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Significant (P\u2009&lt;\u20095\u2009\u00d7\u200910\u20138) results were investigated in the Leeds Melanoma Cohort (LMC; 1,947 patients with melanoma; 370 melanoma deaths). We also developed a CM-susceptibility PRS using a large independent GWAS meta-analysis (23,913 cases, 342,870 controls). The PRS was tested for an association with MSS in the MIA and UKB cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two loci were significantly associated with MSS in the meta-analysis of MIA and UKB with lead SNPs rs41309643 (G allele frequency 1.6%, HR\u2009=\u20092.09, 95%CI\u2009=\u20091.61\u20132.71, P\u2009=\u20092.08\u2009\u00d7\u200910\u20138) on chromosome 1, and rs75682113 (C allele frequency 1.8%, HR\u2009=\u20092.38, 95%CI\u2009=\u20091.77\u20133.21, P\u2009=\u20091.07\u2009\u00d7\u200910\u20138) on chromosome 7. While neither SNP replicated in the LMC, rs75682113 was significantly associated in the combined discovery and replication sets. After adjusting for age at diagnosis, sex and the first ten principal components, a one standard deviation increase in the CM-susceptibility PRS was associated with improved MSS in the discovery meta-analysis (HR\u2009=\u20090.88, 95% CI\u2009=\u20090.83\u20130.94, P\u2009=\u20096.93\u2009\u00d7\u200910\u20135; I2\u2009=\u200988%). However, this was only driven by the high UV setting cohort (MIA HR\u2009=\u20090.84, 95% CI\u2009=\u20090.78\u20130.90).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found two loci potentially associated with MSS. Increased genetic susceptibility to develop CM is associated with improved MSS in a high UV setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-022-03613-2","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T16:37:13Z","timestamp":1662395833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-3283","authenticated-orcid":false,"given":"Mathias","family":"Seviiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-0013","authenticated-orcid":false,"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-8785","authenticated-orcid":false,"given":"D. 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The UK Biobank study was approved by the United Kingdom\u2019s National North West Multi-Centre Research Ethics Committee (ref. 11\/NW\/0382). Leeds Melanoma Cohort approved by Northern and Yorkshire Research Ethics Committee in the United Kingdom. The Human Research Ethics Committee of QIMR Berghofer Medical Research Institute, Brisbane, Australia approved the QSkin study protocol (P1309), and this study (P2121). In all the respective studies, all participants provided written informed consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JFT has received honoraria for advisory board participation from BMS Australia, MSD Australia, GSK and Provectus Inc, and travel and conference support from GSK, Provectus Inc and Novartis. RAS has received fees for professional services from F. Hoffmann-La Roche Ltd, Evaxion, Provectus Biopharmaceuticals Australia, Qbiotics, Novartis, Merck Sharp & Dohme, NeraCare, AMGEN Inc., Bristol-Myers Squibb, Myriad Genetics, GlaxoSmithKline. The rest of the authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"403"}}