine mesenchymal stromal cells: phenotype, differentiation potential, immunomodulation and cardiac improvement after transplantation. J Cell Mol Med. 2012;16(8):1827\u201339.","journal-title":"J Cell Mol Med"},{"key":"1877_CR9","doi-asserted-by":"publisher","first-page":"9581350","DOI":"10.1155\/2016\/9581350","volume":"2016","author":"SA Ock","year":"2016","unstructured":"Ock SA, Baregundi Subbarao R, Lee YM, Lee JH, Jeon RH, Lee SL, et al. Comparison of immunomodulation properties of porcine mesenchymal stromal\/stem cells derived from the bone marrow, adipose tissue, and dermal skin tissue. Stem Cells Int. 2016;2016:9581350.","journal-title":"Stem Cells Int"},{"issue":"26","key":"1877_CR10","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1056\/NEJMoa050849","volume":"353","author":"AH Gershlick","year":"2005","unstructured":"Gershlick AH, Stephens-Lloyd A, Hughes S, Abrams KR, Stevens SE, Uren NG, et al. Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction. N Engl J Med. 2005;353(26):2758\u201368.","journal-title":"N Engl J Med"},{"issue":"18","key":"1877_CR11","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","volume":"342","author":"LB Ware","year":"2000","unstructured":"Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1334\u201349.","journal-title":"N Engl J Med"},{"issue":"161","key":"1877_CR12","doi-asserted-by":"publisher","first-page":"161ra50","DOI":"10.1126\/scitranslmed.3004660","volume":"4","author":"T Menge","year":"2012","unstructured":"Menge T, Zhao Y, Zhao J, Wataha K, Gerber M, Zhang J, et al. Mesenchymal stem cells regulate blood\u2013brain barrier integrity through TIMP3 release after traumatic brain injury. Sci Transl Med. 2012;4(161):161ra50.","journal-title":"Sci Transl Med"},{"issue":"1","key":"1877_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1089\/scd.2010.0013","volume":"20","author":"S Pati","year":"2011","unstructured":"Pati S, Khakoo AY, Zhao J, Jimenez F, Gerber MH, Harting M, et al. Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin\/beta-catenin signaling. Stem Cells Dev. 2011;20(1):89\u2013101.","journal-title":"Stem Cells Dev"},{"issue":"2","key":"1877_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/TA.0000000000001744","volume":"84","author":"DR Potter","year":"2018","unstructured":"Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, et al. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2018;84(2):245\u201356.","journal-title":"J Trauma Acute Care Surg"},{"issue":"2","key":"1877_CR15","doi-asserted-by":"publisher","first-page":"e0192363","DOI":"10.1371\/journal.pone.0192363","volume":"13","author":"S Pati","year":"2018","unstructured":"Pati S, Peng Z, Wataha K, Miyazawa B, Potter DR, Kozar RA. Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock. PLoS ONE. 2018;13(2):e0192363.","journal-title":"PLoS ONE"},{"issue":"2","key":"1877_CR16","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/stem.2551","volume":"35","author":"MA Matthay","year":"2017","unstructured":"Matthay MA, Pati S, Lee JW. Concise review: mesenchymal stem (stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis. Stem Cells. 2017;35(2):316\u201324.","journal-title":"Stem Cells"},{"issue":"2","key":"1877_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2014.01.013","volume":"14","author":"M Mendicino","year":"2014","unstructured":"Mendicino M, Bailey AM, Wonnacott K, Puri RK, Bauer SR. MSC-based product characterization for clinical trials: an FDA perspective. Cell Stem Cell. 2014;14(2):141\u20135.","journal-title":"Cell Stem Cell"},{"issue":"9","key":"1877_CR18","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3390\/ijms18091852","volume":"18","author":"FJ Vizoso","year":"2017","unstructured":"Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine. Int J Mol Sci. 2017;18(9):1852.","journal-title":"Int J Mol Sci"},{"issue":"14","key":"1877_CR19","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1089\/scd.2016.0048","volume":"25","author":"AO Pires","year":"2016","unstructured":"Pires AO, Mendes-Pinheiro B, Teixeira FG, Anjo SI, Ribeiro-Samy S, Gomes ED, et al. Unveiling the differences of secretome of human bone marrow mesenchymal stem cells, adipose tissue-derived stem cells, and human umbilical cord perivascular cells: a proteomic analysis. Stem Cells Dev. 2016;25(14):1073\u201383.","journal-title":"Stem Cells Dev"},{"issue":"4","key":"1877_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s12276-017-0014-9","volume":"50","author":"I Kang","year":"2018","unstructured":"Kang I, Lee BC, Choi SW, Lee JY, Kim JJ, Kim BE, et al. Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia. Exp Mol Med. 2018;50(4):35.","journal-title":"Exp Mol Med"},{"issue":"9 Suppl","key":"1877_CR21","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1097\/TP.0b013e3181a283ee","volume":"87","author":"M Dominici","year":"2009","unstructured":"Dominici M, Paolucci P, Conte P, Horwitz EM. Heterogeneity of multipotent mesenchymal stromal cells: from stromal cells to stem cells and vice versa. Transplantation. 2009;87(9 Suppl):S36\u201342.","journal-title":"Transplantation"},{"issue":"5","key":"1877_CR22","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/stem.2603","volume":"35","author":"DJ Kota","year":"2017","unstructured":"Kota DJ, Prabhakara KS, Toledano-Furman N, Bhattarai D, Chen Q, DiCarlo B, et al. Prostaglandin E2 indicates therapeutic efficacy of mesenchymal stem cells in experimental traumatic brain injury. Stem Cells. 2017;35(5):1416\u201330.","journal-title":"Stem Cells"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1877-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-1877-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1877-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T09:06:43Z","timestamp":1589533603000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-1877-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1877"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-1877-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,17]]},"assertion":[{"value":"3 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"128"}}