{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:59:13Z","timestamp":1793325553246,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Shanghai Health Committee General Project","award":["202140227"],"award-info":[{"award-number":["202140227"]}]},{"name":"Shanghai Health Committee Youth Project","award":["20234Y0117"],"award-info":[{"award-number":["20234Y0117"]}]},{"name":"New Star Project of Hospital in Qingpu District","award":["YY2023-55"],"award-info":[{"award-number":["YY2023-55"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and plays a major role in disability and death in DM patients. NADH: ubiquinone oxidoreductase subunit B5 (NDUFB5) plays an important role in maintaining mitochondrial respiration, but whether it is involved in regulating the progression of advanced glycation end products (AGEs)-mediated DFU is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Firstly, the role of AGEs on cell viability, migration, and mitochondrial respiration in human umbilical vein endothelial cells (HUVECs) was explored in vitro. Next, NDUFB5 expression was detected in human samples and AGEs-treated HUVECs, and NDUFB5\u2019s effect on AGEs-induced HUVECs injury and skin wound in diabetic mice was further clarified. In addition, the role of m6A modification mediated by methyltransferase-like 3 (METTL3) in regulating NDUFB5 expression and AGEs-induced HUVECs injury was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NDUFB5 promoted cell viability, migration, and mitochondrial respiration in AGEs-treated HUVECs, whereas mitochondrial fusion promoter M1 facilitated cell viability, migration, and mitochondrial oxiadative respiration in NDUFB5 knockdown HUVECs. Meanwhile, NDUFB5 promotes skin wound healing in diabetic mice. Besides, METTL3-mediated m6A modification and insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) enhanced NDUFB5 expression in HUVECs. Furthermore, METTL3 promoted cell viability, migration, and mitochondrial respiration in AGEs-treated HUVECs by increasing NDUFB5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>METTL3-mediated NDUFB5 m6A modification inhibits AGEs-induced cell injury in HUVECs. METTL3 and NDUFB5 might serve as potential targets for DFU therapy in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-024-05463-6","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:06:41Z","timestamp":1720512401000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer"],"prefix":"10.1186","volume":"22","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"5463_CR1","doi-asserted-by":"publisher","first-page":"174843","DOI":"10.1016\/j.ejphar.2022.174843","volume":"920","author":"H Sun","year":"2022","unstructured":"Sun H, Zhang A, Gong Y, Sun W, Yan B, Lei S, Yao LH. Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged ins-1 cells. Eur J Pharmacol. 2022;920:174843.","journal-title":"Eur J Pharmacol"},{"issue":"Suppl 1","key":"5463_CR2","doi-asserted-by":"publisher","first-page":"e3272","DOI":"10.1002\/dmrr.3272","volume":"36","author":"M Monteiro-Soares","year":"2020","unstructured":"Monteiro-Soares M, Boyko EJ, Jeffcoate W, Mills JL, Russell D, Morbach S, Game F. Diabetic foot ulcer classifications: a critical review. Diabetes Metab Res Rev. 2020;36(Suppl 1):e3272.","journal-title":"Diabetes Metab Res Rev"},{"key":"5463_CR3","doi-asserted-by":"publisher","first-page":"110991","DOI":"10.1016\/j.biopha.2020.110991","volume":"133","author":"Y Wang","year":"2021","unstructured":"Wang Y, Shao T, Wang J, Huang X, Deng X, Cao Y, Zhou M, Zhao C. An update on potential biomarkers for diagnosing diabetic foot ulcer at early stage. Biomed Pharmacother. 2021;133:110991.","journal-title":"Biomed Pharmacother"},{"key":"5463_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10719-020-09908-0","volume":"37","author":"X Li","year":"2020","unstructured":"Li X, Tao Y, Wang X, Wang T, Liu J. Advanced glycosylation end products (ages) controls proliferation, invasion and permeability through orchestrating arhgap18\/rhoa pathway in human umbilical vein endothelial cells. Glycoconj J. 2020;37:209\u201319.","journal-title":"Glycoconj J"},{"key":"5463_CR5","first-page":"311","volume":"54","author":"X Li","year":"2022","unstructured":"Li X, Wang T, Tao Y, Wang X, Li L, Liu J. Inhibition of usp7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53. Acta Biochim Biophys Sin (Shanghai). 2022;54:311\u201320.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"5463_CR6","doi-asserted-by":"publisher","first-page":"110933","DOI":"10.1016\/j.biopha.2020.110933","volume":"132","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Wang X, Yang S, Song X, Sun N, Chen C, Zhang Y, Yao D, Huang J, Wang J, Zhang Y, Yang B. Kanglexin accelerates diabetic wound healing by promoting angiogenesis via fgfr1\/erk signaling. Biomed Pharmacother. 2020;132:110933.","journal-title":"Biomed Pharmacother"},{"key":"5463_CR7","doi-asserted-by":"publisher","first-page":"3818196","DOI":"10.1155\/2020\/3818196","volume":"2020","author":"A Perrone","year":"2020","unstructured":"Perrone A, Giovino A, Benny J, Martinelli F. Advanced glycation end products (ages): Biochemistry, signaling, analytical methods, and epigenetic effects. Oxid Med Cell Longev. 2020;2020:3818196.","journal-title":"Oxid Med Cell Longev"},{"key":"5463_CR8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12933-015-0176-5","volume":"14","author":"S Yamagishi","year":"2015","unstructured":"Yamagishi S, Fukami K, Matsui T. Crosstalk between advanced glycation end products (ages)-receptor rage axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications. Cardiovasc Diabetol. 2015;14:2.","journal-title":"Cardiovasc Diabetol"},{"key":"5463_CR9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.diabres.2011.12.006","volume":"96","author":"L Zhang","year":"2012","unstructured":"Zhang L, Chen B, Tang L. Metabolic memory: mechanisms and implications for diabetic retinopathy. Diabetes Res Clin Pract. 2012;96:286\u201393.","journal-title":"Diabetes Res Clin Pract"},{"key":"5463_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tem.2013.08.002","volume":"25","author":"MB Manigrasso","year":"2014","unstructured":"Manigrasso MB, Juranek J, Ramasamy R, Schmidt AM. Unlocking the biology of rage in diabetic microvascular complications. Trends Endocrinol Metab. 2014;25:15\u201322.","journal-title":"Trends Endocrinol Metab"},{"key":"5463_CR11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12902-021-00697-7","volume":"21","author":"S Papachristou","year":"2021","unstructured":"Papachristou S, Pafili K, Papanas N. Skin ages and diabetic neuropathy. BMC Endocr Disord. 2021;21:28.","journal-title":"BMC Endocr Disord"},{"key":"5463_CR12","doi-asserted-by":"publisher","first-page":"176083","DOI":"10.1016\/j.ejphar.2023.176083","volume":"959","author":"A Harb","year":"2023","unstructured":"Harb A, Elbatreek MH, Elshahat A, El-Akabawy N, Barakat W, Elkomy NM. Repurposing alagebrium for diabetic foot ulcer healing: impact on ages\/nfkappab\/nox1 signaling. Eur J Pharmacol. 2023;959:176083.","journal-title":"Eur J Pharmacol"},{"key":"5463_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12902-023-01430-2","volume":"23","author":"M Tian","year":"2023","unstructured":"Tian M, Tang J, Huang R, Dong J, Jia H. Circ_072697 knockdown promotes advanced glycation end products-induced cell proliferation and migration in hacat cells via mir-3150a-3p\/kdm2a axis. BMC Endocr Disord. 2023;23:200.","journal-title":"BMC Endocr Disord"},{"key":"5463_CR14","doi-asserted-by":"publisher","first-page":"e13638","DOI":"10.1111\/srt.13638","volume":"30","author":"J Dugrain","year":"2024","unstructured":"Dugrain J, Canaple L, Picard N, Sigaudo-Roussel D, Bonod C. Exploring mitochondrial metabolism of wild-type and diabetic mice skin explants using the seahorse technology. Skin Res Technol. 2024;30:e13638.","journal-title":"Skin Res Technol"},{"key":"5463_CR15","doi-asserted-by":"crossref","unstructured":"Shu DY, Butcher ER, Saint-Geniez M. Suppression of pgc-1\u03b1 drives metabolic dysfunction in tgf\u03b22-induced emt of retinal pigment epithelial cells. Int J Mol Sci 2021;22.","DOI":"10.3390\/ijms22094701"},{"key":"5463_CR16","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.bbrc.2016.11.055","volume":"482","author":"C Wu","year":"2017","unstructured":"Wu C, Xu G, Tsai SA, Freed WJ, Lee CT. Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections. Biochem Biophys Res Commun. 2017;482:282\u20138.","journal-title":"Biochem Biophys Res Commun"},{"key":"5463_CR17","doi-asserted-by":"publisher","first-page":"111283","DOI":"10.1016\/j.intimp.2023.111283","volume":"126","author":"Y Liu","year":"2024","unstructured":"Liu Y, Li Z, Li W, Chen X, Yang L, Lu S, Zhou S, Li M, Xiong W, Zhang X, Liu Y, Zhou J. Discovery of \u03b2-sitosterol\u2019s effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages. Int Immunopharmacol. 2024;126:111283.","journal-title":"Int Immunopharmacol"},{"key":"5463_CR18","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","volume":"29","author":"C Ling","year":"2019","unstructured":"Ling C, Ronn T. Epigenetics in human obesity and type 2 diabetes. Cell Metab. 2019;29:1028\u201344.","journal-title":"Cell Metab"},{"key":"5463_CR19","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/nar\/gkz1206","volume":"48","author":"S An","year":"2020","unstructured":"An S, Huang W, Huang X, Cun Y, Cheng W, Sun X, Ren Z, Chen Y, Chen W, Wang J. Integrative network analysis identifies cell-specific trans regulators of m6a. Nucleic Acids Res. 2020;48:1715\u201329.","journal-title":"Nucleic Acids Res"},{"key":"5463_CR20","doi-asserted-by":"publisher","first-page":"e10529","DOI":"10.7717\/peerj.10529","volume":"9","author":"Y Li","year":"2021","unstructured":"Li Y, Wei W, An S, Jiang J, He J, Zhang H, Wang G, Han J, Liang B, Ye L, Liang H. Identification and analysis of lncrna, microrna and mrna expression profiles and construction of cerna network in talaromyces marneffei-infected thp-1 macrophage. PeerJ. 2021;9:e10529.","journal-title":"PeerJ"},{"key":"5463_CR21","doi-asserted-by":"publisher","first-page":"1221609","DOI":"10.3389\/fimmu.2023.1221609","volume":"14","author":"B Song","year":"2023","unstructured":"Song B, Zeng Y, Cao Y, Zhang J, Xu C, Pan Y, Zhao X, Liu J. Emerging role of mettl3 in inflammatory diseases: mechanisms and therapeutic applications. Front Immunol. 2023;14:1221609.","journal-title":"Front Immunol"},{"key":"5463_CR22","doi-asserted-by":"publisher","first-page":"e22147","DOI":"10.1096\/fj.202101610R","volume":"36","author":"Y Lin","year":"2022","unstructured":"Lin Y, Shen X, Ke Y, Lan C, Chen X, Liang B, Zhang Y, Yan S. Activation of osteoblast ferroptosis via the mettl3\/ask1-p38 signaling pathway in high glucose and high fat (hghf)-induced diabetic bone loss. FASEB J. 2022;36:e22147.","journal-title":"FASEB J"},{"key":"5463_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.7150\/thno.63441","volume":"12","author":"L Suo","year":"2022","unstructured":"Suo L, Liu C, Zhang QY, Yao MD, Ma Y, Yao J, Jiang Q, Yan B. Mettl3-mediated n(6)-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication. Theranostics. 2022;12:277\u201389.","journal-title":"Theranostics"},{"key":"5463_CR24","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.ymthe.2022.01.002","volume":"30","author":"L Jiang","year":"2022","unstructured":"Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, Huang Y, Zhu W, Wang J, Wen J, Meng X, Wu Y. Mettl3-mediated m(6)a modification of timp2 mrna promotes podocyte injury in diabetic nephropathy. Mol Ther. 2022;30:1721\u201340.","journal-title":"Mol Ther"},{"key":"5463_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s11033-023-09089-7","volume":"51","author":"J Shen","year":"2024","unstructured":"Shen J, Chen H, Dai J. Genome-wide screening of m6a profiling of cutaneous wound healing in diabetic mice. Mol Biol Rep. 2024;51:175.","journal-title":"Mol Biol Rep"},{"key":"5463_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s10020-021-00406-z","volume":"27","author":"J Zhou","year":"2021","unstructured":"Zhou J, Wei T, He Z. Adscs enhance vegfr3-mediated lymphangiogenesis via mettl3-mediated vegf-c m(6)a modification to improve wound healing of diabetic foot ulcers. Mol Med. 2021;27:146.","journal-title":"Mol Med"},{"key":"5463_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11010-020-03692-z","volume":"466","author":"Y Guo","year":"2020","unstructured":"Guo Y, Liang F, Zhao F, Zhao J. Resibufogenin suppresses tumor growth and warburg effect through regulating mir-143-3p\/hk2 axis in breast cancer. Mol Cell Biochem. 2020;466:103\u201315.","journal-title":"Mol Cell Biochem"},{"key":"5463_CR28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12890-021-01456-z","volume":"21","author":"Y Yang","year":"2021","unstructured":"Yang Y, Di T, Zhang Z, Liu J, Fu C, Wu Y, Bian T. Dynamic evolution of emphysema and airway remodeling in two mouse models of copd. BMC Pulm Med. 2021;21:134.","journal-title":"BMC Pulm Med"},{"key":"5463_CR29","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1006\/bbrc.1997.7707","volume":"241","author":"C Ton","year":"1997","unstructured":"Ton C, Hwang DM, Dempsey AA, Liew CC. Identification and primary structure of five human nadh-ubiquinone oxidoreductase subunits. Biochem Biophys Res Commun. 1997;241:589\u201394.","journal-title":"Biochem Biophys Res Commun"},{"key":"5463_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","volume":"391","author":"JN Meyer","year":"2017","unstructured":"Meyer JN, Leuthner TC, Luz AL. Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology. 2017;391:42\u201353.","journal-title":"Toxicology"},{"key":"5463_CR31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12943-022-01608-7","volume":"21","author":"B Yao","year":"2022","unstructured":"Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q. Circezh2\/mir-133b\/igf2bp2 aggravates colorectal cancer progression via enhancing the stability of m(6)a-modified creb1 mrna. Mol Cancer. 2022;21:140.","journal-title":"Mol Cancer"},{"key":"5463_CR32","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.tem.2020.05.007","volume":"31","author":"N Dai","year":"2020","unstructured":"Dai N. The diverse functions of imp2\/igf2bp2 in metabolism. Trends Endocrinol Metab. 2020;31:670\u20139.","journal-title":"Trends Endocrinol Metab"},{"key":"5463_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12935-021-01799-x","volume":"21","author":"J Wang","year":"2021","unstructured":"Wang J, Chen L, Qiang P. The role of igf2bp2, an m6a reader gene, in human metabolic diseases and cancers. Cancer Cell Int. 2021;21:99.","journal-title":"Cancer Cell Int"},{"key":"5463_CR34","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nrendo.2011.74","volume":"7","author":"H Vlassara","year":"2011","unstructured":"Vlassara H, Striker GE. Age restriction in diabetes mellitus: a paradigm shift. Nat Rev Endocrinol. 2011;7:526\u201339.","journal-title":"Nat Rev Endocrinol"},{"key":"5463_CR35","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1007\/s00109-005-0688-7","volume":"83","author":"A Bierhaus","year":"2005","unstructured":"Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP. Understanding rage, the receptor for advanced glycation end products. J Mol Med (Berl). 2005;83:876\u201386.","journal-title":"J Mol Med (Berl)"},{"key":"5463_CR36","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2174\/1871527313666140806144831","volume":"13","author":"JC Tobon-Velasco","year":"2014","unstructured":"Tobon-Velasco JC, Cuevas E, Torres-Ramos MA. Receptor for ages (rage) as mediator of nf-kb pathway activation in neuroinflammation and oxidative stress. CNS Neurol Disord Drug Targets. 2014;13:1615\u201326.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"5463_CR37","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.2174\/13816128113199990475","volume":"20","author":"K Fukami","year":"2014","unstructured":"Fukami K, Yamagishi S, Okuda S. Role of ages-rage system in cardiovascular disease. Curr Pharm Des. 2014;20:2395\u2013402.","journal-title":"Curr Pharm Des"},{"key":"5463_CR38","doi-asserted-by":"publisher","first-page":"6989453","DOI":"10.1155\/2016\/6989453","volume":"2016","author":"K Papatheodorou","year":"2016","unstructured":"Papatheodorou K, Papanas N, Banach M, Papazoglou D, Edmonds M. Complications of diabetes 2016. J Diabetes Res. 2016;2016:6989453.","journal-title":"J Diabetes Res"},{"key":"5463_CR39","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/CIRCRESAHA.109.212217","volume":"106","author":"SF Yan","year":"2010","unstructured":"Yan SF, Ramasamy R, Schmidt AM. The rage axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ Res. 2010;106:842\u201353.","journal-title":"Circ Res"},{"key":"5463_CR40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejphar.2018.06.001","volume":"833","author":"D Sanajou","year":"2018","unstructured":"Sanajou D, Ghorbani Haghjo A, Argani H, Aslani S. Age-rage axis blockade in diabetic nephropathy: current status and future directions. Eur J Pharmacol. 2018;833:158\u201364.","journal-title":"Eur J Pharmacol"},{"key":"5463_CR41","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ijcard.2007.10.047","volume":"132","author":"KM Choi","year":"2009","unstructured":"Choi KM, Yoo HJ, Kim HY, Lee KW, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH. Association between endogenous secretory rage, inflammatory markers and arterial stiffness. Int J Cardiol. 2009;132:96\u2013101.","journal-title":"Int J Cardiol"},{"key":"5463_CR42","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.amjhyper.2006.08.009","volume":"20","author":"M McNulty","year":"2007","unstructured":"McNulty M, Mahmud A, Feely J. Advanced glycation end-products and arterial stiffness in hypertension. Am J Hypertens. 2007;20:242\u20137.","journal-title":"Am J Hypertens"},{"key":"5463_CR43","doi-asserted-by":"crossref","unstructured":"Khalid M, Petroianu G, Adem A. Advanced glycation end products and diabetes mellitus: mechanisms and perspectives. Biomolecules 2022;12.","DOI":"10.3390\/biom12040542"},{"key":"5463_CR44","doi-asserted-by":"publisher","first-page":"172797","DOI":"10.1016\/j.ejphar.2019.172797","volume":"867","author":"R Hu","year":"2020","unstructured":"Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wu XH, Wang YJ, Lu L, Wei LB. Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the ampk\/nf-kappab\/nlrp3 signaling pathway in ages-induced huvecs. Eur J Pharmacol. 2020;867:172797.","journal-title":"Eur J Pharmacol"},{"key":"5463_CR45","doi-asserted-by":"publisher","first-page":"147030","DOI":"10.1016\/j.gene.2022.147030","volume":"851","author":"M Cheng","year":"2023","unstructured":"Cheng M, Yang Z, Qiao L, Yang Y, Deng Y, Zhang C, Mi T. Ages induce endothelial cells senescence and endothelial barrier dysfunction via mir-1-3p\/mlck signaling pathways. Gene. 2023;851:147030.","journal-title":"Gene"},{"key":"5463_CR46","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1146\/annurev-biochem-070511-103700","volume":"82","author":"J Hirst","year":"2013","unstructured":"Hirst J. Mitochondrial complex i. Annu Rev Biochem. 2013;82:551\u201375.","journal-title":"Annu Rev Biochem"},{"key":"5463_CR47","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nature19754","volume":"538","author":"DA Stroud","year":"2016","unstructured":"Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT. Accessory subunits are integral for assembly and function of human mitochondrial complex i. Nature. 2016;538:123\u20136.","journal-title":"Nature"},{"key":"5463_CR48","doi-asserted-by":"publisher","first-page":"110931","DOI":"10.1016\/j.cellsig.2023.110931","volume":"112","author":"J Noone","year":"2023","unstructured":"Noone J, Rochfort KD, O\u2019Sullivan F, O\u2019Gorman DJ. Sirt4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion. Cell Signal. 2023;112:110931.","journal-title":"Cell Signal"},{"key":"5463_CR49","doi-asserted-by":"publisher","first-page":"e21620","DOI":"10.1096\/fj.202100067R","volume":"35","author":"M Adebayo","year":"2021","unstructured":"Adebayo M, Singh S, Singh AP, Dasgupta S. Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis. FASEB J. 2021;35:e21620.","journal-title":"FASEB J"},{"key":"5463_CR50","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/joim.13031","volume":"287","author":"L Colina-Tenorio","year":"2020","unstructured":"Colina-Tenorio L, Horten P, Pfanner N, Rampelt H. Shaping the mitochondrial inner membrane in health and disease. J Intern Med. 2020;287:645\u201364.","journal-title":"J Intern Med"},{"key":"5463_CR51","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1111\/febs.15103","volume":"286","author":"CT Madreiter-Sokolowski","year":"2019","unstructured":"Madreiter-Sokolowski CT, Ramadani-Muja J, Ziomek G, Burgstaller S, Bischof H, Koshenov Z, Gottschalk B, Malli R, Graier WF. Tracking intra- and inter-organelle signaling of mitochondria. Febs j. 2019;286:4378\u2013401.","journal-title":"Febs j"},{"key":"5463_CR52","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.gendis.2021.12.005","volume":"9","author":"S An","year":"2022","unstructured":"An S, Xie Z, Liao Y, Jiang J, Dong W, Yin F, Li WX, Ye L, Lin J, Liang H. Systematic analysis of clinical relevance and molecular characterization of m(6)a in covid-19 patients. Genes Dis. 2022;9:1170\u20133.","journal-title":"Genes Dis"},{"key":"5463_CR53","doi-asserted-by":"publisher","first-page":"756288","DOI":"10.3389\/fimmu.2021.756288","volume":"12","author":"S An","year":"2021","unstructured":"An S, Li Y, Lin Y, Chu J, Su J, Chen Q, Wang H, Pan P, Zheng R, Li J, Jiang J, Ye L, Liang H. Genome-wide profiling reveals alternative polyadenylation of innate immune-related mrna in patients with covid-19. Front Immunol. 2021;12:756288.","journal-title":"Front Immunol"},{"key":"5463_CR54","doi-asserted-by":"publisher","first-page":"1223583","DOI":"10.3389\/fendo.2023.1223583","volume":"14","author":"D Benak","year":"2023","unstructured":"Benak D, Benakova S, Plecita-Hlavata L, Hlavackova M. The role of m(6)a and m(6)am rna modifications in the pathogenesis of diabetes mellitus. Front Endocrinol (Lausanne). 2023;14:1223583.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5463_CR55","doi-asserted-by":"crossref","unstructured":"Ren Y, Li Z, Li J, Liang R, Wang Z, Bai Y, Yang Y, Tang Q, Fu Y, Zhang X, Zhang Y, Yu Y, Xiong Y. M(6) a mrna methylation: Biological features, mechanisms, and therapeutic potentials in type 2 diabetes mellitus. Obes Rev 2023.","DOI":"10.1111\/obr.13639"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05463-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T09:11:22Z","timestamp":1720516282000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05463-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5463"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05463-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"12 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted under the approval of the Ethics Committee of the Qingpu Branch of Zhongshan Hospital, affiliated to Fudan University (No.Qingyi2021-20), and all procedures in the animal experiment were conducted in accordance with the <i>Guide for the Care and Use of Laboratory Animals<\/i>.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"643"}}