{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:35:11Z","timestamp":1790508911837,"version":"4.1.0"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21621037"],"award-info":[{"award-number":["21621037"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sclerostin is the protein product of the<jats:italic>SOST<\/jats:italic>gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporosis. Oral health is one of the essential aspects of general human health. Hereditary bone dysplasia syndrome caused by sclerostin deficiency is often accompanied by some dental malformations, inspiring the therapeutic exploration of sclerostin in the oral and dental fields. Recent studies have found that sclerostin is expressed in several functional cell types in oral tissues, and the expression level of sclerostin is altered in pathological conditions. Sclerostin not only exerts similar negative outcomes on the formation of alveolar bone and bone-like tissues, including dentin and cementum, but also participates in the development of oral inflammatory diseases such as periodontitis, pulpitis, and peri-implantitis. This review aims to highlight related research progress of sclerostin in oral cavity, propose necessary further research in this field, and discuss its potential as a therapeutic target for dental indications and regenerative dentistry.<\/jats:p>","DOI":"10.1186\/s12967-022-03417-4","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T11:09:48Z","timestamp":1652440188000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sclerostin is a promising therapeutic target for oral inflammation and regenerative dentistry"],"prefix":"10.1186","volume":"20","author":[{"given":"Chufang","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"issue":"2","key":"3417_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1086\/301721","volume":"62","author":"W Van Hul","year":"1998","unstructured":"Van Hul W, Balemans W, Van Hul E, Dikkers FG, Obee H, Stokroos RJ, et al. Van buchem disease (hyperostosis corticalis generalisata) maps to chromosome 17q12-q21. Am J Hum Genet. 1998;62(2):391\u20139.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"3417_CR2","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1086\/302416","volume":"64","author":"W Balemans","year":"1999","unstructured":"Balemans W, Van Den Ende J, Paes-Alves AF, Dikkers FG, Willems PJ, Vanhoenacker F, et al. Localization of the gene for sclerosteosis to the van buchem disease\u2013gene region on chromosome 17q12\u2013q21. Am J Hum Genet. 1999;64(6):1661\u20139.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"3417_CR3","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1359\/jbmr.080216","volume":"23","author":"X Li","year":"2008","unstructured":"Li X, Ominsky MS, Niu Q, Sun N, Daugherty B, D\u2019Agostin D, et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008;23(6):860\u20139.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"3417_CR4","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.bone.2004.05.023","volume":"35","author":"MK Sutherland","year":"2004","unstructured":"Sutherland MK, Geoghegan JC, Yu C, Turcott E, Skonier JE, Winkler DG, et al. Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation. Bone. 2004;35(4):828\u201335.","journal-title":"Bone"},{"issue":"9","key":"3417_CR5","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms21093199","volume":"21","author":"AD Mar\u00e9","year":"2020","unstructured":"Mar\u00e9 AD, D\u2019Haese PC, Verhulst A. The role of sclerostin in bone and ectopic calcification. Int J Mol Sci. 2020;21(9):3199.","journal-title":"Int J Mol Sci"},{"issue":"164","key":"3417_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.602330","volume":"12","author":"M Sun","year":"2021","unstructured":"Sun M, Chen Z, Wu X, Yu Y, Wang L, Lu A, et al. The roles of sclerostin in immune system and the applications of aptamers in immune-related research. Front Immunol. 2021;12(164): 602330.","journal-title":"Front Immunol"},{"issue":"4","key":"3417_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s40265-019-01072-6","volume":"79","author":"A Markham","year":"2019","unstructured":"Markham A. Romosozumab: first global approval. Drugs. 2019;79(4):471\u20136.","journal-title":"Drugs"},{"issue":"3","key":"3417_CR8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1086\/318811","volume":"68","author":"ME Brunkow","year":"2001","unstructured":"Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, Proll S, et al. Bone dysplasia sclerosteosis results from loss of the sost gene product, a novel cystine knot\u2013containing protein. Am J Hum Genet. 2001;68(3):577\u201389.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"3417_CR9","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","volume":"10","author":"W Balemans","year":"2001","unstructured":"Balemans W, Ebeling M, Patel N, Van Hul E, Olson P, Dioszegi M, et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (sost). Hum Mol Genet. 2001;10(5):537\u201344.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"3417_CR10","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/gte.2008.0036","volume":"12","author":"CA Kim","year":"2008","unstructured":"Kim CA, Honjo R, Bertola D, Albano L, Oliveira L, Jales S, et al. A known sost gene mutation causes sclerosteosis in a familial and an isolated case from brazilian origin. Genet Test. 2008;12(4):475\u20139.","journal-title":"Genet Test"},{"issue":"7","key":"3417_CR11","doi-asserted-by":"publisher","first-page":"E1526","DOI":"10.1002\/humu.21274","volume":"31","author":"E Piters","year":"2010","unstructured":"Piters E, Culha C, Moester M, Van Bezooijen R, Adriaensen D, Mueller T, et al. First missense mutation in the sost gene causing sclerosteosis by loss of sclerostin function. Hum Mutat. 2010;31(7):E1526\u201343.","journal-title":"Hum Mutat"},{"issue":"2","key":"3417_CR12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/jmg.39.2.91","volume":"39","author":"W Balemans","year":"2002","unstructured":"Balemans W, Patel N, Ebeling M, Van Hul E, Wuyts W, Lacza C, et al. Identification of a 52 kb deletion downstream of the sost gene in patients with van buchem disease. J Med Genet. 2002;39(2):91\u20137.","journal-title":"J Med Genet"},{"issue":"2","key":"3417_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/ajmg.10401","volume":"110","author":"K Staehling-Hampton","year":"2002","unstructured":"Staehling-Hampton K, Proll S, Paeper BW, Zhao L, Charmley P, Brown A, et al. A 52-kb deletion in the sost-meox1 intergenic region on 17q12-q21 is associated with van buchem disease in the dutch population. Am J Med Genet. 2002;110(2):144\u201352.","journal-title":"Am J Med Genet"},{"issue":"10","key":"3417_CR14","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1359\/jbmr.090411","volume":"24","author":"C Lin","year":"2009","unstructured":"Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, et al. Sclerostin mediates bone response to mechanical unloading through antagonizing wnt\/beta-catenin signaling. J Bone Miner Res. 2009;24(10):1651\u201361.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"3417_CR15","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1074\/jbc.M705092200","volume":"283","author":"A Robling","year":"2008","unstructured":"Robling A, Niziolek P, Baldridge L, Condon K, Allen M, Alam I, et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of sost\/sclerostin. J Biol Chem. 2008;283(9):5866\u201375.","journal-title":"J Biol Chem"},{"issue":"4","key":"3417_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10735-007-9096-3","volume":"38","author":"G Silvestrini","year":"2007","unstructured":"Silvestrini G, Ballanti P, Leopizzi M, Sebastiani M, Berni S, Di Vito M, et al. Effects of intermittent parathyroid hormone (pth) administration on sost mrna and protein in rat bone. J Mol Histol. 2007;38(4):261\u20139.","journal-title":"J Mol Histol"},{"issue":"2","key":"3417_CR17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcb.22559","volume":"110","author":"DC Genetos","year":"2010","unstructured":"Genetos DC, Toupadakis CA, Raheja LF, Wong A, Papanicolaou SE, Fyhrie DP, et al. Hypoxia decreases sclerostin expression and increases wnt signaling in osteoblasts. J Cell Biochem. 2010;110(2):457\u201367.","journal-title":"J Cell Biochem"},{"issue":"23","key":"3417_CR18","doi-asserted-by":"publisher","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","volume":"22","author":"DG Winkler","year":"2003","unstructured":"Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, et al. Osteocyte control of bone formation via sclerostin, a novel bmp antagonist. Embo J. 2003;22(23):6267\u201376.","journal-title":"Embo J"},{"issue":"1","key":"3417_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1359\/jbmr.061002","volume":"22","author":"RL van Bezooijen","year":"2007","unstructured":"van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, Karperien M, et al. Wnt but not bmp signaling is involved in the inhibitory action of sclerostin on bmp-stimulated bone formation. J Bone Miner Res. 2007;22(1):19\u201328.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"3417_CR20","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1084\/jem.20031454","volume":"199","author":"RL van Bezooijen","year":"2004","unstructured":"van Bezooijen RL, Roelen BAJ, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical bmp antagonist. J Exp Med. 2004;199(6):805\u201314.","journal-title":"J Exp Med"},{"issue":"5","key":"3417_CR21","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/jbmr.304","volume":"26","author":"Y Rhee","year":"2011","unstructured":"Rhee Y, Allen MR, Condon K, Lezcano V, Ronda AC, Galli C, et al. Pth receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res. 2011;26(5):1035\u201346.","journal-title":"J Bone Miner Res"},{"issue":"26","key":"3417_CR22","doi-asserted-by":"publisher","first-page":"24113","DOI":"10.1074\/jbc.M301716200","volume":"278","author":"N Kusu","year":"2003","unstructured":"Kusu N, Laurikkala J, Imanishi M, Usui H, Konishi M, Miyake A, et al. Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem. 2003;278(26):24113\u20137.","journal-title":"J Biol Chem"},{"issue":"29","key":"3417_CR23","doi-asserted-by":"publisher","first-page":"26770","DOI":"10.1074\/jbc.M504308200","volume":"280","author":"M Semenov","year":"2005","unstructured":"Semenov M, Tamai K, He X. Sost is a ligand for lrp5\/lrp6 and a wnt signaling inhibitor. J Biol Chem. 2005;280(29):26770\u20135.","journal-title":"J Biol Chem"},{"key":"3417_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115708","volume":"143","author":"K-E Lim","year":"2021","unstructured":"Lim K-E, Bullock WA, Horan DJ, Williams BO, Warman ML, Robling AG. Co-deletion of lrp5 and lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration. Bone. 2021;143: 115708.","journal-title":"Bone"},{"issue":"10","key":"3417_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025900","volume":"6","author":"AR Wijenayaka","year":"2011","unstructured":"Wijenayaka AR, Kogawa M, Lim HP, Bonewald LF, Findlay DM, Atkins GJ. Sclerostin stimulates osteocyte support of osteoclast activity by a rankl-dependent pathway. PLoS ONE. 2011;6(10): e25900.","journal-title":"PLoS ONE"},{"issue":"9","key":"3417_CR26","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1210\/jc.2017-02163","volume":"103","author":"EM Lewiecki","year":"2018","unstructured":"Lewiecki EM, Blicharski T, Goemaere S, Lippuner K, Meisner PD, Miller PD, et al. A phase III randomized placebo-controlled trial to evaluate efficacy and safety of romosozumab in men with osteoporosis. J Clin Endocrinol Metab. 2018;103(9):3183\u201393.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"3417_CR27","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1002\/jbmr.3452","volume":"33","author":"MR McClung","year":"2018","unstructured":"McClung MR, Brown JP, Diez-Perez A, Resch H, Caminis J, Meisner P, et al. Effects of 24 months of treatment with romosozumab followed by 12 months of denosumab or placebo in postmenopausal women with low bone mineral density: a randomized, double-blind, phase 2, parallel group study. J Bone Miner Res. 2018;33(8):1397\u2013406.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"3417_CR28","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1177\/1060028020952764","volume":"55","author":"KL Nealy","year":"2021","unstructured":"Nealy KL, Harris KB. Romosozumab: a novel injectable sclerostin inhibitor with anabolic and antiresorptive effects for osteoporosis. Ann Pharmacother. 2021;55(5):677\u201386.","journal-title":"Ann Pharmacother"},{"key":"3417_CR29","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.3389\/fimmu.2018.02467","volume":"9","author":"D Toscani","year":"2018","unstructured":"Toscani D, Bolzoni M, Ferretti M, Palumbo C, Giuliani N. Role of osteocytes in myeloma bone disease: anti-sclerostin antibody as new therapeutic strategy. Front Immunol. 2018;9:2467.","journal-title":"Front Immunol"},{"issue":"4","key":"3417_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/j.1875-595X.2001.tb00840.x","volume":"51","author":"L Stephen","year":"2001","unstructured":"Stephen L, Hamersma H, Gardner J, Beighton P. Dental and oral manifestations of sclerosteosis. Int Dent J. 2001;51(4):287\u201390.","journal-title":"Int Dent J"},{"issue":"6","key":"3417_CR31","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.bone.2005.02.019","volume":"36","author":"W Balemans","year":"2005","unstructured":"Balemans W, Cleiren E, Siebers U, Horst J, Van Hul W. A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the sost gene. Bone. 2005;36(6):943\u20137.","journal-title":"Bone"},{"issue":"12","key":"3417_CR32","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1902\/jop.2015.150270","volume":"86","author":"U Balli","year":"2015","unstructured":"Balli U, Aydogdu A, Dede FO, Turer CC, Guven B. Gingival crevicular fluid levels of sclerostin, osteoprotegerin, and receptor activator of nuclear factor-\u03bab ligand in periodontitis. J Periodontol. 2015;86(12):1396\u2013404.","journal-title":"J Periodontol"},{"issue":"8","key":"3417_CR33","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3390\/medicina57080788","volume":"57","author":"GS Chatzopoulos","year":"2021","unstructured":"Chatzopoulos GS, Costalonga M, Mansky KC, Wolff LF. Wnt-5a and sost levels in gingival crevicular fluid depend on the inflammatory and osteoclastogenic activities of periodontal tissues. Medicina. 2021;57(8):788.","journal-title":"Medicina"},{"key":"3417_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cyto.2018.10.021","volume":"113","author":"N Yakar","year":"2019","unstructured":"Yakar N, Guncu GN, Akman AC, P\u0131nar A, Karabulut E, Nohutcu RM. Evaluation of gingival crevicular fluid and peri-implant crevicular fluid levels of sclerostin, tweak, rankl and opg. Cytokine. 2019;113:433\u20139.","journal-title":"Cytokine"},{"issue":"1","key":"3417_CR35","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10266-020-00520-0","volume":"109","author":"SC Isler","year":"2021","unstructured":"Isler SC, Soysal F, Akca G, Bakirarar B, Ozcan G, Unsal B. The effects of decontamination methods of dental implant surface on cytokine expression analysis in the reconstructive surgical treatment of peri-implantitis. Odontology. 2021;109(1):103\u201313.","journal-title":"Odontology"},{"key":"3417_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0494","author":"AT Gur","year":"2021","unstructured":"Gur AT, Guncu GN, Akman AC, Pinar A, Karabulut E, Nohutcu RM. Evaluation of gcf il-17, il-10, tweak, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis. J Periodontol. 2021. https:\/\/doi.org\/10.1002\/JPER.21-0494.","journal-title":"J Periodontol"},{"issue":"6","key":"3417_CR37","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/jcpe.12245","volume":"41","author":"MH Napimoga","year":"2014","unstructured":"Napimoga MH, Nametala C, da Silva FL, Miranda TS, Bossonaro JP, Demasi APD, et al. Involvement of the wnt-\u03b2-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis. J Clin Periodontol. 2014;41(6):550\u20137.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3417_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12369","volume":"10","author":"PA Sankardas","year":"2019","unstructured":"Sankardas PA, Lavu V, Lakakula BV, Rao SR. Differential expression of periostin, sclerostin, receptor activator of nuclear factor-\u03bab, and receptor activator of nuclear factor-\u03bab ligand genes in severe chronic periodontitis. J Investig Clin Dent. 2019;10(1): e12369.","journal-title":"J Investig Clin Dent"},{"issue":"2","key":"3417_CR39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1600-0765.2009.01227.x","volume":"45","author":"A J\u00e4ger","year":"2010","unstructured":"J\u00e4ger A, G\u00f6tz W, Lossd\u00f6rfer S, Rath-Deschner B. Localization of sost\/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro. J Periodontal Res. 2010;45(2):246\u201354.","journal-title":"J Periodontal Res"},{"issue":"7","key":"3417_CR40","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1177\/0022034515581372","volume":"94","author":"J Manokawinchoke","year":"2015","unstructured":"Manokawinchoke J, Limjeerajarus N, Limjeerajarus C, Sastravaha P, Everts V, Pavasant P. Mechanical force-induced tgfb1 increases expression of sost\/postn by hpdl cells. J Dent Res. 2015;94(7):983\u20139.","journal-title":"J Dent Res"},{"key":"3417_CR41","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.archoralbio.2015.11.010","volume":"62","author":"M Ueda","year":"2016","unstructured":"Ueda M, Goto T, Kuroishi KN, Gunjigake KK, Ikeda E, Kataoka S, et al. Asporin in compressed periodontal ligament cells inhibits bone formation. Arch Oral Biol. 2016;62:86\u201392.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"3417_CR42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.archoralbio.2014.08.013","volume":"60","author":"Y Nishiyama","year":"2015","unstructured":"Nishiyama Y, Matsumoto T, Lee J, Saitou T, Imamura T, Moriyama K, et al. Changes in the spatial distribution of sclerostin in the osteocytic lacuno-canalicular system in alveolar bone due to orthodontic forces, as detected on multimodal confocal fluorescence imaging analyses. Arch Oral Biol. 2015;60(1):45\u201354.","journal-title":"Arch Oral Biol"},{"issue":"1","key":"3417_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12967-018-1438-2","volume":"16","author":"J-H Kim","year":"2018","unstructured":"Kim J-H, Kim AR, Choi YH, Kim A, Sohn Y, Woo G-H, et al. Intermittent pth administration improves alveolar bone formation in type 1 diabetic rats with periodontitis. J Transl Med. 2018;16(1):70.","journal-title":"J Transl Med"},{"key":"3417_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.006","author":"Y Men","year":"2020","unstructured":"Men Y, Wang Y, Yi Y, Jing D, Luo W, Shen B, et al. Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force. Dev Cell. 2020. https:\/\/doi.org\/10.1016\/j.devcel.2020.06.006.","journal-title":"Dev Cell"},{"issue":"3","key":"3417_CR45","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.joen.2010.11.025","volume":"37","author":"T Naka","year":"2011","unstructured":"Naka T, Yokose S. Spatiotemporal expression of sclerostin in odontoblasts during embryonic mouse tooth morphogenesis. J Endod. 2011;37(3):340\u20135.","journal-title":"J Endod"},{"issue":"12","key":"3417_CR46","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1177\/0022034518771331","volume":"97","author":"N Odagaki","year":"2018","unstructured":"Odagaki N, Ishihara Y, Wang Z, Ei Hsu Hlaing E, Nakamura M, Hoshijima M, et al. Role of osteocyte-pdl crosstalk in tooth movement via sost\/sclerostin. J Dent Res. 2018;97(12):1374\u201382.","journal-title":"J Dent Res"},{"issue":"1","key":"3417_CR47","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/ejo\/cjv006","volume":"38","author":"S Yadav","year":"2016","unstructured":"Yadav S, Assefnia A, Gupta H, Vishwanath M, Kalajzic Z, Allareddy V, et al. The effect of low-frequency mechanical vibration on retention in an orthodontic relapse model. Eur J Orthodont. 2016;38(1):44\u201350.","journal-title":"Eur J Orthodont"},{"issue":"1","key":"3417_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167312","volume":"12","author":"R Shu","year":"2017","unstructured":"Shu R, Bai D, Sheu T, He Y, Yang X, Xue C, et al. Sclerostin promotes bone remodeling in the process of tooth movement. PLoS ONE. 2017;12(1): e0167312.","journal-title":"PLoS ONE"},{"issue":"9","key":"3417_CR49","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1177\/0022034518766874","volume":"97","author":"M Liu","year":"2018","unstructured":"Liu M, Kurimoto P, Zhang J, Niu Q, Stolina M, Dechow P, et al. Sclerostin and dkk1 inhibition preserves and augments alveolar bone volume and architecture in rats with alveolar bone loss. J Dent Res. 2018;97(9):1031\u20138.","journal-title":"J Dent Res"},{"issue":"8","key":"3417_CR50","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1902\/jop.2015.150083","volume":"86","author":"J Kim","year":"2015","unstructured":"Kim J, Lee D, Woo G, Cha J, Bak E, Yoo Y. Osteocytic sclerostin expression in alveolar bone in rats with diabetes mellitus and ligature-induced periodontitis. J Periodontol. 2015;86(8):1005\u201311.","journal-title":"J Periodontol"},{"issue":"11","key":"3417_CR51","doi-asserted-by":"publisher","first-page":"e370","DOI":"10.1902\/jop.2014.140230","volume":"85","author":"J Kim","year":"2014","unstructured":"Kim J, Lee D, Cha J, Bak E, Yoo Y. Receptor activator of nuclear factor-\u03bab ligand and sclerostin expression in osteocytes of alveolar bone in rats with ligature-induced periodontitis. J Periodontol. 2014;85(11):e370\u20138.","journal-title":"J Periodontol"},{"issue":"11","key":"3417_CR52","doi-asserted-by":"publisher","first-page":"20779","DOI":"10.1002\/jcp.28684","volume":"234","author":"C Liao","year":"2019","unstructured":"Liao C, Ou Y, Wu Y, Zhou Y, Liang S, Wang Y. Sclerostin inhibits odontogenic differentiation of human pulp-derived odontoblast-like cells under mechanical stress. J Cell Physiol. 2019;234(11):20779\u201389.","journal-title":"J Cell Physiol"},{"key":"3417_CR53","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5808","volume":"6","author":"Y Ou","year":"2018","unstructured":"Ou Y, Zhou Y, Liang S, Wang Y. Sclerostin promotes human dental pulp cells senescence. PeerJ. 2018;6: e5808.","journal-title":"PeerJ"},{"issue":"10","key":"3417_CR54","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1016\/j.ajpath.2016.06.013","volume":"186","author":"N Amri","year":"2016","unstructured":"Amri N, Djole S, Petit S, Babajko S, Coudert A, Castaneda B, et al. Distorted patterns of dentinogenesis and eruption in msx2 null mutants: involvement of sost\/sclerostin. Am J Pathol. 2016;186(10):2577\u201387.","journal-title":"Am J Pathol"},{"key":"3417_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2019.105628","volume":"117","author":"C Liao","year":"2019","unstructured":"Liao C, Wang Y, Ou Y, Wu Y, Zhou Y, Liang S. Effects of sclerostin on lipopolysaccharide-induced inflammatory phenotype in human odontoblasts and dental pulp cells. Int J Biochem Cell Biol. 2019;117: 105628.","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"3417_CR56","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1177\/0022034517698104","volume":"96","author":"A Collignon","year":"2017","unstructured":"Collignon A, Amri N, Lesieur J, Sadoine J, Ribes S, Menashi S, et al. Sclerostin deficiency promotes reparative dentinogenesis. J Dent Res. 2017;96(7):815\u201321.","journal-title":"J Dent Res"},{"key":"3417_CR57","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fbioe.2019.00430","volume":"7","author":"K Janji\u0107","year":"2019","unstructured":"Janji\u0107 K, Samiei M, Moritz A, Agis H. The influence of pro-inflammatory factors on sclerostin and dickkopf-1 production in human dental pulp cells under hypoxic conditions. Front Bioeng Biotechnol. 2019;7:430.","journal-title":"Front Bioeng Biotechnol"},{"key":"3417_CR58","doi-asserted-by":"publisher","first-page":"e058","DOI":"10.1590\/1807-3107bor-2019.vol33.0058","volume":"33","author":"ABD Almeida","year":"2019","unstructured":"Almeida ABD, Santos EJLD, Abuna GF, Ribeiro CS, Casati MZ, Ruiz KGS, et al. Isolation and characterization of a human cementocyte-like cell line, hcy-23. Braz Oral Res. 2019;33:e058.","journal-title":"Braz Oral Res"},{"issue":"5","key":"3417_CR59","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.aanat.2012.02.014","volume":"194","author":"SD Lehnen","year":"2012","unstructured":"Lehnen SD, G\u00f6tz W, Baxmann M, J\u00e4ger A. Immunohistochemical evidence for sclerostin during cementogenesis in mice. Ann Anat. 2012;194(5):415\u201321.","journal-title":"Ann Anat"},{"issue":"2","key":"3417_CR60","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/jbmr.2690","volume":"31","author":"N Zhao","year":"2016","unstructured":"Zhao N, Nociti FH, Duan P, Prideaux M, Zhao H, Foster BL, et al. Isolation and functional analysis of an immortalized murine cementocyte cell line, idg-cm6. J Bone Miner Res. 2016;31(2):430\u201342.","journal-title":"J Bone Miner Res"},{"issue":"2","key":"3417_CR61","first-page":"279","volume":"24","author":"J Klein-Nulend","year":"2012","unstructured":"Klein-Nulend J, Bacabac R, Bakker A. Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton. Eur Cell Mater. 2012;24(2):279\u201391.","journal-title":"Eur Cell Mater"},{"key":"3417_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.778015","author":"Y Du","year":"2021","unstructured":"Du Y, Zhang L, Wang Z, Zhao X, Zou J. Endocrine regulation of extra-skeletal organs by bone-derived secreted protein and the effect of mechanical stimulation. Front Cell Dev Biol. 2021. https:\/\/doi.org\/10.3389\/fcell.2021.778015.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"3417_CR63","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bone.2012.10.013","volume":"54","author":"J Klein-Nulend","year":"2013","unstructured":"Klein-Nulend J, Bakker AD, Bacabac RG, Vatsa A, Weinbaum S. Mechanosensation and transduction in osteocytes. Bone. 2013;54(2):182\u201390.","journal-title":"Bone"},{"issue":"5","key":"3417_CR64","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1210\/jc.2010-0067","volume":"95","author":"A Gaudio","year":"2010","unstructured":"Gaudio A, Pennisi P, Bratengeier C, Torrisi V, Lindner B, Mangiafico RA, et al. Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocr Metab. 2010;95(5):2248\u201353.","journal-title":"J Clin Endocr Metab"},{"issue":"2","key":"3417_CR65","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/ijos.2014.12","volume":"6","author":"U Kuchler","year":"2014","unstructured":"Kuchler U, Schwarze UY, Dobsak T, Heimel P, Bosshardt DD, Kneissel M, et al. Dental and periodontal phenotype in sclerostin knockout mice. Int J Oral Sci. 2014;6(2):70\u20136.","journal-title":"Int J Oral Sci"},{"issue":"1","key":"3417_CR66","doi-asserted-by":"publisher","first-page":"16217","DOI":"10.1038\/s41598-020-73026-y","volume":"10","author":"Y Yao","year":"2020","unstructured":"Yao Y, Kauffmann F, Maekawa S, Sarment LV, Sugai JV, Schmiedeler CA, et al. Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects. Sci Rep. 2020;10(1):16217.","journal-title":"Sci Rep"},{"issue":"S2","key":"3417_CR67","doi-asserted-by":"publisher","first-page":"S467","DOI":"10.1002\/jbmr.5650081307","volume":"8","author":"MK Jeffcoat","year":"1993","unstructured":"Jeffcoat MK. Bone loss in the oral cavity. J Bone Miner Res. 1993;8(S2):S467\u201373.","journal-title":"J Bone Miner Res"},{"issue":"Suppl 5","key":"3417_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02375.x","volume":"23","author":"WL Tan","year":"2012","unstructured":"Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implan Res. 2012;23(Suppl 5):1\u201321.","journal-title":"Clin Oral Implan Res"},{"key":"3417_CR69","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/617032","volume":"2014","author":"H Kitaura","year":"2014","unstructured":"Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, et al. Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane. Sci World J. 2014;2014: 617032.","journal-title":"Sci World J"},{"issue":"9429","key":"3417_CR70","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","volume":"364","author":"B Seo","year":"2004","unstructured":"Seo B, Miura M, Gronthos S, Bartold P, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364(9429):149\u201355.","journal-title":"Lancet"},{"issue":"2","key":"3417_CR71","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.gene.2011.09.031","volume":"491","author":"M Liu","year":"2012","unstructured":"Liu M, Dai J, Lin Y, Yang L, Dong H, Li Y, et al. Effect of the cyclic stretch on the expression of osteogenesis genes in human periodontal ligament cells. Gene. 2012;491(2):187\u201393.","journal-title":"Gene"},{"issue":"10","key":"3417_CR72","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1002\/jcp.24972","volume":"230","author":"D Ren","year":"2015","unstructured":"Ren D, Wei F, Hu L, Yang S, Wang C, Yuan X. Phosphorylation of runx2, induced by cyclic mechanical tension via erk1\/2 pathway, contributes to osteodifferentiation of human periodontal ligament fibroblasts. J Cell Physiol. 2015;230(10):2426\u201336.","journal-title":"J Cell Physiol"},{"issue":"3","key":"3417_CR73","doi-asserted-by":"publisher","first-page":"422","DOI":"10.5114\/aoms.2012.28810","volume":"8","author":"N Tang","year":"2012","unstructured":"Tang N, Zhao Z, Zhang L, Yu Q, Li J, Xu Z, et al. Up-regulated osteogenic transcription factors during early response of human periodontal ligament stem cells to cyclic tensile strain. Arch Med Sci. 2012;8(3):422\u201330.","journal-title":"Arch Med Sci"},{"issue":"3","key":"3417_CR74","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1600-0722.2008.00533.x","volume":"116","author":"Y Zhao","year":"2008","unstructured":"Zhao Y, Wang C, Li S, Song H, Wei F, Pan K, et al. Expression of osterix in mechanical stress-induced osteogenic differentiation of periodontal ligament cells in vitro. Eur J Oral Sci. 2008;116(3):199\u2013206.","journal-title":"Eur J Oral Sci"},{"issue":"6","key":"3417_CR75","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.1016\/j.ajodo.2020.08.006","volume":"158","author":"E Ei Hsu Hlaing","year":"2020","unstructured":"Ei Hsu Hlaing E, Ishihara Y, Odagaki N, Wang Z, Ikegame M, Kamioka H. The expression and regulation of wnt1 in tooth movement-initiated mechanotransduction. Am J Orthod Dentofacial Orthop. 2020;158(6):e151-60.","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"3417_CR76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s002239900189","volume":"60","author":"T Lundgren","year":"1997","unstructured":"Lundgren T, Linde A. Voltage-gated calcium channels and nonvoltage-gated calcium uptake pathways in the rat incisor odontoblast plasma membrane. Calcif Tissue Int. 1997;60(1):79\u201385.","journal-title":"Calcif Tissue Int"},{"key":"3417_CR77","first-page":"1","volume":"154","author":"P Lundquist","year":"2002","unstructured":"Lundquist P. Odontoblast phosphate and calcium transport in dentinogenesis. Swed Dent J Suppl. 2002;154:1\u201352.","journal-title":"Swed Dent J Suppl"},{"issue":"10","key":"3417_CR78","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1369\/0022155420960403","volume":"68","author":"Q Liu","year":"2020","unstructured":"Liu Q, Ma N, Zhu Q, Duan X, Shi H, Xiang D, et al. Dentin sialophosphoprotein deletion leads to femoral head cartilage attenuation and subchondral bone ill-mineralization. J Histochem Cytochem. 2020;68(10):703\u201318.","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"3417_CR79","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/08959374010150011201","volume":"15","author":"H Magloire","year":"2001","unstructured":"Magloire H, Romeas A, Melin M, Couble M, Bleicher F, Farges J. Molecular regulation of odontoblast activity under dentin injury. Adv Dent Res. 2001;15(1):46\u201350.","journal-title":"Adv Dent Res"},{"issue":"12","key":"3417_CR80","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1177\/154405910408301202","volume":"83","author":"T Mitsiadis","year":"2004","unstructured":"Mitsiadis T, Rahiotis C. Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res. 2004;83(12):896\u2013902.","journal-title":"J Dent Res"},{"issue":"10","key":"3417_CR81","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.dental.2009.04.006","volume":"25","author":"K Karan","year":"2009","unstructured":"Karan K, Yao X, Xu C, Wang Y. Chemical profile of the dentin substrate in non-carious cervical lesions. Dent Mater. 2009;25(10):1205\u201312.","journal-title":"Dent Mater"},{"issue":"2","key":"3417_CR82","first-page":"313","volume":"78","author":"T Yagi","year":"1990","unstructured":"Yagi T, Suga S. Sem investigations on the human sclerosed dentinal tubules. Shigaku. 1990;78(2):313\u201337.","journal-title":"Shigaku"},{"issue":"4","key":"3417_CR83","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1177\/154405910608500405","volume":"85","author":"D Bartlett","year":"2006","unstructured":"Bartlett D, Shah P. A critical review of non-carious cervical (wear) lesions and the role of abfraction, erosion, and abrasion. J Dent Res. 2006;85(4):306\u201312.","journal-title":"J Dent Res"},{"issue":"5","key":"3417_CR84","first-page":"405","volume":"96","author":"J Bergstrom","year":"1988","unstructured":"Bergstrom J, Eliasson S. Cervical abrasion in relation to toothbrushing and periodontal health. Scand J Dent Res. 1988;96(5):405\u201311.","journal-title":"Scand J Dent Res"},{"issue":"1","key":"3417_CR85","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1046\/j.1365-2842.2003.00959.x","volume":"30","author":"M Tanaka","year":"2003","unstructured":"Tanaka M, Naito T, Yokota M, Kohno M. Finite element analysis of the possible mechanism of cervical lesion formation by occlusal force. J Oral Rehabil. 2003;30(1):60\u20137.","journal-title":"J Oral Rehabil"},{"issue":"6","key":"3417_CR86","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1177\/0022034509338340","volume":"88","author":"R van Bezooijen","year":"2009","unstructured":"van Bezooijen R, Bronckers A, Gortzak R, Hogendoorn P, Van der Wee-Pals L, Balemans W, et al. Sclerostin in mineralized matrices and van buchem disease. J Dent Res. 2009;88(6):569\u201374.","journal-title":"J Dent Res"},{"issue":"2","key":"3417_CR87","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/0022034516677539","volume":"96","author":"A Iglesias-Linares","year":"2017","unstructured":"Iglesias-Linares A, Hartsfield JK. Cellular and molecular pathways leading to external root resorption. J Dent Res. 2017;96(2):145\u201352.","journal-title":"J Dent Res"},{"issue":"10","key":"3417_CR88","doi-asserted-by":"publisher","first-page":"21140","DOI":"10.3390\/ijms141021140","volume":"14","author":"X Bao","year":"2013","unstructured":"Bao X, Liu Y, Han G, Zuo Z, Hu M. The effect on proliferation and differentiation of cementoblast by using sclerostin as inhibitor. Int J Mol Sci. 2013;14(10):21140\u201352.","journal-title":"Int J Mol Sci"},{"key":"3417_CR89","volume":"2014","author":"X Bao","year":"2014","unstructured":"Bao X, Liu X, Zhang Y, Cui Y, Yao J, Hu M. Strontium promotes cementoblasts differentiation through inhibiting sclerostin expression in vitro. Biomed Res Int. 2014;2014: 487535.","journal-title":"Biomed Res Int"},{"issue":"4","key":"3417_CR90","first-page":"3174","volume":"20","author":"T Wei","year":"2020","unstructured":"Wei T, Xie Y, Wen X, Zhao N, Shen G. Establishment of three-dimensional cementocyte differentiation scaffolds to study orthodontic root resorption. Exp Ther Med. 2020;20(4):3174\u201384.","journal-title":"Exp Ther Med"},{"issue":"2","key":"3417_CR91","first-page":"162","volume":"37","author":"S Bai","year":"2019","unstructured":"Bai S, Chen Y, Dai H, Huang L. Effect of sclerostin on the functions and related mechanisms of cementoblasts under mechanical stress. Hua Xi Kou Qiang Yi Xue Za Zhi. 2019;37(2):162\u20137.","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"5","key":"3417_CR92","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.4049\/jimmunol.176.5.2880","volume":"176","author":"SH Durand","year":"2006","unstructured":"Durand SH, Flacher V, Rom\u00e9as A, Carrouel F, Colomb E, Vincent C, et al. Lipoteichoic acid increases tlr and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts. J Immunol. 2006;176(5):2880\u20137.","journal-title":"J Immunol"},{"issue":"4","key":"3417_CR93","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.imbio.2010.08.006","volume":"216","author":"JC Farges","year":"2011","unstructured":"Farges JC, Carrouel F, Keller JF, Baudouin C, Msika P, Bleicher F, et al. Cytokine production by human odontoblast-like cells upon toll-like receptor-2 engagement. Immunobiology. 2011;216(4):513\u20137.","journal-title":"Immunobiology"},{"key":"3417_CR94","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jdent.2017.05.001","volume":"63","author":"R Abdalla","year":"2017","unstructured":"Abdalla R, Mitchell RJ, Fang Ren Y. Non-carious cervical lesions imaged by focus variation microscopy. J Dent. 2017;63:14\u201320.","journal-title":"J Dent"},{"issue":"2","key":"3417_CR95","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.archoralbio.2004.11.009","volume":"50","author":"O T\u00e9cl\u00e8s","year":"2005","unstructured":"T\u00e9cl\u00e8s O, Laurent P, Zygouritsas S, Burger A, Camps J, Dejou J, et al. Activation of human dental pulp progenitor\/stem cells in response to odontoblast injury. Arch Oral Biol. 2005;50(2):103\u20138.","journal-title":"Arch Oral Biol"},{"issue":"2","key":"3417_CR96","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1601-0825.2006.01346.x","volume":"13","author":"A Sloan","year":"2007","unstructured":"Sloan A, Smith A. Stem cells and the dental pulp: Potential roles in dentine regeneration and repair. Oral Dis. 2007;13(2):151\u20137.","journal-title":"Oral Dis"},{"issue":"10","key":"3417_CR97","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1136\/annrheumdis-2013-203345","volume":"72","author":"X Chen","year":"2013","unstructured":"Chen X, Baum W, Dwyer D, Stock M, Schwabe K, Ke H, et al. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013;72(10):1732\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"3417_CR98","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1359\/jbmr.090403","volume":"24","author":"A Eddleston","year":"2009","unstructured":"Eddleston A, Marenzana M, Moore AR, Stephens P, Muzylak M, Marshall D, et al. A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis. J Bone Miner Res. 2009;24(10):1662\u201371.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"3417_CR99","doi-asserted-by":"publisher","first-page":"R125","DOI":"10.1186\/ar4305","volume":"15","author":"M Marenzana","year":"2013","unstructured":"Marenzana M, Vugler A, Moore A, Robinson M. Effect of sclerostin-neutralising antibody on periarticular and systemic bone in a murine model of rheumatoid arthritis: a microct study. Arthritis Res Ther. 2013;15(5):R125.","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"3417_CR100","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00441-014-1799-7","volume":"356","author":"X Feng","year":"2014","unstructured":"Feng X, Feng G, Xing J, Shen B, Tan W, Huang D, et al. Repeated lipopolysaccharide stimulation promotes cellular senescence in human dental pulp stem cells (dpscs). Cell Tissue Res. 2014;356(2):369\u201380.","journal-title":"Cell Tissue Res"},{"issue":"6","key":"3417_CR101","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.semnephrol.2009.07.002","volume":"29","author":"C Mei","year":"2009","unstructured":"Mei C, Zheng F. Chronic inflammation potentiates kidney aging. Semin Nephrol. 2009;29(6):555\u201368.","journal-title":"Semin Nephrol"},{"key":"3417_CR102","doi-asserted-by":"publisher","first-page":"175","DOI":"10.22203\/eCM.v037a11","volume":"37","author":"I Iezzi","year":"2019","unstructured":"Iezzi I, Pagella P, Mattioli-Belmonte M, Mitsiadis TA. The effects of ageing on dental pulp stem cells, the tooth longevity elixir. Eur Cell Mater. 2019;37:175\u201385.","journal-title":"Eur Cell Mater"},{"key":"3417_CR103","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.605996","volume":"8","author":"H Maeda","year":"2020","unstructured":"Maeda H. Aging and senescence of dental pulp and hard tissues of the tooth. Front Cell Dev Biol. 2020;8: 605996.","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"3417_CR104","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/jbmr.217","volume":"26","author":"UI M\u00f6dder","year":"2011","unstructured":"M\u00f6dder UI, Hoey KA, Amin S, McCready LK, Achenbach SJ, Riggs BL, et al. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. J Bone Miner Res. 2011;26(2):373\u20139.","journal-title":"J Bone Miner Res"},{"key":"3417_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bone.2013.10.019","volume":"59","author":"MM Roforth","year":"2014","unstructured":"Roforth MM, Fujita K, McGregor UI, Kirmani S, McCready LK, Peterson JM, et al. Effects of age on bone mrna levels of sclerostin and other genes relevant to bone metabolism in humans. Bone. 2014;59:1\u20136.","journal-title":"Bone"},{"issue":"330","key":"3417_CR106","doi-asserted-by":"publisher","first-page":"330ra35","DOI":"10.1126\/scitranslmed.aac4351","volume":"8","author":"C Wehmeyer","year":"2016","unstructured":"Wehmeyer C, Frank S, Beckmann D, B\u00f6ttcher M, Cromme C, K\u00f6nig U, et al. Sclerostin inhibition promotes tnf-dependent inflammatory joint destruction. Sci Transl Med. 2016;8(330):330ra35.","journal-title":"Sci Transl Med"},{"issue":"1","key":"3417_CR107","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1186\/s12967-020-02664-7","volume":"18","author":"X Huang","year":"2020","unstructured":"Huang X, Xie M, Xie Y, Mei F, Lu X, Li X, et al. The roles of osteocytes in alveolar bone destruction in periodontitis. J Transl Med. 2020;18(1):479.","journal-title":"J Transl Med"},{"issue":"5","key":"3417_CR108","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/JPER.16-0435","volume":"91","author":"L Korah","year":"2020","unstructured":"Korah L, Amri N, Bugueno IM, Hotton D, Tenenbaum H, Huck O, et al. Experimental periodontitis in msx2 mutant mice induces alveolar bone necrosis. J Periodontol. 2020;91(5):693\u2013704.","journal-title":"J Periodontol"},{"issue":"11","key":"3417_CR109","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1002\/jbmr.1984","volume":"28","author":"AD Taut","year":"2013","unstructured":"Taut AD, Jin Q, Chung J, Galindo-Moreno P, Yi ES, Sugai JV, et al. Sclerostin antibody stimulates bone regeneration after experimental periodontitis. J Bone Miner Res. 2013;28(11):2347\u201356.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"3417_CR110","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/jre.12254","volume":"50","author":"U Balli","year":"2015","unstructured":"Balli U, Keles ZP, Avci B, Guler S, Cetinkaya BO, Keles GC. Assessment of periostin levels in serum and gingival crevicular fluid of patients with periodontal disease. J Periodontal Res. 2015;50(6):707\u201313.","journal-title":"J Periodontal Res"},{"issue":"3","key":"3417_CR111","first-page":"986","volume":"39","author":"CA Aral","year":"2016","unstructured":"Aral CA, K\u00f6seo\u011flu S, Sa\u011flam M, Pekba\u011fr\u0131yan\u0131k T, Savran L. Gingival crevicular fluid and salivary periostin levels in non-smoker subjects with chronic and aggressive periodontitis\u202f: periostin levels in chronic and aggressive periodontitis. Inflammation. 2016;39(3):986\u201393.","journal-title":"Inflammation"},{"issue":"8","key":"3417_CR112","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1902\/jop.2008.070624","volume":"79","author":"HF R\u00edos","year":"2008","unstructured":"R\u00edos HF, Ma D, Xie Y, Giannobile WV, Bonewald L, Conway S, et al. Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice. J Periodontol. 2008;79(8):1480\u201390.","journal-title":"J Periodontol"},{"issue":"7","key":"3417_CR113","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1096\/fj.14-265496","volume":"29","author":"Y Ren","year":"2015","unstructured":"Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, et al. Removal of sost or blocking its product sclerostin rescues defects in the periodontitis mouse model. Faseb J. 2015;29(7):2702\u201311.","journal-title":"Faseb J"},{"issue":"18","key":"3417_CR114","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.2106\/JBJS.K.00344","volume":"94","author":"AS Virdi","year":"2012","unstructured":"Virdi AS, Liu M, Sena K, Maletich J, McNulty M, Ke HZ, et al. Sclerostin antibody increases bone volume and enhances implant fixation in a rat model. J Bone Joint Surg Am. 2012;94(18):1670\u201380.","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"3417_CR115","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1002\/art.37697","volume":"64","author":"S Liu","year":"2012","unstructured":"Liu S, Virdi AS, Sena K, Sumner DR. Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model. Arthritis Rheum. 2012;64(12):4012\u201320.","journal-title":"Arthritis Rheum"},{"issue":"21\u201322","key":"3417_CR116","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1089\/ten.tea.2018.0013","volume":"24","author":"SH Yu","year":"2018","unstructured":"Yu SH, Hao J, Fretwurst T, Liu M, Kostenuik P, Giannobile WV, et al. Sclerostin-neutralizing antibody enhances bone regeneration around oral implants. Tissue Eng Part A. 2018;24(21\u201322):1672\u20139.","journal-title":"Tissue Eng Part A"},{"key":"3417_CR117","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.actbio.2021.11.046","volume":"140","author":"S Maillard","year":"2022","unstructured":"Maillard S, Sicard L, Andrique C, Torrens C, Lesieur J, Baroukh B, et al. Combining sclerostin neutralization with tissue engineering: an improved strategy for craniofacial bone repair. Acta Biomater. 2022;140:178\u201389.","journal-title":"Acta Biomater"},{"key":"3417_CR118","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.actbio.2018.06.017","volume":"76","author":"B Hu","year":"2018","unstructured":"Hu B, Li Y, Wang M, Zhu Y, Zhou Y, Sui B, et al. Functional reconstruction of critical-sized load-bearing bone defects using a sclerostin-targeting mir-210-3p-based construct to enhance osteogenic activity. Acta Biomater. 2018;76:275\u201382.","journal-title":"Acta Biomater"},{"key":"3417_CR119","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.archoralbio.2016.11.012","volume":"74","author":"R Shu","year":"2017","unstructured":"Shu R, Ai D, Bai D, Song J, Zhao M, Han X. The effects of sost on implant osseointegration in ovariectomy osteoporotic mice. Arch Oral Biol. 2017;74:82\u201391.","journal-title":"Arch Oral Biol"},{"key":"3417_CR120","doi-asserted-by":"publisher","first-page":"333","DOI":"10.22203\/eCM.v037a20","volume":"37","author":"P Korn","year":"2019","unstructured":"Korn P, Kramer I, Schlottig F, T\u00f6dtmann N, Eckelt U, B\u00fcrki A, et al. Systemic sclerostin antibody treatment increases osseointegration and biomechanical competence of zoledronic-acid-coated dental implants in a rat osteoporosis model. Eur Cell Mater. 2019;37:333\u201346.","journal-title":"Eur Cell Mater"},{"key":"3417_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104771","volume":"123","author":"X Chen","year":"2021","unstructured":"Chen X, Moriyama Y, Takemura Y, Rokuta M, Ayukawa Y. Influence of osteoporosis and mechanical loading on bone around osseointegrated dental implants: a rodent study. J Mech Behav Biomed Mater. 2021;123: 104771.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"1","key":"3417_CR122","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11914-020-00652-w","volume":"19","author":"C Fixen","year":"2021","unstructured":"Fixen C, Tunoa J. Romosozumab: a review of efficacy, safety, and cardiovascular risk. Curr Osteoporos Rep. 2021;19(1):15\u201322.","journal-title":"Curr Osteoporos Rep"},{"issue":"1","key":"3417_CR123","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-021-06095-y","volume":"33","author":"S Singh","year":"2022","unstructured":"Singh S, Dutta S, Khasbage S, Kumar T, Sachin J, Sharma J, et al. A systematic review and meta-analysis of efficacy and safety of romosozumab in postmenopausal osteoporosis. Osteoporos Int. 2022;33(1):1\u201312.","journal-title":"Osteoporos Int"},{"key":"3417_CR124","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab623","author":"Y Nakagawa","year":"2022","unstructured":"Nakagawa Y, Komaba H, Hamano N, Tanaka H, Wada T, Ishida H, et al. Interrelationships between sclerostin, secondary hyperparathyroidism, and bone metabolism in patients on hemodialysis. J Clin Endocrinol Metab. 2022. https:\/\/doi.org\/10.1210\/clinem\/dgab623.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"3417_CR125","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/ndt\/gfy129","volume":"34","author":"VM Brandenburg","year":"2019","unstructured":"Brandenburg VM, Verhulst A, Babler A, D\u2019Haese PC, Evenepoel P, Kaesler N. Sclerostin in chronic kidney disease-mineral bone disorder think first before you block it! Nephrol Dial Transplant. 2019;34(3):408\u201314.","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03417-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-022-03417-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03417-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:29:20Z","timestamp":1700576960000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-022-03417-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":125,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3417"],"URL":"https:\/\/doi.org\/10.1186\/s12967-022-03417-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,13]]},"assertion":[{"value":"28 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors contributed to and approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"221"}}