{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:30:01Z","timestamp":1788838201650,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["jcsz2020304-9"],"award-info":[{"award-number":["jcsz2020304-9"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2021YFE0108000"],"award-info":[{"award-number":["2021YFE0108000"]}]},{"name":"Medical Support Program of the Jilin University","award":["No. 20170311032YY"],"award-info":[{"award-number":["No. 20170311032YY"]}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["No. 20222131"],"award-info":[{"award-number":["No. 20222131"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5\u00a0years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics.<\/jats:p>","DOI":"10.1186\/s12967-022-03487-4","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:04:05Z","timestamp":1655798645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Advances of exosomes in periodontitis treatment"],"prefix":"10.1186","volume":"20","author":[{"given":"Hongbing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"issue":"1","key":"3487_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15(1):30\u201344.","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"3487_CR2","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;16(12):745\u201359.","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"3487_CR3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/prd.12313","volume":"82","author":"G Hajishengallis","year":"2000","unstructured":"Hajishengallis G. 2020 New developments in neutrophil biology and periodontitis. Periodontol. 2000;82(1):78\u201392.","journal-title":"Periodontol"},{"issue":"3","key":"3487_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","volume":"11","author":"W Pan","year":"2019","unstructured":"Pan W, Wang Q, Chen Q. The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci. 2019;11(3):30.","journal-title":"Int J Oral Sci"},{"key":"3487_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126459","author":"M Elashiry","year":"2021","unstructured":"Elashiry M, Morandini AC, Cornelius Timothius CJ, Ghaly M, Cutler CW. Selective antimicrobial therapies for periodontitis: win the \u201cBATTLE and the War.\u201d Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22126459.","journal-title":"Int J Mol Sci"},{"issue":"19","key":"3487_CR6","doi-asserted-by":"publisher","first-page":"9412","DOI":"10.1016\/S0021-9258(18)48095-7","volume":"262","author":"RM Johnstone","year":"1987","unstructured":"Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262(19):9412\u201320.","journal-title":"J Biol Chem."},{"issue":"9","key":"3487_CR7","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1021\/acs.molpharmaceut.8b00277","volume":"15","author":"G Kibria","year":"2018","unstructured":"Kibria G, Ramos EK, Wan Y, Gius DR, Liu H. exosomes as a drug delivery system in cancer therapy: potential and challenges. Mol Pharm. 2018;15(9):3625\u201333.","journal-title":"Mol Pharm"},{"issue":"3","key":"3487_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1021\/acs.molpharmaceut.1c00182","volume":"19","author":"F Ahmed","year":"2022","unstructured":"Ahmed F, Tamma M, Pathigadapa U, Reddanna P, Yenuganti VR. Drug loading and functional efficacy of cow, buffalo, and goat milk-derived exosomes: a comparative study. Mol Pharm. 2022;19(3):763\u201374.","journal-title":"Mol Pharm"},{"key":"3487_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020186","author":"A Akbar","year":"2022","unstructured":"Akbar A, Malekian F, Baghban N, Kodam SP, Ullah M. Methodologies to isolate and purify clinical grade extracellular vesicles for medical applications. Cells. 2022. https:\/\/doi.org\/10.3390\/cells11020186.","journal-title":"Cells"},{"key":"3487_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-0716-2014-4_4","volume":"2435","author":"P Kanlikilicer","year":"2022","unstructured":"Kanlikilicer P. Exosome-related methods and potential use as vaccines. Methods Mol Biol. 2022;2435:35\u201341.","journal-title":"Methods Mol Biol"},{"key":"3487_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020. https:\/\/doi.org\/10.1126\/science.aau6977.","journal-title":"Science"},{"key":"3487_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20204987","author":"O Trubiani","year":"2019","unstructured":"Trubiani O, Marconi GD, Pierdomenico SD, Piattelli A, Diomede F, Pizzicannella J. Human oral stem cells, biomaterials and extracellular vesicles: a promising tool in bone tissue repair. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20204987.","journal-title":"Int J Mol Sci"},{"key":"3487_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071635","author":"X Wang","year":"2021","unstructured":"Wang X, He L, Huang X, Zhang S, Cao W, Che F, et al. Recent progress of exosomes in multiple myeloma: pathogenesis, diagnosis prognosis and therapeutic strategies. Cancers (Basel). 2021. https:\/\/doi.org\/10.3390\/cancers13071635.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"3487_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","volume":"19","author":"S Gurung","year":"2021","unstructured":"Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Signal. 2021;19(1):47.","journal-title":"Cell Commun Signal"},{"issue":"2","key":"3487_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","volume":"75","author":"NP Hessvik","year":"2018","unstructured":"Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75(2):193\u2013208.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"3487_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/002215540205000105","volume":"50","author":"W Mobius","year":"2002","unstructured":"Mobius W, Ohno-Iwashita Y, van Donselaar EG, Oorschot VM, Shimada Y, Fujimoto T, et al. Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O. J Histochem Cytochem. 2002;50(1):43\u201355.","journal-title":"J Histochem Cytochem"},{"issue":"7290","key":"3487_CR17","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature08849","volume":"464","author":"T Wollert","year":"2010","unstructured":"Wollert T, Hurley JH. Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature. 2010;464(7290):864\u20139.","journal-title":"Nature"},{"key":"3487_CR18","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.2147\/IJN.S264498","volume":"15","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine. 2020;15:6917\u201334.","journal-title":"Int J Nanomedicine"},{"issue":"5867","key":"3487_CR19","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","volume":"319","author":"K Trajkovic","year":"2008","unstructured":"Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008;319(5867):1244\u20137.","journal-title":"Science"},{"issue":"2","key":"3487_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41422-020-00409-1","volume":"31","author":"D Wei","year":"2021","unstructured":"Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, et al. RAB31 marks and controls an ESCRT-independent exosome pathway. Cell Res. 2021;31(2):157\u201377.","journal-title":"Cell Res"},{"issue":"13","key":"3487_CR21","doi-asserted-by":"publisher","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","volume":"102","author":"A de Gassart","year":"2003","unstructured":"de Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M. Lipid raft-associated protein sorting in exosomes. Blood. 2003;102(13):4336\u201344.","journal-title":"Blood"},{"issue":"2","key":"3487_CR22","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1042\/BST0390559","volume":"39","author":"S Rana","year":"2011","unstructured":"Rana S, Zoller M. Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis. Biochem Soc Trans. 2011;39(2):559\u201362.","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"3487_CR23","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1083\/jcb.200508014","volume":"172","author":"AM Booth","year":"2006","unstructured":"Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol. 2006;172(6):923\u201335.","journal-title":"J Cell Biol"},{"issue":"1","key":"3487_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.7150\/ijbs.53671","volume":"17","author":"H Wei","year":"2021","unstructured":"Wei H, Chen Q, Lin L, Sha C, Li T, Liu Y, et al. Regulation of exosome production and cargo sorting. Int J Biol Sci. 2021;17(1):163\u201377.","journal-title":"Int J Biol Sci"},{"key":"3487_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.03.032","author":"A Yokoi","year":"2021","unstructured":"Yokoi A, Ochiya T. Exosomes and extracellular vesicles: rethinking the essential values in cancer biology. Semin Cancer Biol. 2021. https:\/\/doi.org\/10.1016\/j.semcancer.2021.03.032.","journal-title":"Semin Cancer Biol"},{"key":"3487_CR26","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2147\/IJN.S291956","volume":"16","author":"S Gurunathan","year":"2021","unstructured":"Gurunathan S, Kang MH, Kim JH. A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes. Int J Nanomedicine. 2021;16:1281\u2013312.","journal-title":"Int J Nanomedicine"},{"issue":"2","key":"3487_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10544-019-0396-7","volume":"21","author":"S Busatto","year":"2019","unstructured":"Busatto S, Pham A, Suh A, Shapiro S, Wolfram J. Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles. Biomedical Microdevices. 2019;21(2):1\u201317.","journal-title":"Biomedical Microdevices"},{"issue":"8","key":"3487_CR28","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri855","volume":"2","author":"C Th\u00e9ry","year":"2002","unstructured":"Th\u00e9ry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002;2(8):569\u201379.","journal-title":"Nat Rev Immunol"},{"key":"3487_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2016.1191477","author":"L Tan","year":"2016","unstructured":"Tan L, Wu H, Liu Y, Zhao M, Li D, Lu Q. Recent advances of exosomes in immune modulation and autoimmune diseases. Autoimmunity. 2016. https:\/\/doi.org\/10.1080\/08916934.2016.1191477.","journal-title":"Autoimmunity"},{"issue":"8","key":"3487_CR30","doi-asserted-by":"publisher","first-page":"R435","DOI":"10.1016\/j.cub.2018.01.059","volume":"28","author":"J Meldolesi","year":"2018","unstructured":"Meldolesi J. Exosomes and ectosomes in intercellular communication. Curr Biol. 2018;28(8):R435\u201344.","journal-title":"Curr Biol"},{"issue":"7","key":"3487_CR31","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/tra.12803","volume":"22","author":"J Donoso-Quezada","year":"2021","unstructured":"Donoso-Quezada J, Ayala-Mar S, Gonzalez-Valdez J. The role of lipids in exosome biology and intercellular communication: Function, analytics and applications. Traffic. 2021;22(7):204\u201320.","journal-title":"Traffic"},{"key":"3487_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194684","author":"N Ludwig","year":"2019","unstructured":"Ludwig N, Whiteside TL, Reichert TE. Challenges in exosome isolation and analysis in health and disease. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20194684.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"3487_CR33","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.7150\/thno.41580","volume":"10","author":"D Yang","year":"2020","unstructured":"Yang D, Zhang W, Zhang H, Zhang F, Chen L, Ma L, et al. Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684\u2013707.","journal-title":"Theranostics"},{"key":"3487_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101066","author":"J Wang","year":"2021","unstructured":"Wang J, Ma P, Kim DH, Liu BF, Demirci U. Towards microfluidic-based exosome isolation and detection for tumor therapy. Nano Today. 2021. https:\/\/doi.org\/10.1016\/j.nantod.2020.101066.","journal-title":"Nano Today"},{"key":"3487_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186466","author":"K Sidhom","year":"2020","unstructured":"Sidhom K, Obi PO, Saleem A. A review of exosomal isolation methods: is size exclusion chromatography the best option? Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21186466.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"3487_CR36","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.1039\/D1AN00024A","volume":"146","author":"K Singh","year":"2021","unstructured":"Singh K, Nalabotala R, Koo KM, Bose S, Nayak R, Shiddiky MJA. Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges. Analyst. 2021;146(12):3731\u201349.","journal-title":"Analyst"},{"issue":"1","key":"3487_CR37","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13045-020-00987-y","volume":"13","author":"L Zhu","year":"2020","unstructured":"Zhu L, Sun HT, Wang S, Huang SL, Zheng Y, Wang CQ, et al. Isolation and characterization of exosomes for cancer research. J Hematol Oncol. 2020;13(1):152.","journal-title":"J Hematol Oncol"},{"issue":"Suppl 1","key":"3487_CR38","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 2018;89(Suppl 1):S173\u201382.","journal-title":"J Periodontol"},{"key":"3487_CR39","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13578-020-00424-0","volume":"10","author":"Q Peng","year":"2020","unstructured":"Peng Q, Yang JY, Zhou G. Emerging functions and clinical applications of exosomes in human oral diseases. Cell Biosci. 2020;10:68.","journal-title":"Cell Biosci"},{"key":"3487_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.587381","author":"NNS Nik Mohamed Kamal","year":"2020","unstructured":"Nik Mohamed Kamal NNS, Awang RAR, Mohamad S, Shahidan WNS. Plasma- and saliva exosome profile reveals a distinct MicroRNA signature in chronic periodontitis. Front Physiol. 2020. https:\/\/doi.org\/10.3389\/fphys.2020.587381.","journal-title":"Front Physiol"},{"key":"3487_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14145","author":"EJ Kwon","year":"2022","unstructured":"Kwon EJ, Kim HJ, Woo BH, Joo JY, Kim YH, Park HR. Profiling of plasma-derived exosomal RNA expression in patients with periodontitis: a pilot study. Oral Dis. 2022. https:\/\/doi.org\/10.1111\/odi.14145.","journal-title":"Oral Dis"},{"key":"3487_CR42","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fgene.2019.00202","volume":"10","author":"J Yu","year":"2019","unstructured":"Yu J, Lin Y, Xiong X, Li K, Yao Z, Dong H, et al. Detection of exosomal PD-L1 RNA in saliva of patients with periodontitis. Front Genet. 2019;10:202.","journal-title":"Front Genet"},{"issue":"1","key":"3487_CR43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/odi.13217","volume":"26","author":"X Huang","year":"2020","unstructured":"Huang X, Hu X, Zhao M, Zhang Q. Analysis of salivary exosomal proteins in young adults with severe periodontitis. Oral Dis. 2020;26(1):173\u201381.","journal-title":"Oral Dis"},{"issue":"4","key":"3487_CR44","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/jcpe.13099","volume":"46","author":"SI Tobon-Arroyave","year":"2019","unstructured":"Tobon-Arroyave SI, Celis-Mejia N, Cordoba-Hidalgo MP, Isaza-Guzman DM. Decreased salivary concentration of CD9 and CD81 exosome-related tetraspanins may be associated with the periodontal clinical status. J Clin Periodontol. 2019;46(4):470\u201380.","journal-title":"J Clin Periodontol"},{"key":"3487_CR45","doi-asserted-by":"publisher","first-page":"798682","DOI":"10.3389\/fphys.2021.798682","volume":"12","author":"NNS Nik Mohamed Kamal","year":"2021","unstructured":"Nik Mohamed Kamal NNS, Shahidan WNS. Salivary exosomes: from waste to promising periodontitis treatment. Front Physiol. 2021;12:798682.","journal-title":"Front Physiol"},{"issue":"1","key":"3487_CR46","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41368-021-00150-4","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Chen J, Fu H, Kuang S, He F, Zhang M, et al. Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell\/Treg balance in inflamed periodontium. Int J Oral Sci. 2021;13(1):43.","journal-title":"Int J Oral Sci"},{"issue":"4","key":"3487_CR47","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.bioactmat.2020.07.002","volume":"5","author":"Z Shen","year":"2020","unstructured":"Shen Z, Kuang S, Zhang Y, Yang M, Qin W, Shi X, et al. Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism. Bioact Mater. 2020;5(4):1113\u201326.","journal-title":"Bioact Mater"},{"issue":"1","key":"3487_CR48","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/jre.12949","volume":"57","author":"Y Shimizu","year":"2022","unstructured":"Shimizu Y, Takeda-Kawaguchi T, Kuroda I, Hotta Y, Kawasaki H, Hariyama T, et al. Exosomes from dental pulp cells attenuate bone loss in mouse experimental periodontitis. J Periodontal Res. 2022;57(1):162\u201372.","journal-title":"J Periodontal Res"},{"key":"3487_CR49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.actbio.2021.12.035","volume":"141","author":"F Lei","year":"2022","unstructured":"Lei F, Li M, Lin T, Zhou H, Wang F, Su X. Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes. Acta Biomater. 2022;141:333\u201343.","journal-title":"Acta Biomater"},{"key":"3487_CR50","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","volume":"122","author":"Y Nakao","year":"2021","unstructured":"Nakao Y, Fukuda T, Zhang Q, Sanui T, Shinjo T, Kou X, et al. Exosomes from TNF-alpha-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater. 2021;122:306\u201324.","journal-title":"Acta Biomater"},{"issue":"4","key":"3487_CR51","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10735-020-09896-3","volume":"51","author":"J Wei","year":"2020","unstructured":"Wei J, Song Y, Du Z, Yu F, Zhang Y, Jiang N, et al. Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis. J Mol Histol. 2020;51(4):455\u201366.","journal-title":"J Mol Histol"},{"issue":"7","key":"3487_CR52","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1021\/acsbiomaterials.9b00607","volume":"5","author":"J Wu","year":"2019","unstructured":"Wu J, Chen L, Wang R, Song Z, Shen Z, Zhao Y, et al. Exosomes secreted by stem cells from human exfoliated deciduous teeth promote alveolar bone defect repair through the regulation of angiogenesis and osteogenesis. ACS Biomater Sci Eng. 2019;5(7):3561\u201371.","journal-title":"ACS Biomater Sci Eng"},{"issue":"1","key":"3487_CR53","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12951-022-01314-y","volume":"20","author":"X Chen","year":"2022","unstructured":"Chen X, Wan Z, Yang L, Song S, Fu Z, Tang K, et al. Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA. J Nanobiotechnology. 2022;20(1):110.","journal-title":"J Nanobiotechnology"},{"key":"3487_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/biom8040167","author":"E Mohammed","year":"2018","unstructured":"Mohammed E, Khalil E, Sabry D. Effect of adipose-derived stem cells and their Exo as adjunctive therapy to nonsurgical periodontal treatment: a histologic and histomorphometric study in rats. Biomolecules. 2018. https:\/\/doi.org\/10.3390\/biom8040167.","journal-title":"Biomolecules"},{"key":"3487_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775046","volume":"12","author":"JS Byun","year":"2021","unstructured":"Byun JS, Lee HY, Tian J, Moon JS, Choi J, Lee SH, et al. Effect of salivary exosomal miR-25-3p on periodontitis with insulin resistance. Front Immunol. 2021;12: 775046.","journal-title":"Front Immunol"},{"issue":"8","key":"3487_CR56","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1080\/08820139.2020.1801720","volume":"50","author":"M Taghavi-Farahabadi","year":"2021","unstructured":"Taghavi-Farahabadi M, Mahmoudi M, Rezaei N, Hashemi SM. Wharton\u2019s jelly mesenchymal stem cells exosomes and conditioned media increased neutrophil lifespan and phagocytosis capacity. Immunol Invest. 2021;50(8):1042\u201357.","journal-title":"Immunol Invest"},{"key":"3487_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020720","author":"B Zhang","year":"2021","unstructured":"Zhang B, Lai RC, Sim WK, Choo ABH, Lane EB, Lim SK. Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22020720.","journal-title":"Int J Mol Sci"},{"key":"3487_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105689","volume":"74","author":"M Mahmoudi","year":"2019","unstructured":"Mahmoudi M, Taghavi-Farahabadi M, Rezaei N, Hashemi SM. Comparison of the effects of adipose tissue mesenchymal stromal cell-derived exosomes with conditioned media on neutrophil function and apoptosis. Int Immunopharmacol. 2019;74: 105689.","journal-title":"Int Immunopharmacol"},{"key":"3487_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.791648","volume":"12","author":"A Murao","year":"2021","unstructured":"Murao A, Tan C, Jha A, Wang P, Aziz M. Exosome-mediated eCIRP release from macrophages to induce inflammation in sepsis. Front Pharmacol. 2021;12: 791648.","journal-title":"Front Pharmacol"},{"issue":"7","key":"3487_CR60","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","volume":"115","author":"J Zhao","year":"2019","unstructured":"Zhao J, Li X, Hu J, Chen F, Qiao S, Sun X, et al. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res. 2019;115(7):1205\u201316.","journal-title":"Cardiovasc Res"},{"key":"3487_CR61","volume":"26","author":"Y Shi","year":"2020","unstructured":"Shi Y, Kang X, Wang Y, Bian X, He G, Zhou M, et al. Exosomes derived from bone marrow stromal cells (BMSCs) enhance tendon-bone healing by regulating macrophage polarization. Med Sci Monit. 2020;26: e923328.","journal-title":"Med Sci Monit"},{"issue":"6","key":"3487_CR62","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1097\/SHK.0000000000001549","volume":"54","author":"H Deng","year":"2020","unstructured":"Deng H, Wu L, Liu M, Zhu L, Chen Y, Zhou H, et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in macrophages. Shock. 2020;54(6):828\u201343.","journal-title":"Shock"},{"issue":"1","key":"3487_CR63","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1186\/s13287-021-02591-4","volume":"12","author":"H Ning","year":"2021","unstructured":"Ning H, Chen H, Deng J, Xiao C, Xu M, Shan L, et al. Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-kappaB signaling pathway and Nrf2\/HO-1 axis. Stem Cell Res Ther. 2021;12(1):519.","journal-title":"Stem Cell Res Ther"},{"key":"3487_CR64","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.actbio.2020.06.029","volume":"113","author":"L Xin","year":"2020","unstructured":"Xin L, Lin X, Zhou F, Li C, Wang X, Yu H, et al. A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomater. 2020;113:252\u201366.","journal-title":"Acta Biomater"},{"issue":"1","key":"3487_CR65","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s13287-021-02244-6","volume":"12","author":"B Dong","year":"2021","unstructured":"Dong B, Wang C, Zhang J, Zhang J, Gu Y, Guo X, et al. Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Res Ther. 2021;12(1):204.","journal-title":"Stem Cell Res Ther"},{"key":"3487_CR66","doi-asserted-by":"publisher","first-page":"1621394","DOI":"10.1155\/2020\/1621394","volume":"2020","author":"JS Heo","year":"2020","unstructured":"Heo JS, Lim JY, Yoon DW, Pyo S, Kim J. Exosome and melatonin additively attenuates inflammation by transferring miR-34a, miR-124, and miR-135b. Biomed Res Int. 2020;2020:1621394.","journal-title":"Biomed Res Int"},{"issue":"2","key":"3487_CR67","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2337\/db17-0356","volume":"67","author":"H Zhao","year":"2018","unstructured":"Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, et al. Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and Beiging in white adipose tissue. Diabetes. 2018;67(2):235\u201347.","journal-title":"Diabetes"},{"key":"3487_CR68","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2021.01.023","volume":"165","author":"K Shen","year":"2021","unstructured":"Shen K, Jia Y, Wang X, Zhang J, Liu K, Wang J, et al. Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2\/HO-1 axis in macrophages. Free Radic Biol Med. 2021;165:54\u201366.","journal-title":"Free Radic Biol Med"},{"key":"3487_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106030","volume":"81","author":"R Wang","year":"2020","unstructured":"Wang R, Ji Q, Meng C, Liu H, Fan C, Lipkind S, et al. Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions. Int Immunopharmacol. 2020;81: 106030.","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"3487_CR70","doi-asserted-by":"publisher","first-page":"7043","DOI":"10.1002\/jcp.29601","volume":"235","author":"M Shahir","year":"2020","unstructured":"Shahir M, Mahmoud Hashemi S, Asadirad A, Varahram M, Kazempour-Dizaji M, Folkerts G, et al. Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells. J Cell Physiol. 2020;235(10):7043\u201355.","journal-title":"J Cell Physiol"},{"issue":"1","key":"3487_CR71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1089\/jir.2021.0146","volume":"42","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Yan J, Li Z, Zheng J, Sun Q. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate psoriasis-like skin inflammation. J Interferon Cytokine Res. 2022;42(1):8\u201318.","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"3487_CR72","doi-asserted-by":"publisher","first-page":"1795362","DOI":"10.1080\/20013078.2020.1795362","volume":"9","author":"M Elashiry","year":"2020","unstructured":"Elashiry M, Elashiry MM, Elsayed R, Rajendran M, Auersvald C, Zeitoun R, et al. Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo. J Extracell Vesicles. 2020;9(1):1795362.","journal-title":"J Extracell Vesicles"},{"issue":"6","key":"3487_CR73","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1083\/jcb.201612051","volume":"217","author":"M Brown","year":"2018","unstructured":"Brown M, Johnson LA, Leone DA, Majek P, Vaahtomeri K, Senfter D, et al. Lymphatic exosomes promote dendritic cell migration along guidance cues. J Cell Biol. 2018;217(6):2205\u201321.","journal-title":"J Cell Biol"},{"issue":"5","key":"3487_CR74","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.7150\/thno.21072","volume":"8","author":"S Cosenza","year":"2018","unstructured":"Cosenza S, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics. 2018;8(5):1399\u2013410.","journal-title":"Theranostics"},{"issue":"1","key":"3487_CR75","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.yexcr.2017.12.021","volume":"363","author":"YM Du","year":"2018","unstructured":"Du YM, Zhuansun YX, Chen R, Lin L, Lin Y, Li JG. Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Exp Cell Res. 2018;363(1):114\u201320.","journal-title":"Exp Cell Res"},{"key":"3487_CR76","first-page":"6696525","volume":"2021","author":"J Zhou","year":"2021","unstructured":"Zhou J, Lu Y, Wu W, Feng Y. HMSC-derived exosome inhibited Th2 cell differentiation via regulating miR-146a-5p\/SERPINB2 pathway. J Immunol Res. 2021;2021:6696525.","journal-title":"J Immunol Res"},{"issue":"11","key":"3487_CR77","doi-asserted-by":"publisher","first-page":"20662","DOI":"10.1002\/jcp.28671","volume":"234","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Dong C, Yang J, Jin Y, Zheng W, Zhou Q, et al. Exosomal microRNA-155-5p from PDLSCs regulated Th17\/Treg balance by targeting sirtuin-1 in chronic periodontitis. J Cell Physiol. 2019;234(11):20662\u201374.","journal-title":"J Cell Physiol"},{"issue":"8","key":"3487_CR78","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1111\/jcmm.15130","volume":"24","author":"L Xu","year":"2020","unstructured":"Xu L, Geng T, Zang G, Bo L, Liang Y, Zhou H, et al. Exosome derived from CD137-modified endothelial cells regulates the Th17 responses in atherosclerosis. J Cell Mol Med. 2020;24(8):4659\u201367.","journal-title":"J Cell Mol Med"},{"issue":"9","key":"3487_CR79","doi-asserted-by":"publisher","first-page":"798","DOI":"10.21037\/atm-21-1838","volume":"9","author":"F Xiao","year":"2021","unstructured":"Xiao F, Zuo B, Tao B, Wang C, Li Y, Peng J, et al. Exosomes derived from cyclic mechanical stretch-exposed bone marrow mesenchymal stem cells inhibit RANKL-induced osteoclastogenesis through the NF-kappaB signaling pathway. Ann Transl Med. 2021;9(9):798.","journal-title":"Ann Transl Med"},{"issue":"6","key":"3487_CR80","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jbiosc.2021.02.007","volume":"131","author":"L Zhang","year":"2021","unstructured":"Zhang L, Wang Q, Su H, Cheng J. Exosomes from adipose derived mesenchymal stem cells alleviate diabetic osteoporosis in rats through suppressing NLRP3 inflammasome activation in osteoclasts. J Biosci Bioeng. 2021;131(6):671\u20138.","journal-title":"J Biosci Bioeng"},{"issue":"1","key":"3487_CR81","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bbrc.2018.11.109","volume":"508","author":"L Ren","year":"2019","unstructured":"Ren L, Song ZJ, Cai QW, Chen RX, Zou Y, Fu Q, et al. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia\/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro. Biochem Biophys Res Commun. 2019;508(1):138\u201344.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"3487_CR82","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12195-021-00699-4","volume":"15","author":"L Zhang","year":"2022","unstructured":"Zhang L, Wang Q, Su H, Cheng J. Exosomes from adipose tissues derived mesenchymal stem cells overexpressing MicroRNA-146a alleviate diabetic osteoporosis in rats. Cell Mol Bioeng. 2022;15(1):87\u201397.","journal-title":"Cell Mol Bioeng"},{"issue":"7","key":"3487_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2021.151790","volume":"123","author":"Q Wang","year":"2021","unstructured":"Wang Q, Shen X, Chen Y, Chen J, Li Y. Osteoblasts-derived exosomes regulate osteoclast differentiation through miR-503-3p\/Hpse axis. Acta Histochem. 2021;123(7): 151790.","journal-title":"Acta Histochem"},{"issue":"6","key":"3487_CR84","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1111\/jcmm.14228","volume":"23","author":"Y Cui","year":"2019","unstructured":"Cui Y, Fu S, Sun D, Xing J, Hou T, Wu X. EPC-derived exosomes promote osteoclastogenesis through LncRNA-MALAT1. J Cell Mol Med. 2019;23(6):3843\u201354.","journal-title":"J Cell Mol Med"},{"key":"3487_CR85","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.pharmthera.2017.02.020","volume":"174","author":"L Barile","year":"2017","unstructured":"Barile L, Vassalli G. Exosomes: therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 2017;174:63\u201378.","journal-title":"Pharmacol Ther"},{"key":"3487_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105236","author":"A Gugliandolo","year":"2021","unstructured":"Gugliandolo A, Fonticoli L, Trubiani O, Rajan TS, Marconi GD, Bramanti P, et al. Oral bone tissue regeneration: mesenchymal stem cells, secretome, and biomaterials. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22105236.","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03487-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-022-03487-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-022-03487-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:09:15Z","timestamp":1655798955000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-022-03487-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3487"],"URL":"https:\/\/doi.org\/10.1186\/s12967-022-03487-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"21 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"279"}}