{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:07Z","timestamp":1787241967640,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-1956-6","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T06:02:46Z","timestamp":1561010566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk factors for the occurrence of visual-threatening posterior capsule opacification"],"prefix":"10.1186","volume":"17","author":[{"given":"Hung-Chi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Fa","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"1956_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0002-9394(03)00226-5","volume":"136","author":"RJ Olson","year":"2003","unstructured":"Olson RJ, Mamalis N, Werner L, Apple DJ. Cataract treatment in the beginning of the 21st century. Am J Ophthalmol. 2003;136:146\u201354.","journal-title":"Am J Ophthalmol"},{"key":"1956_CR2","first-page":"201","volume":"8","author":"M Chen","year":"2015","unstructured":"Chen M, Swinney C, Chen M. Comparing the intraoperative complication rate of femtosecond laser-assisted cataract surgery to traditional phacoemulsification. Int J Ophthalmol. 2015;8:201\u20133.","journal-title":"Int J Ophthalmol"},{"key":"1956_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/archophthalmol.2009.3","volume":"127","author":"N Awasthi","year":"2009","unstructured":"Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: a problem reduced but not yet eradicated. Arch Ophthalmol. 2009;127:555\u201362.","journal-title":"Arch Ophthalmol"},{"key":"1956_CR4","first-page":"45","volume":"3","author":"E Karahan","year":"2014","unstructured":"Karahan E, Er D, Kaynak S. An overview of Nd:YAG laser capsulotomy. Med Hypothesis Discov Innov Ophthalmol. 2014;3:45\u201350.","journal-title":"Med Hypothesis Discov Innov Ophthalmol"},{"key":"1956_CR5","doi-asserted-by":"publisher","first-page":"e77864","DOI":"10.1371\/journal.pone.0077864","volume":"8","author":"Y Li","year":"2013","unstructured":"Li Y, Wang J, Chen Z, Tang X. Effect of hydrophobic acrylic versus hydrophilic acrylic intraocular lens on posterior capsule opacification: meta-analysis. PLoS ONE. 2013;8:e77864.","journal-title":"PLoS ONE"},{"key":"1956_CR6","first-page":"cd003738","volume":"2","author":"O Findl","year":"2010","unstructured":"Findl O, Buehl W, Bauer P, Sycha T. Interventions for preventing posterior capsule opacification. Cochrane Database Syst Rev. 2010;2:cd003738.","journal-title":"Cochrane Database Syst Rev"},{"key":"1956_CR7","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/08820538.2017.1353815","volume":"33","author":"SM Llop","year":"2018","unstructured":"Llop SM, Papaliodis GN. Cataract surgery complications in uveitis patients: a review article. Semin Ophthalmol. 2018;33:64\u20139.","journal-title":"Semin Ophthalmol"},{"key":"1956_CR8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jcjo.2016.10.007","volume":"52","author":"H Chiu","year":"2017","unstructured":"Chiu H, Dang H, Cheung C, Khosla D, Arjmand P, Rabinovitch T, et al. Ten-year retrospective review of outcomes following phacoemulsification with intraocular lens implantation in patients with pre-existing uveitis. Can J Ophthalmol. 2017;52:175\u201380.","journal-title":"Can J Ophthalmol"},{"key":"1956_CR9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1442-9071.2006.01263.x","volume":"34","author":"MA Elgohary","year":"2006","unstructured":"Elgohary MA, Dowler JG. Incidence and risk factors of Nd:YAG capsulotomy after phacoemulsification in non-diabetic and diabetic patients. Clin Exp Ophthalmol. 2006;34:526\u201334.","journal-title":"Clin Exp Ophthalmol"},{"key":"1956_CR10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2017.08.001","volume":"60","author":"DY Shu","year":"2017","unstructured":"Shu DY, Lovicu FJ. Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. Prog Retin Eye Res. 2017;60:44\u201365.","journal-title":"Prog Retin Eye Res"},{"key":"1956_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.exer.2008.10.016","volume":"88","author":"IM Wormstone","year":"2009","unstructured":"Wormstone IM, Wang L, Liu CS. Posterior capsule opacification. Exp Eye Res. 2009;88:257\u201369.","journal-title":"Exp Eye Res"},{"issue":"Pt 3b","key":"1956_CR12","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/eye.1999.126","volume":"13","author":"JM Marcantonio","year":"1999","unstructured":"Marcantonio JM, Vrensen GF. Cell biology of posterior capsular opacification. Eye (Lond). 1999;13(Pt 3b):484\u20138.","journal-title":"Eye (Lond)"},{"key":"1956_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1136\/bjo.85.2.179","volume":"85","author":"P Hiscott","year":"2001","unstructured":"Hiscott P, Magee RM, Colthurst M, Lois N, Wong D. Clinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponade. Br J Ophthalmol. 2001;85:179\u201383.","journal-title":"Br J Ophthalmol"},{"key":"1956_CR14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.mehy.2012.12.042","volume":"80","author":"AC Lewis","year":"2013","unstructured":"Lewis AC. Interleukin-6 in the pathogenesis of posterior capsule opacification and the potential role for interleukin-6 inhibition in the future of cataract surgery. Med Hypotheses. 2013;80:466\u201374.","journal-title":"Med Hypotheses"},{"key":"1956_CR15","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1167\/iovs.16-19114","volume":"57","author":"SJ Das","year":"2016","unstructured":"Das SJ, Lovicu FJ, Collinson EJ. Nox4 plays a role in TGF-beta-dependent lens epithelial to mesenchymal transition. Invest Ophthalmol Vis Sci. 2016;57:3665\u201373.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1956_CR16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.2165\/00126839-200405030-00001","volume":"5","author":"MA Babizhayev","year":"2004","unstructured":"Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes. Drugs R D. 2004;5:125\u201339.","journal-title":"Drugs R D"},{"key":"1956_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jtos.2016.09.003","volume":"15","author":"K Tsubota","year":"2017","unstructured":"Tsubota K, Yokoi N, Shimazaki J, Watanabe H, Dogru M, Yamada M, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the asia dry eye society. Ocul Surf. 2017;15:65\u201376.","journal-title":"Ocul Surf"},{"key":"1956_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1097\/IAE.0000000000001392","volume":"37","author":"DS Boyer","year":"2017","unstructured":"Boyer DS, Schmidt-Erfurth U, van Lookeren Campagne M, Henry EC, Brittain C. The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target. Retina. 2017;37:819\u201335.","journal-title":"Retina"},{"key":"1956_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1159\/000228926","volume":"223","author":"Z Ni","year":"2009","unstructured":"Ni Z, Hui P. Emerging pharmacologic therapies for wet age-related macular degeneration. Ophthalmologica. 2009;223:401\u201310.","journal-title":"Ophthalmologica"},{"key":"1956_CR20","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.exer.2015.03.011","volume":"136","author":"LM Nibourg","year":"2015","unstructured":"Nibourg LM, Gelens E, Kuijer R, Hooymans JM, van Kooten TG, Koopmans SA. Prevention of posterior capsular opacification. Exp Eye Res. 2015;136:100\u201315.","journal-title":"Exp Eye Res"},{"key":"1956_CR21","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/S0161-6420(98)99051-0","volume":"105","author":"R Krishna","year":"1998","unstructured":"Krishna R, Meisler DM, Lowder CY, Estafanous M, Foster RE. Long-term follow-up of extracapsular cataract extraction and posterior chamber intraocular lens implantation in patients with uveitis. Ophthalmology. 1998;105:1765\u20139.","journal-title":"Ophthalmology"},{"key":"1956_CR22","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1136\/bjophthalmol-2017-310975","volume":"102","author":"CY Lee","year":"2018","unstructured":"Lee CY, Chen HC, Lin HW, Huang JY, Chao SC, Yeh CB, et al. Blepharitis as an early sign of metabolic syndrome: a nationwide population-based study. Br J Ophthalmol. 2018;102:1283\u20137.","journal-title":"Br J Ophthalmol"},{"key":"1956_CR23","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1038\/s41598-017-05368-z","volume":"7","author":"A Chen","year":"2017","unstructured":"Chen A, Chen HT, Chen HC, Chen YT, Hwang YH, Sun CC, et al. Asymptomatic meibomian gland dysfunction and cardiovascular disease risk factors in a middle-aged population in Taiwan\u2014a cross-sectional analysis. Sci Rep. 2017;7:4935.","journal-title":"Sci Rep"},{"key":"1956_CR24","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3748\/wjg.v16.i10.1188","volume":"16","author":"M Sugimoto","year":"2010","unstructured":"Sugimoto M, Yamaoka Y, Furuta T. Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer. World J Gastroenterol. 2010;16:1188\u2013200.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1956_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/bjhp.12341","volume":"24","author":"J Hanmer","year":"2019","unstructured":"Hanmer J, Yu L, Li J, Kavalieratos D, Peterson L, Hess R. The diagnosis of asymptomatic disease is associated with fewer healthy days: a cross sectional analysis from the national health and nutrition examination survey. Br J Health Psychol. 2019;24(1):88\u2013101.","journal-title":"Br J Health Psychol"},{"key":"1956_CR26","doi-asserted-by":"publisher","first-page":"2687385","DOI":"10.1155\/2018\/2687385","volume":"2018","author":"C Perez-Vives","year":"2018","unstructured":"Perez-Vives C. Biomaterial influence on intraocular lens performance: an overview. J Ophthalmol. 2018;2018:2687385.","journal-title":"J Ophthalmol"},{"key":"1956_CR27","doi-asserted-by":"publisher","first-page":"e8301","DOI":"10.1097\/MD.0000000000008301","volume":"96","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Yang K, Li J, Huang Y, Zhu S. Comparison of hydrophobic and hydrophilic intraocular lens in preventing posterior capsule opacification after cataract surgery: an updated meta-analysis. Medicine (Baltimore). 2017;96:e8301.","journal-title":"Medicine (Baltimore)"},{"key":"1956_CR28","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.jcrs.2009.03.013","volume":"35","author":"JM Biber","year":"2009","unstructured":"Biber JM, Sandoval HP, Trivedi RH, de Castro LE, French JW, Solomon KD. Comparison of the incidence and visual significance of posterior capsule opacification between multifocal spherical, monofocal spherical, and monofocal aspheric intraocular lenses. J Cataract Refract Surg. 2009;35:1234\u20138.","journal-title":"J Cataract Refract Surg"},{"key":"1956_CR29","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1016\/j.jcrs.2013.06.021","volume":"39","author":"C Leydolt","year":"2013","unstructured":"Leydolt C, Kriechbaum K, Schriefl S, Pachala M, Menapace R. Posterior capsule opacification and neodymium:YAG rates with 2 single-piece hydrophobic acrylic intraocular lenses: three-year results. J Cataract Refract Surg. 2013;39:1886\u201392.","journal-title":"J Cataract Refract Surg"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1956-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-1956-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-1956-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T20:54:10Z","timestamp":1721422450000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-1956-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1956"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-1956-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]},"assertion":[{"value":"15 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the institutional review board of Chung Shan Medical University Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"209"}}