{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:07:26Z","timestamp":1788559646667,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54 NS105539"],"award-info":[{"award-number":["U54 NS105539"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity of OI in ME\/CFS (Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome). The 10-minute NASA Lean Test (NLT) is a simple, point-of-care method that can aid ME\/CFS diagnosis and guide management and treatment of OI. The objective of this study was to understand the hemodynamic changes that occur in ME\/CFS patients during the 10-minute NLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 150 ME\/CFS patients and 75 age, gender and race matched healthy controls (HCs) were enrolled. We recruited 75 ME\/CFS patients who had been sick for less than 4\u00a0years (&lt;\u20094 ME\/CFS) and 75 ME\/CFS patients sick for more than 10\u00a0years (&gt;\u200910 ME\/CFS). The 10-minute NLT involves measurement of blood pressure and heart rate while resting supine and every minute for 10\u00a0min while standing with shoulder-blades on the wall for a relaxed stance. Spontaneously reported symptoms are recorded during the test. ANOVA and regression analysis were used to test for differences and relationships in hemodynamics, symptoms and upright activity between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At least 5\u00a0min of the 10-minute NLT were required to detect hemodynamic changes. The\u2009&lt;\u20094 ME\/CFS group had significantly higher heart rate and abnormally narrowed pulse pressure compared to\u2009&gt;\u200910 ME\/CFS and HCs. The\u2009&lt;\u20094 ME\/CFS group experienced significantly more OI symptoms compared to\u2009&gt;\u200910 ME\/CFS and HCs. The circulatory decompensation observed in the\u2009&lt;\u20094 ME\/CFS group was not related to age or medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulatory decompensation characterized by increased heart rate and abnormally narrow pulse pressure was identified in a subgroup of ME\/CFS patients who have been sick for\u2009&lt;\u20094\u00a0years. This suggests inadequate ventricular filling from low venous pressure. The 10-minute NLT can be used to diagnose and treat the circulatory decompensation in this newly recognized subgroup of ME\/CFS patients. The\u2009&gt;\u200910 ME\/CFS group had less pronounced hemodynamic changes during the NLT possibly from adaptation and compensation that occurs over time. The 10-minute NLT is a simple and clinically useful point-of-care method that can be used for early diagnosis of ME\/CFS and help guide OI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-020-02481-y","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T03:02:37Z","timestamp":1597460557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME\/CFS patients"],"prefix":"10.1186","volume":"18","author":[{"given":"Jihyun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-8914","authenticated-orcid":false,"given":"Suzanne D.","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Jeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Unutmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brayden","family":"Yellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"key":"2481_CR1","volume-title":"Beyond Myalgic encephalomyelitis\/chronic fatigue syndrome: redefining an illness","author":"Institute of Medicine","year":"2015","unstructured":"Institute of Medicine. 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Procedures were carried out with the adequate understanding and written consent of the subjects.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Our manuscript does not contain any identifiable individual\u2019s data in any form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"314"}}