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Published studies have proposed that deconditioning is an important pathophysiological mechanism in various forms of OI, including postural orthostatic tachycardia syndrome (POTS), however conflicting opinions exist. Deconditioning can be classified objectively using the predicted peak oxygen consumption (VO<jats:sub>2<\/jats:sub>) values from cardiopulmonary exercise testing (CPET). Therefore, if deconditioning is an important contributor to OI symptomatology, one would expect a relation between the degree of reduction in peak VO<jats:sub>2<\/jats:sub>during CPET and the degree of reduction in CBF during head-up tilt testing (HUT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>In 22 healthy controls and 199 ME\/CFS patients were included. Deconditioning was classified by the CPET response as follows: %peak VO<jats:sub>2<\/jats:sub>\u2009\u2265\u200985%\u2009=\u2009no deconditioning, %peak VO<jats:sub>2<\/jats:sub> 65\u201385%\u2009=\u2009mild deconditioning, and %peak VO<jats:sub>2<\/jats:sub>\u2009&lt;\u200965%\u2009=\u2009severe deconditioning. HC had higher oxygen consumption at the ventilatory threshold and at peak exercise as compared to ME\/CFS patients (p ranging between 0.001 and\u2009&lt;\u20090.0001). Although ME\/CFS patients had significantly greater CBF reduction than HC (p\u2009&lt;\u20090.0001), there were no differences in CBF reduction among ME\/CFS patients with no, mild, or severe deconditioning. We classified the hemodynamic response to HUT into three categories: those with a normal heart rate and blood pressure response, postural orthostatic tachycardia syndrome, or orthostatic hypotension. No difference in the degree of CBF reduction was shown in those three groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study shows that in ME\/CFS patients orthostatic intolerance is not caused by deconditioning as defined on cardiopulmonary exercise testing. An abnormal high decline in cerebral blood flow during orthostatic stress was present in all ME\/CFS patients regardless of their %peak VO<jats:sub>2<\/jats:sub> results on cardiopulmonary exercise testing.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-021-02819-0","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T13:03:57Z","timestamp":1620133437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Deconditioning does not explain orthostatic intolerance in ME\/CFS (myalgic encephalomyelitis\/chronic fatigue syndrome)"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-0914","authenticated-orcid":false,"given":"C. (Linda) M. 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All ME\/CFS participants and HC gave informed, written consent authorizing us to use their medical records for research purposes. The study of the use of clinical data was approved by the medical ethics committee of the Slotervaart Hospital, number P1736, Amsterdam, NL. The testing of HC was approved by the same ethics committee, number P1411\u201d.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of publication"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}