{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T18:11:07Z","timestamp":1794507067614,"version":"4.9.1"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities. In recent years, exosomes have received increasing research attention in their role in the induction of carcinogenesis and metastasis in the lung. In this review, recent studies on the contribution of exosomes to lung cancer metastasis are discussed, particularly highlighting the role of lung tumor-derived exosomes in immune system evasion, epithelial-mesenchymal transition, and angiogenesis, and their involvement at both the pre-metastatic and metastatic phases. The clinical application of exosomes as therapeutic drug carriers, their role in antitumor drug resistance, and their utility as predictive biomarkers in diagnosis and prognosis are also presented. The metastatic activity, a complex multistep process of cancer cell invasion, survival in blood vessels, attachment and subsequent colonization of the host's organs, is integrated with exosomal effects. Exosomes act as functional mediating factors in cell\u2013cell communication, influencing various steps of the metastatic cascade. To this end, lung cancer cell-derived exosomes enhance cell proliferation, angiogenesis, and metastasis, regulate drug resistance, and antitumor immune activities during lung carcinogenesis, and are currently being explored as an important component in liquid biopsy assessment for diagnosing lung cancer. These nano-sized extracellular vesicles are also being explored as delivery vehicles for therapeutic molecules owing to their unique properties of biocompatibility, circulatory stability, decreased toxicity, and tumor specificity. The current knowledge of the role of exosomes highlights an array of exosome-dependent pathways and cargoes that are ripe for exploiting therapeutic targets to treat lung cancer metastasis, and for predictive value assessment in diagnosis, prognosis, and anti-tumor drug resistance.<\/jats:p>","DOI":"10.1186\/s12967-021-02985-1","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T08:03:35Z","timestamp":1626681815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["The role of exosomes in lung cancer metastasis and clinical applications: an updated review"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-694X","authenticated-orcid":false,"given":"Lei","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghao","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"2985_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ccm.2019.10.001","volume":"41","author":"BC Bade","year":"2020","unstructured":"Bade BC, Cruz CSD. Lung cancer 2020. Clin Chest Med. 2020;41:1\u201324.","journal-title":"Clin Chest Med"},{"key":"2985_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.17219\/acem\/68631","volume":"27","author":"A Romaszko","year":"2018","unstructured":"Romaszko A, Doboszy\u0144ska A. Multiple primary lung cancer: a literature review. Adv Clin Exp Med. 2018;27:725\u201330.","journal-title":"Adv Clin Exp Med"},{"key":"2985_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12943-021-01312-y","volume":"20","author":"M-Y Li","year":"2021","unstructured":"Li M-Y, Liu L-Z, Dong M. Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis. Mol Cancer. 2021;20:22.","journal-title":"Mol Cancer"},{"key":"2985_CR4","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ctrv.2013.10.001","volume":"40","author":"SL Wood","year":"2014","unstructured":"Wood SL, Pernemalm M, Crosbie PA, Whetton AD. The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev. 2014;40:558\u201366.","journal-title":"Cancer Treat Rev"},{"key":"2985_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41467-017-02583-0","volume":"9","author":"T Fang","year":"2018","unstructured":"Fang T, Lv H, Lv G, Li T, Wang C, Han Q, et al. Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 2018;9:191.","journal-title":"Nat Commun"},{"key":"2985_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12943-017-0706-8","volume":"16","author":"W Li","year":"2017","unstructured":"Li W, Li C, Zhou T, Liu X, Liu X, Li X, et al. Role of exosomal proteins in cancer diagnosis. Mol Cancer. 2017;16:145.","journal-title":"Mol Cancer"},{"key":"2985_CR7","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3389\/fimmu.2018.00819","volume":"9","author":"SD Alipoor","year":"2018","unstructured":"Alipoor SD, Mortaz E, Varahram M, Movassaghi M, Kraneveld AD, Garssen J, et al. The potential biomarkers and immunological effects of tumor-derived exosomes in lung cancer. Front Immunol. 2018;9:819.","journal-title":"Front Immunol"},{"key":"2985_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.molmed.2015.07.004","volume":"21","author":"Y Fujita","year":"2015","unstructured":"Fujita Y, Kosaka N, Araya J, Kuwano K, Ochiya T. Extracellular vesicles in lung microenvironment and pathogenesis. Trends Mol Med. 2015;21:533\u201342.","journal-title":"Trends Mol Med"},{"key":"2985_CR9","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1111\/brv.12608","volume":"95","author":"DKW Ocansey","year":"2020","unstructured":"Ocansey DKW, Zhang L, Wang Y, Yan Y, Qian H, Zhang X, et al. Exosome-mediated effects and applications in inflammatory bowel disease. Biol Rev Camb Philos Soc. 2020;95:1287\u2013307.","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2985_CR10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","volume":"367","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367: eaau6977.","journal-title":"Science"},{"key":"2985_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12943-019-0991-5","volume":"18","author":"L Mashouri","year":"2019","unstructured":"Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK. Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Mol Cancer. 2019;18:75.","journal-title":"Mol Cancer"},{"key":"2985_CR12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Th\u00e9ry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255\u201389.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2985_CR13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","volume":"75","author":"NP Hessvik","year":"2018","unstructured":"Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75:193\u2013208.","journal-title":"Cell Mol Life Sci"},{"key":"2985_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"2985_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12828","volume":"53","author":"C Hu","year":"2020","unstructured":"Hu C, Meiners S, Lukas C, Stathopoulos GT, Chen J. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif. 2020;53: e12828.","journal-title":"Cell Prolif"},{"key":"2985_CR16","doi-asserted-by":"publisher","first-page":"6909","DOI":"10.1002\/cam4.3379","volume":"9","author":"J Wu","year":"2020","unstructured":"Wu J, Shen Z. Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer. Cancer Med. 2020;9:6909\u201322.","journal-title":"Cancer Med"},{"key":"2985_CR17","doi-asserted-by":"publisher","first-page":"S1373","DOI":"10.21037\/jtd.2017.10.67","volume":"9","author":"P Reclusa","year":"2017","unstructured":"Reclusa P, Taverna S, Pucci M, Durendez E, Calabuig S, Manca P, et al. Exosomes as diagnostic and predictive biomarkers in lung cancer. J Thorac Dis. 2017;9:S1373-82.","journal-title":"J Thorac Dis"},{"key":"2985_CR18","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.2174\/0929867325666180831150259","volume":"26","author":"N Arrighetti","year":"2019","unstructured":"Arrighetti N, Corbo C, Evangelopoulos M, Past\u00f2 A, Zuco V, Tasciotti E. Exosome-like nanovectors for drug delivery in cancer. Curr Med Chem. 2019;26:6132\u201348.","journal-title":"Curr Med Chem"},{"key":"2985_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","volume":"142","author":"D Yuan","year":"2017","unstructured":"Yuan D, Zhao Y, Banks WA, Bullock KM, Haney M, Batrakova E, et al. Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials. 2017;142:1\u201312.","journal-title":"Biomaterials"},{"key":"2985_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","volume":"207","author":"MJ Haney","year":"2015","unstructured":"Haney MJ, Klyachko NL, Zhao Y, Gupta R, Plotnikova EG, He Z, et al. Exosomes as drug delivery vehicles for Parkinson\u2019s disease therapy. J Control Release. 2015;207:18\u201330.","journal-title":"J Control Release"},{"key":"2985_CR21","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/aps.2017.12","volume":"38","author":"X Luan","year":"2017","unstructured":"Luan X, Sansanaphongpricha K, Myers I, Chen H, Yuan H, Sun D. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017;38:754\u201363.","journal-title":"Acta Pharmacol Sin"},{"key":"2985_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","volume":"6","author":"D Ha","year":"2016","unstructured":"Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B. 2016;6:287\u201396.","journal-title":"Acta Pharm Sin B"},{"key":"2985_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.pharmthera.2017.02.020","volume":"174","author":"L Barile","year":"2017","unstructured":"Barile L, Vassalli G. Exosomes: therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 2017;174:63\u201378.","journal-title":"Pharmacol Ther"},{"key":"2985_CR24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.2174\/0929867327666200204141952","volume":"28","author":"A Amiri","year":"2020","unstructured":"Amiri A, Pourhanifeh MH, Mirzaei HR, Nahand JS, Moghoofei M, Sahebnasagh R, et al. Exosomes and lung cancer: roles in pathophysiology, diagnosis and therapeutic applications. Curr Med Chem. 2020;28:308\u201328.","journal-title":"Curr Med Chem"},{"key":"2985_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/sji.12247","volume":"81","author":"M Frydrychowicz","year":"2015","unstructured":"Frydrychowicz M, Kolecka-Bednarczyk A, Madejczyk M, Yasar S, Dworacki G. Exosomes\u2014structure, biogenesis and biological role in non-small-cell lung cancer. Scand J Immunol. 2015;81:2\u201310.","journal-title":"Scand J Immunol"},{"key":"2985_CR26","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1007\/s00018-019-03233-y","volume":"76","author":"R Chen","year":"2019","unstructured":"Chen R, Xu X, Qian Z, Zhang C, Niu Y, Wang Z, et al. The biological functions and clinical applications of exosomes in lung cancer. Cell Mol Life Sci. 2019;76:4613\u201333.","journal-title":"Cell Mol Life Sci"},{"key":"2985_CR27","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13045-019-0772-z","volume":"12","author":"X Tian","year":"2019","unstructured":"Tian X, Shen H, Li Z, Wang T, Wang S. Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment. J Hematol Oncol. 2019;12:84.","journal-title":"J Hematol Oncol"},{"key":"2985_CR28","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1172\/JCI81136","volume":"126","author":"TL Whiteside","year":"2016","unstructured":"Whiteside TL. Exosomes and tumor-mediated immune suppression. J Clin Invest. 2016;126:1216\u201323.","journal-title":"J Clin Invest"},{"key":"2985_CR29","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","volume":"560","author":"G Chen","year":"2018","unstructured":"Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018;560:382\u20136.","journal-title":"Nature"},{"key":"2985_CR30","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","volume":"177","author":"M Poggio","year":"2019","unstructured":"Poggio M, Hu T, Pai C-C, Chu B, Belair CD, Chang A, et al. Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory. Cell. 2019;177:414-27.e13.","journal-title":"Cell"},{"key":"2985_CR31","first-page":"1","volume":"51","author":"DH Kim","year":"2019","unstructured":"Kim DH, Kim H, Choi YJ, Kim SY, Lee J-E, Sung KJ, et al. Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Exp Mol Med. 2019;51:1\u201313.","journal-title":"Exp Mol Med"},{"key":"2985_CR32","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1062968","volume":"5","author":"G Berchem","year":"2016","unstructured":"Berchem G, Noman MZ, Bosseler M, Paggetti J, Baconnais S, Le cam E, et al. Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-\u03b2 and miR23a transfer. Oncoimmunology. 2016;5: e1062968.","journal-title":"Oncoimmunology"},{"key":"2985_CR33","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3109\/07357907.2013.789905","volume":"31","author":"S Huang","year":"2013","unstructured":"Huang S, Li Y, Zhang J, Rong J, Ye S. Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells. Cancer Invest. 2013;31:330\u20135.","journal-title":"Cancer Invest"},{"key":"2985_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.semcdb.2015.02.008","volume":"40","author":"D Greening","year":"2015","unstructured":"Greening D, Gopal S, Mathias R. Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression. Semin Cell Dev Biol. 2015;40:60\u201371.","journal-title":"Semin Cell Dev Biol"},{"key":"2985_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3390\/cancers9080105","volume":"9","author":"R Blackwell","year":"2017","unstructured":"Blackwell R, Foreman K, Gupta G. The role of cancer-derived exosomes in tumorigenicity & epithelial-to-mesenchymal transition. Cancers. 2017;9:105.","journal-title":"Cancers"},{"key":"2985_CR36","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.bbrc.2016.07.124","volume":"478","author":"J Kim","year":"2016","unstructured":"Kim J, Kim TY, Lee MS, Mun JY, Ihm C, Kim SA. Exosome cargo reflects TGF-\u03b21-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma cells. Biochem Biophys Res Commun. 2016;478:643\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"2985_CR37","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1186\/s12864-018-5143-6","volume":"19","author":"Y-T Tang","year":"2018","unstructured":"Tang Y-T, Huang Y-Y, Li J-H, Qin S-H, Xu Y, An T-X, et al. Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines. BMC Genomics. 2018;19:802.","journal-title":"BMC Genomics"},{"key":"2985_CR38","doi-asserted-by":"publisher","first-page":"54852","DOI":"10.18632\/oncotarget.10243","volume":"7","author":"MA Rahman","year":"2016","unstructured":"Rahman MA, Barger JF, Lovat F, Gao M, Otterson GA, Nana-Sinkam P. Lung cancer exosomes as drivers of epithelial mesenchymal transition. Oncotarget. 2016;7:54852\u201366.","journal-title":"Oncotarget"},{"key":"2985_CR39","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrc.2017.6","volume":"17","author":"H Peinado","year":"2017","unstructured":"Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17:302\u201317.","journal-title":"Nat Rev Cancer"},{"key":"2985_CR40","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/bs.acc.2015.12.005","volume":"74","author":"TL Whiteside","year":"2016","unstructured":"Whiteside TL. Tumor-derived exosomes and their role in cancer progression. Adv Clin Chem. 2016;74:103\u201341.","journal-title":"Adv Clin Chem"},{"key":"2985_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2476175","volume":"2019","author":"Y Cheng","year":"2019","unstructured":"Cheng Y, Dai X, Yang T, Zhang N, Liu Z, Jiang Y. Low long noncoding RNA growth arrest-specific transcript 5 expression in the exosomes of lung cancer cells promotes tumor angiogenesis. J Oncol. 2019;2019:1\u201313.","journal-title":"J Oncol"},{"key":"2985_CR42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s13046-020-01680-1","volume":"39","author":"S Mao","year":"2020","unstructured":"Mao S, Lu Z, Zheng S, Zhang H, Zhang G, Wang F, et al. Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer. J Exp Clin Cancer Res. 2020;39:193.","journal-title":"J Exp Clin Cancer Res"},{"key":"2985_CR43","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1042\/CS20200039","volume":"134","author":"J Fan","year":"2020","unstructured":"Fan J, Xu G, Chang Z, Zhu L, Yao J. miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2\/STAT3 pathway. Clin Sci. 2020;134:807\u201325.","journal-title":"Clin Sci"},{"key":"2985_CR44","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1159\/000495673","volume":"51","author":"M Liu","year":"2018","unstructured":"Liu M, Sun X, Shi S. MORC2 enhances tumor growth by promoting angiogenesis and tumor-associated macrophage recruitment via Wnt\/\u03b2-catenin in lung cancer. Cell Physiol Biochem. 2018;51:1679\u201394.","journal-title":"Cell Physiol Biochem"},{"key":"2985_CR45","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.canlet.2017.08.003","volume":"407","author":"L Zhou","year":"2017","unstructured":"Zhou L, Lv T, Zhang Q, Zhu Q, Zhan P, Zhu S, et al. The biology, function and clinical implications of exosomes in lung cancer. Cancer Lett. 2017;407:84\u201392.","journal-title":"Cancer Lett"},{"key":"2985_CR46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mam.2018.07.003","volume":"70","author":"MA Iqbal","year":"2019","unstructured":"Iqbal MA, Arora S, Prakasam G, Calin GA, Syed MA. MicroRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance. Mol Aspects Med. 2019;70:3\u201320.","journal-title":"Mol Aspects Med"},{"key":"2985_CR47","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3892\/ol.2015.4044","volume":"11","author":"Y Wang","year":"2016","unstructured":"Wang Y, Yi J, Chen X, Zhang Y, Xu M, Yang Z. The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-\u03b2 and IL-10. Oncol Lett. 2016;11:1527\u201330.","journal-title":"Oncol Lett"},{"key":"2985_CR48","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/ijc.29444","volume":"137","author":"C-F Wu","year":"2015","unstructured":"Wu C-F, Andzinski L, Kasnitz N, Kr\u00f6ger A, Klawonn F, Lienenklaus S, et al. The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung. Int J Cancer. 2015;137:837\u201347.","journal-title":"Int J Cancer"},{"key":"2985_CR49","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ccell.2016.06.021","volume":"30","author":"Y Liu","year":"2016","unstructured":"Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, et al. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell. 2016;30:243\u201356.","journal-title":"Cancer Cell"},{"key":"2985_CR50","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature15756","volume":"527","author":"A Hoshino","year":"2015","unstructured":"Hoshino A, Costa-Silva B, Shen T-L, Rodrigues G, Hashimoto A, Mark MT, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329\u201335.","journal-title":"Nature"},{"key":"2985_CR51","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.1158\/0008-5472.CAN-10-4455","volume":"71","author":"JL Hood","year":"2011","unstructured":"Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 2011;71:3792\u2013801.","journal-title":"Cancer Res"},{"key":"2985_CR52","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/nature04186","volume":"438","author":"RN Kaplan","year":"2005","unstructured":"Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820\u20137.","journal-title":"Nature"},{"key":"2985_CR53","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nm.2753","volume":"18","author":"H Peinado","year":"2012","unstructured":"Peinado H, Ale\u010dkovi\u0107 M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18:883\u201391.","journal-title":"Nat Med"},{"key":"2985_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21873\/cgp.20015","volume":"14","author":"UH Weidle","year":"2017","unstructured":"Weidle UH, Birzele F, Kollmorgen G, R\u00fcger R. The multiple roles of exosomes in metastasis. Cancer Genomics Proteomics. 2017;14:1\u201316.","journal-title":"Cancer Genomics Proteomics"},{"key":"2985_CR55","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","volume":"9","author":"Z Zeng","year":"2018","unstructured":"Zeng Z, Li Y, Pan Y, Lan X, Song F, Sun J, et al. Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat Commun. 2018;9:5395.","journal-title":"Nat Commun"},{"key":"2985_CR56","doi-asserted-by":"publisher","first-page":"7312","DOI":"10.1073\/pnas.1220998110","volume":"110","author":"P Kucharzewska","year":"2013","unstructured":"Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringner M, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci. 2013;110:7312\u20137.","journal-title":"Proc Natl Acad Sci"},{"key":"2985_CR57","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1055\/s-0030-1267043","volume":"36","author":"J Rak","year":"2010","unstructured":"Rak J. Microparticles in cancer. Semin Thromb Hemost. 2010;36:888\u2013906.","journal-title":"Semin Thromb Hemost"},{"key":"2985_CR58","first-page":"457","volume":"120","author":"F Chalmin","year":"2010","unstructured":"Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin J-P, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest. 2010;120:457\u201371.","journal-title":"J Clin Invest"},{"key":"2985_CR59","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fimmu.2015.00066","volume":"6","author":"A Benito-Martin","year":"2015","unstructured":"Benito-Martin A, Di Giannatale A, Ceder S, Peinado H. The new deal: a potential role for secreted vesicles in innate immunity and tumor progression. Front Immunol. 2015;6:66.","journal-title":"Front Immunol"},{"key":"2985_CR60","doi-asserted-by":"publisher","first-page":"4920","DOI":"10.1158\/0008-5472.CAN-12-0925","volume":"72","author":"A Bobrie","year":"2012","unstructured":"Bobrie A, Krumeich S, Reyal F, Recchi C, Moita LF, Seabra MC, et al. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 2012;72:4920\u201330.","journal-title":"Cancer Res"},{"key":"2985_CR61","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1158\/1078-0432.CCR-16-2819","volume":"23","author":"S Ludwig","year":"2017","unstructured":"Ludwig S, Floros T, Theodoraki M-N, Hong C-S, Jackson EK, Lang S, et al. Suppression of lymphocyte functions by plasma exosomes correlates with disease activity in patients with head and neck cancer. Clin Cancer Res. 2017;23:4843\u201354.","journal-title":"Clin Cancer Res"},{"key":"2985_CR62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00005-016-0453-3","volume":"65","author":"L Czernek","year":"2017","unstructured":"Czernek L, D\u00fcchler M. Functions of cancer-derived extracellular vesicles in immunosuppression. Arch Immunol Ther Exp. 2017;65:311\u201323.","journal-title":"Arch Immunol Ther Exp"},{"key":"2985_CR63","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/s41467-017-01433-3","volume":"8","author":"MP Plebanek","year":"2017","unstructured":"Plebanek MP, Angeloni NL, Vinokour E, Li J, Henkin A, Martinez-Marin D, et al. Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche. Nat Commun. 2017;8:1319.","journal-title":"Nat Commun"},{"key":"2985_CR64","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/cells9051303","volume":"9","author":"A Pritchard","year":"2020","unstructured":"Pritchard A, Tousif S, Wang Y, Hough K, Khan S, Strenkowski J, et al. Lung tumor cell-derived exosomes promote M2 macrophage polarization. Cells. 2020;9:1303.","journal-title":"Cells"},{"key":"2985_CR65","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jprot.2015.12.023","volume":"133","author":"DJ Clark","year":"2016","unstructured":"Clark DJ, Fondrie WE, Yang A, Mao L. Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes. J Proteomics. 2016;133:161\u20139.","journal-title":"J Proteomics"},{"key":"2985_CR66","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12943-020-01221-6","volume":"19","author":"N Zhang","year":"2020","unstructured":"Zhang N, Nan A, Chen L, Li X, Jia Y, Qiu M, et al. Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells. Mol Cancer. 2020;19:101.","journal-title":"Mol Cancer"},{"key":"2985_CR67","first-page":"599","volume":"24","author":"Y Qi","year":"2019","unstructured":"Qi Y, Zha W, Zhang W. Exosomal miR-660-5p promotes tumor growth and metastasis in non-small cell lung cancer. J BUON. 2019;24:599\u2013607.","journal-title":"J BUON"},{"key":"2985_CR68","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13046-020-01648-1","volume":"39","author":"W Hong","year":"2020","unstructured":"Hong W, Xue M, Jiang J, Zhang Y, Gao X. Circular RNA circ-CPA4\/ let-7 miRNA\/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC). J Exp Clin Cancer Res. 2020;39:149.","journal-title":"J Exp Clin Cancer Res"},{"key":"2985_CR69","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.1002\/cam4.1758","volume":"7","author":"D Wu","year":"2018","unstructured":"Wu D, Deng S, Liu T, Han R, Zhang T, Xu Y. TGF-\u03b2-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression. Cancer Med. 2018;7:5118\u201329.","journal-title":"Cancer Med"},{"key":"2985_CR70","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/tox.22930","volume":"35","author":"J Yao","year":"2020","unstructured":"Yao J, Lu X, Wang Y, Li J, Ni B. Long noncoding RNAs AC026904.1 is essential for TGF-\u03b2-induced migration and epithelial-mesenchymal transition through functioning as an enhancer of slug in lung cancer cells. Environ Toxicol. 2020;35:942\u201351.","journal-title":"Environ Toxicol"},{"key":"2985_CR71","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.canlet.2018.01.036","volume":"418","author":"C Li","year":"2018","unstructured":"Li C, Wan L, Liu Z, Xu G, Wang S, Su Z, et al. Long non-coding RNA XIST promotes TGF-\u03b2-induced epithelial-mesenchymal transition by regulating miR-367\/141-ZEB2 axis in non-small-cell lung cancer. Cancer Lett. 2018;418:185\u201395.","journal-title":"Cancer Lett"},{"key":"2985_CR72","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s12032-011-0083-x","volume":"29","author":"L Chen","year":"2012","unstructured":"Chen L, Xu S, Xu H, Zhang J, Ning J, Wang S. MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. Med Oncol. 2012;29:1673\u201380.","journal-title":"Med Oncol"},{"key":"2985_CR73","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.canlet.2020.01.023","volume":"475","author":"DH Kim","year":"2020","unstructured":"Kim DH, Park S, Kim H, Choi YJ, Kim SY, Sung KJ, et al. Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4. Cancer Lett. 2020;475:2\u201313.","journal-title":"Cancer Lett"},{"key":"2985_CR74","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1038\/s41598-017-03460-y","volume":"7","author":"S Taverna","year":"2017","unstructured":"Taverna S, Pucci M, Giallombardo M, Di Bella MA, Santarpia M, Reclusa P, et al. Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway. Sci Rep. 2017;7:3170.","journal-title":"Sci Rep"},{"key":"2985_CR75","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1159\/000494533","volume":"50","author":"T Liao","year":"2018","unstructured":"Liao T, Chen W, Sun J, Zhang Y, Hu X, Yang S, et al. CXCR4 accelerates osteoclastogenesis induced by non-small cell lung carcinoma cells through self-potentiation and VCAM1 secretion. Cell Physiol Biochem. 2018;50:1084\u201399.","journal-title":"Cell Physiol Biochem"},{"key":"2985_CR76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058361","volume":"8","author":"X Peng","year":"2013","unstructured":"Peng X, Guo W, Ren T, Lou Z, Lu X, Zhang S, et al. Differential expression of the RANKL\/RANK\/OPG System is associated with bone metastasis in human non-small cell lung cancer. PLoS ONE. 2013;8: e58361.","journal-title":"PLoS ONE"},{"key":"2985_CR77","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13045-018-0689-y","volume":"12","author":"S Raimondo","year":"2019","unstructured":"Raimondo S, Saieva L, Vicario E, Pucci M, Toscani D, Manno M, et al. Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis. J Hematol Oncol. 2019;12:2.","journal-title":"J Hematol Oncol"},{"key":"2985_CR78","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10585-020-10062-y","volume":"38","author":"X-R Yang","year":"2020","unstructured":"Yang X-R, Pi C, Yu R, Fan X-J, Peng X-X, Zhang X-C, et al. Correlation of exosomal microRNA clusters with bone metastasis in non-small cell lung cancer. Clin Exp Metastasis. 2020;38:109\u201317.","journal-title":"Clin Exp Metastasis"},{"key":"2985_CR79","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1096\/fj.201800428R","volume":"33","author":"Z-H Xu","year":"2019","unstructured":"Xu Z-H, Miao Z-W, Jiang Q-Z, Gan D-X, Wei X-G, Xue X-Z, et al. Brain microvascular endothelial cell exosome-mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain. FASEB J. 2019;33:1742\u201357.","journal-title":"FASEB J"},{"key":"2985_CR80","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.18632\/aging.102201","volume":"11","author":"C Wei","year":"2019","unstructured":"Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, et al. MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. Aging. 2019;11:6734\u201361.","journal-title":"Aging"},{"key":"2985_CR81","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.celrep.2014.07.050","volume":"8","author":"HS Leong","year":"2014","unstructured":"Leong HS, Robertson AE, Stoletov K, Leith SJ, Chin CA, Chien AE, et al. Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. Cell Rep. 2014;8:1558\u201370.","journal-title":"Cell Rep"},{"key":"2985_CR82","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12943-018-0889-7","volume":"17","author":"L Wang","year":"2018","unstructured":"Wang L, Tong X, Zhou Z, Wang S, Lei Z, Zhang T, et al. Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-\u03b2-induced epithelial-mesenchymal transition and metastasis by controlling TIF1\u03b3 in non-small cell lung cancer. Mol Cancer. 2018;17:140.","journal-title":"Mol Cancer"},{"key":"2985_CR83","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/qjmed\/hcz093","volume":"112","author":"J You","year":"2019","unstructured":"You J, Li M, Cao LM, Gu QH, Deng PB, Tan Y, et al. Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes. QJM An Int J Med. 2019;112:581\u201390.","journal-title":"QJM An Int J Med"},{"key":"2985_CR84","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.canlet.2018.04.026","volume":"428","author":"X Zhao","year":"2018","unstructured":"Zhao X, Wu X, Qian M, Song Y, Wu D, Zhang W. Knockdown of TGF-\u03b21 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells. Cancer Lett. 2018;428:34\u201344.","journal-title":"Cancer Lett"},{"key":"2985_CR85","doi-asserted-by":"publisher","first-page":"81880","DOI":"10.18632\/oncotarget.18737","volume":"8","author":"J Wang","year":"2017","unstructured":"Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S. Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells. Oncotarget. 2017;8:81880\u201391.","journal-title":"Oncotarget"},{"key":"2985_CR86","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12943-019-0959-5","volume":"18","author":"X Zhang","year":"2019","unstructured":"Zhang X, Sai B, Wang F, Wang L, Wang Y, Zheng L, et al. Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT. Mol Cancer. 2019;18:40.","journal-title":"Mol Cancer"},{"key":"2985_CR87","doi-asserted-by":"publisher","first-page":"8251","DOI":"10.2147\/OTT.S181673","volume":"11","author":"Q Wang","year":"2018","unstructured":"Wang Q, Li Z, Sun L, Chen B, Zhao Y, Shen B, et al. Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis. Onco Targets Ther. 2018;11:8251\u201363.","journal-title":"Onco Targets Ther"},{"key":"2985_CR88","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trecan.2015.07.009","volume":"1","author":"AC Obenauf","year":"2015","unstructured":"Obenauf AC, Massagu\u00e9 J. Surviving at a distance: organ-specific metastasis. Trends Cancer. 2015;1:76\u201391.","journal-title":"Trends Cancer"},{"key":"2985_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drup.2019.07.003","volume":"45","author":"N Milman","year":"2019","unstructured":"Milman N, Ginini L, Gil Z. Exosomes and their role in tumorigenesis and anticancer drug resistance. Drug Resist Updat. 2019;45:1\u201312.","journal-title":"Drug Resist Updat"},{"key":"2985_CR90","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ijc.30669","volume":"141","author":"D-H Bach","year":"2017","unstructured":"Bach D-H, Hong J-Y, Park HJ, Lee SK. The role of exosomes and miRNAs in drug-resistance of cancer cells. Int J Cancer. 2017;141:220\u201330.","journal-title":"Int J Cancer"},{"key":"2985_CR91","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.257","volume":"10","author":"S Li","year":"2020","unstructured":"Li S, Yi M, Dong B, Jiao Y, Luo S, Wu K. The roles of exosomes in cancer drug resistance and its therapeutic application. Clin Transl Med. 2020;10: e257.","journal-title":"Clin Transl Med"},{"key":"2985_CR92","doi-asserted-by":"publisher","first-page":"7374","DOI":"10.1074\/jbc.M111.312157","volume":"287","author":"J Pasquier","year":"2012","unstructured":"Pasquier J, Galas L, Boulang\u00e9-Lecomte C, Rioult D, Bultelle F, Magal P, et al. Different modalities of intercellular membrane exchanges mediate cell-to-cell p-glycoprotein transfers in MCF-7 breast cancer cells. J Biol Chem. 2012;287:7374\u201387.","journal-title":"J Biol Chem"},{"key":"2985_CR93","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.7150\/thno.51797","volume":"11","author":"D Wang","year":"2021","unstructured":"Wang D, Zhao C, Xu F, Zhang A, Jin M, Zhang K, et al. Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2. Theranostics. 2021;11:2860\u201375.","journal-title":"Theranostics"},{"key":"2985_CR94","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.2147\/IJN.S131516","volume":"12","author":"X Qin","year":"2017","unstructured":"Qin X, Yu S, Zhou L, Shi M, Hu Y, Xu X, et al. Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner. Int J Nanomed. 2017;12:3721\u201333.","journal-title":"Int J Nanomed"},{"key":"2985_CR95","doi-asserted-by":"publisher","first-page":"24510","DOI":"10.18632\/oncotarget.8229","volume":"7","author":"Q Chen","year":"2016","unstructured":"Chen Q, Jiao D, Wang J, Hu H, Tang X, Chen J, et al. miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET. Oncotarget. 2016;7:24510\u201326.","journal-title":"Oncotarget"},{"key":"2985_CR96","first-page":"2650","volume":"21","author":"D-L Yuwen","year":"2017","unstructured":"Yuwen D-L, Sheng B-B, Liu J, Wenyu W, Shu Y-Q. MiR-146a-5p level in serum exosomes predicts therapeutic effect of cisplatin in non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 2017;21:2650\u20138.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2985_CR97","first-page":"3438","volume":"40","author":"Y Lei","year":"2018","unstructured":"Lei Y, Guo W, Chen B, Chen L, Gong J, Li W. Tumor-released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non-small cell lung cancer. Oncol Rep. 2018;40:3438\u201346.","journal-title":"Oncol Rep"},{"key":"2985_CR98","first-page":"527","volume":"53","author":"W Zhang","year":"2018","unstructured":"Zhang W, Cai X, Yu J, Lu X, Qian Q, Qian W. Exosome-mediated transfer of lncRNA RP11-838N2.4 promotes erlotinib resistance in non-small cell lung cancer. Int J Oncol. 2018;53:527\u201338.","journal-title":"Int J Oncol"},{"key":"2985_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2020.100540","volume":"44","author":"S Kumar","year":"2020","unstructured":"Kumar S, Sharawat SK, Ali A, Gaur V, Malik PS, Kumar S, et al. Identification of differentially expressed circulating serum microRNA for the diagnosis and prognosis of Indian non-small cell lung cancer patients. Curr Probl Cancer. 2020;44: 100540.","journal-title":"Curr Probl Cancer"},{"key":"2985_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117297","volume":"244","author":"S Sun","year":"2020","unstructured":"Sun S, Chen H, Xu C, Zhang Y, Zhang Q, Chen L, et al. Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN. Life Sci. 2020;244: 117297.","journal-title":"Life Sci"},{"key":"2985_CR101","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.26659","volume":"4","author":"KR Jakobsen","year":"2015","unstructured":"Jakobsen KR, Paulsen BS, B\u00e6k R, Varming K, Sorensen BS, J\u00f8rgensen MM. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma. J Extracell Vesicles. 2015;4: 26659.","journal-title":"J Extracell Vesicles"},{"key":"2985_CR102","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1002\/elps.201000598","volume":"32","author":"Y Li","year":"2011","unstructured":"Li Y, Zhang Y, Qiu F, Qiu Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis. 2011;32:1976\u201383.","journal-title":"Electrophoresis"},{"key":"2985_CR103","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.jtho.2016.05.034","volume":"11","author":"B Sandfeld-Paulsen","year":"2016","unstructured":"Sandfeld-Paulsen B, Jakobsen KR, B\u00e6k R, Folkersen BH, Rasmussen TR, Meldgaard P, et al. Exosomal proteins as diagnostic biomarkers in lung cancer. J Thorac Oncol. 2016;11:1701\u201310.","journal-title":"J Thorac Oncol"},{"key":"2985_CR104","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1158\/1078-0432.CCR-18-1447","volume":"25","author":"L Li","year":"2019","unstructured":"Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, et al. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Clin Cancer Res. 2019;25:1302\u201317.","journal-title":"Clin Cancer Res"},{"key":"2985_CR105","doi-asserted-by":"publisher","first-page":"41975","DOI":"10.18632\/oncotarget.16715","volume":"8","author":"L Li","year":"2017","unstructured":"Li L, Song W, Yan X, Li A, Zhang X, Li W, et al. Friend leukemia virus integration 1 promotes tumorigenesis of small cell lung cancer cells by activating the miR-17-92 pathway. Oncotarget. 2017;8:41975\u201387.","journal-title":"Oncotarget"},{"key":"2985_CR106","doi-asserted-by":"publisher","first-page":"8183","DOI":"10.2147\/OTT.S259232","volume":"13","author":"H Wang","year":"2020","unstructured":"Wang H, Feng L, Zheng Y, Li W, Liu L, Xie S, et al. LINC00680 promotes the progression of non-small cell lung cancer and functions as a sponge of miR-410-3p to enhance HMGB1 expression. Onco Targets Ther. 2020;13:8183\u201396.","journal-title":"Onco Targets Ther"},{"key":"2985_CR107","first-page":"515","volume":"4","author":"RD Hall","year":"2015","unstructured":"Hall RD, Le TM, Haggstrom DE, Gentzler RD. Angiogenesis inhibition as a therapeutic strategy in non-small cell lung cancer (NSCLC). Transl Lung Cancer Res. 2015;4:515\u201323.","journal-title":"Transl Lung Cancer Res"},{"key":"2985_CR108","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.6004\/jnccn.2013.0146","volume":"11","author":"PE Lammers","year":"2013","unstructured":"Lammers PE, Horn L. Targeting angiogenesis in advanced non-small cell lung cancer. J Natl Compr Cancer Netw. 2013;11:1235\u201347.","journal-title":"J Natl Compr Cancer Netw"},{"key":"2985_CR109","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cam4.1238","volume":"7","author":"X Xu","year":"2018","unstructured":"Xu X, Zhu S, Tao Z, Ye S. High circulating miR-18a, miR-20a, and miR-92a expression correlates with poor prognosis in patients with non-small cell lung cancer. Cancer Med. 2018;7:21\u201331.","journal-title":"Cancer Med"},{"key":"2985_CR110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090009","volume":"9","author":"AL Coelho","year":"2014","unstructured":"Coelho AL, Ara\u00fajo A, Gomes M, Catarino R, Marques A, Medeiros R. Circulating Ang-2 mRNA expression levels: looking ahead to a new prognostic factor for NSCLC. PLoS ONE. 2014;9: e90009.","journal-title":"PLoS ONE"},{"key":"2985_CR111","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.923210","volume":"26","author":"Q Dong","year":"2020","unstructured":"Dong Q, Dong L, Liu S, Kong Y, Zhang M, Wang X. Tumor-derived exosomal eIF4E as a biomarker for survival prediction in patients with non-small cell lung cancer. Med Sci Monit. 2020;26: e923210.","journal-title":"Med Sci Monit"},{"key":"2985_CR112","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1159\/000443111","volume":"38","author":"J Li","year":"2016","unstructured":"Li J, Yu J, Zhang H, Wang B, Guo H, Bai J, et al. Exosomes-derived MiR-302b suppresses lung cancer cell proliferation and migration via TGF\u03b2RII inhibition. Cell Physiol Biochem. 2016;38:1715\u201326.","journal-title":"Cell Physiol Biochem"},{"key":"2985_CR113","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.canlet.2018.10.031","volume":"442","author":"W-T Huang","year":"2019","unstructured":"Huang W-T, Chong I-W, Chen H-L, Li C-Y, Hsieh C-C, Kuo H-F, et al. Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer Lett. 2019;442:287\u201398.","journal-title":"Cancer Lett"},{"key":"2985_CR114","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.molmed.2009.08.003","volume":"15","author":"ML Broadhead","year":"2009","unstructured":"Broadhead ML, Dass CR, Choong PFM. Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy. Trends Mol Med. 2009;15:461\u20137.","journal-title":"Trends Mol Med"},{"key":"2985_CR115","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.yexcr.2018.08.021","volume":"371","author":"X Huang","year":"2018","unstructured":"Huang X, Ding J, Li Y, Liu W, Ji J, Wang H, et al. Exosomes derived from PEDF modified adipose-derived mesenchymal stem cells ameliorate cerebral ischemia-reperfusion injury by regulation of autophagy and apoptosis. Exp Cell Res. 2018;371:269\u201377.","journal-title":"Exp Cell Res"},{"key":"2985_CR116","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41392-020-0133-y","volume":"5","author":"W Huang","year":"2020","unstructured":"Huang W, Yan Y, Liu Y, Lin M, Ma J, Zhang W, et al. Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin \u03b12\u03b21. Signal Transduct Target Ther. 2020;5:39.","journal-title":"Signal Transduct Target Ther"},{"key":"2985_CR117","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13046-020-01688-7","volume":"39","author":"M Liang","year":"2020","unstructured":"Liang M, Chen X, Wang L, Qin L, Wang H, Sun Z, et al. Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression. J Exp Clin Cancer Res. 2020;39:176.","journal-title":"J Exp Clin Cancer Res"},{"key":"2985_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111111","volume":"134","author":"K Xu","year":"2021","unstructured":"Xu K, Zhang C, Du T, Gabriel ANA, Wang X, Li X, et al. Progress of exosomes in the diagnosis and treatment of lung cancer. Biomed Pharmacother. 2021;134: 111111.","journal-title":"Biomed Pharmacother"},{"key":"2985_CR119","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120467","author":"P Wu","year":"2020","unstructured":"Wu P, Zhang B, Ocansey DKW, Xu W, Qian H. Extracellular vesicles: a bright star of nanomedicine. Biomaterials. 2020. https:\/\/doi.org\/10.1016\/j.biomaterials.2020.120467.","journal-title":"Biomaterials"},{"key":"2985_CR120","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1039\/C9NR09011H","volume":"12","author":"H Nie","year":"2020","unstructured":"Nie H, Xie X, Zhang D, Zhou Y, Li B, Li F, et al. Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer. Nanoscale. 2020;12:877\u201387.","journal-title":"Nanoscale"},{"key":"2985_CR121","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1111\/1759-7714.13175","volume":"10","author":"D Hao","year":"2019","unstructured":"Hao D, Li Y, Zhao G, Zhang M. Soluble fms-like tyrosine kinase-1-enriched exosomes suppress the growth of small cell lung cancer by inhibiting endothelial cell migration. Thorac Cancer. 2019;10:1962\u201372.","journal-title":"Thorac Cancer"},{"key":"2985_CR122","doi-asserted-by":"publisher","DOI":"10.1038\/srep38541","volume":"6","author":"A Srivastava","year":"2016","unstructured":"Srivastava A, Amreddy N, Babu A, Panneerselvam J, Mehta M, Muralidharan R, et al. Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells. Sci Rep. 2016;6: 38541.","journal-title":"Sci Rep"},{"key":"2985_CR123","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.canlet.2017.02.004","volume":"393","author":"R Munagala","year":"2017","unstructured":"Munagala R, Aqil F, Jeyabalan J, Agrawal AK, Mudd AM, Kyakulaga AH, et al. Exosomal formulation of anthocyanidins against multiple cancer types. Cancer Lett. 2017;393:94\u2013102.","journal-title":"Cancer Lett"},{"key":"2985_CR124","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.nano.2017.09.011","volume":"14","author":"MS Kim","year":"2018","unstructured":"Kim MS, Haney MJ, Zhao Y, Yuan D, Deygen I, Klyachko NL, et al. Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations. Nanomedicine. 2018;14:195\u2013204.","journal-title":"Nanomedicine"},{"key":"2985_CR125","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.2147\/OTT.S261054","volume":"13","author":"Y Yu","year":"2020","unstructured":"Yu Y, Luo Y, Fang Z, Teng W, Yu Y, Tian J, et al. Mechanism of sanguinarine in inhibiting macrophages to promote metastasis and proliferation of lung cancer via modulating the exosomes in A549 cells. Onco Targets Ther. 2020;13:8989\u20139003.","journal-title":"Onco Targets Ther"},{"key":"2985_CR126","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s10555-013-9420-1","volume":"32","author":"J Sceneay","year":"2013","unstructured":"Sceneay J, Smyth MJ, M\u00f6ller A. The pre-metastatic niche: finding common ground. Cancer Metastasis Rev. 2013;32:449\u201364.","journal-title":"Cancer Metastasis Rev"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-021-02985-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-021-02985-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-021-02985-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T05:08:00Z","timestamp":1675573680000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-021-02985-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":126,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["2985"],"URL":"https:\/\/doi.org\/10.1186\/s12967-021-02985-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,19]]},"assertion":[{"value":"21 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"312"}}