{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:12:42Z","timestamp":1790331162005,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571570"],"award-info":[{"award-number":["81571570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81602595"],"award-info":[{"award-number":["No. 81602595"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313039"],"award-info":[{"award-number":["2016A030313039"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A010105014"],"award-info":[{"award-number":["2017A010105014"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20170818142053544"],"award-info":[{"award-number":["JCYJ20170818142053544"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012228","name":"Development and Reform Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["Shenzhen City 2016 Biochemistry Discipline Construction"],"award-info":[{"award-number":["Shenzhen City 2016 Biochemistry Discipline Construction"]}],"id":[{"id":"10.13039\/501100012228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12967-019-2026-9","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T13:03:04Z","timestamp":1566306184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["CDK4\/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation"],"prefix":"10.1186","volume":"17","author":[{"given":"Yi-Bo","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunmei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Tong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-8450","authenticated-orcid":false,"given":"Jia-Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"issue":"5","key":"2026_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","volume":"18","author":"SJ Galli","year":"2012","unstructured":"Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med. 2012;18(5):693\u2013704.","journal-title":"Nat Med"},{"issue":"1","key":"2026_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40413-015-0080-1","volume":"8","author":"FE Simons","year":"2015","unstructured":"Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J. 2015;8(1):32.","journal-title":"World Allergy Organ J."},{"issue":"1","key":"2026_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1365-2222.2008.03134.x","volume":"39","author":"C Flohr","year":"2009","unstructured":"Flohr C, Quinnell RJ, Britton J. Do helminth parasites protect against atopy and allergic disease? Clin Exp Allergy. 2009;39(1):20\u201332.","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"2026_CR4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jep.2012.12.046","volume":"146","author":"JD Kim","year":"2013","unstructured":"Kim JD, Kim DK, Kim HS, Kim AR, Kim B, Her E, et al. Morus bombycis extract suppresses mast cell activation and IgE-mediated allergic reaction in mice. J Ethnopharmacol. 2013;146(1):287\u201393.","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"2026_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1615\/CritRevImmunol.v31.i6.30","volume":"31","author":"AM Gilfillan","year":"2011","unstructured":"Gilfillan AM, Beaven MA. Regulation of mast cell responses in health and disease. Crit Rev Immunol. 2011;31(6):475\u2013529.","journal-title":"Crit Rev Immunol"},{"key":"2026_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13601-018-0213-z","volume":"8","author":"J Hu","year":"2018","unstructured":"Hu J, Chen J, Ye L, Cai Z, Sun J, Ji K. Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE(+) B cells. Clin Transl Allergy. 2018;8:27.","journal-title":"Clin Transl Allergy."},{"issue":"1","key":"2026_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/eji.200838899","volume":"39","author":"MA Beaven","year":"2009","unstructured":"Beaven MA. Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol. 2009;39(1):11\u201325.","journal-title":"Eur J Immunol"},{"issue":"4 Pt 2","key":"2026_CR8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0091-6749(05)80223-4","volume":"86","author":"MV White","year":"1990","unstructured":"White MV. The role of histamine in allergic diseases. J Allergy Clin Immunol. 1990;86(4 Pt 2):599\u2013605.","journal-title":"J Allergy Clin Immunol."},{"issue":"11","key":"2026_CR9","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/j.1398-9995.2008.01774.x","volume":"63","author":"F Meiler","year":"2008","unstructured":"Meiler F, Klunker S, Zimmermann M, Akdis CA, Akdis M. Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors. Allergy. 2008;63(11):1455\u201363.","journal-title":"Allergy"},{"issue":"5","key":"2026_CR10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S1081-1206(10)60355-9","volume":"103","author":"MA Kaliner","year":"2009","unstructured":"Kaliner MA. Azelastine and olopatadine in the treatment of allergic rhinitis. Ann Allergy Asthma Immunol. 2009;103(5):373\u201380.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2026_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8710-3","author":"S Anvari","year":"2018","unstructured":"Anvari S, Miller J, Yeh CY, Davis CM. IgE-mediated food allergy. Clin Rev Allergy Immunol. 2018. https:\/\/doi.org\/10.1007\/s12016-018-8710-3 .","journal-title":"Clin Rev Allergy Immunol."},{"issue":"18","key":"2026_CR12","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.2165\/00003495-200767180-00006","volume":"67","author":"H Van Hoecke","year":"2007","unstructured":"Van Hoecke H, Vandenbulcke L, Van Cauwenberge P. Histamine and leukotriene receptor antagonism in the treatment of allergic rhinitis: an update. Drugs. 2007;67(18):2717\u201326.","journal-title":"Drugs."},{"key":"2026_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejphar.2015.05.071","volume":"778","author":"T Zhang","year":"2016","unstructured":"Zhang T, Finn DF, Barlow JW, Walsh JJ. Mast cell stabilisers. Eur J Pharmacol. 2016;778:158\u201368.","journal-title":"Eur J Pharmacol"},{"key":"2026_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2147\/NDT.S193125","volume":"15","author":"A Alachkar","year":"2019","unstructured":"Alachkar A, Khan N, Lazewska D, Kiec-Kononowicz K, Sadek B. Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. Neuropsychiatr Dis Treat. 2019;15:531\u201342.","journal-title":"Neuropsychiatr Dis Treat."},{"issue":"3","key":"2026_CR15","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/ACI.0000000000000524","volume":"19","author":"LK Tanno","year":"2019","unstructured":"Tanno LK, Alvarez-Perea A, Pouessel G. Therapeutic approach of anaphylaxis. Curr Opin Allergy Clin Immunol. 2019;19(3):198\u2013203.","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"20","key":"2026_CR16","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1056\/NEJMoa1607303","volume":"375","author":"RS Finn","year":"2016","unstructured":"Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, et al. Palbociclib and letrozole in advanced breast cancer. N Engl J Med. 2016;375(20):1925\u201336.","journal-title":"N Engl J Med"},{"issue":"2","key":"2026_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1001\/jamaoncol.2015.4701","volume":"2","author":"AS Clark","year":"2016","unstructured":"Clark AS, Karasic TB, DeMichele A, Vaughn DJ, O\u2019Hara M, Perini R, et al. Palbociclib (PD0332991)-a selective and potent cyclin-dependent kinase inhibitor: a review of pharmacodynamics and clinical development. JAMA Oncol. 2016;2(2):253\u201360.","journal-title":"JAMA Oncol."},{"key":"2026_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-1-4939-7896-0_8","volume":"1799","author":"HL Caslin","year":"2018","unstructured":"Caslin HL, Taruselli MT, Paranjape A, Kiwanuka K, Haque T, Chumanevich AP, et al. The use of human and mouse mast cell and basophil cultures to assess type 2 inflammation. Methods Mol Biol. 2018;1799:81\u201392.","journal-title":"Methods Mol Biol"},{"key":"2026_CR19","first-page":"12","volume":"19","author":"C Shao","year":"2018","unstructured":"Shao C, Fu B, Ji N, Pan S, Zhao X, Zhang Z, et al. Alisol B 23-acetate inhibits IgE\/Ag-mediated mast cell activation and allergic reaction. Int J Mol Sci. 2018;19:12.","journal-title":"Int J Mol Sci."},{"key":"2026_CR20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.bcp.2018.05.012","volume":"154","author":"YH Park","year":"2018","unstructured":"Park YH, Kim DK, Kim HW, Kim HS, Lee D, Lee MB, et al. Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn. Biochem Pharmacol. 2018;154:270\u20137.","journal-title":"Biochem Pharmacol"},{"key":"2026_CR21","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3389\/fphar.2018.00591","volume":"9","author":"MJ Kim","year":"2018","unstructured":"Kim MJ, Kim YY, Choi YA, Baek MC, Lee B, Park PH, et al. Elaeocarpusin inhibits mast cell-mediated allergic inflammation. Front Pharmacol. 2018;9:591.","journal-title":"Front Pharmacol."},{"issue":"8","key":"2026_CR22","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.4049\/jimmunol.1600614","volume":"197","author":"T Groot Kormelink","year":"2016","unstructured":"Groot Kormelink T, Arkesteijn GJ, van de Lest CH, Geerts WJ, Goerdayal SS, Altelaar MA, et al. Mast cell degranulation is accompanied by the release of a selective subset of extracellular vesicles that contain mast cell-specific proteases. J Immunol. 2016;197(8):3382\u201392.","journal-title":"J Immunol."},{"key":"2026_CR23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-1-4939-7113-8_14","volume":"1627","author":"N Puebla-Osorio","year":"2017","unstructured":"Puebla-Osorio N, Sarchio SNE, Ullrich SE, Byrne SN. Detection of infiltrating mast cells using a modified toluidine blue staining. Methods Mol Biol. 2017;1627:213\u201322.","journal-title":"Methods Mol Biol"},{"issue":"11","key":"2026_CR24","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.3390\/molecules23113039","volume":"23","author":"S Fu","year":"2018","unstructured":"Fu S, Ni S, Wang D, Hong T. Coptisine suppresses mast cell degranulation and ovalbumin-induced allergic rhinitis. Molecules. 2018;23(11):3039.","journal-title":"Molecules"},{"issue":"11","key":"2026_CR25","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1172\/JCI87492","volume":"126","author":"WX Ang","year":"2016","unstructured":"Ang WX, Church AM, Kulis M, Choi HW, Burks AW, Abraham SN. Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. J Clin Invest. 2016;126(11):4103\u201318.","journal-title":"J Clin Invest."},{"issue":"3","key":"2026_CR26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nri1782","volume":"6","author":"AM Gilfillan","year":"2006","unstructured":"Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol. 2006;6(3):218\u201330.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2026_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1710-1492-10-27","volume":"10","author":"P Begin","year":"2014","unstructured":"Begin P, Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy Asthma Clin Immunol. 2014;10(1):27.","journal-title":"Allergy Asthma Clin Immunol."},{"issue":"2","key":"2026_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nri2018","volume":"7","author":"SC Bischoff","year":"2007","unstructured":"Bischoff SC. Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol. 2007;7(2):93\u2013104.","journal-title":"Nat Rev Immunol"},{"key":"2026_CR29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.toxlet.2017.11.005","volume":"293","author":"LB Joseph","year":"2018","unstructured":"Joseph LB, Composto GM, Perez RM, Kim HD, Casillas RP, Heindel ND, et al. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett. 2018;293:77\u201381.","journal-title":"Toxicol Lett"},{"issue":"Pt B","key":"2026_CR30","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/j.ijbiomac.2018.07.096","volume":"118","author":"TS Vo","year":"2018","unstructured":"Vo TS, Kim YS, Ngo DH, Le PU, Kim SY, Kim SK. Spirulina maxima peptides suppress mast cell degranulation via inactivating Akt and MAPKs phosphorylation in RBL-2H3 cells. Int J Biol Macromol. 2018;118(Pt B):2224\u20139.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"2026_CR31","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41467-017-00294-0","volume":"8","author":"SB Mkaddem","year":"2017","unstructured":"Mkaddem SB, Murua A, Flament H, Titeca-Beauport D, Bounaix C, Danelli L, et al. Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation. Nat Commun. 2017;8(1):246.","journal-title":"Nat Commun."},{"issue":"2","key":"2026_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/1087057114563024","volume":"20","author":"GF Wilkinson","year":"2015","unstructured":"Wilkinson GF, Pritchard K. In vitro screening for drug repositioning. J Biomol Screen. 2015;20(2):167\u201379.","journal-title":"J Biomol Screen"},{"issue":"5","key":"2026_CR33","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.tips.2013.03.004","volume":"34","author":"N Novac","year":"2013","unstructured":"Novac N. Challenges and opportunities of drug repositioning. Trends Pharmacol Sci. 2013;34(5):267\u201372.","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"2026_CR34","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s40265-015-0416-8","volume":"75","author":"U Hostalek","year":"2015","unstructured":"Hostalek U, Gwilt M, Hildemann S. Therapeutic use of metformin in prediabetes and diabetes prevention. Drugs. 2015;75(10):1071\u201394.","journal-title":"Drugs."},{"issue":"5","key":"2026_CR35","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/21691401.2017.1347879","volume":"46","author":"R Farajzadeh","year":"2018","unstructured":"Farajzadeh R, Pilehvar-Soltanahmadi Y, Dadashpour M, Javidfar S, Lotfi-Attari J, Sadeghzadeh H, et al. Nano-encapsulated metformin-curcumin in PLGA\/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells. Artif Cells Nanomed Biotechnol. 2018;46(5):917\u201325.","journal-title":"Artif Cells Nanomed Biotechnol."},{"issue":"1","key":"2026_CR36","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1080\/21691401.2019.1573737","volume":"47","author":"L Faramarzi","year":"2019","unstructured":"Faramarzi L, Dadashpour M, Sadeghzadeh H, Mahdavi M, Zarghami N. Enhanced anti-proliferative and pro-apoptotic effects of metformin encapsulated PLGA-PEG nanoparticles on SKOV3 human ovarian carcinoma cells. Artif Cells Nanomed Biotechnol. 2019;47(1):737\u201346.","journal-title":"Artif Cells Nanomed Biotechnol."},{"issue":"12","key":"2026_CR37","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/annonc\/mdw410","volume":"27","author":"C Coyle","year":"2016","unstructured":"Coyle C, Cafferty FH, Vale C, Langley RE. Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis. Ann Oncol. 2016;27(12):2184\u201395.","journal-title":"Ann Oncol"},{"issue":"12","key":"2026_CR38","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1002\/eji.201847706","volume":"48","author":"HC Wang","year":"2018","unstructured":"Wang HC, Huang SK. Metformin inhibits IgE- and aryl hydrocarbon receptor-mediated mast cell activation in vitro and in vivo. Eur J Immunol. 2018;48(12):1989\u201396.","journal-title":"Eur J Immunol"},{"issue":"11","key":"2026_CR39","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.18632\/oncotarget.20807","volume":"9","author":"H Wang","year":"2018","unstructured":"Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2018;9(11):10135\u201346.","journal-title":"Oncotarget."},{"key":"2026_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2019.02.041","volume":"71","author":"S Fu","year":"2019","unstructured":"Fu S, Ni S, Wang D, Fu M, Hong T. Berberine suppresses mast cell-mediated allergic responses via regulating FcvarepsilonRI-mediated and MAPK signaling. Int Immunopharmacol. 2019;71:1\u20136.","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"2026_CR41","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/14737140.2017.1347506","volume":"17","author":"J Ettl","year":"2017","unstructured":"Ettl J, Harbeck N. The safety and efficacy of palbociclib in the treatment of metastatic breast cancer. Expert Rev Anticancer Ther. 2017;17(8):661\u20138.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"1","key":"2026_CR42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1470-2045(14)71159-3","volume":"16","author":"RS Finn","year":"2015","unstructured":"Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, et al. The cyclin-dependent kinase 4\/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1\/TRIO-18): a randomised phase 2 study. Lancet Oncol. 2015;16(1):25\u201335.","journal-title":"Lancet Oncol."},{"key":"2026_CR43","doi-asserted-by":"publisher","first-page":"175883591879332","DOI":"10.1177\/1758835918793326","volume":"10","author":"M Thill","year":"2018","unstructured":"Thill M, Schmidt M. Management of adverse events during cyclin-dependent kinase 4\/6 (CDK4\/6) inhibitor-based treatment in breast cancer. Ther Adv Med Oncol. 2018;10:1758835918793326.","journal-title":"Ther Adv Med Oncol."},{"issue":"11","key":"2026_CR44","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","volume":"3","author":"DW Fry","year":"2004","unstructured":"Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, et al. Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004;3(11):1427\u201338.","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"2026_CR45","doi-asserted-by":"publisher","first-page":"R77","DOI":"10.1186\/bcr2419","volume":"11","author":"RS Finn","year":"2009","unstructured":"Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ, et al. PD 0332991, a selective cyclin D kinase 4\/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5):R77.","journal-title":"Breast Cancer Res"},{"issue":"7668","key":"2026_CR46","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nature23465","volume":"548","author":"S Goel","year":"2017","unstructured":"Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, et al. CDK4\/6 inhibition triggers anti-tumour immunity. Nature. 2017;548(7668):471\u20135.","journal-title":"Nature"},{"issue":"2","key":"2026_CR47","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.molcel.2013.12.002","volume":"53","author":"K Handschick","year":"2014","unstructured":"Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Muller H, Soelch J, et al. Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-kappaB-dependent gene expression. Mol Cell. 2014;53(2):193\u2013208.","journal-title":"Mol Cell"},{"issue":"2","key":"2026_CR48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.tips.2015.10.004","volume":"37","author":"ML Schmitz","year":"2016","unstructured":"Schmitz ML, Kracht M. Cyclin-dependent kinases as coregulators of inflammatory gene expression. Trends Pharmacol Sci. 2016;37(2):101\u201313.","journal-title":"Trends Pharmacol Sci"},{"issue":"Suppl 1","key":"2026_CR49","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1182\/blood-2018-99-116525","volume":"132","author":"MA Schneeweiss","year":"2018","unstructured":"Schneeweiss MA, Stefanzl G, Berger D, Eisenwort G, Jawhar M, Georg G, et al. The CDK4\/6 inhibitor palbociclib exerts growth-inhibitory effects on neoplastic mast cells and synergizes with midostaurin in producing growth arrest. Blood. 2018;132(Suppl 1):1363.","journal-title":"Blood"},{"issue":"10","key":"2026_CR50","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1111\/j.1398-9995.2012.02879.x.","volume":"67","author":"Y Okayama","year":"2012","unstructured":"Okayama Y, Kashiwakura JI, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, et al. The interaction between Lyn and FcepsilonRIbeta is indispensable for FcepsilonRI-mediated human mast cell activation. Allergy. 2012;67(10):1241\u20139.","journal-title":"Allergy"},{"issue":"12","key":"2026_CR51","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.4049\/jimmunol.1600066","volume":"196","author":"SH Polukort","year":"2016","unstructured":"Polukort SH, Rovatti J, Carlson L, Thompson C, Ser-Dolansky J, Kinney SR, et al. IL-10 enhances IgE-mediated mast cell responses and is essential for the development of experimental food allergy in IL-10-deficient mice. J Immunol. 2016;196(12):4865\u201376.","journal-title":"J Immunol."},{"issue":"7","key":"2026_CR52","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1172\/JCI18246","volume":"112","author":"D Laouini","year":"2003","unstructured":"Laouini D, Alenius H, Bryce P, Oettgen H, Tsitsikov E, Geha RS. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest. 2003;112(7):1058\u201366.","journal-title":"J Clin Invest."}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-2026-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12967-019-2026-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-019-2026-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T23:25:20Z","timestamp":1664148320000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-019-2026-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2026"],"URL":"https:\/\/doi.org\/10.1186\/s12967-019-2026-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"5 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All studies involving mice were performed according to protocols approved by the Animal Care and Use Committee of the School of Medicine of Shenzhen University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"276"}}