{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:08:01Z","timestamp":1790816881451,"version":"4.1.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52250710155"],"award-info":[{"award-number":["52250710155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Key Research and Development Program of China","award":["2021YFA1101200"],"award-info":[{"award-number":["2021YFA1101200"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFA1105501"],"award-info":[{"award-number":["2022YFA1105501"]}]},{"name":"the Project of the State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University","award":["J02-20210201"],"award-info":[{"award-number":["J02-20210201"]}]},{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y2020227"],"award-info":[{"award-number":["Y2020227"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y2020920"],"award-info":[{"award-number":["Y2020920"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Retinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials for RD treatment. However, it remains unknown what kinds of stem cells are most effective for the treatment. Therefore, we investigated the subretinal transplantation of several types of stem cells, human adipose-derived stem cells (hADSCs), amniotic fluid stem cells (hAFSCs), bone marrow stem cells (hBMSCs), dental pulp stem cells (hDPSCs), induced pluripotent stem cell (hiPSC), and hiPSC-derived retinal pigment epithelium (RPE) cells for protection effects, paracrine effects and treatment efficiency in an RD disease model rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The generation and characterization of these stem cells and hiPSC-derived RPE cells were performed before transplantation. The stem cells or hiPSC-derived RPE cell suspension labelled with CellTracker Green to detect transplanted cells were delivered into the subretinal space of 3-week-old RCS rats. The control group received subretinal PBS injection or non-injection. A series of detections including fundus photography, optomotor response (OMR) evaluations, light\u2013dark box testing, electroretinography (ERG), and hematoxylin and eosin (HE) staining of retinal sections were conducted after subretinal injection of the cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Each stem cell, hiPSC-derived RPE cell or PBS (blank experiment) was successfully transplanted into at least six RCS rats subretinally. Compared with the control rats, RCS rats subjected to subretinal transplantation of any stem cells except hiPSCs showed higher ERG waves (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and quantitative OMR (qOMR) index values (hADSCs: 1.166, hAFSCs: 1.249, hBMSCs: 1.098, hDPSCs: 1.238, hiPSCs: 1.208, hiPSC-RPE cells: 1.294, non-injection: 1.03, PBS: 1.06), which indicated better visual function, at 4\u00a0weeks post-injection. However, only rats that received hiPSC-derived RPE cells maintained their visual function at 8\u00a0weeks post-injection (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The outer nuclear layer thickness observed in histological sections after HE staining showed the same pattern as the ERG and qOMR results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Compared to hiPSC-derived RPE cells, adult and fetal stem cells yielded improvements in visual function for up to 4\u00a0weeks post-injection; this outcome was mainly based on the paracrine effects of several types of growth factors secreted by the stem cells. Patients with RD will benefit from the stem cell therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-023-04785-1","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T06:09:41Z","timestamp":1702534181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of retinal degeneration treatment with four types of different mesenchymal stem cells, human induced pluripotent stem cells and RPE cells in a rat retinal degeneration model"],"prefix":"10.1186","volume":"21","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Cheng","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akon","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"4785_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.preteyeres.2014.06.003","volume":"42","author":"M Hoon","year":"2014","unstructured":"Hoon M, Okawa H, Della Santina L, Wong RO. Functional architecture of the retina: development and disease. Prog Retin Eye Res. 2014;42:44\u201384.","journal-title":"Prog Retin Eye Res"},{"issue":"10153","key":"4785_CR2","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","volume":"392","author":"P Mitchell","year":"2018","unstructured":"Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392(10153):1147\u201359.","journal-title":"Lancet"},{"issue":"4","key":"4785_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/gim.2014.138","volume":"17","author":"XF Huang","year":"2015","unstructured":"Huang XF, Huang F, Wu KC, Wu J, Chen J, Pang CP, et al. Genotype-phenotype correlation and mutation spectrum in a large cohort of patients with inherited retinal dystrophy revealed by next-generation sequencing. Genet Med. 2015;17(4):271\u20138.","journal-title":"Genet Med"},{"issue":"10","key":"4785_CR4","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00439-014-1460-2","volume":"133","author":"Y Xu","year":"2014","unstructured":"Xu Y, Guan L, Shen T, Zhang J, Xiao X, Jiang H, et al. Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing. Hum Genet. 2014;133(10):1255\u201371.","journal-title":"Hum Genet"},{"key":"4785_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2018.11.003","volume":"69","author":"ZB Jin","year":"2019","unstructured":"Jin ZB, Gao ML, Deng WL, Wu KC, Sugita S, Mandai M, et al. Stemming retinal regeneration with pluripotent stem cells. Prog Retin Eye Res. 2019;69:38\u201356.","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"4785_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3928\/23258160-20201223-06","volume":"52","author":"TR Rosenblatt","year":"2021","unstructured":"Rosenblatt TR, Vail D, Saroj N, Boucher N, Moshfeghi DM, Moshfeghi AA. Increasing incidence and prevalence of common retinal diseases in retina practices across the United States. Ophthalmic Surg Lasers Imaging Retina. 2021;52(1):29\u201336.","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"1","key":"4785_CR7","first-page":"19","volume":"8","author":"G Binate","year":"2023","unstructured":"Binate G, Ganbarov K. Biological activity of chalcones as carbonyl compound derivatives. Adv Biol Earth Sci. 2023;8(1):19\u201326.","journal-title":"Adv Biol Earth Sci"},{"key":"4785_CR8","doi-asserted-by":"publisher","first-page":"101029","DOI":"10.1016\/j.preteyeres.2021.101029","volume":"89","author":"N Schneider","year":"2022","unstructured":"Schneider N, Sundaresan Y, Gopalakrishnan P, Beryozkin A, Hanany M, Levanon EY, et al. Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities. Prog Retin Eye Res. 2022;89:101029.","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"4785_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.cell.2018.03.021","volume":"173","author":"RS Apte","year":"2018","unstructured":"Apte RS. Gene therapy for retinal degeneration. Cell. 2018;173(1):5.","journal-title":"Cell"},{"issue":"11","key":"4785_CR10","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nrd3790","volume":"11","author":"BA Syed","year":"2012","unstructured":"Syed BA, Evans JB, Bielory L. Wet AMD market. Nat Rev Drug Discovery. 2012;11(11):827.","journal-title":"Nat Rev Drug Discovery"},{"issue":"6","key":"4785_CR11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.cell.2020.02.028","volume":"180","author":"RS Apte","year":"2020","unstructured":"Apte RS. Reducing treatment burden in AMD. Cell. 2020;180(6):1033.","journal-title":"Cell"},{"issue":"2","key":"4785_CR12","first-page":"169","volume":"6","author":"V Ramazanli","year":"2021","unstructured":"Ramazanli V. Effect of pH and temperature on the synthesis of silver nano particles extracted from olive leaf. Adv Biol Earth Sci. 2021;6(2):169\u201373.","journal-title":"Adv Biol Earth Sci"},{"issue":"11","key":"4785_CR13","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.tibtech.2017.06.016","volume":"35","author":"A Higuchi","year":"2017","unstructured":"Higuchi A, Kumar SS, Benelli G, Alarfaj AA, Munusamy MA, Umezawa A, et al. Stem cell therapies for reversing vision loss. Trends Biotechnol. 2017;35(11):1102\u201317.","journal-title":"Trends Biotechnol"},{"issue":"6","key":"4785_CR14","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.stem.2018.05.013","volume":"22","author":"JH Stern","year":"2018","unstructured":"Stern JH, Tian Y, Funderburgh J, Pellegrini G, Zhang K, Goldberg JL, et al. Regenerating eye tissues to preserve and restore vision. Cell Stem Cell. 2018;22(6):834\u201349.","journal-title":"Cell Stem Cell"},{"issue":"475","key":"4785_CR15","doi-asserted-by":"publisher","first-page":"eaat5580","DOI":"10.1126\/scitranslmed.aat5580","volume":"11","author":"R Sharma","year":"2019","unstructured":"Sharma R, Khristov V, Rising A, Jha BS, Dejene R, Hotaling N, et al. Clinical-grade stem cell-derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs. Sci Transl Med. 2019;11(475):eaat5580.","journal-title":"Sci Transl Med"},{"issue":"9817","key":"4785_CR16","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0140-6736(12)60028-2","volume":"379","author":"SD Schwartz","year":"2012","unstructured":"Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012;379(9817):713\u201320.","journal-title":"Lancet"},{"issue":"9967","key":"4785_CR17","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0140-6736(14)61376-3","volume":"385","author":"SD Schwartz","year":"2015","unstructured":"Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, et al. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt\u2019s macular dystrophy: follow-up of two open-label phase 1\/2 studies. Lancet. 2015;385(9967):509\u201316.","journal-title":"Lancet"},{"issue":"4","key":"4785_CR18","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nbt.4114","volume":"36","author":"L da Cruz","year":"2018","unstructured":"da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018;36(4):328\u201337.","journal-title":"Nat Biotechnol"},{"issue":"435","key":"4785_CR19","doi-asserted-by":"publisher","first-page":"eaao4097","DOI":"10.1126\/scitranslmed.aao4097","volume":"10","author":"AH Kashani","year":"2018","unstructured":"Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, et al. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018;10(435):eaao4097.","journal-title":"Sci Transl Med"},{"issue":"11","key":"4785_CR20","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/j.ophtha.2018.04.037","volume":"125","author":"MS Mehat","year":"2018","unstructured":"Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, et al. Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmology. 2018;125(11):1765\u201375.","journal-title":"Ophthalmology"},{"issue":"9","key":"4785_CR21","doi-asserted-by":"publisher","first-page":"e13100","DOI":"10.1111\/cpr.13100","volume":"54","author":"SY Li","year":"2021","unstructured":"Li SY, Liu Y, Wang L, Wang F, Zhao TT, Li QY, et al. A phase I clinical trial of human embryonic stem cell-derived retinal pigment epithelial cells for early-stage Stargardt macular degeneration: 5-years\u2019 follow-up. Cell Prolif. 2021;54(9):e13100.","journal-title":"Cell Prolif"},{"issue":"6","key":"4785_CR22","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1136\/bjophthalmol-2020-316225","volume":"105","author":"Y Sung","year":"2021","unstructured":"Sung Y, Lee MJ, Choi J, Jung SY, Chong SY, Sung JH, et al. Long-term safety and tolerability of subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium in Asian Stargardt disease patients. Br J Ophthalmol. 2021;105(6):829\u201337.","journal-title":"Br J Ophthalmol"},{"key":"4785_CR23","doi-asserted-by":"publisher","first-page":"100779","DOI":"10.1016\/j.preteyeres.2019.100779","volume":"75","author":"MS Singh","year":"2020","unstructured":"Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, et al. Retinal stem cell transplantation: balancing safety and potential. Prog Retin Eye Res. 2020;75:100779.","journal-title":"Prog Retin Eye Res"},{"key":"4785_CR24","doi-asserted-by":"publisher","first-page":"120233","DOI":"10.1016\/j.biomaterials.2020.120233","volume":"257","author":"N Mitrousis","year":"2020","unstructured":"Mitrousis N, Hacibekiroglu S, Ho MT, Sauv\u00e9 Y, Nagy A, van der Kooy D, et al. Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration. Biomaterials. 2020;257:120233.","journal-title":"Biomaterials"},{"issue":"1","key":"4785_CR25","first-page":"5","volume":"8","author":"R Khalilov","year":"2023","unstructured":"Khalilov R. A comprehensive review of advanced nano-biomaterials in regenerative medicine and drug delivery. Adv Biol Earth Sci. 2023;8(1):5\u201318.","journal-title":"Adv Biol Earth Sci"},{"key":"4785_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.exer.2013.10.023","volume":"118","author":"A Tzameret","year":"2014","unstructured":"Tzameret A, Sher I, Belkin M, Treves AJ, Meir A, Nagler A, et al. Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy. Exp Eye Res. 2014;118:135\u201344.","journal-title":"Exp Eye Res"},{"issue":"3","key":"4785_CR27","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41418-020-00636-4","volume":"28","author":"CL Deng","year":"2021","unstructured":"Deng CL, Hu CB, Ling ST, Zhao N, Bao LH, Zhou F, et al. Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration. Cell Death Differ. 2021;28(3):1041\u201361.","journal-title":"Cell Death Differ"},{"key":"4785_CR28","doi-asserted-by":"publisher","first-page":"111561","DOI":"10.1016\/j.jphotobiol.2019.111561","volume":"198","author":"HA Alsaeedi","year":"2019","unstructured":"Alsaeedi HA, Koh AE, Lam C, Rashid MBA, Harun MHN, Saleh M, et al. Dental pulp stem cells therapy overcome photoreceptor cell death and protects the retina in a rat model of sodium iodate-induced retinal degeneration. J Photochem Photobiol B. 2019;198:111561.","journal-title":"J Photochem Photobiol B"},{"issue":"1","key":"4785_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s13770-020-00312-1","volume":"18","author":"C Lam","year":"2021","unstructured":"Lam C, Alsaeedi HA, Koh AE, Harun MHN, Hwei ANM, Mok PL, et al. Human dental pulp stem cells (DPSCs) therapy in rescuing photoreceptors and establishing a sodium iodate-induced retinal degeneration rat model. Tissue Eng Regen Med. 2021;18(1):143\u201354.","journal-title":"Tissue Eng Regen Med"},{"issue":"8","key":"4785_CR30","doi-asserted-by":"publisher","first-page":"102340","DOI":"10.1016\/j.jksus.2022.102340","volume":"34","author":"S Shahi","year":"2022","unstructured":"Shahi S, Dehghani F, Abdolahinia ED, Sharifi S, Ahmadian E, Gajd\u00e1cs M, et al. Effect of gelatinous spongy scaffold containing nano-hydroxyapatite on the induction of odontogenic activity of dental pulp stem cells. J King Saud Univ-Sci. 2022;34(8):102340.","journal-title":"J King Saud Univ-Sci"},{"issue":"6","key":"4785_CR31","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2174\/1566524016666160607090538","volume":"16","author":"Z Li","year":"2016","unstructured":"Li Z, Wang J, Gao F, Zhang J, Tian H, Shi X, et al. Human adipose-derived stem cells delay retinal degeneration in royal college of surgeons rats through anti-apoptotic and VEGF-mediated neuroprotective effects. Curr Mol Med. 2016;16(6):553\u201366.","journal-title":"Curr Mol Med"},{"issue":"1","key":"4785_CR32","doi-asserted-by":"publisher","first-page":"e84671","DOI":"10.1371\/journal.pone.0084671","volume":"9","author":"G Rajashekhar","year":"2014","unstructured":"Rajashekhar G, Ramadan A, Abburi C, Callaghan B, Traktuev DO, Evans-Molina C, et al. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS ONE. 2014;9(1):e84671.","journal-title":"PLoS ONE"},{"issue":"5","key":"4785_CR33","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/stem.1960","volume":"33","author":"J Sun","year":"2015","unstructured":"Sun J, Mandai M, Kamao H, Hashiguchi T, Shikamura M, Kawamata S, et al. Protective effects of human iPS-derived retinal pigmented epithelial cells in comparison with human mesenchymal stromal cells and human neural stem cells on the degenerating retina in rd1 mice. Stem Cells. 2015;33(5):1543\u201353.","journal-title":"Stem Cells"},{"key":"4785_CR34","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.omtm.2021.02.006","volume":"20","author":"A Salas","year":"2021","unstructured":"Salas A, Duarri A, Fontrodona L, Ram\u00edrez DM, Badia A, Isla-Magran\u00e9 H, et al. Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration. Mol Ther Methods Clin Dev. 2021;20:688\u2013702.","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"421","key":"4785_CR35","doi-asserted-by":"publisher","first-page":"eaai7471","DOI":"10.1126\/scitranslmed.aai7471","volume":"9","author":"K Ben M'Barek","year":"2017","unstructured":"Ben M\u2019Barek K, Habeler W, Plancheron A, Jarraya M, Regent F, Terray A, et al. Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration. Sci Transl Med. 2017;9(421):eaai7471.","journal-title":"Sci Transl Med"},{"issue":"6","key":"4785_CR36","doi-asserted-by":"publisher","first-page":"567","DOI":"10.2174\/1566524016666160607090953","volume":"16","author":"P Li","year":"2016","unstructured":"Li P, Tian H, Li Z, Wang L, Gao F, Ou Q, et al. Subpopulations of bone marrow mesenchymal stem cells exhibit differential effects in delaying retinal degeneration. Curr Mol Med. 2016;16(6):567\u201381.","journal-title":"Curr Mol Med"},{"key":"4785_CR37","doi-asserted-by":"publisher","first-page":"16010","DOI":"10.1038\/mtm.2016.10","volume":"3","author":"M Riera","year":"2016","unstructured":"Riera M, Fontrodona L, Albert S, Ramirez DM, Seriola A, Salas A, et al. Comparative study of human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) as a treatment for retinal dystrophies. Mol Ther Methods Clin Dev. 2016;3:16010.","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"6","key":"4785_CR38","first-page":"421","volume":"17","author":"L Wang","year":"2017","unstructured":"Wang L, Li P, Tian Y, Li Z, Lian C, Ou Q, et al. Human umbilical cord mesenchymal stem cells: subpopulations and their difference in cell biology and effects on retinal degeneration in RCS rats. Curr Mol Med. 2017;17(6):421\u201335.","journal-title":"Curr Mol Med"},{"key":"4785_CR39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/bs.pmbts.2023.02.010","volume":"199","author":"Q Liu","year":"2023","unstructured":"Liu Q, Liu J, Higuchi A. hPSC-derived RPE transplantation for the treatment of macular degeneration. Prog Mol Biol Transl Sci. 2023;199:227\u201369.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"10","key":"4785_CR40","doi-asserted-by":"publisher","first-page":"e109305","DOI":"10.1371\/journal.pone.0109305","volume":"9","author":"B Mead","year":"2014","unstructured":"Mead B, Logan A, Berry M, Leadbeater W, Scheven BA. Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells. PLoS ONE. 2014;9(10):e109305.","journal-title":"PLoS ONE"},{"issue":"4","key":"4785_CR41","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1093\/hmg\/9.4.645","volume":"9","author":"PM D'Cruz","year":"2000","unstructured":"D\u2019Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet. 2000;9(4):645\u201351.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"4785_CR42","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1186\/s13287-020-01986-z","volume":"11","author":"L Ru","year":"2020","unstructured":"Ru L, Wu N, Wei K, Zeng Y, Li Q, Weng C, et al. Improving cell survival and engraftment in vivo via layer-by-layer nanocoating of hESC-derived RPE cells. Stem Cell Res Ther. 2020;11(1):495.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4785_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13287-021-02134-x","volume":"12","author":"H Surendran","year":"2021","unstructured":"Surendran H, Nandakumar S, Reddy KV, Stoddard J, Mohan KV, Upadhyay PK, et al. Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration. Stem Cell Res Ther. 2021;12(1):70.","journal-title":"Stem Cell Res Ther"},{"key":"4785_CR44","doi-asserted-by":"publisher","first-page":"102506","DOI":"10.1016\/j.redox.2022.102506","volume":"57","author":"A Mart\u00ednez-Vacas","year":"2022","unstructured":"Mart\u00ednez-Vacas A, Di Pierdomenico J, Gallego-Ortega A, Valiente-Soriano FJ, Vidal-Sanz M, Picaud S, et al. Systemic taurine treatment affords functional and morphological neuroprotection of photoreceptors and restores retinal pigment epithelium function in RCS rats. Redox Biol. 2022;57:102506.","journal-title":"Redox Biol"},{"issue":"6","key":"4785_CR45","first-page":"2693","volume":"35","author":"MO Tso","year":"1994","unstructured":"Tso MO, Zhang C, Abler AS, Chang CJ, Wong F, Chang GQ, et al. Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. Invest Ophthalmol Vis Sci. 1994;35(6):2693\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"4785_CR46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.61.11.34","volume":"61","author":"B Lin","year":"2020","unstructured":"Lin B, McLelland BT, Aramant RB, Thomas BB, Nistor G, Keirstead HS, et al. Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction. Invest Ophthalmol Vis Sci. 2020;61(11):34.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"27","key":"4785_CR47","doi-asserted-by":"publisher","first-page":"5345","DOI":"10.1039\/C7TB01152K","volume":"5","author":"S Muduli","year":"2017","unstructured":"Muduli S, Lee HH, Yang JS, Chen TY, Higuchi A, Kumar SS, et al. Proliferation and osteogenic differentiation of amniotic fluid-derived stem cells. J Mater Chem B. 2017;5(27):5345\u201354.","journal-title":"J Mater Chem B"},{"key":"4785_CR48","doi-asserted-by":"publisher","first-page":"893241","DOI":"10.3389\/fcell.2022.893241","volume":"10","author":"Y Gao","year":"2022","unstructured":"Gao Y, Tian Z, Liu Q, Wang T, Ban LK, Lee HH, et al. Neuronal cell differentiation of human dental pulp stem cells on synthetic polymeric surfaces coated with ECM proteins. Front Cell Dev Biol. 2022;10:893241.","journal-title":"Front Cell Dev Biol"},{"issue":"35","key":"4785_CR49","doi-asserted-by":"publisher","first-page":"10950","DOI":"10.1073\/pnas.1422818112","volume":"112","author":"J Maruotti","year":"2015","unstructured":"Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin KJ, Ranganathan V, et al. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci USA. 2015;112(35):10950\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"4785_CR50","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.stemcr.2019.04.012","volume":"12","author":"EN Smith","year":"2019","unstructured":"Smith EN, D\u2019Antonio-Chronowska A, Greenwald WW, Borja V, Aguiar LR, Pogue R, et al. Human iPSC-derived retinal pigment epithelium: a model system for prioritizing and functionally characterizing causal variants at AMD risk loci. Stem Cell Reports. 2019;12(6):1342\u201353.","journal-title":"Stem Cell Reports"},{"issue":"5","key":"4785_CR51","doi-asserted-by":"publisher","first-page":"e20220776","DOI":"10.1084\/jem.20220776","volume":"220","author":"H Qin","year":"2023","unstructured":"Qin H, Zhang W, Zhang S, Feng Y, Xu W, Qi J, et al. Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas. J Exp Med. 2023;220(5):e20220776.","journal-title":"J Exp Med"},{"issue":"1","key":"4785_CR52","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13287-020-01608-8","volume":"11","author":"D Zhu","year":"2020","unstructured":"Zhu D, Xie M, Gademann F, Cao J, Wang P, Guo Y, et al. Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease. Stem Cell Res Ther. 2020;11(1):98.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4785_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","volume":"136","author":"AG Robson","year":"2018","unstructured":"Robson AG, Nilsson J, Li S, Jalali S, Fulton AB, Tormene AP, et al. ISCEV guide to visual electrodiagnostic procedures. Doc Ophthalmol. 2018;136(1):1\u201326.","journal-title":"Doc Ophthalmol"},{"issue":"1","key":"4785_CR54","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s13287-021-02395-6","volume":"12","author":"Z Liu","year":"2021","unstructured":"Liu Z, Ilmarinen T, Tan GSW, Hongisto H, Wong EYM, Tsai ASH, et al. Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model. Stem Cell Res Ther. 2021;12(1):423.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4785_CR55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13287-020-1568-3","volume":"11","author":"F Michelet","year":"2020","unstructured":"Michelet F, Balasankar A, Teo N, Stanton LW, Singhal S. Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting. Stem Cell Res Ther. 2020;11(1):47.","journal-title":"Stem Cell Res Ther"},{"key":"4785_CR56","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbrc.2021.03.012","volume":"552","author":"A Ito","year":"2021","unstructured":"Ito A, Ye K, Onda M, Morimoto N, Osakada F. Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells. Biochem Biophys Res Commun. 2021;552:66\u201372.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"4785_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/tvst.6.3.17","volume":"6","author":"TJ McGill","year":"2017","unstructured":"McGill TJ, Bohana-Kashtan O, Stoddard JW, Andrews MD, Pandit N, Rosenberg-Belmaker LR, et al. Long-term efficacy of GMP grade xeno-free hESC-derived RPE cells following transplantation. Transl Vis Sci Technol. 2017;6(3):17.","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"4785_CR58","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1167\/iovs.13-11740","volume":"55","author":"A Muniz","year":"2014","unstructured":"Muniz A, Greene WA, Plamper ML, Choi JH, Johnson AJ, Tsin AT, et al. Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle. Invest Ophthalmol Vis Sci. 2014;55(1):198\u2013209.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"4785_CR59","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1038\/s41467-022-31368-3","volume":"13","author":"S Francia","year":"2022","unstructured":"Francia S, Shmal D, Di Marco S, Chiaravalli G, Maya-Vetencourt JF, Mantero G, et al. Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats. Nat Commun. 2022;13(1):3677.","journal-title":"Nat Commun"},{"issue":"2","key":"4785_CR60","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41551-020-00632-6","volume":"5","author":"S Suh","year":"2021","unstructured":"Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, et al. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021;5(2):169\u201378.","journal-title":"Nat Biomed Eng"},{"issue":"1","key":"4785_CR61","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1038\/s41467-018-04781-w","volume":"9","author":"R Yin","year":"2018","unstructured":"Yin R, Xu Z, Mei M, Chen Z, Wang K, Liu Y, et al. Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram. Nat Commun. 2018;9(1):2334.","journal-title":"Nat Commun"},{"issue":"7","key":"4785_CR62","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00417-015-3037-8","volume":"253","author":"R Tzekov","year":"2015","unstructured":"Tzekov R. Full-field ERG in diabetic retinopathy: a screening tool? Graefes Arch Clin Exp Ophthalmol. 2015;253(7):987\u20138.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4785_CR63","doi-asserted-by":"publisher","first-page":"700634","DOI":"10.3389\/fcell.2021.700634","volume":"9","author":"G Valiulien\u0117","year":"2021","unstructured":"Valiulien\u0117 G, Zentelyt\u0117 A, Ber\u017eanskyt\u0117 E, Navakauskien\u0117 R. Metabolic profile and neurogenic potential of human amniotic fluid stem cells from normal vs. fetus-affected gestations. Front Cell Dev Biol. 2021;9:700634.","journal-title":"Front Cell Dev Biol"},{"key":"4785_CR64","first-page":"33","volume":"13","author":"TW Tsutsui","year":"2020","unstructured":"Tsutsui TW. Dental pulp stem cells: advances to applications. Stem Cells Cloning. 2020;13:33\u201342.","journal-title":"Stem Cells Cloning"},{"issue":"1","key":"4785_CR65","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13287-020-01651-5","volume":"11","author":"X Liu","year":"2020","unstructured":"Liu X, Chen F, Chen Y, Lu H, Lu X, Peng X, et al. Paracrine effects of intraocularly implanted cells on degenerating retinas in mice. Stem Cell Res Ther. 2020;11(1):142.","journal-title":"Stem Cell Res Ther"},{"key":"4785_CR66","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.exer.2018.07.019","volume":"177","author":"S Bobba","year":"2018","unstructured":"Bobba S, Di Girolamo N, Munsie M, Chen F, P\u00e9bay A, Harkin D, et al. The current state of stem cell therapy for ocular disease. Exp Eye Res. 2018;177:65\u201375.","journal-title":"Exp Eye Res"},{"issue":"11","key":"4785_CR67","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/stcltm\/szad054","volume":"12","author":"S Shahin","year":"2023","unstructured":"Shahin S, Tan P, Chetsawang J, Lu B, Svendsen S, Ramirez S, et al. Human neural progenitors expressing GDNF enhance retinal protection in a rodent model of retinal degeneration. Stem Cells Transl Med. 2023;12(11):727\u201344.","journal-title":"Stem Cells Transl Med"},{"issue":"5","key":"4785_CR68","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/j.1471-4159.2012.07842.x","volume":"122","author":"M Ohnaka","year":"2012","unstructured":"Ohnaka M, Miki K, Gong YY, Stevens R, Iwase T, Hackett SF, et al. Long-term expression of glial cell line-derived neurotrophic factor slows, but does not stop retinal degeneration in a model of retinitis pigmentosa. J Neurochem. 2012;122(5):1047\u201353.","journal-title":"J Neurochem"},{"issue":"11","key":"4785_CR69","first-page":"2724","volume":"40","author":"M Frasson","year":"1999","unstructured":"Frasson M, Picaud S, L\u00e9veillard T, Simonutti M, Mohand-Said S, Dreyfus H, et al. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd\/rd mouse. Invest Ophthalmol Vis Sci. 1999;40(11):2724\u201334.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4785_CR70","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jns.2016.02.024","volume":"363","author":"M Afarid","year":"2016","unstructured":"Afarid M, Torabi-Nami M, Zare B. Neuroprotective and restorative effects of the brain-derived neurotrophic factor in retinal diseases. J Neurol Sci. 2016;363:43\u201350.","journal-title":"J Neurol Sci"},{"issue":"Suppl 2","key":"4785_CR71","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12920-019-0493-8","volume":"12","author":"DV Telegina","year":"2019","unstructured":"Telegina DV, Kolosova NG, Kozhevnikova OS. Immunohistochemical localization of NGF, BDNF, and their receptors in a normal and AMD-like rat retina. BMC Med Genomics. 2019;12(Suppl 2):48.","journal-title":"BMC Med Genomics"},{"key":"4785_CR72","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exer.2019.04.008","volume":"184","author":"A Hern\u00e1ndez-Pinto","year":"2019","unstructured":"Hern\u00e1ndez-Pinto A, Polato F, Subramanian P, Rocha-Mu\u00f1oz A, Vitale S, de la Rosa EJ, et al. PEDF peptides promote photoreceptor survival in rd10 retina models. Exp Eye Res. 2019;184:24\u20139.","journal-title":"Exp Eye Res"},{"key":"4785_CR73","doi-asserted-by":"publisher","first-page":"109171","DOI":"10.1016\/j.exer.2022.109171","volume":"222","author":"X Chen","year":"2022","unstructured":"Chen X, Xu M, Zhang X, Barnstable CJ, Li X, Tombran-Tink J. Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina. Exp Eye Res. 2022;222:109171.","journal-title":"Exp Eye Res"},{"issue":"5","key":"4785_CR74","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3390\/biom11050712","volume":"11","author":"YZ Le","year":"2021","unstructured":"Le YZ, Xu B, Chucair-Elliott AJ, Zhang H, Zhu M. VEGF mediates retinal M\u00fcller cell viability and neuroprotection through BDNF in diabetes. Biomolecules. 2021;11(5):712.","journal-title":"Biomolecules"},{"issue":"4","key":"4785_CR75","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.ajpath.2012.12.032","volume":"182","author":"RH Foxton","year":"2013","unstructured":"Foxton RH, Finkelstein A, Vijay S, Dahlmann-Noor A, Khaw PT, Morgan JE, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013;182(4):1379\u201390.","journal-title":"Am J Pathol"},{"issue":"8","key":"4785_CR76","first-page":"4360","volume":"130","author":"SK Wang","year":"2020","unstructured":"Wang SK, Xue Y, Cepko CL. Microglia modulation by TGF-\u03b21 protects cones in mouse models of retinal degeneration. J Clin Invest. 2020;130(8):4360\u20139.","journal-title":"J Clin Invest"},{"issue":"2","key":"4785_CR77","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.stemcr.2013.12.007","volume":"2","author":"H Kamao","year":"2014","unstructured":"Kamao H, Mandai M, Okamoto S, Sakai N, Suga A, Sugita S, et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Reports. 2014;2(2):205\u201318.","journal-title":"Stem Cell Reports"},{"issue":"11","key":"4785_CR78","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","volume":"376","author":"M Mandai","year":"2017","unstructured":"Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C, Daimon T, et al. Autologous induced stem-cell-derived retinal cells for macular degeneration. N Engl J Med. 2017;376(11):1038\u201346.","journal-title":"N Engl J Med"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-023-04785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-023-04785-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-023-04785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T06:12:52Z","timestamp":1702534372000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-023-04785-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["4785"],"URL":"https:\/\/doi.org\/10.1186\/s12967-023-04785-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"6 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments in this study were approved by the ethics committees of Wenzhou Medical University (wydw2022-0474). Animal experiments were approved by the Laboratory Animal Ethics Committee of Wenzhou Medical University (No. wydw2021-0230).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"910"}}