{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:10:41Z","timestamp":1780438241748,"version":"3.54.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170809"],"award-info":[{"award-number":["82170809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800291"],"award-info":[{"award-number":["81800291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["7232232"],"award-info":[{"award-number":["7232232"]}]},{"name":"Outstanding Young Talent Program of Beijing Tongren Hospital","award":["2021-YJJ-ZZL-006"],"award-info":[{"award-number":["2021-YJJ-ZZL-006"]}]},{"name":"Beijing Municipal Administration of Hospitals Incubating Program","award":["PX2023006"],"award-info":[{"award-number":["PX2023006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05558-0","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T13:04:01Z","timestamp":1722863041000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Accumulated \u03b2-catenin is associated with human atrial fibrosis and atrial fibrillation"],"prefix":"10.1186","volume":"22","author":[{"given":"Ying","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Feng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Wan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-2333","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"5558_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/ehjqcco\/qcaa093","volume":"8","author":"P Burdett","year":"2022","unstructured":"Burdett P, Lip GYH. Atrial fibrillation in the Uk: Predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs. Eur Heart J Qual care Clin Outcomes. 2022;8:187\u201394.","journal-title":"Eur Heart J Qual care Clin Outcomes"},{"key":"5558_CR2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1055\/s-0040-1716408","volume":"121","author":"TS Potpara","year":"2021","unstructured":"Potpara TS, Lip GYH, Blomstrom-Lundqvist C, Boriani G, Van Gelder IC, Heidbuchel H, et al. The 4s-af scheme (stroke risk; symptoms; severity of burden; substrate): a novel approach to in-depth characterization (rather than classification) of atrial fibrillation. Thromb Haemost. 2021;121:270\u20138.","journal-title":"Thromb Haemost"},{"key":"5558_CR3","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","volume":"14","author":"GYH Lip","year":"2017","unstructured":"Lip GYH. The abc pathway: an integrated approach to improve af management. Nat Rev Cardiol. 2017;14:627\u20138.","journal-title":"Nat Rev Cardiol"},{"key":"5558_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1055\/s-0041-1739411","volume":"122","author":"TF Chao","year":"2022","unstructured":"Chao TF, Joung B, Takahashi Y, Lim TW, Choi EK, Chan YH, et al. 2021 focused update consensus guidelines of the asia pacific heart rhythm society on stroke prevention in atrial fibrillation: executive summary. Thromb Haemost. 2022;122:20\u201347.","journal-title":"Thromb Haemost"},{"key":"5558_CR5","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1073\/pnas.102657399","volume":"99","author":"SS Cheon","year":"2002","unstructured":"Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, et al. Beta-catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA. 2002;99:6973\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5558_CR6","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/S0002-9440(10)64601-9","volume":"157","author":"WM Blankesteijn","year":"2000","unstructured":"Blankesteijn WM, van Gijn ME, Essers-Janssen YP, Daemen MJ, Smits JF. Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Am J Pathol. 2000;157:877\u201383.","journal-title":"Am J Pathol"},{"key":"5558_CR7","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/S0002-9440(10)64282-4","volume":"162","author":"M Chilosi","year":"2003","unstructured":"Chilosi M, Poletti V, Zam\u00f2 A, Lestani M, Montagna L, Piccoli P, et al. Aberrant wnt\/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol. 2003;162:1495\u2013502.","journal-title":"Am J Pathol"},{"key":"5558_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.carpath.2012.03.004","volume":"22","author":"B Ye","year":"2013","unstructured":"Ye B, Ge Y, Perens G, Hong L, Xu H, Fishbein MC, et al. Canonical wnt\/\u03b2-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction. Cardiovasc Pathology: Official J Soc Cardiovasc Pathol. 2013;22:54\u20137.","journal-title":"Cardiovasc Pathology: Official J Soc Cardiovasc Pathol"},{"key":"5558_CR9","doi-asserted-by":"publisher","first-page":"H1324","DOI":"10.1152\/ajpheart.00653.2013","volume":"306","author":"T Nakashima","year":"2014","unstructured":"Nakashima T, Ohkusa T, Okamoto Y, Yoshida M, Lee JK, Mizukami Y, et al. Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014;306:H1324\u20131333.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5558_CR10","first-page":"1","volume":"2019","author":"X Lv","year":"2019","unstructured":"Lv X, Li J, Hu Y, Wang S, Yang C, Li C, et al. Overexpression of mir-27b-3p targeting wnt3a regulates the signaling pathway of wnt\/\u03b2-catenin and attenuates atrial fibrosis in rats with atrial fibrillation. Oxidative Med Cell Longev. 2019;2019:1\u201313.","journal-title":"Oxidative Med Cell Longev"},{"key":"5558_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/0040-8166(85)90001-1","volume":"17","author":"MS Forbes","year":"1985","unstructured":"Forbes MS, Sperelakis N. Intercalated discs of mammalian heart: a review of structure and function. Tissue Cell. 1985;17:605\u201348.","journal-title":"Tissue Cell"},{"key":"5558_CR12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.hlc.2005.06.011","volume":"15","author":"M Wilhelm","year":"2006","unstructured":"Wilhelm M, Kirste W, Kuly S, Amann K, Neuhuber W, Weyand M, et al. Atrial distribution of connexin 40 and 43 in patients with intermittent, persistent, and postoperative atrial fibrillation. Heart Lung Circ. 2006;15:30\u20137.","journal-title":"Heart Lung Circ"},{"key":"5558_CR13","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1136\/hrt.2003.024216","volume":"91","author":"U Wetzel","year":"2005","unstructured":"Wetzel U, Boldt A, Lauschke J, Weigl J, Schirdewahn P, Dorszewski A, et al. Expression of connexins 40 and 43 in human left atrium in atrial fibrillation of different aetiologies. Heart. 2005;91:166\u201370.","journal-title":"Heart"},{"key":"5558_CR14","doi-asserted-by":"crossref","unstructured":"Spagnol G, Trease AJ, Zheng L, Gutierrez M, Basu I, Sarmiento C et al. Connexin43 carboxyl-terminal domain directly interacts with \u03b2-catenin. Int J Mol Sci. 2018;19.","DOI":"10.3390\/ijms19061562"},{"issue":"Pt 12","key":"5558_CR15","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1242\/jcs.107.12.3655","volume":"107","author":"H Aberle","year":"1994","unstructured":"Aberle H, Butz S, Stappert J, Weissig H, Kemler R, Hoschuetzky H. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci. 1994;107(Pt 12):3655\u201363.","journal-title":"J Cell Sci"},{"key":"5558_CR16","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/0955-0674(94)90098-1","volume":"6","author":"J H\u00fclsken","year":"1994","unstructured":"H\u00fclsken J, Behrens J, Birchmeier W. Tumor-suppressor gene products in cell contacts: the cadherin-apc-armadillo connection. Curr Opin Cell Biol. 1994;6:711\u20136.","journal-title":"Curr Opin Cell Biol"},{"key":"5558_CR17","doi-asserted-by":"publisher","first-page":"5067","DOI":"10.1073\/pnas.92.11.5067","volume":"92","author":"TS Jou","year":"1995","unstructured":"Jou TS, Stewart DB, Stappert J, Nelson WJ, Marrs JA. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc Natl Acad Sci USA. 1995;92:5067\u201371.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5558_CR18","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/382638a0","volume":"382","author":"J Behrens","year":"1996","unstructured":"Behrens J, von Kries JP, K\u00fchl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of beta-catenin with the transcription factor lef-1. Nature. 1996;382:638\u201342.","journal-title":"Nature"},{"key":"5558_CR19","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1073\/pnas.231619298","volume":"99","author":"CL Antos","year":"2002","unstructured":"Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, et al. Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA. 2002;99:907\u201312.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5558_CR20","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1002\/cncr.34332","volume":"128","author":"RF Riedel","year":"2022","unstructured":"Riedel RF, Agulnik M. Evolving strategies for management of desmoid tumor. Cancer. 2022;128:3027\u201340.","journal-title":"Cancer"},{"key":"5558_CR21","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","volume":"119","author":"M Ackers-Johnson","year":"2016","unstructured":"Ackers-Johnson M, Li PY, Holmes AP, O\u2019Brien SM, Pavlovic D, Foo RS. A simplified, langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart. Circul Res. 2016;119:909\u201320.","journal-title":"Circul Res"},{"key":"5558_CR22","doi-asserted-by":"crossref","unstructured":"Guo G-r, Chen L, Rao M, Chen K, Song J-p. Hu S-s. A modified method for isolation of human cardiomyocytes to model cardiac diseases. J Translational Med. 2018;16.","DOI":"10.1186\/s12967-018-1649-6"},{"key":"5558_CR23","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.hrthm.2019.04.008","volume":"16","author":"L Jiang","year":"2019","unstructured":"Jiang L, Li L, Ruan Y, Zuo S, Wu X, Zhao Q, et al. Ibrutinib promotes atrial fibrillation by inducing structural remodeling and calcium dysregulation in the atrium. Heart Rhythm. 2019;16:1374\u201382.","journal-title":"Heart Rhythm"},{"key":"5558_CR24","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/cr.2018.11","volume":"28","author":"M Duan","year":"2018","unstructured":"Duan M, Hao J, Cui S, Worthley DL, Zhang S, Wang Z, et al. Diverse modes of clonal evolution in hbv-related hepatocellular carcinoma revealed by single-cell genome sequencing. Cell Res. 2018;28:359\u201373.","journal-title":"Cell Res"},{"key":"5558_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4103\/0366-6999.222330","volume":"131","author":"Y Bai","year":"2018","unstructured":"Bai Y, Shi XB, Zhang YQ, Wang YL, Liu XY, Esteve-Pastor MA. Differences of matrix metalloproteinase 2 expression between left and right ventricles in response to nandrolone decanoate and\/or swimming training in mice. Chin Med J (Engl). 2018;131:207\u201312.","journal-title":"Chin Med J (Engl)"},{"key":"5558_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cbi.2019.04.024","volume":"307","author":"L Shang","year":"2019","unstructured":"Shang L, Pin L, Zhu S, Zhong X, Zhang Y, Shun M, et al. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the hdac2 and akt\/ gsk-3\u03b2 signaling pathway. Chem Biol Interact. 2019;307:21\u20138.","journal-title":"Chem Biol Interact"},{"key":"5558_CR27","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.2337\/db20-0069","volume":"69","author":"H Wang","year":"2020","unstructured":"Wang H, Mizuno K, Takahashi N, Kobayashi E, Shirakawa J, Terauchi Y, et al. Melanophilin accelerates insulin granule fusion without predocking to the plasma membrane. Diabetes. 2020;69:2655\u201366.","journal-title":"Diabetes"},{"key":"5558_CR28","doi-asserted-by":"crossref","unstructured":"Wang H, Yuan Y-C, Chang C, Izumi T, Wang H-H, Yang J-K. The signaling protein giv\/girdin mediates the nephrin-dependent insulin secretion of pancreatic islet \u03b2 cells in response to high glucose. J Biol Chem. 2023;299.","DOI":"10.1016\/j.jbc.2023.103045"},{"key":"5558_CR29","doi-asserted-by":"publisher","first-page":"C723","DOI":"10.1152\/ajpcell.00462.2010","volume":"300","author":"KW Dunn","year":"2011","unstructured":"Dunn KW, Kamocka MM, McDonald JH. A practical guide to evaluating colocalization in biological microscopy. Am J Physiology-Cell Physiol. 2011;300:C723\u201342.","journal-title":"Am J Physiology-Cell Physiol"},{"key":"5558_CR30","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1540-8167.2011.02187.x","volume":"23","author":"D Corradi","year":"2012","unstructured":"Corradi D, Callegari S, Maestri R, Ferrara D, Mangieri D, Alinovi R, et al. Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study. J Cardiovasc Electrophys. 2012;23:271\u20139.","journal-title":"J Cardiovasc Electrophys"},{"key":"5558_CR31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.carpath.2013.12.001","volume":"23","author":"D Corradi","year":"2014","unstructured":"Corradi D. Atrial fibrillation from the pathologist\u2019s perspective. Cardiovasc Pathology: Official J Soc Cardiovasc Pathol. 2014;23:71\u201384.","journal-title":"Cardiovasc Pathology: Official J Soc Cardiovasc Pathol"},{"key":"5558_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1172\/JCI7798","volume":"105","author":"Z Ai","year":"2000","unstructured":"Ai Z, Fischer A, Spray DC, Brown AM, Fishman GI. Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest. 2000;105:161\u201371.","journal-title":"J Clin Invest"},{"key":"5558_CR33","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1161\/01.CIR.99.11.1508","volume":"99","author":"A Hagendorff","year":"1999","unstructured":"Hagendorff A, Schumacher B, Kirchhoff S, L\u00fcderitz B, Willecke K. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation. Circulation. 1999;99:1508\u201315.","journal-title":"Circulation"},{"key":"5558_CR34","first-page":"625","volume":"66","author":"N Tribulova","year":"2015","unstructured":"Tribulova N, Egan Benova T, Szeiffova Bacova B, Viczenczova C, Barancik M. New aspects of pathogenesis of atrial fibrillation: remodelling of intercalated discs. J Physiol Pharmacol. 2015;66:625\u201334.","journal-title":"J Physiol Pharmacol"},{"key":"5558_CR35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2017.08.011","volume":"492","author":"B Kim","year":"2017","unstructured":"Kim B, Song TY, Jung KY, Kim SG, Cho EJ. Direct interaction of menin leads to ubiquitin-proteasomal degradation of \u03b2-catenin. Biochem Biophys Res Commun. 2017;492:128\u201334.","journal-title":"Biochem Biophys Res Commun"},{"key":"5558_CR36","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41419-018-0645-3","volume":"9","author":"C Chen","year":"2018","unstructured":"Chen C, Zhu D, Zhang H, Han C, Xue G, Zhu T, et al. Yap-dependent ubiquitination and degradation of \u03b2-catenin mediates inhibition of wnt signalling induced by physalin f in colorectal cancer. Cell Death Dis. 2018;9:591.","journal-title":"Cell Death Dis"},{"key":"5558_CR37","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.cell.2012.05.002","volume":"149","author":"VS Li","year":"2012","unstructured":"Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, et al. Wnt signaling through inhibition of \u03b2-catenin degradation in an intact axin1 complex. Cell. 2012;149:1245\u201356.","journal-title":"Cell"},{"key":"5558_CR38","doi-asserted-by":"crossref","unstructured":"Lai CH, Pandey S, Day CH, Ho TJ, Chen RJ, Chang RL et al. \u0392-catenin\/lef1\/igf-iir signaling axis galvanizes the angiotensin-ii- induced cardiac hypertrophy. Int J Mol Sci. 2019;20.","DOI":"10.3390\/ijms20174288"},{"key":"5558_CR39","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","volume":"65","author":"F van Roy","year":"2008","unstructured":"van Roy F, Berx G. The cell-cell adhesion molecule e-cadherin. Cell Mol Life Sci. 2008;65:3756\u201388.","journal-title":"Cell Mol Life Sci"},{"key":"5558_CR40","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1038\/emboj.2012.150","volume":"31","author":"T Valenta","year":"2012","unstructured":"Valenta T, Hausmann G, Basler K. The many faces and functions of \u03b2-catenin. Embo j. 2012;31:2714\u201336.","journal-title":"Embo j"},{"key":"5558_CR41","doi-asserted-by":"crossref","unstructured":"Bian J, Dannappel M, Wan C, Firestein R. Transcriptional regulation of wnt\/\u03b2-catenin pathway in colorectal cancer. Cells. 2020;9.","DOI":"10.3390\/cells9092125"},{"key":"5558_CR42","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.3892\/ol.2014.1970","volume":"7","author":"L Kanczuga-Koda","year":"2014","unstructured":"Kanczuga-Koda L, Wincewicz A, Fudala A, Abrycki T, Famulski W, Baltaziak M, et al. E-cadherin and \u03b2-catenin adhesion proteins correlate positively with connexins in colorectal cancer. Oncol Lett. 2014;7:1863\u201370.","journal-title":"Oncol Lett"},{"key":"5558_CR43","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41420-021-00654-2","volume":"7","author":"H Li","year":"2021","unstructured":"Li H, Liu S, Jin R, Xu H, Li Y, Chen Y, et al. Pyrvinium pamoate regulates mgmt expression through suppressing the wnt\/\u03b2-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide. Cell Death Discovery. 2021;7:288.","journal-title":"Cell Death Discovery"},{"key":"5558_CR44","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1111\/jce.13200","volume":"28","author":"A Fukui","year":"2017","unstructured":"Fukui A, Ikebe-Ebata Y, Kondo H, Saito S, Aoki K, Fukunaga N, et al. Hyperleptinemia exacerbates high\u2010fat diet\u2010mediated atrial fibrosis and fibrillation. J Cardiovasc Electrophys. 2017;28:702\u201310.","journal-title":"J Cardiovasc Electrophys"},{"key":"5558_CR45","doi-asserted-by":"crossref","unstructured":"Deli MA, Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E et al. Pyrvinium, a potent small molecule wnt inhibitor, promotes wound repair and post-mi cardiac remodeling. PLoS ONE. 2010;5.","DOI":"10.1371\/journal.pone.0015521"},{"key":"5558_CR46","doi-asserted-by":"publisher","first-page":"5703764","DOI":"10.1155\/2019\/5703764","volume":"2019","author":"X Lv","year":"2019","unstructured":"Lv X, Li J, Hu Y, Wang S, Yang C, Li C, et al. Overexpression of mir-27b-3p targeting wnt3a regulates the signaling pathway of wnt\/\u03b2-catenin and attenuates atrial fibrosis in rats with atrial fibrillation. Oxid Med Cell Longev. 2019;2019:5703764.","journal-title":"Oxid Med Cell Longev"},{"key":"5558_CR47","doi-asserted-by":"publisher","first-page":"679","DOI":"10.5114\/aoms.2015.52375","volume":"11","author":"H Yang","year":"2015","unstructured":"Yang H, Wu C, Xiao Y, Zhou S. Connexin and fibrosis related micrornas in complex fractionated atrial electrograms. Archives Med Science: AMS. 2015;11:679\u201382.","journal-title":"Archives Med Science: AMS"},{"key":"5558_CR48","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/bies.950180907","volume":"18","author":"DB Gros","year":"1996","unstructured":"Gros DB, Jongsma HJ. Connexins in mammalian heart function. BioEssays: News Reviews Mol Cell Dev Biology. 1996;18:719\u201330.","journal-title":"BioEssays: News Reviews Mol Cell Dev Biology"},{"key":"5558_CR49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cardiores.2003.12.009","volume":"62","author":"BN Giepmans","year":"2004","unstructured":"Giepmans BN. Gap junctions and connexin-interacting proteins. Cardiovascular Res. 2004;62:233\u201345.","journal-title":"Cardiovascular Res"},{"key":"5558_CR50","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1161\/CIRCRESAHA.108.183400","volume":"105","author":"B Burstein","year":"2009","unstructured":"Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh YH, et al. Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circul Res. 2009;105:1213\u201322.","journal-title":"Circul Res"},{"key":"5558_CR51","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000210398","volume":"114","author":"X Liu","year":"2009","unstructured":"Liu X, Shi HF, Tan HW, Wang XH, Zhou L, Gu JN. Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms. Cardiology. 2009;114:22\u20139.","journal-title":"Cardiology"},{"key":"5558_CR52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.yjmcc.2015.08.001","volume":"87","author":"V Meraviglia","year":"2015","unstructured":"Meraviglia V, Azzimato V, Colussi C, Florio MC, Binda A, Panariti A, et al. Acetylation mediates cx43 reduction caused by electrical stimulation. J Mol Cell Cardiol. 2015;87:54\u201364.","journal-title":"J Mol Cell Cardiol"},{"key":"5558_CR53","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1055\/s-0032-1332795","volume":"61","author":"B Pfannm\u00fcller","year":"2013","unstructured":"Pfannm\u00fcller B, Boldt A, Reutemann A, Duerrschmidt N, Krabbes-Graube S, Mohr FW, et al. Gender-specific remodeling in atrial fibrillation? Thorac Cardiovasc Surg. 2013;61:66\u201373.","journal-title":"Thorac Cardiovasc Surg"},{"key":"5558_CR54","doi-asserted-by":"publisher","first-page":"H1231","DOI":"10.1152\/ajpheart.00607.2006","volume":"293","author":"K Ryu","year":"2007","unstructured":"Ryu K, Li L, Khrestian CM, Matsumoto N, Sahadevan J, Ruehr ML, et al. Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias. Am J Physiol Heart Circ Physiol. 2007;293:H1231\u20131241.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5558_CR55","doi-asserted-by":"publisher","first-page":"H1402","DOI":"10.1152\/ajpheart.01094.2010","volume":"300","author":"JM Tuomi","year":"2011","unstructured":"Tuomi JM, Tyml K, Jones DL. Atrial tachycardia\/fibrillation in the connexin 43 g60s mutant (oculodentodigital dysplasia) mouse. Am J Physiol Heart Circ Physiol. 2011;300:H1402\u20131411.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5558_CR56","doi-asserted-by":"publisher","first-page":"H1324","DOI":"10.1152\/ajpheart.00653.2013","volume":"306","author":"T Nakashima","year":"2014","unstructured":"Nakashima T, Ohkusa T, Okamoto Y, Yoshida M, Lee J-K, Mizukami Y, et al. Rapid electrical stimulation causes alterations in cardiac intercellular junction proteins of cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014;306:H1324\u201333.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5558_CR57","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.yjmcc.2007.06.006","volume":"43","author":"J Qu","year":"2007","unstructured":"Qu J, Zhou J, Yi XP, Dong B, Zheng H, Miller LM, et al. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction. J Mol Cell Cardiol. 2007;43:319\u201326.","journal-title":"J Mol Cell Cardiol"},{"key":"5558_CR58","doi-asserted-by":"publisher","first-page":"4610","DOI":"10.1073\/pnas.0835895100","volume":"100","author":"S Haq","year":"2003","unstructured":"Haq S, Michael A, Andreucci M, Bhattacharya K, Dotto P, Walters B, et al. Stabilization of beta-catenin by a wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci USA. 2003;100:4610\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 8","key":"5558_CR59","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1242\/jcs.112.8.1237","volume":"112","author":"S Orsulic","year":"1999","unstructured":"Orsulic S, Huber O, Aberle H, Arnold S, Kemler R. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin\/lef-1-mediated transactivation. J Cell Sci. 1999;112(Pt 8):1237\u201345.","journal-title":"J Cell Sci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05558-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05558-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05558-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T14:03:34Z","timestamp":1722866614000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05558-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5558"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05558-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]},"assertion":[{"value":"1 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by clinical research ethics committee of Beijing Tongren Hospital (No.2021-041) and Beijing Anzhen Hospital (No. 2021038X), Capital Medical University and individual written consent was obtained from each patient before inclusion. Animal experiments followed the national ethical guidelines implemented by our Institutional Animal Care and Use Committee and were approved by the Ethical Review Committee of the Institute of Zoology, Capital Medical University, Beijing, China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no conflicts of interest with the contents of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"734"}}