{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T15:52:38Z","timestamp":1779983558445,"version":"3.53.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Ministry of Health & Welfare, Republic of Korea","award":["HI15C1062"],"award-info":[{"award-number":["HI15C1062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used a collagen-induced arthritis (CIA) model in\n                      <jats:italic>Macaca fascicularis<\/jats:italic>\n                      . CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In conclusion, we established CIA in\n                      <jats:italic>M. fascicularis<\/jats:italic>\n                      , and the results can be used for drug evaluation models.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-020-02402-z","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T14:59:53Z","timestamp":1593529193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The establishment of a rheumatoid arthritis primate model in Macaca fascicularis"],"prefix":"10.1186","volume":"18","author":[{"given":"Hyun Sik","family":"Na","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-yeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Ki","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-je","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyeon","family":"Jhun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ki","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-3989","authenticated-orcid":false,"given":"Mi-La","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"2402_CR1","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","volume":"389","author":"GR Burmester","year":"2017","unstructured":"Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017;389:2338\u201348.","journal-title":"Lancet"},{"key":"2402_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","volume":"40","author":"N Choudhary","year":"2018","unstructured":"Choudhary N, Bhatt LK, Prabhavalkar KS. Experimental animal models for rheumatoid arthritis. Immunopharmacol Immunotoxicol. 2018;40:193\u2013200.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2402_CR3","doi-asserted-by":"publisher","first-page":"R200","DOI":"10.1186\/ar3172","volume":"12","author":"MP Vierboom","year":"2010","unstructured":"Vierboom MP, Breedveld E, Kondova I, Hart BA. Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis. Arthritis Res Ther. 2010;12:R200.","journal-title":"Arthritis Res Ther"},{"key":"2402_CR4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1084\/jem.175.4.933","volume":"175","author":"NP Bakker","year":"1992","unstructured":"Bakker NP, van Erck MG, Otting N, Lardy NM, Noort RC, Hart BA, et al. Resistance to collagen-induced arthritis in a nonhuman primate species maps to the major histocompatibility complex class I region. J Exp Med. 1992;175:933\u20137.","journal-title":"J Exp Med"},{"key":"2402_CR5","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1073\/pnas.0409084102","volume":"102","author":"N Otting","year":"2005","unstructured":"Otting N, Heijmans CM, Noort RC, de Groot NG, Doxiadis GG, van Rood JJ, et al. Unparalleled complexity of the MHC class I region in rhesus macaques. Proc Natl Acad Sci U S A. 2005;102:1626\u201331.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2402_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.yexmp.2008.03.003","volume":"84","author":"A Kato","year":"2008","unstructured":"Kato A, Matsuo S, Takai H, Uchiyama Y, Mihara M, Suzuki M. Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model. Exp Mol Pathol. 2008;84:262\u201370.","journal-title":"Exp Mol Pathol"},{"key":"2402_CR7","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1006\/clim.2000.4989","volume":"98","author":"M Mihara","year":"2001","unstructured":"Mihara M, Kotoh M, Nishimoto N, Oda Y, Kumagai E, Takagi N, et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol. 2001;98:319\u201326.","journal-title":"Clin Immunol"},{"key":"2402_CR8","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1038\/s41598-018-20566-z","volume":"8","author":"EW Choi","year":"2018","unstructured":"Choi EW, Lee KW, Park H, Kim H, Lee JH, Song JW, et al. Therapeutic effects of anti-CD154 antibody in cynomolgus monkeys with advanced rheumatoid arthritis. Sci Rep. 2018;8:2135.","journal-title":"Sci Rep"},{"key":"2402_CR9","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1124\/jpet.117.243493","volume":"364","author":"MC Ruzek","year":"2018","unstructured":"Ruzek MC, Huang L, Zhang TT, Bryant S, Slivka PF, Cuff CA, et al. Dual blockade of interleukin-1\u03b2 and interleukin-17A reduces murine arthritis pathogenesis but also leads to spontaneous skin infections in nonhuman primates. J Pharmacol Exp Ther. 2018;364:474\u201384.","journal-title":"J Pharmacol Exp Ther"},{"key":"2402_CR10","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/BOR.0000000000000267","volume":"28","author":"M Dougados","year":"2016","unstructured":"Dougados M. Comorbidities in rheumatoid arthritis. Curr Opin Rheumatol. 2016;28:282\u20138.","journal-title":"Curr Opin Rheumatol"},{"key":"2402_CR11","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00251-008-0311-5","volume":"60","author":"N Otting","year":"2008","unstructured":"Otting N, Heijmans CM, van der Wiel M, de Groot NG, Doxiadis GG, Bontrop RE. A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin. Immunogenetics. 2008;60:507\u201314.","journal-title":"Immunogenetics"},{"key":"2402_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/ar1773","volume":"7","author":"MPM Vierboom","year":"2005","unstructured":"Vierboom MPM, Jonker M, Bontrop RE, Hart BT. Modeling human arthritic diseases in nonhuman primates. Arthritis Res Ther. 2005;7:145.","journal-title":"Arthritis Res Ther"},{"key":"2402_CR13","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205\u201319.","journal-title":"N Engl J Med"},{"key":"2402_CR14","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/art.38637","volume":"66","author":"EA James","year":"2014","unstructured":"James EA, Rieck M, Pieper J, Gebe JA, Yue BB, Tatum M, et al. Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. Arthritis Rheumatol. 2014;66:1712\u201322.","journal-title":"Arthritis Rheumatol"},{"key":"2402_CR15","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1189\/jlb.5A0116-025R","volume":"100","author":"JM Pandya","year":"2016","unstructured":"Pandya JM, Lundell A-C, Hallstr\u00f6m M, Andersson K, Nordstr\u00f6m I, Rudin A. Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects. J Leukoc Biol. 2016;100:823\u201333.","journal-title":"J Leukoc Biol"},{"key":"2402_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/nat.2015.0567","volume":"26","author":"M Hirota","year":"2016","unstructured":"Hirota M, Murakami I, Ishikawa Y, Suzuki T, Sumida S, Ibaragi S, et al. Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys. Nucleic Acid Ther. 2016;26:10\u20139.","journal-title":"Nucleic Acid Ther"},{"key":"2402_CR17","doi-asserted-by":"publisher","first-page":"e0141330","DOI":"10.1371\/journal.pone.0141330","volume":"10","author":"S Ranganath","year":"2015","unstructured":"Ranganath S, Bhandari A, Avitahl-Curtis N, McMahon J, Wachtel D, Zhang J, et al. Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivo. PLoS ONE. 2015;10:e0141330.","journal-title":"PLoS ONE"},{"key":"2402_CR18","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.intimp.2007.06.009","volume":"7","author":"N Yamamoto","year":"2007","unstructured":"Yamamoto N, Nakashima T, Torikai M, Naruse T, Morimoto J, Kon S, et al. Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody. Int Immunopharmacol. 2007;7:1460\u201370.","journal-title":"Int Immunopharmacol"},{"key":"2402_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12967-014-0284-0","volume":"12","author":"XC Xu","year":"2014","unstructured":"Xu XC, Chen H, Zhang X, Zhai ZJ, Liu XQ, Qin A, et al. Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy. J Transl Med. 2014;12:284.","journal-title":"J Transl Med"},{"key":"2402_CR20","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","volume":"10","author":"JR Deuis","year":"2017","unstructured":"Deuis JR, Dvorakova LS, Vetter I. Methods used to evaluate pain behaviors in rodents. Front Mol Neurosci. 2017;10:284.","journal-title":"Front Mol Neurosci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-020-02402-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-020-02402-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-020-02402-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T19:33:16Z","timestamp":1624995196000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-020-02402-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2402"],"URL":"https:\/\/doi.org\/10.1186\/s12967-020-02402-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-18690\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-18690\/v1","asserted-by":"object"}]},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"assertion":[{"value":"20 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animals: All animal research procedures were conducted in accordance with the Laboratory Animals Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Guidelines and Policies for Non-human Primate (NHP) Experiments provided by the Institutional Animal Care and Use Committee (ORIENT-IACUC-16255).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}