{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:07:11Z","timestamp":1793725631670,"version":"4.6.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371271"],"award-info":[{"award-number":["81371271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liaoning BaiQianWan Talents Program","award":["-"],"award-info":[{"award-number":["-"]}]},{"name":"Shenyang Science and technology plan project","award":["19-112-4-045"],"award-info":[{"award-number":["19-112-4-045"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Huntington\u2019s disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD (pre-HD) patients; however, the underlying molecular pathogenesis is still uncertain and no effective treatments are available until now. Here, we reanalyzed HD-related differentially expressed genes from the GEO database between symptomatic HD patients, pre-HD individuals, and healthy controls using bioinformatics analysis, hoping to get more insight in the pathogenesis of both pre-HD and HD, and shed a light in the potential therapeutic targets of the disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Pre-HD and symptomatic HD differentially expressed genes (DEGs) were screened by bioinformatics analysis Gene Expression Omnibus (GEO) dataset GSE1751. A protein\u2013protein interaction (PPI) network was used to select hub genes. Subsequently, Gene Ontology (GO) enrichment analysis of DEGs and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of hub genes were applied. Dataset GSE24250 was downloaded to verify our hub genes by the Kaplan\u2013Meier method using Graphpad Prism 5.0. Finally, target miRNAs of intersected hub genes involved in pre-HD and symptomatic HD were predicted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 37 and 985 DEGs were identified in pre-HD and symptomatic HD, respectively. The hub genes, SIRT1, SUZ12, and PSMC6, may be implicated in pre-HD, and the hub genes, FIS1, SIRT1, CCNH, SUZ12, and 10 others, may be implicated in symptomatic HD. The intersected hub genes, SIRT1 and SUZ12, and their predicted target miRNAs, in particular miR-22-3p and miR-19b, may be significantly associated with pre-HD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The PSMC6, SIRT1, and SUZ12 genes and their related ubiquitin-mediated proteolysis, transcriptional dysregulation, and histone metabolism are significantly associated with pre-HD. FIS1, CCNH, and their related mitochondrial disruption and transcriptional dysregulation processes are related to symptomatic HD, which might shed a light on the elucidation of potential therapeutic targets in HD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-020-02549-9","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T13:02:45Z","timestamp":1602680565000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bioinformatic gene analysis for potential therapeutic targets of Huntington\u2019s disease in pre-symptomatic and symptomatic stage"],"prefix":"10.1186","volume":"18","author":[{"given":"Chunchen","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengri","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"issue":"6","key":"2549_CR1","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"ME MacDonald","year":"1993","unstructured":"MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L, Barnes G, Taylor SA, James M, Groot N, MacFarlane H. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group. Cell. 1993;72(6):971\u201383.","journal-title":"Cell."},{"issue":"11","key":"2549_CR2","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S1474-4422(18)30294-1","volume":"17","author":"C Fusilli","year":"2018","unstructured":"Fusilli C, Migliore S, Mazza T, Consoli F, De Luca A, Barbagallo G, Ciammola A, Gatto EM, Cesarini M, Etcheverry JL, et al. Biological and clinical manifestations of juvenile Huntington's disease: a retrospective analysis. Lancet Neurol. 2018;17(11):986\u201393.","journal-title":"Lancet Neurol"},{"issue":"4","key":"2549_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","volume":"10","author":"CA Ross","year":"2014","unstructured":"Ross CA, Aylward EH, Wild EJ, Langbehn DR, Long JD, Warner JH, Scahill RI, Leavitt BR, Stout JC, Paulsen JS, et al. Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat Rev Neurol. 2014;10(4):204\u201316.","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2549_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","volume":"63","author":"EH Aylward","year":"2004","unstructured":"Aylward EH, Sparks BF, Field KM, Yallapragada V, Shpritz BD, Rosenblatt A, Brandt J, Gourley LM, Liang K, Zhou H, et al. Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology. 2004;63(1):66\u201372.","journal-title":"Neurology"},{"issue":"6","key":"2549_CR5","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"JP Vonsattel","year":"1985","unstructured":"Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr. Neuropathological classification of Huntington\u2019s disease. J Neuropathol Exp Neurol. 1985;44(6):559\u201377.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"18","key":"2549_CR6","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1158\/0008-5472.CAN-04-0452","volume":"64","author":"WA Freije","year":"2004","unstructured":"Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS, Nelson SF. Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 2004;64(18):6503\u201310.","journal-title":"Cancer Res"},{"issue":"5","key":"2549_CR7","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1158\/1078-0432.CCR-09-2607","volume":"16","author":"K De Preter","year":"2010","unstructured":"De Preter K, Vermeulen J, Brors B, Delattre O, Eggert A, Fischer M, Janoueix-Lerosey I, Lavarino C, Maris JM, Mora J, et al. Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature. Clin Cancer Res. 2010;16(5):1532\u201341.","journal-title":"Clin Cancer Res"},{"issue":"4","key":"2549_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/neuonc\/nor012","volume":"13","author":"YW Kim","year":"2011","unstructured":"Kim YW, Liu TJ, Koul D, Tiao N, Feroze AH, Wang J, Powis G, Yung WK. Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. Neuro-oncology. 2011;13(4):367\u201375.","journal-title":"Neuro-oncology"},{"issue":"4","key":"2549_CR9","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.3233\/JAD-180400","volume":"65","author":"JW Liang","year":"2018","unstructured":"Liang JW, Fang ZY, Huang Y, Liuyang ZY, Zhang XL, Wang JL, Wei H, Wang JZ, Wang XC, Zeng J, et al. Application of weighted gene co-expression network analysis to explore the key genes in Alzheimer's disease. J Alzheimer's Dis. 2018;65(4):1353\u201364.","journal-title":"J Alzheimer's Dis"},{"issue":"1","key":"2549_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12967-019-1790-x","volume":"17","author":"R Zou","year":"2019","unstructured":"Zou R, Zhang D, Lv L, Shi W, Song Z, Yi B, Lai B, Chen Q, Yang S, Hua P. Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. J Translat Med. 2019;17(1):45.","journal-title":"J Translat Med"},{"issue":"11","key":"2549_CR11","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/s41388-018-0531-6","volume":"38","author":"CY Wei","year":"2019","unstructured":"Wei CY, Zhu MX, Lu NH, Peng R, Yang X, Zhang PF, Wang L, Gu JY. Bioinformatics-based analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma. Oncogene. 2019;38(11):1876\u201391.","journal-title":"Oncogene"},{"issue":"5","key":"2549_CR12","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843\u201354.","journal-title":"Cell."},{"issue":"1","key":"2549_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","volume":"20","author":"T Treiber","year":"2019","unstructured":"Treiber T, Treiber N, Meister G. Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol. 2019;20(1):5\u201320.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2549_CR14","doi-asserted-by":"publisher","first-page":"e264","DOI":"10.1212\/WNL.0000000000004844","volume":"90","author":"ER Reed","year":"2018","unstructured":"Reed ER, Latourelle JC, Bockholt JH, Bregu J, Smock J, Paulsen JS, Myers RH. MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study. Neurology. 2018;90(4):e264\u2013e272272.","journal-title":"Neurology"},{"issue":"8","key":"2549_CR15","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/S1470-2045(16)30108-5","volume":"17","author":"M Bagnoli","year":"2016","unstructured":"Bagnoli M, Canevari S, Califano D, Losito S, Maio MD, Raspagliesi F, Carcangiu ML, Toffoli G, Cecchin E, Sorio R, et al. Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study. Lancet Oncol. 2016;17(8):1137\u201346.","journal-title":"Lancet Oncol"},{"issue":"31","key":"2549_CR16","doi-asserted-by":"publisher","first-page":"11023","DOI":"10.1073\/pnas.0504921102","volume":"102","author":"F Borovecki","year":"2005","unstructured":"Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, et al. Genome-wide expression profiling of human blood reveals biomarkers for Huntington\u2019s disease. Proc Natl Acad Sci USA. 2005;102(31):11023\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Database issue","key":"2549_CR17","first-page":"D991","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al. NCBI GEO: archive for functional genomics data sets-update. Nucleic Acids Res. 2013;41(Database issue):D991\u2013D99595.","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2549_CR18","first-page":"D808","volume":"41","author":"A Franceschini","year":"2013","unstructured":"Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C, et al. STRING v9.1: protein\u2013protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41(1):D808\u2013D815815.","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2549_CR19","first-page":"91","volume":"113","author":"L Spinelli","year":"2013","unstructured":"Spinelli L, Gambette P, Chapple CE, Robisson B, Baudot A, Garreta H, Tichit L, Guenoche A, Brun C. Clust&See: a Cytoscape plugin for the identification, visualization and manipulation of network clusters. Bio Syst. 2013;113(2):91\u20135.","journal-title":"Bio Syst"},{"issue":"1","key":"2549_CR20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W da Huang","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44\u201357.","journal-title":"Nat Protoc"},{"issue":"1","key":"2549_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15\u201320.","journal-title":"Cell"},{"key":"2549_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/978-1-60761-811-9_19","volume":"667","author":"X Wang","year":"2010","unstructured":"Wang X. Computational prediction of microRNA targets. Methods Mol Biol. 2010;667:283\u201395.","journal-title":"Methods Mol Biol"},{"issue":"21","key":"2549_CR23","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","volume":"10","author":"RL Camp","year":"2004","unstructured":"Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clinical Cancer Res. 2004;10(21):7252\u20139.","journal-title":"Clinical Cancer Res"},{"issue":"1","key":"2549_CR24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","volume":"227","author":"ST Lee","year":"2011","unstructured":"Lee ST, Chu K, Im WS, Yoon HJ, Im JY, Park JE, Park KH, Jung KH, Lee SK, Kim M, et al. Altered microRNA regulation in Huntington\u2019s disease models. Exp Neurol. 2011;227(1):172\u20139.","journal-title":"Exp Neurol"},{"issue":"3","key":"2549_CR25","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.bbrc.2010.05.007","volume":"396","author":"M Sinha","year":"2010","unstructured":"Sinha M, Ghose J, Das E, Bhattarcharyya NP. Altered microRNAs in STHdh(Q111)\/Hdh(Q111) cells: miR-146a targets TBP. Biochem Biophys Res Commun. 2010;396(3):742\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"20","key":"2549_CR26","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1093\/nar\/gkq575","volume":"38","author":"E Marti","year":"2010","unstructured":"Marti E, Pantano L, Banez-Coronel M, Llorens F, Minones-Moyano E, Porta S, Sumoy L, Ferrer I, Estivill X. A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing. Nucleic Acids Res. 2010;38(20):7219\u201335.","journal-title":"Nucleic Acids Res"},{"key":"2549_CR27","first-page":"509","volume":"9","author":"E Kerschbamer","year":"2015","unstructured":"Kerschbamer E, Biagioli M. Huntington's disease as neurodevelopmental disorder: altered chromatin regulation, coding, and non-coding RNA transcription. Front Neurosci. 2015;9:509.","journal-title":"Front Neurosci"},{"key":"2549_CR28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.nbd.2016.09.006","volume":"96","author":"EE Arteaga-Bracho","year":"2016","unstructured":"Arteaga-Bracho EE, Gulinello M, Winchester ML, Pichamoorthy N, Petronglo JR, Zambrano AD, Inocencio J, De Jesus CD, Louie JO, Gokhan S, et al. Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease. Neurobiol Dis. 2016;96:144\u201355.","journal-title":"Neurobiol Dis"},{"issue":"4","key":"2549_CR29","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1007\/s12035-017-0477-7","volume":"55","author":"K Wiatr","year":"2018","unstructured":"Wiatr K, Szlachcic WJ, Trzeciak M, Figlerowicz M, Figiel M. Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells. Mol Neurobiol. 2018;55(4):3351\u201371.","journal-title":"Mol Neurobiol"},{"key":"2549_CR30","first-page":"1278081","volume":"2017","author":"M Liu","year":"2017","unstructured":"Liu M, Xu Z, Du Z, Wu B, Jin T, Xu K, Xu L, Li E, Xu H. The Identification of key genes and pathways in glioma by bioinformatics analysis. J Immunol Res. 2017;2017:1278081.","journal-title":"J Immunol Res"},{"key":"2549_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnins.2019.00002","volume":"13","author":"S Mukherjee","year":"2019","unstructured":"Mukherjee S, Klaus C, Pricop-Jeckstadt M, Miller JA, Struebing FL. A microglial signature directing human aging and neurodegeneration-related gene networks. Front Neurosci. 2019;13:2.","journal-title":"Front Neurosci"},{"issue":"1\u20132","key":"2549_CR32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0378-1119(96)00463-5","volume":"181","author":"VW Bauer","year":"1996","unstructured":"Bauer VW, Swaffield JC, Johnston SA, Andrews MT. CADp44: a novel regulatory subunit of the 26S proteasome and the mammalian homolog of yeast Sug2p. Gene. 1996;181(1\u20132):63\u20139.","journal-title":"Gene"},{"issue":"1","key":"2549_CR33","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1006\/bbrc.1997.7892","volume":"243","author":"N Tanahashi","year":"1998","unstructured":"Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases. Biochem Biophys Res Commun. 1998;243(1):229\u201332.","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"2549_CR34","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.tibs.2013.05.003","volume":"38","author":"J Labbadia","year":"2013","unstructured":"Labbadia J, Morimoto RI. Huntington's disease: underlying molecular mechanisms and emerging concepts. Trends Biochem Sci. 2013;38(8):378\u201385.","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"2549_CR35","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1074\/jbc.M806256200","volume":"284","author":"E Rousseau","year":"2009","unstructured":"Rousseau E, Kojima R, Hoffner G, Djian P, Bertolotti A. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. J Biol Chem. 2009;284(3):1917\u201329.","journal-title":"J Biol Chem"},{"key":"2549_CR36","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1038\/srep02407","volume":"3","author":"R Moslehi","year":"2013","unstructured":"Moslehi R, Mills JL, Signore C, Kumar A, Ambroggio X, Dzutsev A. Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia. Sci Rep. 2013;3:2407.","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"2549_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-328X(02)00450-3","volume":"109","author":"WM van Roon-Mom","year":"2002","unstructured":"van Roon-Mom WM, Reid SJ, Jones AL, MacDonald ME, Faull RL, Snell RG. Insoluble TATA-binding protein accumulation in Huntington's disease cortex. Brain Res Mol Brain Res. 2002;109(1\u20132):1\u201310.","journal-title":"Brain Res Mol Brain Res"},{"issue":"5","key":"2549_CR38","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.devcel.2006.10.009","volume":"11","author":"DC Chan","year":"2006","unstructured":"Chan DC. Dissecting mitochondrial fusion. Dev Cell. 2006;11(5):592\u20134.","journal-title":"Dev Cell"},{"issue":"1\u20134","key":"2549_CR39","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.bbrc.2018.11.031","volume":"507","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Sun X, Qi X. Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington's disease. Biochem Biophys Res Commun. 2018;507(1\u20134):319\u201323.","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"2549_CR40","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/acn3.135","volume":"1","author":"M Jiang","year":"2014","unstructured":"Jiang M, Zheng J, Peng Q, Hou Z, Zhang J, Mori S, Ellis JL, Vlasuk GP, Fries H, Suri V, et al. Sirtuin 1 activator SRT2104 protects Huntington\u2019s disease mice. Ann Clin Transl Neurol. 2014;1(12):1047\u201352.","journal-title":"Ann Clin Transl Neurol"},{"issue":"11","key":"2549_CR41","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1093\/hmg\/ddu010","volume":"23","author":"MR Smith","year":"2014","unstructured":"Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington\u2019s disease. Hum Mol Genet. 2014;23(11):2995\u20133007.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2549_CR42","doi-asserted-by":"publisher","first-page":"e12318","DOI":"10.1111\/1755-5922.12318","volume":"36","author":"Q Tang","year":"2018","unstructured":"Tang Q, Len Q, Liu Z, Wang W. Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1. Cardiovasc Therap. 2018;36(2):e12318.","journal-title":"Cardiovasc Therap."},{"issue":"7","key":"2549_CR43","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1007\/s12035-016-0048-3","volume":"54","author":"L Naia","year":"2017","unstructured":"Naia L, Rosenstock TR, Oliveira AM, Oliveira-Sousa SI, Caldeira GL, Carmo C, Laco MN, Hayden MR, Oliveira CR, Rego AC. Comparative mitochondrial-based protective effects of resveratrol and nicotinamide in Huntington's disease models. Mol Neurobiol. 2017;54(7):5385\u201399.","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2549_CR44","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.expneurol.2010.05.006","volume":"225","author":"DJ Ho","year":"2010","unstructured":"Ho DJ, Calingasan NY, Wille E, Dumont M, Beal MF. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Exp Neurol. 2010;225(1):74\u201384.","journal-title":"Exp Neurol"},{"issue":"24","key":"2549_CR45","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1128\/MCB.00307-13","volume":"33","author":"AN Rai","year":"2013","unstructured":"Rai AN, Vargas ML, Wang L, Andersen EF, Miller EL, Simon JA. Elements of the polycomb repressor SU(Z)12 needed for histone H3\u2013K27 methylation, the interface with E(Z), and in vivo function. Mol Cell Biol. 2013;33(24):4844\u201356.","journal-title":"Mol Cell Biol"},{"issue":"7330","key":"2549_CR46","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature09784","volume":"469","author":"R Margueron","year":"2011","unstructured":"Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469(7330):343\u20139.","journal-title":"Nature"},{"key":"2549_CR47","doi-asserted-by":"publisher","first-page":"13661","DOI":"10.1038\/ncomms13661","volume":"7","author":"S Cooper","year":"2016","unstructured":"Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661.","journal-title":"Nat Commun"},{"issue":"12","key":"2549_CR48","doi-asserted-by":"publisher","first-page":"e0144398","DOI":"10.1371\/journal.pone.0144398","volume":"10","author":"X Dong","year":"2015","unstructured":"Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z. The role of H3K4me3 in transcriptional regulation is altered in Huntington's disease. PLoS ONE. 2015;10(12):e0144398.","journal-title":"PLoS ONE"},{"issue":"3","key":"2549_CR49","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.molcel.2011.03.025","volume":"42","author":"FW Schmitges","year":"2011","unstructured":"Schmitges FW, Prusty AB, Faty M, Stutzer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, et al. Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell. 2011;42(3):330\u201341.","journal-title":"Mol Cell"},{"issue":"4","key":"2549_CR50","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/hmg\/ddp524","volume":"19","author":"IS Seong","year":"2010","unstructured":"Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, et al. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010;19(4):573\u201383.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"2549_CR51","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s13238-013-2124-z","volume":"4","author":"L Han","year":"2013","unstructured":"Han L, Wang P, Zhao G, Wang H, Wang M, Chen J, Tong T. Upregulation of SIRT1 by 17 beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1. Protein Cell. 2013;4(4):310\u201321.","journal-title":"Protein Cell"},{"issue":"6","key":"2549_CR52","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/1878-0261.12067","volume":"11","author":"S Ling","year":"2017","unstructured":"Ling S, Li J, Shan Q, Dai H, Lu D, Wen X, Song P, Xie H, Zhou L, Liu J, et al. USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1\/AKT\/MRP1 signaling pathway. Mol Oncol. 2017;11(6):682\u201395.","journal-title":"Mol Oncol"},{"key":"2549_CR53","doi-asserted-by":"publisher","first-page":"9643","DOI":"10.18632\/aging.102410","volume":"11","author":"H Liu","year":"2019","unstructured":"Liu H, Liu N, Zhao Y, Zhu X, Wang C, Liu Q, Gao C, Zhao X, Li J. Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc\/NAMPT\/SIRT1-dependent FOXO1 and YAP signaling. Aging. 2019;11:9643.","journal-title":"Aging."},{"issue":"2","key":"2549_CR54","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3892\/etm.2017.4590","volume":"14","author":"Q Zou","year":"2017","unstructured":"Zou Q, Tang Q, Pan Y, Wang X, Dong X, Liang Z, Huang D. MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1. Exp Ther Med. 2017;14(2):1009\u2013166.","journal-title":"Exp Ther Med"},{"issue":"41","key":"2549_CR55","doi-asserted-by":"publisher","first-page":"17141","DOI":"10.1073\/pnas.1104409108","volume":"108","author":"Y Hu","year":"2011","unstructured":"Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, et al. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci USA. 2011;108(41):17141\u20136.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-020-02549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-020-02549-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-020-02549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:05:03Z","timestamp":1634169903000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-020-02549-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2549"],"URL":"https:\/\/doi.org\/10.1186\/s12967-020-02549-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]},"assertion":[{"value":"19 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"388"}}