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Peripapillary retinal nerve fibre layer (pRNFL) imaging was performed with SD-OCT. Visual field (VF) tests were performed with the 30-2 SITA standard program on the Humphrey 750i Visual Field Analyzer and were grouped into 8 regions that matched the structure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The pRNFL had no significant difference in all groups (p\u2009=\u20090.422). The average pVD were significantly lower in group 4 (47.61\u2009\u00b1\u20096.58) than in group 2 and 3 (51.49\u2009\u00b1\u20093.21, 50.48\u2009\u00b1\u20093.43 respectively) (p\u2009&lt;\u20090.05). While both pVD in group2 and 3 were statistically lower than group1 (52.77\u2009\u00b1\u20092.86). The average VFMS was significantly lower in group 4 (901.85\u2009\u00b1\u2009386.54) than other three groups (1169.15\u2009\u00b1\u2009328.94, 1081.77\u2009\u00b1\u2009338.83, 1076.89\u2009\u00b1\u2009358.18, for group1,2,3 respectively). The pVD and VFMS were positively correlated in group3 (r\u2009=\u20090.184) and group4 (r\u2009=\u20090.476) (p\u2009&lt;\u20090.05). Linear regression analysis demonstrated that VFMS were positively associated with pVD especially in temporal and nasal quadrants in myopic eyes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The pVD shows a significant positive correlation with VFMS in highly myopic eyes with SE\u2009\u2264\u2009\u2212\u20098.00D. We suggest that pVD measurement by OCTA could be a sensitive and useful method for monitoring myopic functional change.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-022-03323-9","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:05:59Z","timestamp":1646910359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes"],"prefix":"10.1186","volume":"20","author":[{"given":"Hua","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Cun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-2005","authenticated-orcid":false,"given":"Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"3323_CR1","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","volume":"1","author":"RR Bourne","year":"2013","unstructured":"Bourne RR, Stevens GA, White RA, et al. 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