{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T14:21:00Z","timestamp":1794061260901,"version":"4.8.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200961"],"award-info":[{"award-number":["82200961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Science and Technology Commission of Shanghai","award":["20DZ2270800"],"award-info":[{"award-number":["20DZ2270800"]}]},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology","award":["2022SKLE-KFKT004"],"award-info":[{"award-number":["2022SKLE-KFKT004"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720091"],"award-info":[{"award-number":["2022M720091"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Uveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages. Angiogenesis is critical for UM development, however, not only the role of vascular endothelial dysfunction in UM remains unknown, but also their analysis at the single-cell level has been lacking. A comprehensive analysis is essential to clarify the role of the endothelium in the development of UM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>By using single-cell RNA transcriptomics data of 11 cases of primary and liver metastasis UM, we analyzed the endothelial cell status. In addition, we analyzed and validated ECs in the in vitro model and collected clinical specimens. Subsequently, we explored the impact of endothelial dysfunction on UM cell migration and explored the mechanisms responsible for the endothelial cell abnormalities and the reasons for their peripheral effects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>UM metastasis has a significantly higher percentage of vascular endothelial cells compared to in situ tumors, and endothelial cells in metastasis show significant senescence. Senescent endothelial cells in metastatic tumors showed significant Kr\u00fcppel-like factor 4 (KLF4) upregulation, overexpression of KLF4 in normal endothelial cells induced senescence, and knockdown of KLF4 in senescent endothelium inhibited senescence, suggesting that KLF4 is a driver gene for endothelial senescence. KLF4-induced endothelial senescence drove tumor cell migration through a senescence-associated secretory phenotype (SASP), of which the most important component of the effector was CXCL12 (C-X-C motif chemokine ligand 12), and participated in the composition of the immunosuppressive microenvironment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study provides an undesirable insight of senescent endothelial cells in promoting UM metastasis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-024-05430-1","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T22:02:10Z","timestamp":1719871330000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution"],"prefix":"10.1186","volume":"22","author":[{"given":"Liang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidian","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-7896","authenticated-orcid":false,"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"issue":"3","key":"5430_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.62476\/abes9s11","volume":"20","author":"E Trimm","year":"2023","unstructured":"Trimm E, Red-Horse K. Vascular endothelial cell development and diversity. Nat Rev Cardiol. 2023;20(3):197\u2013210. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"5430_CR2","doi-asserted-by":"publisher","first-page":"544","DOI":"10.62476\/abes9s11","volume":"23","author":"Q Zeng","year":"2023","unstructured":"Zeng Q, Mousa M, Nadukkandy AS, Franssens L, Alnaqbi H, Alshamsi FY, Safar HA, Carmeliet P. Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer. 2023;23(8):544\u201364. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"5430_CR3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.62476\/abes9s11","volume":"99","author":"A Calcinotto","year":"2019","unstructured":"Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. Cellular Senescence: aging, Cancer, and Injury. Physiol Rev. 2019;99(2):1047\u201378. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Physiol Rev"},{"key":"5430_CR4","doi-asserted-by":"publisher","first-page":"182","DOI":"10.62476\/abes9s11","volume":"62","author":"E Mavrogonatou","year":"2020","unstructured":"Mavrogonatou E, Pratsinis H, Kletsas D. The role of senescence in cancer development. Semin Cancer Biol. 2020;62:182\u201391. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Semin Cancer Biol"},{"key":"5430_CR5","doi-asserted-by":"publisher","first-page":"10104111","DOI":"10.62476\/abes9s11","volume":"90","author":"ES Rantala","year":"2022","unstructured":"Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivel\u00e4 TT. Metastatic uveal melanoma: the final frontier. Prog Retin Eye Res. 2022;90:10104111\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"5430_CR6","doi-asserted-by":"publisher","first-page":"49611","DOI":"10.62476\/abes9s11","volume":"11","author":"MA Durante","year":"2020","unstructured":"Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW. Single-cell analysis reveals new evolutionary complexity in uveal melanoma. Nat Commun. 2020;11(1):49611\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Commun"},{"issue":"7661","key":"5430_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.62476\/abes9s11","volume":"547","author":"A Giladi","year":"2017","unstructured":"Giladi A, Amit I. Immunology, one cell at a time. Nature. 2017;547(7661):27. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nature"},{"key":"5430_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.62476\/abes9s11","volume":"490","author":"HJ Hwang","year":"2020","unstructured":"Hwang HJ, Lee Y-R, Kang D, Lee HC, Seo HR, Ryu J-K, Kim Y-N, Ko Y-G, Park HJ, Lee J-S. Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells. Cancer Lett. 2020;490:100\u201310. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cancer Lett"},{"issue":"5","key":"5430_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.62476\/abes9s11","volume":"7","author":"W Lin","year":"2021","unstructured":"Lin W, Beasley AB, Ardakani NM, Denisenko E, Calapre L, Jones M, Wood BA, Warburton L, Forrest ARR, Gray ES. Intra- and intertumoral heterogeneity of liver metastases in a patient with uveal melanoma revealed by single-cell RNA sequencing. Cold Spring Harb Mol Case Stud. 2021;7(5):11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"12","key":"5430_CR10","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.62476\/abes9s11","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh PR, Raychaudhuri S. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat Methods. 2019;16(12):1289\u201396. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Methods"},{"key":"5430_CR11","doi-asserted-by":"publisher","unstructured":"Becht E, McInnes L, Healy J, Dutertre CA, Kwok IWH, Ng LG, Ginhoux F, Newell EW. Dimensionality reduction for visualizing single-cell data using UMAP. Nat Biotechnol. 2018;11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","DOI":"10.62476\/abes9s11"},{"issue":"6","key":"5430_CR12","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.62476\/abes9s11","volume":"28","author":"C Pandiani","year":"2021","unstructured":"Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, B\u00e9ranger G, Lassalle S, et al. Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease. Cell Death Differ. 2021;28(6):1990\u20132000. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cell Death Differ"},{"issue":"3","key":"5430_CR13","doi-asserted-by":"publisher","first-page":"374","DOI":"10.62476\/abes9s11","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser KE, Joyce JA. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41(3):374\u2013403. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cancer Cell"},{"issue":"1","key":"5430_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.62476\/abes9s11","volume":"39","author":"I Guccini","year":"2021","unstructured":"Guccini I, Revandkar A, D\u2019Ambrosio M, Colucci M, Pasquini E, Mosole S, Troiani M, Brina D, Sheibani-Tezerji R, Elia AR, et al. Senescence Reprogramming by TIMP1 Deficiency promotes prostate Cancer Metastasis. Cancer Cell. 2021;39(1):68\u2013e82. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cancer Cell"},{"issue":"1","key":"5430_CR15","doi-asserted-by":"publisher","first-page":"9211","DOI":"10.62476\/abes9s11","volume":"8","author":"H Wang","year":"2023","unstructured":"Wang H, Guo M, Wei H, Chen Y. Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal Transduct Target Therapy. 2023;8(1):9211\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Signal Transduct Target Therapy"},{"issue":"46","key":"5430_CR16","doi-asserted-by":"publisher","first-page":"5975","DOI":"10.62476\/abes9s11","volume":"27","author":"AL Fridman","year":"2008","unstructured":"Fridman AL, Tainsky MA. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene. 2008;27(46):5975\u201387. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Oncogene"},{"issue":"52","key":"5430_CR17","doi-asserted-by":"publisher","first-page":"7302","DOI":"10.62476\/abes9s11","volume":"26","author":"X Tang","year":"2007","unstructured":"Tang X, Milyavsky M, Goldfinger N, Rotter V. Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress. Oncogene. 2007;26(52):7302\u201312. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Oncogene"},{"issue":"1","key":"5430_CR18","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.62476\/abes9s11","volume":"30","author":"Z Wu","year":"2023","unstructured":"Wu Z, Uhl B, Gires O, Reichel CA. A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence. J Biomed Sci. 2023;30(1):2111\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"J Biomed Sci"},{"issue":"11","key":"5430_CR19","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.62476\/abes9s11","volume":"7","author":"BD Rowland","year":"2005","unstructured":"Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol. 2005;7(11):1074\u201382. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"5430_CR20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.62476\/abes9s11","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D. Hallmarks of Cancer: New dimensions. Cancer Discov. 2022;12(1):31\u201346. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cancer Discov"},{"issue":"8","key":"5430_CR21","doi-asserted-by":"publisher","first-page":"10877911","DOI":"10.62476\/abes9s11","volume":"34","author":"T Yasuda","year":"2021","unstructured":"Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, et al. Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination. Cell Rep. 2021;34(8):10877911\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cell Rep"},{"issue":"10","key":"5430_CR22","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.62476\/abes9s11","volume":"25","author":"N Borcherding","year":"2019","unstructured":"Borcherding N, Voigt AP, Liu V, Link BK, Zhang W, Jabbari A. Single-cell profiling of cutaneous T-Cell lymphoma reveals underlying Heterogeneity Associated with Disease Progression. Clin Cancer Res. 2019;25(10):2996\u20133005. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Clin Cancer Res"},{"issue":"D1","key":"5430_CR23","doi-asserted-by":"publisher","first-page":"D1083","DOI":"10.62476\/abes9s11","volume":"46","author":"R Tacutu","year":"2018","unstructured":"Tacutu R, Thornton D, Johnson E, Budovsky A, Barardo D, Craig T, Diana E, Lehmann G, Toren D, Wang J, et al. Human ageing genomic resources: new and updated databases. Nucleic Acids Res. 2018;46(D1):D1083\u2013d. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nucleic Acids Res"},{"issue":"7836","key":"5430_CR24","doi-asserted-by":"publisher","first-page":"124","DOI":"10.62476\/abes9s11","volume":"588","author":"Y Lu","year":"2020","unstructured":"Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588(7836):124\u20139. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nature"},{"issue":"24","key":"5430_CR25","doi-asserted-by":"publisher","first-page":"26221","DOI":"10.62476\/abes9s11","volume":"12","author":"Y Tian","year":"2020","unstructured":"Tian Y, Yang J, Lan M, Zou T. Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure. Aging. 2020;12(24):26221\u201335. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Aging"},{"issue":"7051","key":"5430_CR26","doi-asserted-by":"publisher","first-page":"720","DOI":"10.62476\/abes9s11","volume":"436","author":"C Michaloglou","year":"2005","unstructured":"Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436(7051):720\u20134. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nature"},{"issue":"1","key":"5430_CR27","doi-asserted-by":"publisher","first-page":"10311","DOI":"10.62476\/abes9s11","volume":"22","author":"D Wang","year":"2020","unstructured":"Wang D, Xiao F, Feng Z, Li M, Kong L, Huang L, Wei Y, Li H, Liu F, Zhang H, et al. Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence. Breast Cancer Res. 2020;22(1):10311\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Breast Cancer Res"},{"issue":"1","key":"5430_CR28","doi-asserted-by":"publisher","first-page":"6811","DOI":"10.62476\/abes9s11","volume":"15","author":"MK Conley-LaComb","year":"2016","unstructured":"Conley-LaComb MK, Semaan L, Singareddy R, Li Y, Heath EI, Kim S, Cher ML, Chinni SR. Pharmacological targeting of CXCL12\/CXCR4 signaling in prostate cancer bone metastasis. Mol Cancer. 2016;15(1):6811\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Mol Cancer"},{"issue":"1","key":"5430_CR29","doi-asserted-by":"publisher","first-page":"108811","DOI":"10.62476\/abes9s11","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, Myung P, Plikus MV, Nie Q. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12(1):108811\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Commun"},{"issue":"5","key":"5430_CR30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.62476\/abes9s11","volume":"23","author":"A Salminen","year":"2011","unstructured":"Salminen A, Kaarniranta K. Control of p53 and NF-\u03baB signaling by WIP1 and MIF: role in cellular senescence and organismal aging. Cell Signal. 2011;23(5):747\u201352. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cell Signal"},{"issue":"9","key":"5430_CR31","doi-asserted-by":"publisher","first-page":"555","DOI":"10.62476\/abes9s11","volume":"15","author":"S Shetty","year":"2018","unstructured":"Shetty S, Lalor PF, Adams DH. Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol. 2018;15(9):555\u201367. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"10","key":"5430_CR32","doi-asserted-by":"publisher","first-page":"611","DOI":"10.62476\/abes9s11","volume":"18","author":"W Huang","year":"2022","unstructured":"Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022;18(10):611\u201327. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"5430_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.62476\/abes9s11","volume":"12","author":"A Gazzillo","year":"2023","unstructured":"Gazzillo A, Volponi C, Soldani C, Polidoro MA, Franceschini B, Lleo A, Bonavita E, Donadon M. Cellular Senescence in Liver Cancer: how dying cells become Zombie enemies. Biomedicines. 2023;12(1):11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Biomedicines"},{"key":"5430_CR34","doi-asserted-by":"publisher","first-page":"1520811","DOI":"10.62476\/abes9s11","volume":"8","author":"YH Kim","year":"2017","unstructured":"Kim YH, Choi YW, Lee J, Soh EY, Kim JH, Park TJ. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun. 2017;8:1520811\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Nat Commun"},{"issue":"2","key":"5430_CR35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.62476\/abes9s11","volume":"186","author":"JH Yang","year":"2023","unstructured":"Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023;186(2):305\u2013e326. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Cell"},{"issue":"1","key":"5430_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.62476\/abes9s11","volume":"386","author":"HA Tawbi","year":"2022","unstructured":"Tawbi HA, Schadendorf D, Lipson EJ, Ascierto PA, Matamala L, Castillo Guti\u00e9rrez E, Rutkowski P, Gogas HJ, Lao CD, De Menezes JJ, et al. Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma. N Engl J Med. 2022;386(1):24\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"N Engl J Med"},{"key":"5430_CR37","doi-asserted-by":"publisher","unstructured":"Huseynov E, Novel nanomaterials for hepatobiliary diseases treatment and future perspectives. Adv Biology Earth Sci. 2024;11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","DOI":"10.62476\/abes9s11"},{"key":"5430_CR38","doi-asserted-by":"publisher","unstructured":"Jin S, Wang Y, Wu X, Li Z, Zhu L, Niu Y, Zhou Y, Liu Y. Young Exosome Bio-nanoparticles restore aging-impaired Tendon Stem\/Progenitor cell function and reparative capacity. Adv Mater. 2023;35(18). https:\/\/doi.org\/10.62476\/abes9s11.","DOI":"10.62476\/abes9s11"},{"key":"5430_CR39","doi-asserted-by":"publisher","unstructured":"Khalilov RK, Future prospects of biomaterials in nanomedicine. Adv Biology Earth Sci. 2024;11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","DOI":"10.62476\/abes9s11"},{"issue":"Special Issue","key":"5430_CR40","doi-asserted-by":"publisher","first-page":"11","DOI":"10.62476\/abes9s11","volume":"9","author":"G Rosic","year":"2024","unstructured":"Rosic G, Selakovic D, Omarova S. Cancer signaling, cell\/gene therapy, diagnosis and role of nanobiomaterials. Adv Biology Earth Sci. 2024;9(Special Issue):11\u201334. https:\/\/doi.org\/10.62476\/abes9s11.","journal-title":"Adv Biology Earth Sci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05430-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05430-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05430-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T22:03:10Z","timestamp":1719871390000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05430-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5430"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05430-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"14 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all patients in accordance with the Declaration of Helsinki. This study was approved by the Human Ethics Committee of Ninth People\u2019s Hospital (Shanghai JiaoTong University School of Medicine, Shanghai, China). All experiments on the participants in this study were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests in this section.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"605"}}