{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:32:46Z","timestamp":1793230366195,"version":"4.5.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance Analysis (BIA), represents an indicator of the chronic inflammatory state. The Mediterranean diet (MD) is a healthy dietary pattern that can exert anti-inflammatory effects in several inflammatory diseases. We aimed to investigate the difference in PhA and adherence to the MD and their associations with the severity of acne in a sample of na\u00efve treatment patients with acne compared to control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials<\/jats:title>\n                <jats:p>In this cross-sectional, case\u2013control, observational study, we enrolled 51 patients with acne and 51 control individuals. Body composition was evaluated by a BIA phase-sensitive system (50\u00a0kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy, Akern). For adherence to the MD, we have used the PREvenci\u00f3n con DIeta MEDiterr\u00e1nea (PREDIMED) questionnaire. The clinical severity of acne was assessed by using the global acne grading system (GAGS), a quantitative scoring system to assess acne severity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with acne had a worse body composition, in particular smaller PhA (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), and a lower adherence to the MD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) than the control group, in spite of no differences in gender, age and BMI between the two groups. Stratifying patients with acne according to GAGS categories, both PhA (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and PREDIMED score (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) decreased significantly in severe acne than mild\/moderate acne. The GAGS score was negative correlations with PhA (r\u2009=\u2009\u2212 0.478, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and PREDIMED score (r\u2009=\u2009\u2212 0.504, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The results of the multivariate analysis showed PhA and PREDIMED score were the major determinants of GAGS score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The receiver operator characteristic (ROC) analysis reporting a value of PhA of\u2009\u2264\u20096.1\u00b0 and a PREDIMED score of\u2009\u2264\u20099 identified patients with acne with the highest clinical severity of the disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Novel correlations were reported between PhA and the degree of adherence to the MD with acne severity. Of interest, PhA and PREDIMED scores might represent possible markers of the severity of acne in a clinical setting. This study highlights how a cooperation between dermatologist and nutritionists might provide a combination key in the complex management of acne patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-021-02826-1","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T11:03:11Z","timestamp":1619434991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Phase angle and Mediterranean diet in patients with acne: Two easy tools for assessing the clinical severity of disease"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-456X","authenticated-orcid":false,"given":"Luigi","family":"Barrea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Donnarumma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cacciapuoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Muscogiuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"De Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Blasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Savastano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Fabbrocini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"issue":"14","key":"2826_CR1","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1056\/NEJMcp1702493","volume":"379","author":"AL Zaenglein","year":"2018","unstructured":"Zaenglein AL. Acne vulgaris. N Engl J Med. 2018;379(14):1343\u201352. https:\/\/doi.org\/10.1056\/NEJMcp1702493.","journal-title":"N Engl J Med"},{"issue":"1","key":"2826_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00005-018-0528-4","volume":"67","author":"A Balato","year":"2019","unstructured":"Balato A, Cacciapuoti S, Di Caprio R, Marasca C, Masar\u00e0 A, Raimondo A, et al. Human microbiome: composition and role in inflammatory skin disease. Arch Immunol Ther Exp (Warsz). 2019;67(1):1\u201318. https:\/\/doi.org\/10.1007\/s00005-018-0528-4.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"6","key":"2826_CR3","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jaad.2012.02.018","volume":"67","author":"A Di Landro","year":"2012","unstructured":"Di Landro A, Cazzaniga S, Parazzini F, Ingordo V, Cusano F, Atzori L, et al. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J Am Acad Dermatol. 2012;67(6):1129\u201335. https:\/\/doi.org\/10.1016\/j.jaad.2012.02.018.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2826_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000090655","volume":"212","author":"F Ballanger","year":"2006","unstructured":"Ballanger F, Baudry P, N\u2019Guyen JM, Khammari A, Dr\u00e9no B. Heredity: a prognostic factor for acne. Dermatology. 2006;212(2):145\u20139. https:\/\/doi.org\/10.1159\/000090655.","journal-title":"Dermatology"},{"issue":"3","key":"2826_CR5","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1590\/abd1806-4841.20142100","volume":"89","author":"E Bagatin","year":"2014","unstructured":"Bagatin E, Timpano DL, Guadanhim dos LRS, Nogueira VMA, Terzian LR, Steiner D, et al. Acne vulgaris: prevalence and clinical forms in adolescents from S\u00e3o Paulo, Brazil. An Bras Dermatol. 2014;89(3):428\u201335. https:\/\/doi.org\/10.1590\/abd1806-4841.20142100.","journal-title":"An Bras Dermatol"},{"issue":"2","key":"2826_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000,362,809","volume":"229","author":"G Fabbrocini","year":"2014","unstructured":"Fabbrocini G, Izzo R, Donnarumma M, Marasca C, Monfrecola G. Acne smart club: an educational program for patients with acne. Dermatology. 2014;229(2):136\u201340. https:\/\/doi.org\/10.1159\/000,362,809.","journal-title":"Dermatology"},{"issue":"12","key":"2826_CR7","first-page":"s44","volume":"17","author":"G Fabbrocini","year":"2018","unstructured":"Fabbrocini G, Cacciapuoti S. Evaluation, prevention, and management of acne scars: issues, strategies, and enhanced outcomes. J Drugs Dermatol. 2018;17(12):s44-48.","journal-title":"J Drugs Dermatol"},{"issue":"5","key":"2826_CR8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1046\/j.1365-4362.2000.00907.x","volume":"39","author":"S Aktan","year":"2000","unstructured":"Aktan S, Ozmen E, Sanli B. Anxiety, depression, and nature of acne vulgaris in adolescents. Int J Dermatol. 2000;39(5):354\u20137. https:\/\/doi.org\/10.1046\/j.1365-4362.2000.00907.x.","journal-title":"Int J Dermatol"},{"issue":"1","key":"2826_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s13555-018-0224-7","volume":"8","author":"G Fabbrocini","year":"2018","unstructured":"Fabbrocini G, Cacciapuoti S, Monfrecola G. A qualitative investigation of the impact of acne on health-related quality of life (HRQL): development of a conceptual model. Dermatol Ther (Heidelb). 2018;8(1):85\u201399. https:\/\/doi.org\/10.1007\/s13555-018-0224-7.","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"6","key":"2826_CR10","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1111\/bjd.17851","volume":"181","author":"SA Bernales","year":"2019","unstructured":"Bernales SA. Acne vulgaris: role of the immune system. Br J Dermatol. 2019;181(6):1226\u201337. https:\/\/doi.org\/10.1111\/bjd.17851.","journal-title":"Br J Dermatol"},{"issue":"9","key":"2826_CR11","first-page":"27","volume":"6","author":"EA Tanghetti","year":"2013","unstructured":"Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6(9):27\u201335.","journal-title":"J Clin Aesthet Dermatol"},{"issue":"9","key":"2826_CR12","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/exd.14172","volume":"29","author":"CC Zouboulis","year":"2020","unstructured":"Zouboulis CC. Endocrinology and immunology of acne: two sides of the same coin. Exp Dermatol. 2020;29(9):840\u201359. https:\/\/doi.org\/10.1111\/exd.14172.","journal-title":"Exp Dermatol"},{"key":"2826_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15390","author":"F Dalloglio","year":"2021","unstructured":"Dalloglio F, Nasca MR, Fiorentini F, Micali G. Diet and acne: review of the evidence from 2009 to 2020. Int J Dermatol. 2021. https:\/\/doi.org\/10.1111\/ijd.15390 (Online ahead of print).","journal-title":"Int J Dermatol"},{"issue":"1","key":"2826_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/ced.12673","volume":"41","author":"G Fabbrocini","year":"2016","unstructured":"Fabbrocini G, Izzo R, Faggiano A, Del Prete M, Donnarumma M, Marasca C, et al. Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments. Clin Exp Dermatol. 2016;41(1):38\u201342. https:\/\/doi.org\/10.1111\/ced.12673.","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"2826_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2340\/00015555-2450","volume":"97","author":"F Fiedler","year":"2017","unstructured":"Fiedler F, Stangl GI, Fiedler E, Taube K-M. Acne and nutrition: a systematic review. Acta Derm Venereol. 2017;97(1):7\u20139. https:\/\/doi.org\/10.2340\/00015555-2450.","journal-title":"Acta Derm Venereol"},{"issue":"10","key":"2826_CR16","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1111\/jdv.14998","volume":"32","author":"JP Claudel","year":"2018","unstructured":"Claudel JP, Auffret N, Leccia MT, Poli F, Dr\u00e9no B. Acne and nutrition: hypotheses, myths and facts. J Eur Acad Dermatol Venereol. 2018;32(10):1631\u20137. https:\/\/doi.org\/10.1111\/jdv.14998.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"2826_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s40257-020-00542-y","volume":"22","author":"H Baldwin","year":"2021","unstructured":"Baldwin H, Tan J. Effects of diet on acne and its response to treatment. Am J Clin Dermatol. 2021;22(1):55\u201365. https:\/\/doi.org\/10.1007\/s40257-020-00542-y.","journal-title":"Am J Clin Dermatol"},{"issue":"5","key":"2826_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3390\/ijerph13070743","volume":"13","author":"L Barrea","year":"2016","unstructured":"Barrea L, Nappi F, Di Somma C, Savanelli MC, Falco A, Balato A, et al. Environmental risk factors in psoriasis: the point of view of the nutritionist. Int J Environ Res Public Health. 2016;13(5):743. https:\/\/doi.org\/10.3390\/ijerph13070743.","journal-title":"Int J Environ Res Public Health"},{"key":"2826_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12967-014-0372-1","volume":"13","author":"L Barrea","year":"2015","unstructured":"Barrea L, Balato N, Di Somma C, Macchia PE, Napolitano M, Savanelli MC, et al. Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet? J Transl Med. 2015;13:18. https:\/\/doi.org\/10.1186\/s12967-014-0372-1.","journal-title":"J Transl Med"},{"issue":"1","key":"2826_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/nu11010057","volume":"11","author":"L Barrea","year":"2018","unstructured":"Barrea L, Fabbrocini G, Annunziata G, Muscogiuri G, Donnarumma M, Marasca C, et al. Role of nutrition and adherence to the mediterranean diet in the multidisciplinary approach of hidradenitis suppurativa: evaluation of nutritional status and its association with severity of disease. Nutrients. 2018;11(1):57\u201374. https:\/\/doi.org\/10.3390\/nu11010057.","journal-title":"Nutrients"},{"issue":"10","key":"2826_CR21","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.3390\/nu11102278","volume":"11","author":"L Barrea","year":"2019","unstructured":"Barrea L, Arnone A, Annunziata G, Muscogiuri G, Laudisio D, Salzano C, et al. Adherence to the mediterranean diet, dietary patterns and body composition in women with polycystic ovary syndrome (PCOS). Nutrients. 2019;11(10):2278\u201399. https:\/\/doi.org\/10.3390\/nu11102278.","journal-title":"Nutrients"},{"issue":"2","key":"2826_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1017\/S0954422418000136","volume":"31","author":"L Barrea","year":"2018","unstructured":"Barrea L, Marzullo P, Muscogiuri G, Di Somma C, Scacchi M, Orio F, et al. Source and amount of carbohydrate in the diet and inflammation in women with polycystic ovary syndrome. Nutr Res Rev. 2018;31(2):291\u2013301. https:\/\/doi.org\/10.1017\/S0954422418000136.","journal-title":"Nutr Res Rev"},{"key":"2826_CR23","doi-asserted-by":"publisher","DOI":"10.23736\/S0391-1977.20.03266-6","author":"D Laudisio","year":"2020","unstructured":"Laudisio D, Castellucci B, Barrea L, Pugliese G, Savastano S, Colao A, et al. Mediterranean diet and breast cancer risk: a narrative review. Minerva Endocrinol. 2020. https:\/\/doi.org\/10.23736\/S0391-1977.20.03266-6 (Online ahead of print).","journal-title":"Minerva Endocrinol"},{"issue":"1","key":"2826_CR24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1017\/S0954422419000167","volume":"33","author":"D Laudisio","year":"2020","unstructured":"Laudisio D, Barrea L, Muscogiuri G, Annunziata G, Colao A, Savastano S. Breast cancer prevention in premenopausal women: Role of the Mediterranean diet and its components. Nutr Res Rev. 2020;33(1):19\u201332. https:\/\/doi.org\/10.1017\/S0954422419000167.","journal-title":"Nutr Res Rev"},{"key":"2826_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ejogrb.2018.03.050","volume":"230","author":"D Laudisio","year":"2018","unstructured":"Laudisio D, Muscogiuri G, Barrea L, Savastano S, Colao A. Obesity and breast cancer in premenopausal women: current evidence and future perspectives. Eur J Obstet Gynecol Reprod Biol. 2018;230:217\u201321. https:\/\/doi.org\/10.1016\/j.ejogrb.2018.03.050.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2826_CR26","doi-asserted-by":"publisher","first-page":"110991","DOI":"10.1016\/j.nut.2020.110991","volume":"79\u201380","author":"G Pugliese","year":"2020","unstructured":"Pugliese G, Barrea L, Laudisio D, Aprano S, Castellucci B, Framondi L, et al. Mediterranean diet as tool to manage obesity in menopause: a narrative review. Nutrition. 2020;79\u201380:110991\u20137. https:\/\/doi.org\/10.1016\/j.nut.2020.110991.","journal-title":"Nutrition"},{"issue":"7","key":"2826_CR27","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1080\/10408398.2020.1755220","volume":"61","author":"L Barrea","year":"2021","unstructured":"Barrea L, Pugliese G, Laudisio D, Colao A, Savastano S, Muscogiuri G. Mediterranean diet as medical prescription in menopausal women with obesity: a practical guide for nutritionists. Crit Rev Food Sci Nutr. 2021;61(7):1201\u201311. https:\/\/doi.org\/10.1080\/10408398.2020.1755220.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"18","key":"2826_CR28","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1080\/10408398.2017.1353479","volume":"58","author":"L Barrea","year":"2018","unstructured":"Barrea L, Di Somma C, Muscogiuri G, Tarantino G, Tenore GC, Orio F, et al. Nutrition, inflammation and liver-spleen axis. Crit Rev Food Sci Nutr. 2018;58(18):3141\u201358. https:\/\/doi.org\/10.1080\/10408398.2017.1353479.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2826_CR29","doi-asserted-by":"publisher","unstructured":"Barrea L, Muscogiuri G, Frias-Toral E, Laudisio D, Pugliese G, Castellucci B, et al. Nutrition and immune system: from the Mediterranean diet to dietary supplementary through the microbiota. Crit Rev Food Sci Nutr. 2020;1\u201325. https:\/\/doi.org\/10.1080\/10408398.2020.1792826.","DOI":"10.1080\/10408398.2020.1792826"},{"issue":"3","key":"2826_CR30","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/gerona\/glx227","volume":"73","author":"V Tosti","year":"2018","unstructured":"Tosti V, Bertozzi B, Fontana L. Health benefits of the mediterranean diet: metabolic and molecular mechanisms. J Gerontol A Biol Sci Med Sci. 2018;73(3):318\u201326. https:\/\/doi.org\/10.1093\/gerona\/glx227.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"2826_CR31","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1177\/1403494812454235","volume":"40","author":"N Skroza","year":"2012","unstructured":"Skroza N, Tolino E, Proietti I, Bernardini N, Nicolucci F, Viola G, et al. Mediterranean diet and familial dysmetabolism as factors influencing the development of acne. Scand J Public Health. 2012;40(5):466\u201374. https:\/\/doi.org\/10.1177\/1403494812454235.","journal-title":"Scand J Public Health"},{"issue":"11","key":"2826_CR32","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s13312-017-1182-3","volume":"54","author":"S Chiplonkar","year":"2017","unstructured":"Chiplonkar S, Kajale N, Ekbote V, Mandlik R, Parthasarathy L, Khadilkar V, et al. Validation of bioelectric impedance analysis against dual-energy X-ray absorptiometry for assessment of body composition in Indian children aged 5 to 18 years. Indian Pediatr. 2017;54(11):919\u201324. https:\/\/doi.org\/10.1007\/s13312-017-1182-3.","journal-title":"Indian Pediatr"},{"issue":"11","key":"2826_CR33","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.nutres.2015.08.005","volume":"35","author":"AC Huang","year":"2015","unstructured":"Huang AC, Chen YY, Chuang CL, Chiang LM, Lu HK, Lin HC, et al. Cross-mode bioelectrical impedance analysis in a standing position for estimating fat-free mass validated against dual-energy x-ray absorptiometry. Nutr Res. 2015;35(11):982\u20139. https:\/\/doi.org\/10.1016\/j.nutres.2015.08.005.","journal-title":"Nutr Res"},{"key":"2826_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exger.2017.11.019","volume":"102","author":"CM Tomeleri","year":"2018","unstructured":"Tomeleri CM, Cavaglieri CR, de Souza MF, Cavalcante EF, Antunes M, Nabbuco HCG, et al. Phase angle is related with inflammatory and oxidative stress biomarkers in older women. Exp Gerontol. 2018;102:12\u20138. https:\/\/doi.org\/10.1016\/j.exger.2017.11.019.","journal-title":"Exp Gerontol"},{"issue":"5","key":"2826_CR35","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/MCO.0000000000000387","volume":"20","author":"HC Lukaski","year":"2017","unstructured":"Lukaski HC, Kyle UG, Kondrup J. Assessment of adult malnutrition and prognosis with bioelectrical impedance analysis: phase angle and impedance ratio. Curr Opin Clin Nutr Metab Care. 2017;20(5):330\u20139. https:\/\/doi.org\/10.1097\/MCO.0000000000000387.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"2826_CR36","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/01.mco.0000165011.69943.39","volume":"8","author":"MCG Barbosa-Silva","year":"2005","unstructured":"Barbosa-Silva MCG, Barros AJD. Bioelectrical impedance analysis in clinical practice: a new perspective on its use beyond body composition equations. Curr Opin Clin Nutr Metab Care. 2005;8(3):311\u20137. https:\/\/doi.org\/10.1097\/01.mco.0000165011.69943.39.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"6","key":"2826_CR37","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.clnu.2012.05.008","volume":"31","author":"K Norman","year":"2012","unstructured":"Norman K, Stob\u00e4us N, Pirlich M, Bosy-Westphal A. Bioelectrical phase angle and impedance vector analysis\u2014clinical relevance and applicability of impedance parameters. Clin Nutr. 2012;31(6):854\u201361. https:\/\/doi.org\/10.1016\/j.clnu.2012.05.008.","journal-title":"Clin Nutr"},{"issue":"6","key":"2826_CR38","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1079\/bjn20041292","volume":"92","author":"N Stob\u00e4us","year":"2004","unstructured":"Stob\u00e4us N, Pirlich M, Valentini L, Schulzke JD, Norman K. Determinants of bioelectrical phase angle in disease. Br J Nutr. 2004;92(6):957\u201362. https:\/\/doi.org\/10.1079\/bjn20041292.","journal-title":"Br J Nutr"},{"issue":"3","key":"2826_CR39","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3945\/ajcn.115.116772","volume":"103","author":"MC Gonzalez","year":"2016","unstructured":"Gonzalez MC, Barbosa-Silva TG, Bielemann RM, Gallagher D, Heymsfield SB. Phase angle and its determinants in healthy subjects: influence of body composition. Am J Clin Nutr. 2016;103(3):712\u20136. https:\/\/doi.org\/10.3945\/ajcn.115.116772.","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"2826_CR40","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.clnu.2004.09.012","volume":"23","author":"UG Kyle","year":"2004","unstructured":"Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, G\u00f3mez JM, et al. Bioelectrical impedance analysis\u2014Part II: utilization in clinical practice. Clin Nutr. 2004;23(6):1430\u201353. https:\/\/doi.org\/10.1016\/j.clnu.2004.09.012.","journal-title":"Clin Nutr"},{"issue":"3","key":"2826_CR41","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3945\/ajcn.2010.29215","volume":"92","author":"K Norman","year":"2010","unstructured":"Norman K, Stob\u00e4us N, Zocher D, Bosy-Westphal A, Szramek A, Scheufele R, et al. Cutoff percentiles of bioelectrical phase angle predict functionality, quality of life, and mortality in patients with cancer. Am J Clin Nutr. 2010;92(3):612\u20139. https:\/\/doi.org\/10.3945\/ajcn.2010.29215.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2826_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09637486.2020.1765152","volume":"72","author":"G Muscogiuri","year":"2021","unstructured":"Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Aprano S, Framondi L, et al. The opera prevention project. Int J Food Sci Nutr. 2021;72(1):1\u20133. https:\/\/doi.org\/10.1080\/09637486.2020.1765152.","journal-title":"Int J Food Sci Nutr"},{"issue":"12","key":"2826_CR43","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"RS Legro","year":"2013","unstructured":"Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(12):4565\u201392. https:\/\/doi.org\/10.1210\/jc.2013-2350.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2826_CR44","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.3390\/nu11123034","volume":"11","author":"G Muscogiuri","year":"2019","unstructured":"Muscogiuri G, Barrea L, Di Somma C, Laudisio D, Salzano C, Pugliese G, et al. Sex differences of vitamin D status across BMI classes: an observational prospective cohort study. Nutrients. 2019;11(12):3034\u201346. https:\/\/doi.org\/10.3390\/nu11123034.","journal-title":"Nutrients"},{"issue":"5","key":"2826_CR45","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3390\/nu12051439","volume":"12","author":"L Barrea","year":"2020","unstructured":"Barrea L, Muscogiuri G, Laudisio D, Pugliese G, de Alteriis G, Colao A, et al. Influence of the mediterranean diet on 25-hydroxyvitamin D levels in adults. Nutrients. 2020;12(5):1439\u201360. https:\/\/doi.org\/10.3390\/nu12051439.","journal-title":"Nutrients"},{"issue":"5","key":"2826_CR46","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1007\/s00204-018-2193-0","volume":"92","author":"L Barrea","year":"2018","unstructured":"Barrea L, Muscogiuri G, Di Somma C, Annunziata G, Megna M, Falco A, et al. Coffee consumption, metabolic syndrome and clinical severity of psoriasis: good or bad stuff? Arch Toxicol. 2018;92(5):1831\u201345. https:\/\/doi.org\/10.1007\/s00204-018-2193-0.","journal-title":"Arch Toxicol"},{"key":"2826_CR47","doi-asserted-by":"publisher","first-page":"6101254","DOI":"10.1155\/2017\/6101254","volume":"2017","author":"L Barrea","year":"2017","unstructured":"Barrea L, Tarantino G, Di SC, Muscogiuri G, Macchia PE, Falco A, et al. Adherence to the mediterranean diet and circulating levels of sirtuin 4 in obese patients: a novel association. Oxid Med Cell Longev. 2017;2017:6101254\u201369. https:\/\/doi.org\/10.1155\/2017\/6101254.","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"2826_CR48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.clnu.2015.12.007","volume":"36","author":"L Barrea","year":"2017","unstructured":"Barrea L, Di Somma C, Macchia PE, Falco A, Savanelli MC, Orio F, et al. Influence of nutrition on somatotropic axis: milk consumption in adult individuals with moderate-severe obesity. Clin Nutr. 2017;36(1):293\u2013301. https:\/\/doi.org\/10.1016\/j.clnu.2015.12.007.","journal-title":"Clin Nutr"},{"issue":"1","key":"2826_CR49","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12020-015-0779-3","volume":"52","author":"MC Savanelli","year":"2016","unstructured":"Savanelli MC, Scarano E, Muscogiuri G, Barrea L, Vuolo L, Rubino M, et al. Cardiovascular risk in adult hypopituitaric patients with growth hormone deficiency: is there a role for vitamin D? Endocrine. 2016;52(1):111\u20139. https:\/\/doi.org\/10.1007\/s12020-015-0779-3.","journal-title":"Endocrine"},{"issue":"1","key":"2826_CR50","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ghir.2014.10.006","volume":"25","author":"S Savastano","year":"2015","unstructured":"Savastano S, Di Somma C, Colao A, Barrea L, Orio F, Finelli C, et al. Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone\/insulin-like growth factor-1 status. Growth Horm IGF Res. 2015;25(1):28\u201333. https:\/\/doi.org\/10.1016\/j.ghir.2014.10.006.","journal-title":"Growth Horm IGF Res"},{"issue":"6","key":"2826_CR51","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/nu11061310","volume":"11","author":"L Barrea","year":"2019","unstructured":"Barrea L, Muscogiuri G, Annunziata G, Laudisio D, Tenore GC, Colao A, et al. A new light on vitamin d in obesity: a novel association with trimethylamine-n-oxide (tmao). Nutrients. 2019;11(6):1310\u201325. https:\/\/doi.org\/10.3390\/nu11061310.","journal-title":"Nutrients"},{"issue":"1","key":"2826_CR52","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s12967-020-02465-y","volume":"18","author":"L Barrea","year":"2020","unstructured":"Barrea L, Pugliese G, Framondi L, Di Matteo R, Laudisio D, Savastano S, et al. Does Sars-Cov-2 threaten our dreams? Effect of quarantine on sleep quality and body mass index. J Transl Med. 2020;18(1):318\u201329. https:\/\/doi.org\/10.1186\/s12967-020-02465-y.","journal-title":"J Transl Med"},{"key":"2826_CR53","unstructured":"World Health Organization. WHO [Internet]. [cited 2021 February 4]. Available from: http:\/\/www.euro.who.int\/en\/health-topics\/disease-prevention\/nutrition\/a-healthy-lifestyle\/body-mass-index-bmi. Accessed 21 Feb 2021."},{"key":"2826_CR54","unstructured":"National Center for Health Statistics. Accessed 21 Feb 2021."},{"issue":"1","key":"2826_CR55","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ejcn.2009.139","volume":"64","author":"C Nishida","year":"2010","unstructured":"Nishida C, Ko GT, Kumanyika S. Body fat distribution and noncommunicable diseases in populations: overview of the 2008 WHO Expert Consultation on Waist Circumference and Waist-Hip Ratio. Eur J Clin Nutr. 2010;64(1):2\u20135. https:\/\/doi.org\/10.1038\/ejcn.2009.139.","journal-title":"Eur J Clin Nutr."},{"issue":"2","key":"2826_CR56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3390\/nu9020151","volume":"9","author":"L Barrea","year":"2017","unstructured":"Barrea L, Muscogiuri G, Macchia PE, Di Somma C, Falco A, Savanelli MC, et al. Mediterranean diet and phase angle in a sample of adult population: results of a pilot study. Nutrients. 2017;9(2):151\u201365. https:\/\/doi.org\/10.3390\/nu9020151.","journal-title":"Nutrients"},{"issue":"4","key":"2826_CR57","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3390\/nu12041132","volume":"12","author":"L Barrea","year":"2020","unstructured":"Barrea L, Muscogiuri G, Pugliese G, Aprano S, de Alteriis G, Di Somma C, et al. The sun\u2019s vitamin in adult patients affected by Prader\u2013Willi syndrome. Nutrients. 2020;12(4):1132\u201348. https:\/\/doi.org\/10.3390\/nu12041132.","journal-title":"Nutrients"},{"issue":"7","key":"2826_CR58","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.3390\/nu12072065","volume":"12","author":"L Barrea","year":"2020","unstructured":"Barrea L, Pugliese G, de Alteriis G, Colao A, Savastano S, Muscogiuri G. Phase angle: could be an easy tool to detect low-grade systemic inflammation in adults affected by Prader\u2013Willi syndrome? Nutrients. 2020;12(7):2065\u201379. https:\/\/doi.org\/10.3390\/nu12072065.","journal-title":"Nutrients"},{"issue":"2","key":"2826_CR59","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/07315724.1992.12098245","volume":"11","author":"RF Kushner","year":"1992","unstructured":"Kushner RF. Bioelectrical impedance analysis: a review of principles and applications. J Am Coll Nutr. 1992;11(2):199\u2013209.","journal-title":"J Am Coll Nutr"},{"key":"2826_CR60","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.bios.2015.10.027","volume":"77","author":"Y Xu","year":"2016","unstructured":"Xu Y, Xie X, Duan Y, Wang L, Cheng Z, Cheng J. A review of impedance measurements of whole cells. Biosens Bioelectron. 2016;77:824\u201336. https:\/\/doi.org\/10.1016\/j.bios.2015.10.027.","journal-title":"Biosens Bioelectron"},{"issue":"1","key":"2826_CR61","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/ajcn.82.1.49","volume":"82","author":"MCG Barbosa-Silva","year":"2005","unstructured":"Barbosa-Silva MCG, Barros AJD, Wang J, Heymsfield SB, Pierson RN. Bioelectrical impedance analysis: population reference values for phase angle by age and sex. Am J Clin Nutr. 2005;82(1):49\u201352. https:\/\/doi.org\/10.1093\/ajcn.82.1.49.","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"2826_CR62","doi-asserted-by":"publisher","first-page":"e43134","DOI":"10.1371\/journal.pone.0043134","volume":"7","author":"MA Mart\u00ednez-Gonz\u00e1lez","year":"2012","unstructured":"Mart\u00ednez-Gonz\u00e1lez MA, Garc\u00eda-Arellano A, Toledo E, Salas-Salvad\u00f3 J, Buil-Cosiales P, Corella D, et al. A 14-item mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial. PLoS ONE. 2012;7(8):e43134. https:\/\/doi.org\/10.1371\/journal.pone.0043134.","journal-title":"PLoS ONE"},{"issue":"2","key":"2826_CR63","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.clnu.2018.03.012","volume":"38","author":"L Barrea","year":"2019","unstructured":"Barrea L, Muscogiuri G, Di Somma C, Tramontano G, De Luca V, Illario M, et al. Association between Mediterranean diet and hand grip strength in older adult women. Clin Nutr. 2019;38(2):721\u20139. https:\/\/doi.org\/10.1016\/j.clnu.2018.03.012.","journal-title":"Clin Nutr"},{"issue":"12","key":"2826_CR64","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.3390\/nu10121854","volume":"10","author":"L Barrea","year":"2018","unstructured":"Barrea L, Altieri B, Muscogiuri G, Laudisio D, Annunziata G, Colao A, et al. Impact of nutritional status on gastroenteropancreatic neuroendocrine tumors (GEP-NET) aggressiveness. Nutrients. 2018;10(12):1854\u201372. https:\/\/doi.org\/10.3390\/nu10121854.","journal-title":"Nutrients"},{"issue":"1","key":"2826_CR65","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s42000-018-0090-9","volume":"18","author":"G Muscogiuri","year":"2019","unstructured":"Muscogiuri G, Barrea L, Di Somma C, Altieri B, Vecchiarini M, Orio F, et al. Patient empowerment and the Mediterranean diet as a possible tool to tackle prediabetes associated with overweight or obesity: a pilot study. Hormones (Athens). 2019;18(1):75\u201384. https:\/\/doi.org\/10.1007\/s42000-018-0090-9.","journal-title":"Hormones (Athens)"},{"issue":"6","key":"2826_CR66","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1046\/j.1365-4362.1997.00099.x","volume":"36","author":"A Doshi","year":"1997","unstructured":"Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36(6):416\u20138. https:\/\/doi.org\/10.1046\/j.1365-4362.1997.00099.x.","journal-title":"Int J Dermatol"},{"key":"2826_CR67","doi-asserted-by":"publisher","first-page":"961","DOI":"10.2147\/CCID.S206935","volume":"12","author":"F Dall\u2019Oglio","year":"2019","unstructured":"Dall\u2019Oglio F, Fabbrocini G, Tedeschi A, Donnarumma M, Chiodini P, Micali G. Licochalcone a in combination with salicylic acid as fluid based and hydroxy-complex 10% cream for the treatment of mild acne: a multicenter prospective trial. Clin Cosmet Investig Dermatol. 2019;12:961\u20137. https:\/\/doi.org\/10.2147\/CCID.S206935.","journal-title":"Clin Cosmet Investig Dermatol."},{"issue":"6","key":"2826_CR68","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00421-001-0570-4","volume":"86","author":"O Selberg","year":"2002","unstructured":"Selberg O, Selberg D. Norms and correlates of bioimpedance phase angle in healthy human subjects, hospitalized patients, and patients with liver cirrhosis. Eur J Appl Physiol. 2002;86(6):509\u201316. https:\/\/doi.org\/10.1007\/s00421-001-0570-4.","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"2826_CR69","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1161\/01.cir.87.6.1915","volume":"87","author":"GDO Lowe","year":"1993","unstructured":"Lowe GDO, Fowkes FGR, Dawes J, Donnan PT, Lennie SE, Housley E. Blood viscosity, fibrinogen, and activation of coagulation and leukocytes in peripheral arterial disease and the normal population in the Edinburgh artery study. Circulation. 1993;87(6):1915\u201320. https:\/\/doi.org\/10.1161\/01.cir.87.6.1915.","journal-title":"Circulation"},{"issue":"1","key":"2826_CR70","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12967-016-0889-6","volume":"14","author":"L Barrea","year":"2016","unstructured":"Barrea L, Macchia PE, Di Somma C, Napolitano M, Balato A, Falco A, et al. Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome. J Transl Med. 2016;14(1):130\u201342. https:\/\/doi.org\/10.1186\/s12967-016-0889-6.","journal-title":"J Transl Med"},{"issue":"8","key":"2826_CR71","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.3390\/nu11081747","volume":"11","author":"L Barrea","year":"2019","unstructured":"Barrea L, Muscogiuri G, Laudisio D, Di Somma C, Salzano C, Pugliese G, et al. Phase angle: a possible biomarker to quantify inflammation in subjects with obesity and 25(OH)D deficiency. Nutrients. 2019;11(8):1747\u201363. https:\/\/doi.org\/10.3390\/nu11081747.","journal-title":"Nutrients"},{"issue":"11","key":"2826_CR72","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s11255-015-1112-z","volume":"47","author":"CG Musso","year":"2015","unstructured":"Musso CG, Jauregui JR, Mac\u00edas N\u00fa\u00f1ez JF. Frailty phenotype and chronic kidney disease: a review of the literature. Int Urol Nephrol. 2015;47(11):1801\u20137. https:\/\/doi.org\/10.1007\/s11255-015-1112-z.","journal-title":"Int Urol Nephrol"},{"issue":"3","key":"2826_CR73","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s12020-012-9647-6","volume":"42","author":"M Del Prete","year":"2012","unstructured":"Del Prete M, Mauriello MC, Faggiano A, Di Somma C, Monfrecola G, Fabbrocini G, et al. Insulin resistance and acne: a new risk factor for men? Endocrine. 2012;42(3):555\u201360. https:\/\/doi.org\/10.1007\/s12020-012-9647-6.","journal-title":"Endocrine"},{"issue":"1","key":"2826_CR74","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jaad.2009.07.043","volume":"63","author":"WP Bowe","year":"2010","unstructured":"Bowe WP, Joshi SS, Shalita AR. Diet and acne. J Am Acad Dermatol. 2010;63(1):124\u201341. https:\/\/doi.org\/10.1016\/j.jaad.2009.07.043.","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"2826_CR75","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.2337\/dc08-1239","volume":"31","author":"FS Atkinson","year":"2008","unstructured":"Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008;31(12):2281\u20133. https:\/\/doi.org\/10.2337\/dc08-1239.","journal-title":"Diabetes Care"},{"issue":"3","key":"2826_CR76","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3390\/ijms21030741","volume":"21","author":"A Bali\u0107","year":"2020","unstructured":"Bali\u0107 A, Vla\u0161i\u0107 D, \u017du\u017eul K, Marinovi\u0107 B, Mokos ZB. Omega-3 versus Omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases. Int J Mol Sci. 2020;21(3):741\u201367. https:\/\/doi.org\/10.3390\/ijms21030741.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2826_CR77","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/nu8030128","volume":"8","author":"AP Simopoulos","year":"2016","unstructured":"Simopoulos AP. An increase in the Omega-6\/Omega-3 fatty acid ratio increases the risk for obesity. Nutrients. 2016;8(3):128\u201345. https:\/\/doi.org\/10.3390\/nu8030128.","journal-title":"Nutrients"},{"key":"2826_CR78","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.plefa.2018.03.003","volume":"132","author":"WS Harris","year":"2018","unstructured":"Harris WS. The Omega-6:Omega-3 ratio: a critical appraisal and possible successor. Prostaglandins Leukot Essent Fatty Acids. 2018;132:34\u201340. https:\/\/doi.org\/10.1016\/j.plefa.2018.03.003.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"2826_CR79","doi-asserted-by":"publisher","first-page":"5754","DOI":"10.1038\/s41598-020-62715-3","volume":"10","author":"AHS Heng","year":"2020","unstructured":"Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020;10(1):5754\u201383. https:\/\/doi.org\/10.1038\/s41598-020-62715-3.","journal-title":"Sci Rep"},{"issue":"3","key":"2826_CR80","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jand.2013.11.010","volume":"114","author":"J Burris","year":"2014","unstructured":"Burris J, Rietkerk W, Woolf K. Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults. J Acad Nutr Diet. 2014;114(3):384\u201392. https:\/\/doi.org\/10.1016\/j.jand.2013.11.010.","journal-title":"J Acad Nutr Diet"},{"issue":"12","key":"2826_CR81","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1111\/jdv.15204","volume":"32","author":"R Dai","year":"2018","unstructured":"Dai R, Hua W, Chen W, Xiong L, Li L. The effect of milk consumption on acne: a meta-analysis of observational studies. J Eur Acad Dermatol Venereol. 2018;32(12):2244\u201353. https:\/\/doi.org\/10.1111\/jdv.15204.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"2826_CR82","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00041433-200202000-00002","volume":"13","author":"FB Hu","year":"2002","unstructured":"Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol. 2002;13(1):3\u20139. https:\/\/doi.org\/10.1097\/00041433-200202000-00002.","journal-title":"Curr Opin Lipidol"},{"key":"2826_CR83","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","volume":"9","author":"F Shahidi","year":"2018","unstructured":"Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu Rev Food Sci Technol. 2018;9:345\u201381. https:\/\/doi.org\/10.1146\/annurev-food-111317-095850.","journal-title":"Annu Rev Food Sci Technol"},{"issue":"5","key":"2826_CR84","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","volume":"167","author":"MS Desai","year":"2016","unstructured":"Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell. 2016;167(5):1339-1353.e21. https:\/\/doi.org\/10.1016\/j.cell.2016.10.043.","journal-title":"Cell"},{"issue":"6","key":"2826_CR85","first-page":"742","volume":"11","author":"WP Bowe","year":"2012","unstructured":"Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. 2012;11(6):742\u20136.","journal-title":"J Drugs Dermatol"},{"issue":"8","key":"2826_CR86","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1017\/S0007114512003339","volume":"109","author":"EE Abiemo","year":"2013","unstructured":"Abiemo EE, Alonso A, Nettleton JA, Steffen LM, Bertoni AG, Jain A, et al. Relationships of the Mediterranean dietary pattern with insulin resistance and diabetes incidence in the Multi-Ethnic Study of Atherosclerosis (MESA). Br J Nutr. 2013;109(8):1490\u20137. https:\/\/doi.org\/10.1017\/S0007114512003339.","journal-title":"Br J Nutr"},{"issue":"18","key":"2826_CR87","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1080\/10408398.2017.1351917","volume":"58","author":"CL Bendall","year":"2018","unstructured":"Bendall CL, Mayr HL, Opie RS, Bes-Rastrollo M, Itsiopoulos C, Thomas CJ. Central obesity and the Mediterranean diet: a systematic review of intervention trials. Crit Rev Food Sci Nutr. 2018;58(18):3070\u201384. https:\/\/doi.org\/10.1080\/10408398.2017.1351917.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2826_CR88","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.nut.2018.11.015","volume":"62","author":"L Barrea","year":"2019","unstructured":"Barrea L, Annunziata G, Muscogiuri G, Laudisio D, Di Somma C, Maisto M, et al. Trimethylamine N-oxide, Mediterranean diet, and nutrition in healthy, normal-weight adults: also a matter of sex? Nutrition. 2019;62:7\u201317. https:\/\/doi.org\/10.1016\/j.nut.2018.11.015.","journal-title":"Nutrition"},{"issue":"9","key":"2826_CR89","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.3390\/nu11092228","volume":"11","author":"G Muscogiuri","year":"2019","unstructured":"Muscogiuri G, Barrea L, Laudisio D, Di Somma C, Pugliese G, Salzano C, et al. Somatotropic axis and obesity: is there any role for the Mediterranean diet? Nutrients. 2019;11(9):2228\u201343. https:\/\/doi.org\/10.3390\/nu11092228.","journal-title":"Nutrients"},{"issue":"6","key":"2826_CR90","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3945\/jn.110.135566","volume":"141","author":"H Schr\u00f6der","year":"2011","unstructured":"Schr\u00f6der H, Fit\u00f3 M, Estruch R, Mart\u00ednez-Gonz\u00e1lez MA, Corella D, Salas-Salvad\u00f3 J, et al. A short screener is valid for assessing Mediterranean diet adherence among older spanish men and women. J Nutr. 2011;141(6):1140\u20135. https:\/\/doi.org\/10.3945\/jn.110.135566.","journal-title":"J Nutr"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-021-02826-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-021-02826-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-021-02826-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T11:11:40Z","timestamp":1619435500000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-021-02826-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2826"],"URL":"https:\/\/doi.org\/10.1186\/s12967-021-02826-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,26]]},"assertion":[{"value":"12 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in full agreement with the national and international regulations and the Declaration of Helsinki (2000). All participants were fully informed about the study requirements and were required to accept the data sharing and privacy policy before participating in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors have conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"171"}}