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TyG-high was defined as a TyG index greater than 8.81 in males and 8.73 in females.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The prevalence of TyG-high status was highest in PDAC-early (68.48%), followed by LAPC (53.33%), and lowest in PDAC-late (44.47%). TyG-high status significantly predicted worse PDAC prognosis (<jats:italic>P<\/jats:italic>\u2009=\u20090.0166), particularly in PDAC-late (<jats:italic>P<\/jats:italic>\u2009=\u20090.0420). Despite similar blood glucose levels across PDAC groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.897), PDAC-early patients showed significantly higher rates of glycemic disturbances (56.33% vs. 32.28%) and TyG-high status (68.48% vs. 47.13%) compared to those with other tumors. Progressive increases in glycemic disturbances and TyG-high status were observed from benign to pre-malignant lesions and PDAC-early. PDAC-early patients at the pancreatic head exhibited higher rates of glycemic disturbances (58.12% vs. 33.33%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), larger pancreatic duct diameters (0.4056\u00a0cm vs. 0.3398\u00a0cm, <jats:italic>P<\/jats:italic>\u2009=\u20090.0043), and poorer prognosis compared to periampullary cancers, although the TyG-high rate and body mass index were similar.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The TyG index exhibits a complex association with PDAC stages, profoundly shaping glycemic profiles. At the initial stages of PDAC, a notable elevation in TyG-high status and glycemic disturbances is observed. However, in advanced PDAC, while the TyG-high rate diminishes, abnormal glucose levels persist.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12967-024-05524-w","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:02:29Z","timestamp":1722358949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis"],"prefix":"10.1186","volume":"22","author":[{"given":"Yunda","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxia","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"5524_CR1","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.2337\/db16-1477","volume":"66","author":"DK Andersen","year":"2017","unstructured":"Andersen DK, Korc M, Petersen GM, et al. 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