{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:00:39Z","timestamp":1790992839842,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the State Key Laboratory of Space Medicine Fundamentals and Application, Chinese Astronaut Research and Training Center","award":["SMFA15K02"],"award-info":[{"award-number":["SMFA15K02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-2021-1","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:02:42Z","timestamp":1566468162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression"],"prefix":"10.1186","volume":"17","author":[{"given":"Liwen","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Chang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5199-9016","authenticated-orcid":false,"given":"Tianqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"2021_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/sc.2010.53","volume":"49","author":"JM Scott","year":"2011","unstructured":"Scott JM, Warburton DER, Williams D, Whelan S, Krassioukov A. Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity. Spinal Cord. 2011;49:4.","journal-title":"Spinal Cord"},{"key":"2021_CR2","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.biocel.2013.05.035","volume":"45","author":"T Yoshida","year":"2013","unstructured":"Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, Delafontaine P. Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013;45:2322\u201332.","journal-title":"Int J Biochem Cell Biol"},{"key":"2021_CR3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.compbiomed.2006.04.003","volume":"37","author":"RL Summers","year":"2007","unstructured":"Summers RL, Martin DS, Meck JV, Coleman TG. Computer systems analysis of spaceflight induced changes in left ventricular mass. Comput Biol Med. 2007;37:358\u201363.","journal-title":"Comput Biol Med"},{"key":"2021_CR4","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/j.resp.2009.04.010","volume":"169","author":"VA Convertino","year":"2009","unstructured":"Convertino VA. Status of cardiovascular issues related to space flight: implications for future research directions. Respir Physiol Neurobiol. 2009;169:S34\u20137.","journal-title":"Respir Physiol Neurobiol"},{"key":"2021_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pss.2012.07.030","volume":"74","author":"N Goswami","year":"2012","unstructured":"Goswami N, Roma PG, De Boever P, Clement G, Hargens AR, Loeppky JA, Evans JM, Stein TP, Blaber AP, Van Loon JJWA. Using the moon as a high-fidelity analogue environment to study biological and behavioral effects of long-duration space exploration. Planet Space Sci. 2012;74:111\u201320.","journal-title":"Planet Space Sci"},{"key":"2021_CR6","doi-asserted-by":"publisher","first-page":"H628","DOI":"10.1152\/ajpheart.00802.2015","volume":"310","author":"RL Hughson","year":"2016","unstructured":"Hughson RL, Robertson AD, Arbeille P, Shoemaker JK, Rush JW, Fraser KS, Greaves DK. Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts. Am J Physiol Heart Circ Physiol. 2016;310:H628\u201338.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021_CR7","first-page":"S62","volume":"4","author":"Y Haruna","year":"1997","unstructured":"Haruna Y, Bonde-Petersen F, Takenaka K, Suzuki Y, Kawakubo K, Gunji A. Effects of the renin\u2013angiotensin\u2013aldosterone system on the cardiovascular system during 20-days bed rest. J Gravit Physiol. 1997;4:S62\u20138.","journal-title":"J Gravit Physiol"},{"key":"2021_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/MAJ.0b013e318222e620","volume":"342","author":"S Sukhanov","year":"2011","unstructured":"Sukhanov S, Semprun-Prieto L, Yoshida T, Michael Tabony A, Higashi Y, Galvez S, Delafontaine P. Angiotensin II, oxidative stress and skeletal muscle wasting. Am J Med Sci. 2011;342:143\u20137.","journal-title":"Am J Med Sci"},{"key":"2021_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1097\/MNH.0b013e3283414d40","volume":"20","author":"J Stegbauer","year":"2011","unstructured":"Stegbauer J, Coffman TM. New insights into angiotensin receptor actions: from blood pressure to aging. Curr Opin Nephrol Hypertens. 2011;20:84\u20138.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2021_CR10","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","volume":"98","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev. 2018;98:1627\u2013738.","journal-title":"Physiol Rev"},{"key":"2021_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.beem.2018.02.003","volume":"32","author":"AD Toth","year":"2018","unstructured":"Toth AD, Turu G, Hunyady L, Balla A. Novel mechanisms of G-protein-coupled receptors functions: AT1 angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk. Best Pract Res Clin Endocrinol Metab. 2018;32:69\u201382.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2021_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87:245\u2013313.","journal-title":"Physiol Rev"},{"key":"2021_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10741-010-9186-2","volume":"16","author":"A Nabeebaccus","year":"2011","unstructured":"Nabeebaccus A, Zhang M, Shah AM. NADPH oxidases and cardiac remodelling. Heart Fail Rev. 2011;16:5\u201312.","journal-title":"Heart Fail Rev"},{"key":"2021_CR14","doi-asserted-by":"publisher","first-page":"e12951","DOI":"10.1111\/eci.12951","volume":"48","author":"SA Belambri","year":"2018","unstructured":"Belambri SA, Rolas L, Raad H, Hurtado-Nedelec M, Dang PM, El-Benna J. NADPH oxidase activation in neutrophils: role of the phosphorylation of its subunits. Eur J Clin Investig. 2018;48:e12951.","journal-title":"Eur J Clin Investig"},{"key":"2021_CR15","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.113.301787","volume":"113","author":"S Sciarretta","year":"2013","unstructured":"Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase\/eukaryotic initiation factor 2\u03b1\/activating transcription factor 4 pathway. Circ Res. 2013;113:1253\u201364.","journal-title":"Circ Res"},{"key":"2021_CR16","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1089\/ars.2009.2808","volume":"12","author":"E Barreiro","year":"2010","unstructured":"Barreiro E, Hussain SNA. Protein carbonylation in skeletal muscles: impact on function. Antioxid Redox Signal. 2010;12:417\u201329.","journal-title":"Antioxid Redox Signal"},{"key":"2021_CR17","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1089\/ars.2009.2578","volume":"11","author":"S Sorce","year":"2009","unstructured":"Sorce S, Krause K-H. NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal. 2009;11:2481\u2013504.","journal-title":"Antioxid Redox Signal"},{"key":"2021_CR18","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1152\/japplphysiol.00969.2001","volume":"92","author":"ER Morey-Holton","year":"2002","unstructured":"Morey-Holton ER, Globus RK. Hindlimb unloading rodent model: technical aspects. J Appl Physiol. 2002;92:1367\u201377.","journal-title":"J Appl Physiol"},{"key":"2021_CR19","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1177\/0363546508315470","volume":"36","author":"HS Bedair","year":"2008","unstructured":"Bedair HS, Karthikeyan T, Quintero A, Li Y, Huard J. Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle. Am J Sports Med. 2008;36:1548\u201354.","journal-title":"Am J Sports Med"},{"key":"2021_CR20","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.2337\/db08-0617","volume":"58","author":"E Shen","year":"2009","unstructured":"Shen E, Li Y, Shan L, Zhu H, Feng Q, Arnold JM, Peng T. Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes. 2009;58:2386\u201395.","journal-title":"Diabetes"},{"key":"2021_CR21","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.2337\/db09-1800","volume":"59","author":"J Li","year":"2010","unstructured":"Li J, Zhu H, Shen E, Wan L, Arnold JM, Peng T. Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes. 2010;59:2033\u201342.","journal-title":"Diabetes"},{"key":"2021_CR22","doi-asserted-by":"publisher","first-page":"8099","DOI":"10.1074\/jbc.M207288200","volume":"278","author":"T Peng","year":"2003","unstructured":"Peng T, Lu X, Lei M, Feng Q. Endothelial nitric-oxide synthase enhances lipopolysaccharide-stimulated tumor necrosis factor-alpha expression via cAMP-mediated p38 MAPK pathway in cardiomyocytes. J Biol Chem. 2003;278:8099\u2013105.","journal-title":"J Biol Chem"},{"key":"2021_CR23","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1021\/bp060018z","volume":"22","author":"X Wang","year":"2006","unstructured":"Wang X, Wei G, Yu W, Zhao Y, Yu X, Ma X. Scalable producing embryoid bodies by rotary cell culture system and constructing engineered cardiac tissue with ES-derived cardiomyocytes in vitro. Biotechnol Prog. 2006;22:811\u20138.","journal-title":"Biotechnol Prog"},{"key":"2021_CR24","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1136\/hrt.2009.191122","volume":"96","author":"G Barnes","year":"2010","unstructured":"Barnes G, Japp AG, Newby DE. Translational promise of the apelin\u2013APJ system. Heart. 2010;96:1011\u20136.","journal-title":"Heart"},{"key":"2021_CR25","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/jcb.22947","volume":"112","author":"H Chang","year":"2011","unstructured":"Chang H, Zhang L, Xu PT, Li Q, Sheng JJ, Wang YY, Chen Y, Zhang LN, Yu ZB. Nuclear translocation of calpain-2 regulates propensity toward apoptosis in cardiomyocytes of tail-suspended rats. J Cell Biochem. 2011;112:571\u201380.","journal-title":"J Cell Biochem"},{"key":"2021_CR26","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.3390\/molecules18032821","volume":"18","author":"MS Petronio","year":"2013","unstructured":"Petronio MS, Zeraik ML, Fonseca LM, Ximenes VF. Apocynin: chemical and biophysical properties of a NADPH oxidase inhibitor. Molecules. 2013;18:2821\u201339.","journal-title":"Molecules"},{"key":"2021_CR27","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1083\/jcb.200901052","volume":"185","author":"S Cohen","year":"2009","unstructured":"Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL. During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009;185:1083\u201395.","journal-title":"J Cell Biol"},{"key":"2021_CR28","doi-asserted-by":"publisher","first-page":"9287","DOI":"10.1158\/0008-5472.CAN-10-2664","volume":"70","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, McLaughlin D, Robinson E, Harvey AP, Hookham MB, Shah AM, McDermott BJ, Grieve DJ. Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with doxorubicin chemotherapy. Cancer Res. 2010;70:9287\u201397.","journal-title":"Cancer Res"},{"key":"2021_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.1999.tb09219.x","volume":"874","author":"M Wagner","year":"1999","unstructured":"Wagner M, Mascareno E, Siddiqui MA. Cardiac hypertrophy: signal transduction, transcriptional adaptation, and altered growth control. Ann N Y Acad Sci. 1999;874:1\u201310.","journal-title":"Ann N Y Acad Sci"},{"key":"2021_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","volume":"41","author":"J El-Benna","year":"2009","unstructured":"El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F. p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med. 2009;41:217\u201325.","journal-title":"Exp Mol Med"},{"key":"2021_CR31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/cvr\/cvr067","volume":"91","author":"L Li","year":"2011","unstructured":"Li L, Fan D, Wang C, Wang JY, Cui XB, Wu D, Zhou Y, Wu LL. Angiotensin II increases periostin expression via Ras\/p38 MAPK\/CREB and ERK1\/2\/TGF-beta1 pathways in cardiac fibroblasts. Cardiovasc Res. 2011;91:80\u20139.","journal-title":"Cardiovasc Res"},{"key":"2021_CR32","first-page":"41","volume":"8","author":"H Zhu","year":"2017","unstructured":"Zhu H, Tan L, Li Y, Li J, Qiu M, Li L, Zhang M, Liang M, Li A. Increased apoptosis in the paraventricular nucleus mediated by AT1R\/Ras\/ERK1\/2 signaling results in sympathetic hyperactivity and renovascular hypertension in rats after kidney injury. Front Physiol. 2017;8:41.","journal-title":"Front Physiol"},{"key":"2021_CR33","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1681\/ASN.2006010083","volume":"17","author":"SH Lecker","year":"2006","unstructured":"Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006;17:1807\u201319.","journal-title":"J Am Soc Nephrol"},{"key":"2021_CR34","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/MCO.0b013e328352b4c2","volume":"15","author":"SK Powers","year":"2012","unstructured":"Powers SK, Smuder A, Judge A. Oxidative stress and disuse muscle atrophy: cause or consequence? Curr Opin Clin Nutr Metab Care. 2012;15:240.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2021_CR35","doi-asserted-by":"publisher","first-page":"R337","DOI":"10.1152\/ajpregu.00469.2004","volume":"288","author":"SK Powers","year":"2005","unstructured":"Powers SK, Kavazis AN, DeRuisseau KC. Mechanisms of disuse muscle atrophy: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2005;288:R337\u201344.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2021_CR36","first-page":"64","volume":"39","author":"P Chowdhury","year":"2009","unstructured":"Chowdhury P, Soulsby ME, Scott JL. Effects of aminoguanidine on tissue oxidative stress induced by hindlimb unloading in rats. Ann Clin Lab Sci. 2009;39:64\u201370.","journal-title":"Ann Clin Lab Sci"},{"key":"2021_CR37","first-page":"140","volume":"42","author":"J Jayroe","year":"2012","unstructured":"Jayroe J, Soulsby M, Chowdhury P. Attenuation of tissue oxidative stress by dietary restriction in rats on simulated microgravity. Ann Clin Lab Sci. 2012;42:140\u20134.","journal-title":"Ann Clin Lab Sci"},{"key":"2021_CR38","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","volume":"86","author":"KK Griendling","year":"2000","unstructured":"Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494\u2013501.","journal-title":"Circ Res"},{"key":"2021_CR39","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1165\/ajrcmb.24.6.4228","volume":"24","author":"S Corda","year":"2001","unstructured":"Corda S, Laplace C, Vicaut E, Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-\u03b1 is mediated by ceramide. Am J Respir Cell Mol Biol. 2001;24:762\u20138.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2021_CR40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.freeradbiomed.2007.10.053","volume":"44","author":"MH Shin","year":"2008","unstructured":"Shin MH, Moon YJ, Seo J-E, Lee Y, Kim KH, Chung JH. Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression. Free Radic Biol Med. 2008;44:635\u201345.","journal-title":"Free Radic Biol Med"},{"key":"2021_CR41","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.111.243972","volume":"110","author":"B Lass\u00e8gue","year":"2012","unstructured":"Lass\u00e8gue B, San Mart\u00edn A, Griendling KK. Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res. 2012;110:1364\u201390.","journal-title":"Circ Res"},{"key":"2021_CR42","doi-asserted-by":"publisher","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","volume":"307","author":"SC Bodine","year":"2014","unstructured":"Bodine SC, Baehr LM. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1. Am J Physiol Endocrinol Metab. 2014;307:E469\u201384.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2021_CR43","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1002\/jcsm.12233","volume":"8","author":"TS Bowen","year":"2017","unstructured":"Bowen TS, Adams V, Werner S, Fischer T, Vinke P, Brogger MN, Mangner N, Linke A, Sehr P, Lewis J, et al. Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia. J Cachexia Sarcopenia Muscle. 2017;8:939\u201353.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2021_CR44","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1161\/CIRCRESAHA.114.305393","volume":"117","author":"P Du Bois","year":"2015","unstructured":"Du Bois P, Pablo Tortola C, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN, Fielitz J. Angiotensin II induces skeletal muscle atrophy by activating TFEB-Mediated MuRF1 expression. Circ Res. 2015;117:424\u201336.","journal-title":"Circ Res"},{"key":"2021_CR45","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1161\/CIRCHEARTFAILURE.113.000713","volume":"7","author":"Y Maejima","year":"2014","unstructured":"Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M, Sadoshima J. Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A. Circ Heart Fail. 2014;7:479\u201390.","journal-title":"Circ Heart Fail"},{"key":"2021_CR46","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.lfs.2011.04.018","volume":"89","author":"GQ Chen","year":"2011","unstructured":"Chen GQ, Mou CY, Yang YQ, Wang S, Zhao ZW. Exercise training has beneficial anti-atrophy effects by inhibiting oxidative stress-induced MuRF1 upregulation in rats with diabetes. Life Sci. 2011;89:44\u20139.","journal-title":"Life Sci"},{"key":"2021_CR47","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/clpt.2013.191","volume":"95","author":"PA Smink","year":"2014","unstructured":"Smink PA, Miao Y, Eijkemans MJ, Bakker SJ, Raz I, Parving HH, Hoekman J, Grobbee DE, de Zeeuw D, Lambers Heerspink HJ. The importance of short-term off-target effects in estimating the long-term renal and cardiovascular protection of angiotensin receptor blockers. Clin Pharmacol Ther. 2014;95:208\u201315.","journal-title":"Clin Pharmacol Ther"},{"key":"2021_CR48","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.tcm.2015.06.004","volume":"26","author":"S Arumugam","year":"2016","unstructured":"Arumugam S, Sreedhar R, Thandavarayan RA, Karuppagounder V, Krishnamurthy P, Suzuki K, Nakamura M, Watanabe K. Angiotensin receptor blockers: focus on cardiac and renal injury. Trends Cardiovasc Med. 2016;26:221\u20138.","journal-title":"Trends Cardiovasc Med"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-2021-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-2021-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-2021-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:11:08Z","timestamp":1597965068000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-2021-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2021"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-2021-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"5 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All co-authors have approved the submission of the manuscript for publication in its present form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"279"}}