{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:16:12Z","timestamp":1784664972887,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A3A04037367"],"award-info":[{"award-number":["2020R1I1A3A04037367"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A5A1025511"],"award-info":[{"award-number":["2018R1A5A1025511"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic membranous nephropathy (IMN) from idiopathic nephrotic syndrome (INS), but also to predict the treatment response of patients with IMN.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We prospectively enrolled 60 participants, including those with IMN (n\u2009=\u200919) and INS (n\u2009=\u200921) and healthy volunteers (HVs; n\u2009=\u200920) in this study. Using RNA sequencing, we assessed the serum EV-miRNA profiles of all participants. To identify the EV-miRNAs predictive of treatment response in IMN, we also analyzed EV-miRNAs among patients with IMN with and without clinical remission.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The expression levels of 3 miRNAs differed between IMN patients, INS patients and HVs. In addition, compared to HVs, RNA sequencing revealed differential expression of 77 and 44 EV-miRNAs in patients with IMN without and with remission, respectively. We also identified statistically significant (|fold change\u2009\u2265\u20092, p\u2009&lt;\u20090.05) differences in the expression levels of 23 miRNAs in IMN without remission. Biological pathway analysis of miRNAs in IMN without remission indicated that they are likely involved in various pathways, including renal fibrosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study identified EV-miRNAs associated with IMN as well as those associations with therapeutic response. Therefore, these circulating EV-miRNAs may be used as potential markers for the diagnosis and prediction of treatment response in patients with IMN.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-022-03430-7","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T13:03:34Z","timestamp":1652533414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Circulating miRNAs in extracellular vesicles related to treatment response in patients with idiopathic membranous nephropathy"],"prefix":"10.1186","volume":"20","author":[{"given":"In O.","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ui","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haekyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoungnae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Soo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Oh","family":"Doh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-4196","authenticated-orcid":false,"given":"Soon Hyo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"issue":"6","key":"3430_CR1","first-page":"479","volume":"93","author":"C Kodner","year":"2016","unstructured":"Kodner C. Diagnosis and management of nephrotic syndrome in adults. Am Fam Physician. 2016;93(6):479\u201385.","journal-title":"Am Fam Physician"},{"issue":"2","key":"3430_CR2","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1093\/ndt\/gfq665","volume":"26","author":"A McGrogan","year":"2011","unstructured":"McGrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol Dial Transplant. 2011;26(2):414\u201330.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"3430_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00467-015-3082-x","volume":"31","author":"JC Davin","year":"2016","unstructured":"Davin JC. The glomerular permeability factors in idiopathic nephrotic syndrome. Pediatr Nephrol. 2016;31(2):207\u201315.","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"3430_CR4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00441-019-03147-y","volume":"379","author":"JJ Candelier","year":"2020","unstructured":"Candelier JJ, Lorenzo HK. Idiopathic nephrotic syndrome and serum permeability factors: a molecular jigsaw puzzle. Cell Tissue Res. 2020;379(2):231\u201343.","journal-title":"Cell Tissue Res"},{"issue":"11","key":"3430_CR5","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.2215\/CJN.03800609","volume":"5","author":"ET McCarthy","year":"2010","unstructured":"McCarthy ET, Sharma M, Savin VJ. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2010;5(11):2115\u201321.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"3430_CR6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1681\/ASN.2016070776","volume":"28","author":"AS De Vriese","year":"2017","unstructured":"De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC. A Proposal for a serology-based approach to membranous nephropathy. J Am Soc Nephrol. 2017;28(2):421\u201330.","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"3430_CR7","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1681\/ASN.2010111125","volume":"22","author":"LH Beck Jr","year":"2011","unstructured":"Beck LH Jr, Fervenza FC, Beck DM, Bonegio RG, Malik FA, Erickson SB, et al. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol. 2011;22(8):1543\u201350.","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3430_CR8","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1681\/ASN.2013040430","volume":"25","author":"E Hoxha","year":"2014","unstructured":"Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA. Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy. J Am Soc Nephrol. 2014;25(6):1357\u201366.","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3430_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12882-017-0636-0","volume":"18","author":"J Wang","year":"2017","unstructured":"Wang J, Xie Q, Sun Z, Xu N, Li Y, Wang L, et al. Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study. BMC Nephrol. 2017;18(1):227.","journal-title":"BMC Nephrol"},{"issue":"7","key":"3430_CR10","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1056\/NEJMc1011678","volume":"364","author":"H Debiec","year":"2011","unstructured":"Debiec H, Ronco P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. N Engl J Med. 2011;364(7):689\u201390.","journal-title":"N Engl J Med"},{"issue":"7","key":"3430_CR11","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ki.2012.209","volume":"82","author":"E Hoxha","year":"2012","unstructured":"Hoxha E, Kneissler U, Stege G, Zahner G, Thiele I, Panzer U, et al. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 2012;82(7):797\u2013804.","journal-title":"Kidney Int"},{"issue":"6","key":"3430_CR12","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.2215\/CJN.07210810","volume":"6","author":"JM Hofstra","year":"2011","unstructured":"Hofstra JM, Beck LH Jr, Beck DM, Wetzels JF, Salant DJ. Anti-phospholipase A(2) receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011;6(6):1286\u201391.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"11","key":"3430_CR13","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/ndt\/gfv228","volume":"30","author":"E Hoxha","year":"2015","unstructured":"Hoxha E, Harendza S, Pinnschmidt HO, Tomas NM, Helmchen U, Panzer U, et al. Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody-negative patients with membranous nephropathy. Nephrol Dial Transplant. 2015;30(11):1862\u20139.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"3430_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa0810457","volume":"361","author":"LH Beck Jr","year":"2009","unstructured":"Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009;361(1):11\u201321.","journal-title":"N Engl J Med"},{"issue":"5","key":"3430_CR15","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/ki.2012.486","volume":"83","author":"D Kanigicherla","year":"2013","unstructured":"Kanigicherla D, Gummadova J, McKenzie EA, Roberts SA, Harris S, Nikam M, et al. Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int. 2013;83(5):940\u20138.","journal-title":"Kidney Int"},{"issue":"6","key":"3430_CR16","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1681\/ASN.2014010091","volume":"25","author":"JM Hofstra","year":"2014","unstructured":"Hofstra JM, Wetzels JF. Phospholipase A2 receptor antibodies in membranous nephropathy: unresolved issues. J Am Soc Nephrol. 2014;25(6):1137\u20139.","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"3430_CR17","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/ki.2010.278","volume":"78","author":"G Camussi","year":"2010","unstructured":"Camussi G, Deregibus MC, Bruno S, Cantaluppi V, Biancone L. Exosomes\/microvesicles as a mechanism of cell-to-cell communication. Kidney Int. 2010;78(9):838\u201348.","journal-title":"Kidney Int"},{"issue":"2","key":"3430_CR18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","volume":"75","author":"NP Hessvik","year":"2018","unstructured":"Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75(2):193\u2013208.","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"3430_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3109\/1354750X.2012.657246","volume":"17","author":"JW Sharkey","year":"2012","unstructured":"Sharkey JW, Antoine DJ, Park BK. Validation of the isolation and quantification of kidney enriched miRNAs for use as biomarkers. Biomarkers. 2012;17(3):231\u20139.","journal-title":"Biomarkers"},{"issue":"2","key":"3430_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1089\/gtmb.2020.0238","volume":"25","author":"CY Yun","year":"2021","unstructured":"Yun CY, Lim JH, Oh JH, Cho AY, Lee KY, Sun IO. Urinary exosomal microRNA-21 as a marker for scrub typhus-associated acute kidney injury. Genet Test Mol Biomarkers. 2021;25(2):140\u20134.","journal-title":"Genet Test Mol Biomarkers"},{"issue":"9","key":"3430_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138618","volume":"10","author":"J Perez-Hernandez","year":"2015","unstructured":"Perez-Hernandez J, Forner MJ, Pinto C, Chaves FJ, Cortes R, Redon J. Increased urinary exosomal microRNAs in patients with systemic lupus erythematosus. PLoS ONE. 2015;10(9): e0138618.","journal-title":"PLoS ONE"},{"issue":"11","key":"3430_CR22","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1177\/0961203312451334","volume":"21","author":"J Guan","year":"2012","unstructured":"Guan J, Wang G, Tam LS, Kwan BC, Li EK, Chow KM, et al. Urinary sediment ICAM-1 level in lupus nephritis. Lupus. 2012;21(11):1190\u20135.","journal-title":"Lupus"},{"issue":"6","key":"3430_CR23","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/MNH.0000000000000641","volume":"29","author":"IO Sun","year":"2020","unstructured":"Sun IO, Kwon SH. Extracellular vesicles: a novel window into kidney function and disease. Curr Opin Nephrol Hypertens. 2020;29(6):613\u20139.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"3430_CR24","doi-asserted-by":"publisher","DOI":"10.1159\/000521730","author":"D Choi","year":"2022","unstructured":"Choi D, Kim S, Woo J, Lee H, Kim H, Jeon JS, et al. Weight change alters the small RNA profile of urinary extracellular vesicles in obesity. Obes Facts. 2022. https:\/\/doi.org\/10.1159\/000521730.","journal-title":"Obes Facts"},{"issue":"4","key":"3430_CR25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/eci.12420","volume":"45","author":"A Ramezani","year":"2015","unstructured":"Ramezani A, Devaney JM, Cohen S, Wing MR, Scott R, Knoblach S, et al. Circulating and urinary microRNA profile in focal segmental glomerulosclerosis: a pilot study. Eur J Clin Invest. 2015;45(4):394\u2013404.","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"3430_CR26","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41419-018-0569-y","volume":"9","author":"B Xiao","year":"2018","unstructured":"Xiao B, Wang LN, Li W, Gong L, Yu T, Zuo QF, et al. Plasma microRNA panel is a novel biomarker for focal segmental glomerulosclerosis and associated with podocyte apoptosis. Cell Death Dis. 2018;9(5):533.","journal-title":"Cell Death Dis"},{"issue":"2","key":"3430_CR27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1053\/j.ajkd.2014.07.013","volume":"65","author":"C Zhang","year":"2015","unstructured":"Zhang C, Zhang W, Chen HM, Liu C, Wu J, Shi S, et al. Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis. Am J Kidney Dis. 2015;65(2):223\u201332.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"3430_CR28","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12967-019-1983-3","volume":"17","author":"H Kim","year":"2019","unstructured":"Kim H, Bae YU, Jeon JS, Noh H, Park HK, Byun DW, et al. The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy. J Transl Med. 2019;17(1):236.","journal-title":"J Transl Med"},{"issue":"7661","key":"3430_CR29","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/S0140-6736(70)91268-7","volume":"1","author":"RH White","year":"1970","unstructured":"White RH, Glasgow EF, Mills RJ. Clinicopathological study of nephrotic syndrome in childhood. Lancet. 1970;1(7661):1353\u20139.","journal-title":"Lancet"},{"issue":"2","key":"3430_CR30","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/oby.22379","volume":"27","author":"YU Bae","year":"2019","unstructured":"Bae YU, Kim Y, Lee H, Kim H, Jeon JS, Noh H, et al. Bariatric surgery alters microRNA content of circulating exosomes in patients with obesity. Obesity (Silver Spring). 2019;27(2):264\u201371.","journal-title":"Obesity (Silver Spring)"},{"key":"3430_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/0471143030.cb0322s30","author":"C Thery","year":"2006","unstructured":"Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30.","journal-title":"Curr Protoc Cell Biol"},{"issue":"1","key":"3430_CR32","doi-asserted-by":"publisher","first-page":"1555419","DOI":"10.1080\/20013078.2018.1555419","volume":"8","author":"LG Rikkert","year":"2019","unstructured":"Rikkert LG, Nieuwland R, Terstappen L, Coumans FAW. Quality of extracellular vesicle images by transmission electron microscopy is operator and protocol dependent. J Extracell Vesicles. 2019;8(1):1555419.","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"3430_CR33","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"C Th\u00e9ry","year":"2018","unstructured":"Th\u00e9ry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.","journal-title":"J Extracell Vesicles"},{"issue":"4","key":"3430_CR34","first-page":"3378","volume":"22","author":"Z Wang","year":"2020","unstructured":"Wang Z, Liao Y, Wang L, Lin Y, Ye Z, Zeng X, et al. Small RNA deep sequencing reveals novel miRNAs in peripheral blood mononuclear cells from patients with IgA nephropathy. Mol Med Rep. 2020;22(4):3378\u201386.","journal-title":"Mol Med Rep"},{"key":"3430_CR35","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1528","volume":"75","author":"W Li","year":"2020","unstructured":"Li W, Liu S, Chen Y, Weng R, Zhang K, He X, et al. Circulating exosomal microRNAs as biomarkers of systemic lupus erythematosus. Clinics (Sao Paulo). 2020;75: e1528.","journal-title":"Clinics (Sao Paulo)"},{"key":"3430_CR36","first-page":"3170927","volume":"2020","author":"J Zhang","year":"2020","unstructured":"Zhang J, Zhu Y, Cai R, Jin J, He Q. Differential expression of urinary exosomal small RNAs in idiopathic membranous nephropathy. Biomed Res Int. 2020;2020:3170927.","journal-title":"Biomed Res Int"},{"issue":"3","key":"3430_CR37","doi-asserted-by":"publisher","first-page":"738","DOI":"10.5114\/aoms.2019.84690","volume":"15","author":"H Ma","year":"2019","unstructured":"Ma H, Xu Y, Zhang R, Guo B, Zhang S, Zhang X. Differential expression study of circular RNAs in exosomes from serum and urine in patients with idiopathic membranous nephropathy. Arch Med Sci. 2019;15(3):738\u201353.","journal-title":"Arch Med Sci"},{"issue":"1","key":"3430_CR38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3892\/ijmm.2013.1554","volume":"33","author":"W Chen","year":"2014","unstructured":"Chen W, Lin X, Huang J, Tan K, Chen Y, Peng W, et al. Integrated profiling of microRNA expression in membranous nephropathy using high-throughput sequencing technology. Int J Mol Med. 2014;33(1):25\u201334.","journal-title":"Int J Mol Med"},{"issue":"12","key":"3430_CR39","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1681\/ASN.2015010091","volume":"26","author":"A Thompson","year":"2015","unstructured":"Thompson A, Cattran DC, Blank M, Nachman PH. Complete and partial remission as surrogate end points in membranous nephropathy. J Am Soc Nephrol. 2015;26(12):2930\u20137.","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"3430_CR40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.kint.2016.09.048","volume":"91","author":"DC Cattran","year":"2017","unstructured":"Cattran DC, Brenchley PE. Membranous nephropathy: integrating basic science into improved clinical management. Kidney Int. 2017;91(3):566\u201374.","journal-title":"Kidney Int"},{"key":"3430_CR41","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.3389\/fimmu.2018.03035","volume":"9","author":"F von Haxthausen","year":"2018","unstructured":"von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, et al. Antigen-specific IgG subclasses in primary and malignancy-associated membranous nephropathy. Front Immunol. 2018;9:3035.","journal-title":"Front Immunol"},{"issue":"1","key":"3430_CR42","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/08923973.2015.1127382","volume":"38","author":"B Sutariya","year":"2016","unstructured":"Sutariya B, Jhonsa D, Saraf MN. TGF-beta: the connecting link between nephropathy and fibrosis. Immunopharmacol Immunotoxicol. 2016;38(1):39\u201349.","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"2","key":"3430_CR43","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000093178","volume":"26","author":"S Tsakas","year":"2006","unstructured":"Tsakas S, Goumenos DS. Accurate measurement and clinical significance of urinary transforming growth factor-beta1. Am J Nephrol. 2006;26(2):186\u201393.","journal-title":"Am J Nephrol"},{"issue":"1","key":"3430_CR44","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5301\/JN.2010.1458","volume":"24","author":"R Camilla","year":"2011","unstructured":"Camilla R, Brachemi S, Pichette V, Cartier P, Laforest-Renald A, MacRae T, et al. Urinary monocyte chemotactic protein 1: marker of renal function decline in diabetic and nondiabetic proteinuric renal disease. J Nephrol. 2011;24(1):60\u20137.","journal-title":"J Nephrol"},{"issue":"3","key":"3430_CR45","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.phrs.2003.10.003","volume":"49","author":"P De Muro","year":"2004","unstructured":"De Muro P, Faedda R, Fresu P, Masala A, Cigni A, Concas G, et al. Urinary transforming growth factor-beta 1 in various types of nephropathy. Pharmacol Res. 2004;49(3):293\u20138.","journal-title":"Pharmacol Res"},{"issue":"12","key":"3430_CR46","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/ndt\/12.12.2562","volume":"12","author":"E Honkanen","year":"1997","unstructured":"Honkanen E, Teppo AM, Tornroth T, Groop PH, Gronhagen-Riska C. Urinary transforming growth factor-beta 1 in membranous glomerulonephritis. Nephrol Dial Transplant. 1997;12(12):2562\u20138.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"3430_CR47","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1681\/ASN.V84664","volume":"8","author":"AG Wasserstein","year":"1997","unstructured":"Wasserstein AG. Membranous glomerulonephritis. J Am Soc Nephrol. 1997;8(4):664\u201374.","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3430_CR48","doi-asserted-by":"publisher","first-page":"445","DOI":"10.5414\/CN107681","volume":"79","author":"K Zuo","year":"2013","unstructured":"Zuo K, Wu Y, Li SJ, Xu F, Zeng CH, Liu ZH. Long-term outcome and prognostic factors of idiopathic membranous nephropathy in the Chinese population. Clin Nephrol. 2013;79(6):445\u201353.","journal-title":"Clin Nephrol"},{"issue":"2","key":"3430_CR49","doi-asserted-by":"publisher","first-page":"C225","DOI":"10.1152\/ajpcell.00441.2020","volume":"320","author":"K Kang","year":"2021","unstructured":"Kang K, Liao X, Li Q, Chen J, Niu Y, Zeng Y, et al. A novel tonicity-responsive microRNA miR-23a-5p modulates renal cell survival under osmotic stress through targeting heat shock protein 70 HSPA1B. Am J Physiol Cell Physiol. 2021;320(2):C225\u201339.","journal-title":"Am J Physiol Cell Physiol"},{"key":"3430_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118794","volume":"266","author":"H Zhang","year":"2021","unstructured":"Zhang H, Yan Y, Hu Q, Zhang X. LncRNA MALAT1\/microRNA let-7f\/KLF5 axis regulates podocyte injury in diabetic nephropathy. Life Sci. 2021;266: 118794.","journal-title":"Life Sci"},{"key":"3430_CR51","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/jcm6010007","volume":"6","author":"B Costanza","year":"2017","unstructured":"Costanza B, Umelo IA, Bellier J, Castronovo V, Turtoi A. Stromal modulators of TGF-beta in cancer. J Clin Med. 2017;6:7.","journal-title":"J Clin Med"},{"key":"3430_CR52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.12703\/P5-17","volume":"5","author":"L Attisano","year":"2013","unstructured":"Attisano L, Wrana JL. Signal integration in TGF-beta, WNT, and Hippo pathways. F1000 Prime Rep. 2013;5:17.","journal-title":"F1000 Prime Rep."},{"issue":"4","key":"3430_CR53","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","volume":"18","author":"X Varelas","year":"2010","unstructured":"Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, et al. The Hippo pathway regulates Wnt\/beta-catenin signaling. Dev Cell. 2010;18(4):579\u201391.","journal-title":"Dev Cell"},{"issue":"7","key":"3430_CR54","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1089\/ars.2017.7041","volume":"29","author":"H Ding","year":"2018","unstructured":"Ding H, Bai F, Cao H, Xu J, Fang L, Wu J, et al. PDE\/cAMP\/Epac\/C\/EBP-beta signaling cascade regulates mitochondria biogenesis of tubular epithelial cells in renal fibrosis. Antioxid Redox Signal. 2018;29(7):637\u201352.","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"3430_CR55","volume":"35","author":"H Wang","year":"2021","unstructured":"Wang H, Chen M, Xu S, Pan Y, Zhang Y, Huang H, et al. Abnormal regulation of microRNAs and related genes in pediatric beta-thalassemia. J Clin Lab Anal. 2021;35(9): e23945.","journal-title":"J Clin Lab Anal"},{"key":"3430_CR56","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2021.0127","author":"Z Zhuo","year":"2021","unstructured":"Zhuo Z, Wang C, Yu H. Plasma microRNAs can be a potential diagnostic biomarker for endometriosis. Ginekol Pol. 2021. https:\/\/doi.org\/10.5603\/GP.a2021.0127.","journal-title":"Ginekol Pol."}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03430-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-022-03430-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03430-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T14:12:40Z","timestamp":1652537560000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-022-03430-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,14]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3430"],"URL":"https:\/\/doi.org\/10.1186\/s12967-022-03430-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,14]]},"assertion":[{"value":"11 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with participants who voluntarily provided informed consent and carried out in accordance with the Declaration of Helsinki, and the study protocol was approved by the institutional review board of Soonchunhyang University Seoul Hospital (2016\u201301-002\u2013007).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"224"}}