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Knowledge of the biological features and clinical relevance of LAMC1 in cancers remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted comprehensive bioinformatics analysis of\n                      <jats:italic>LAMC1<\/jats:italic>\n                      gene expression and clinical relevance in pan-cancer datasets of public databases and validated\n                      <jats:italic>LAMC1<\/jats:italic>\n                      expression in glioma tissues and cell lines. The association and regulatory mechanism between hypoxia inducible factor-1\u03b1 (\n                      <jats:italic>HIF-1\u03b1<\/jats:italic>\n                      ) and\n                      <jats:italic>LAMC1<\/jats:italic>\n                      expression were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LAMC1<\/jats:italic>\n                      expression in most cancers in The Cancer Genome Atlas (TCGA) including glioma was significantly higher than that in normal tissues, which had a poor prognosis and were related to various clinicopathological features. Data from the Chinese Glioma Genome Atlas also showed high expression of\n                      <jats:italic>LAMC1<\/jats:italic>\n                      in glioma associated with poor prognoses. In clinical glioma tissues, LAMC1 protein was highly expressed and correlated to poor overall survival.\n                      <jats:italic>LAMC1<\/jats:italic>\n                      knockdown in Hs683 glioma cells attenuated cell proliferation, migration, and invasion, while overexpression of\n                      <jats:italic>LAMC1<\/jats:italic>\n                      in U251 cells leads to the opposite trend. Most TCGA solid cancers including glioma showed enhancement of\n                      <jats:italic>HIF-1\u03b1<\/jats:italic>\n                      expression. High\n                      <jats:italic>HIF-1\u03b1<\/jats:italic>\n                      expression leads to adverse prognosis in gliomas, besides,\n                      <jats:italic>HIF-1\u03b1<\/jats:italic>\n                      expression was positively related to\n                      <jats:italic>LAMC1<\/jats:italic>\n                      . Mechanistically, HIF-1\u03b1 directly upregulated\n                      <jats:italic>LAMC1<\/jats:italic>\n                      promotor activity. Hypoxia (2% O\n                      <jats:sub>2<\/jats:sub>\n                      )-treated Hs683 and U251 cells exhibited upregulated HIF-1\u03b1 and LAMC1 expression, which was significantly attenuated by HIF-1\u03b1 inhibitor YC-1 and accompanied by attenuated cell proliferation and invasion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      High expression of\n                      <jats:italic>LAMC1<\/jats:italic>\n                      in some solid tumors including gliomas suggests a poor prognosis. The hypoxic microenvironment in gliomas activates the HIF-1\u03b1\/LAMC1 signaling, thereby promoting tumor progression. Targeted intervention on the HIF-1\u03b1\/LAMC1 signaling attenuates cell growth and invasion, suggesting a new strategy for glioma treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-024-05218-3","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T09:01:44Z","timestamp":1714208504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["HIF-1\u03b1-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments"],"prefix":"10.1186","volume":"22","author":[{"given":"Jianrong","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanda","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-1458","authenticated-orcid":false,"given":"Wei","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"issue":"7","key":"5218_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/neuonc\/nou087","volume":"16","author":"QT Ostrom","year":"2014","unstructured":"Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, et al. 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