{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:20:43Z","timestamp":1790274043708,"version":"4.1.0"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Thailand Science Research and Innovation Fund"},{"DOI":"10.13039\/501100010724","name":"Health systems research institute","doi-asserted-by":"crossref","award":["66-101"],"award-info":[{"award-number":["66-101"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A650229"],"award-info":[{"award-number":["N42A650229"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05589-7","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T18:04:13Z","timestamp":1724177053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Cathepsin C in health and disease: from structural insights to therapeutic prospects"],"prefix":"10.1186","volume":"22","author":[{"given":"Chakriya","family":"Chitsamankhun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutwara","family":"Siritongtaworn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P. J.","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokwan","family":"Sriwattanapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanakorn","family":"Theerapanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshman","family":"Samaranayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-9801","authenticated-orcid":false,"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"5589_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113818","volume":"225","author":"XB Shen","year":"2021","unstructured":"Shen XB, Chen X, Zhang ZY, Wu FF, Liu XH. Cathepsin C inhibitors as anti-inflammatory drug discovery: challenges and opportunities. Eur J Med Chem. 2021;225: 113818. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113818.","journal-title":"Eur J Med Chem"},{"issue":"16","key":"5589_CR2","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.1073\/pnas.1200470109","volume":"109","author":"NC Perera","year":"2012","unstructured":"Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE. NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proc Natl Acad Sci USA. 2012;109(16):6229\u201334. https:\/\/doi.org\/10.1073\/pnas.1200470109.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"5589_CR3","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nri1841","volume":"6","author":"CT Pham","year":"2006","unstructured":"Pham CT. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol. 2006;6(7):541\u201350. https:\/\/doi.org\/10.1038\/nri1841.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"5589_CR4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s42003-020-01407-0","volume":"3","author":"AP AhYoung","year":"2020","unstructured":"AhYoung AP, Eckard SC, Gogineni A, Xi H, Lin SJ, Gerhardy S, et al. Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. Commun Biol. 2020;3(1):687. https:\/\/doi.org\/10.1038\/s42003-020-01407-0.","journal-title":"Commun Biol"},{"issue":"15","key":"5589_CR5","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.1073\/pnas.96.15.8627","volume":"96","author":"CT Pham","year":"1999","unstructured":"Pham CT, Ley TJ. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A. 1999;96(15):8627\u201332. https:\/\/doi.org\/10.1073\/pnas.96.15.8627.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"5589_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1172\/jci13462","volume":"109","author":"AM Adkison","year":"2002","unstructured":"Adkison AM, Raptis SZ, Kelley DG, Pham CT. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest. 2002;109(3):363\u201371. https:\/\/doi.org\/10.1172\/jci13462.","journal-title":"J Clin Invest"},{"key":"5589_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.pharmthera.2018.05.011","volume":"190","author":"B Korkmaz","year":"2018","unstructured":"Korkmaz B, Caughey GH, Chapple I, Gauthier F, Hirschfeld J, Jenne DE, et al. Therapeutic targeting of cathepsin C: from pathophysiology to treatment. Pharmacol Ther. 2018;190:202\u201336. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.05.011.","journal-title":"Pharmacol Ther"},{"issue":"6","key":"5589_CR8","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/cpt.1053","volume":"104","author":"R Palm\u00e9r","year":"2018","unstructured":"Palm\u00e9r R, M\u00e4enp\u00e4\u00e4 J, Jauhiainen A, Larsson B, Mo J, Russell M, et al. Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure-dependent reduction in neutrophil elastase activity in healthy subjects. Clin Pharmacol Ther. 2018;104(6):1155\u201364. https:\/\/doi.org\/10.1002\/cpt.1053.","journal-title":"Clin Pharmacol Ther"},{"issue":"12","key":"5589_CR9","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/s2213-2600(22)00261-2","volume":"10","author":"HR Keir","year":"2022","unstructured":"Keir HR, Long MB, Abo-Leyah H, Giam YH, Vadiveloo T, Pembridge T, et al. Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial. Lancet Respir Med. 2022;10(12):1119\u201328. https:\/\/doi.org\/10.1016\/s2213-2600(22)00261-2.","journal-title":"Lancet Respir Med"},{"issue":"10","key":"5589_CR10","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1002\/ajmg.a.61316","volume":"179","author":"M de La Dure-Molla","year":"2019","unstructured":"de La Dure-Molla M, Fournier BP, Manzanares MC, Acevedo AC, Hennekam RC, Friedlander L, et al. Elements of morphology: standard terminology for the teeth and classifying genetic dental disorders. Am J Med Genet Part A. 2019;179(10):1913\u201381. https:\/\/doi.org\/10.1002\/ajmg.a.61316.","journal-title":"Am J Med Genet Part A"},{"issue":"2","key":"5589_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2019.140345","volume":"1868","author":"ND Rawlings","year":"2020","unstructured":"Rawlings ND. Twenty-five years of nomenclature and classification of proteolytic enzymes. Biochim Biophys Acta Proteins Proteom. 2020;1868(2): 140345. https:\/\/doi.org\/10.1016\/j.bbapap.2019.140345.","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"issue":"D1","key":"5589_CR12","doi-asserted-by":"publisher","first-page":"D343","DOI":"10.1093\/nar\/gkv1118","volume":"44","author":"ND Rawlings","year":"2016","unstructured":"Rawlings ND, Barrett AJ, Finn R. Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res. 2016;44(D1):D343\u201350. https:\/\/doi.org\/10.1093\/nar\/gkv1118.","journal-title":"Nucleic Acids Res"},{"key":"5589_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/B978-0-12-819460-7.00212-7","volume-title":"Encyclopedia of biological chemistry III","author":"P Sijwali","year":"2021","unstructured":"Sijwali P, Nivya MA. Cysteine proteases. In: Joseph J, editor. Encyclopedia of biological chemistry III. 3rd ed. Amsterdam: Elsevier; 2021. p. 270\u20139.","edition":"3"},{"key":"5589_CR14","first-page":"1","volume-title":"xPharm: the comprehensive pharmacology reference","author":"KH Cathepsins","year":"2007","unstructured":"Cathepsins KH. In: Enna SJ, Bylund DB, editors. xPharm: the comprehensive pharmacology reference. New York: Elsevier; 2007. p. 1\u20134."},{"issue":"12","key":"5589_CR15","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.1021\/cr0101656","volume":"102","author":"F Lecaille","year":"2002","unstructured":"Lecaille F, Kaleta J, Br\u00f6mme D. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev. 2002;102(12):4459\u201388. https:\/\/doi.org\/10.1021\/cr0101656.","journal-title":"Chem Rev"},{"issue":"7","key":"5589_CR16","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1038\/emboj.2012.42","volume":"31","author":"B Turk","year":"2012","unstructured":"Turk B, Turk D, Turk V. Protease signalling: the cutting edge. Embo J. 2012;31(7):1630\u201343. https:\/\/doi.org\/10.1038\/emboj.2012.42.","journal-title":"Embo J"},{"issue":"23","key":"5589_CR17","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1093\/emboj\/20.23.6570","volume":"20","author":"D Turk","year":"2001","unstructured":"Turk D, Janji\u0107 V, Stern I, Podobnik M, Lamba D, Dahl SW, et al. Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. Embo J. 2001;20(23):6570\u201382. https:\/\/doi.org\/10.1093\/emboj\/20.23.6570.","journal-title":"Embo J"},{"key":"5589_CR18","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/B0-12-370879-6\/00058-2","volume-title":"Encyclopedia of respiratory medicine","author":"F B\u00fchling","year":"2006","unstructured":"B\u00fchling F. Cysteine proteases, cathepsins. In: Laurent GJ, Shapiro SD, editors. Encyclopedia of respiratory medicine. Oxford: Academic Press; 2006. p. 594\u20139."},{"issue":"6","key":"5589_CR19","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1021\/bi001693z","volume":"40","author":"SW Dahl","year":"2001","unstructured":"Dahl SW, Halkier T, Lauritzen C, Dolenc I, Pedersen J, Turk V, Turk B. Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. Biochemistry. 2001;40(6):1671\u20138. https:\/\/doi.org\/10.1021\/bi001693z.","journal-title":"Biochemistry"},{"issue":"16","key":"5589_CR20","doi-asserted-by":"publisher","first-page":"8486","DOI":"10.1074\/jbc.M115.707109","volume":"291","author":"Y Hamon","year":"2016","unstructured":"Hamon Y, Legowska M, Herv\u00e9 V, Dallet-Choisy S, Marchand-Adam S, Vanderlynden L, et al. Neutrophilic Cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases. J Biol Chem. 2016;291(16):8486\u201399. https:\/\/doi.org\/10.1074\/jbc.M115.707109.","journal-title":"J Biol Chem"},{"key":"5589_CR21","doi-asserted-by":"crossref","unstructured":"Turk B, Turk D, Dolenc I, Turk V. Chapter 448\u2014Dipeptidyl-Peptidase I. In: Rawlings ND, Salvesen G, editors. Handbook of proteolytic enzymes, 3rd Edition. Academic Press; 2013. p. 1968\u201374.","DOI":"10.1016\/B978-0-12-382219-2.00447-6"},{"issue":"25","key":"5589_CR22","doi-asserted-by":"publisher","first-page":"16312","DOI":"10.1016\/S0021-9258(18)55298-4","volume":"266","author":"K Ishidoh","year":"1991","unstructured":"Ishidoh K, Muno D, Sato N, Kominami E. Molecular cloning of cDNA for rat cathepsin C. Cathepsin C, a cysteine proteinase with an extremely long propeptide. J Biol Chem. 1991;266(25):16312\u20137. https:\/\/doi.org\/10.1016\/S0021-9258(18)55298-4.","journal-title":"J Biol Chem"},{"issue":"15","key":"5589_CR23","doi-asserted-by":"publisher","first-page":"10260","DOI":"10.1074\/jbc.272.15.10260","volume":"272","author":"NV Rao","year":"1997","unstructured":"Rao NV, Rao GV, Hoidal JR. Human dipeptidyl-peptidase I: gene characterization, localization, and expression. J Biol Chem. 1997;272(15):10260\u20135. https:\/\/doi.org\/10.1074\/jbc.272.15.10260.","journal-title":"J Biol Chem"},{"issue":"4","key":"5589_CR24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s00281-013-0362-z","volume":"35","author":"B Korkmaz","year":"2013","unstructured":"Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, et al. Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis). Semin Immunopathol. 2013;35(4):411\u201321. https:\/\/doi.org\/10.1007\/s00281-013-0362-z.","journal-title":"Semin Immunopathol"},{"issue":"3","key":"5589_CR25","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0014-5793(01)02911-8","volume":"506","author":"JG Olsen","year":"2001","unstructured":"Olsen JG, Kadziola A, Lauritzen C, Pedersen J, Larsen S, Dahl SW. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain. FEBS Lett. 2001;506(3):201\u20136. https:\/\/doi.org\/10.1016\/S0014-5793(01)02911-8.","journal-title":"FEBS Lett"},{"issue":"6","key":"5589_CR26","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1021\/jm401705g","volume":"57","author":"M Furber","year":"2014","unstructured":"Furber M, Tiden AK, Gardiner P, Mete A, Ford R, Millichip I, et al. Cathepsin C inhibitors: property optimization and identification of a clinical candidate. J Med Chem. 2014;57(6):2357\u201367. https:\/\/doi.org\/10.1021\/jm401705g.","journal-title":"J Med Chem"},{"issue":"3","key":"5589_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1042\/bj20061389","volume":"401","author":"A M\u00f8lgaard","year":"2007","unstructured":"M\u00f8lgaard A, Arnau J, Lauritzen C, Larsen S, Petersen G, Pedersen J. The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2. Biochem J. 2007;401(3):645\u201350. https:\/\/doi.org\/10.1042\/bj20061389.","journal-title":"Biochem J"},{"issue":"3","key":"5589_CR28","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1046\/j.1432-1327.1999.00697.x","volume":"264","author":"B Cigic","year":"1999","unstructured":"Cigic B, Pain RH. Location of the binding site for chloride ion activation of cathepsin C. Eur J Biochem. 1999;264(3):944\u201351. https:\/\/doi.org\/10.1046\/j.1432-1327.1999.00697.x.","journal-title":"Eur J Biochem"},{"issue":"7","key":"5589_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1686","volume":"9","author":"H Yu","year":"2021","unstructured":"Yu H, He X, Liu X, Zhang H, Shen Z, Shi Y, Liu X. A novel missense variant in cathepsin C gene leads to PLS in a Chinese patient: a case report and literature review. Mol Genet Genomic Med. 2021;9(7): e1686. https:\/\/doi.org\/10.1002\/mgg3.1686.","journal-title":"Mol Genet Genomic Med"},{"issue":"3","key":"5589_CR30","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/0972-124x.75919","volume":"14","author":"P Pahwa","year":"2010","unstructured":"Pahwa P, Lamba AK, Faraz F, Tandon S. Haim-Munk syndrome. J Indian Soc Periodontol. 2010;14(3):201\u20133. https:\/\/doi.org\/10.4103\/0972-124x.75919.","journal-title":"J Indian Soc Periodontol"},{"issue":"S1","key":"5589_CR31","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.1002\/JPER.16-0480","volume":"89","author":"JM Albandar","year":"2018","unstructured":"Albandar JM, Susin C, Hughes FJ. Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: case definitions and diagnostic considerations. J Periodontol. 2018;89(S1):S183\u2013203. https:\/\/doi.org\/10.1002\/JPER.16-0480.","journal-title":"J Periodontol"},{"issue":"1","key":"5589_CR32","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.tripleo.2009.03.016","volume":"108","author":"PJ Dhanrajani","year":"2009","unstructured":"Dhanrajani PJ. Papillon-Lefevre syndrome: clinical presentation and a brief review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(1):e1-7. https:\/\/doi.org\/10.1016\/j.tripleo.2009.03.016.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"3","key":"5589_CR33","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1067\/mjd.2003.197","volume":"48","author":"C Ullbro","year":"2003","unstructured":"Ullbro C, Crossner CG, Nederfors T, Alfadley A, Thestrup-Pedersen K. Dermatologic and oral findings in a cohort of 47 patients with Papillon\u2013Lef\u00e8vre syndrome. J Am Acad Dermatol. 2003;48(3):345\u201351. https:\/\/doi.org\/10.1067\/mjd.2003.197.","journal-title":"J Am Acad Dermatol"},{"key":"5589_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2147\/ccide.S76080","volume":"7","author":"B Sreeramulu","year":"2015","unstructured":"Sreeramulu B, Shyam ND, Ajay P, Suman P. Papillon\u2013Lef\u00e8vre syndrome: clinical presentation and management options. Clin Cosmet Investig Dent. 2015;7:75\u201381. https:\/\/doi.org\/10.2147\/ccide.S76080.","journal-title":"Clin Cosmet Investig Dent"},{"issue":"5","key":"5589_CR35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1902\/jop.1995.66.5.413","volume":"66","author":"FN Hattab","year":"1995","unstructured":"Hattab FN, Rawashdeh MA, Yassin OM, al-Momani AS, al-Ubosi MM. Papillon\u2013Lef\u00e8vre syndrome: a review of the literature and report of 4 cases. J Periodontol. 1995;66(5):413\u201320. https:\/\/doi.org\/10.1902\/jop.1995.66.5.413.","journal-title":"J Periodontol"},{"issue":"2","key":"5589_CR36","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/jmg.37.2.88","volume":"37","author":"TC Hart","year":"2000","unstructured":"Hart TC, Hart PS, Michalec MD, Zhang Y, Firatli E, Van Dyke TE, et al. Haim-Munk syndrome and Papillon\u2013Lef\u00e8vre syndrome are allelic mutations in cathepsin C. J Med Genet. 2000;37(2):88\u201394. https:\/\/doi.org\/10.1136\/jmg.37.2.88.","journal-title":"J Med Genet"},{"issue":"5","key":"5589_CR37","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1365-4632.2010.04300.x","volume":"49","author":"R Rai","year":"2010","unstructured":"Rai R, Thiagarajan S, Mohandas S, Natarajan K, Shanmuga Sekar C, Ramalingam S. Haim Munk syndrome and Papillon Lefevre syndrome\u2014allelic mutations in cathepsin C with variation in phenotype. Int J Dermatol. 2010;49(5):541\u20133. https:\/\/doi.org\/10.1111\/j.1365-4632.2010.04300.x.","journal-title":"Int J Dermatol"},{"issue":"11","key":"5589_CR38","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1902\/jop.2003.74.11.1696","volume":"74","author":"Science Therapy Committee of the American Academy of Periodontology","year":"2003","unstructured":"Science Therapy Committee of the American Academy of Periodontology. Position paper: periodontal diseases of children and adolescents. J Periodontol. 2003;74(11):1696\u2013704. https:\/\/doi.org\/10.1902\/jop.2003.74.11.1696.","journal-title":"J Periodontol"},{"issue":"10","key":"5589_CR39","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1177\/154405910808701017","volume":"87","author":"B Noack","year":"2008","unstructured":"Noack B, G\u00f6rgens H, Hempel U, Fangh\u00e4nel J, Hoffmann T, Ziegler A, Schackert HK. Cathepsin C gene variants in aggressive periodontitis. J Dent Res. 2008;87(10):958\u201363. https:\/\/doi.org\/10.1177\/154405910808701017.","journal-title":"J Dent Res"},{"issue":"26","key":"5589_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1034\/j.1600-0757.2001.2260106.x","volume":"2001","author":"P Hodge","year":"2000","unstructured":"Hodge P, Michalowicz B. Genetic predisposition to periodontitis in children and young adults. Periodontol. 2000;2001(26):113\u201334. https:\/\/doi.org\/10.1034\/j.1600-0757.2001.2260106.x.","journal-title":"Periodontol"},{"issue":"6","key":"5589_CR41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/154411130301400605","volume":"14","author":"DF Kinane","year":"2003","unstructured":"Kinane DF, Hart TC. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med. 2003;14(6):430\u201349. https:\/\/doi.org\/10.1177\/154411130301400605.","journal-title":"Crit Rev Oral Biol Med"},{"issue":"Suppl 6","key":"5589_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1600-051X.2005.00806.x","volume":"32","author":"BG Loos","year":"2005","unstructured":"Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol. 2005;32(Suppl 6):159\u201379. https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00806.x.","journal-title":"J Clin Periodontol"},{"issue":"5","key":"5589_CR43","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.4049\/jimmunol.1301293","volume":"191","author":"NC Perera","year":"2013","unstructured":"Perera NC, Wiesm\u00fcller KH, Larsen MT, Schacher B, Eickholz P, Borregaard N, Jenne DE. NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. J Immunol. 2013;191(5):2700\u20137. https:\/\/doi.org\/10.4049\/jimmunol.1301293.","journal-title":"J Immunol"},{"issue":"11","key":"5589_CR44","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1084\/jem.20311fta","volume":"203","author":"R Williams","year":"2006","unstructured":"Williams R. Killing controversy. J Exp Med. 2006;203(11):2404. https:\/\/doi.org\/10.1084\/jem.20311fta.","journal-title":"J Exp Med"},{"issue":"7","key":"5589_CR45","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1902\/jop.1995.66.7.653","volume":"66","author":"A Stabholz","year":"1995","unstructured":"Stabholz A, Taichman NS, Soskolne WA. Occurrence of Actinobacillus actinomycetemcomitans and anti-leukotoxin antibodies in some members of an extended family affected by Papillon\u2013Lef\u00e8vre syndrome. J Periodontol. 1995;66(7):653\u20137. https:\/\/doi.org\/10.1902\/jop.1995.66.7.653.","journal-title":"J Periodontol"},{"issue":"3","key":"5589_CR46","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/jlb.61.3.361","volume":"61","author":"KJ Leavell","year":"1997","unstructured":"Leavell KJ, Peterson MW, Gross TJ. Human neutrophil elastase abolishes interleukin-8 chemotactic activity. J Leukoc Biol. 1997;61(3):361\u20136. https:\/\/doi.org\/10.1002\/jlb.61.3.361.","journal-title":"J Leukoc Biol"},{"issue":"17","key":"5589_CR47","doi-asserted-by":"publisher","first-page":"17415","DOI":"10.1074\/jbc.M500340200","volume":"280","author":"OH Ryu","year":"2005","unstructured":"Ryu OH, Choi SJ, Firatli E, Choi SW, Hart PS, Shen RF, et al. Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases. J Biol Chem. 2005;280(17):17415\u201321. https:\/\/doi.org\/10.1074\/jbc.M500340200.","journal-title":"J Biol Chem"},{"issue":"2","key":"5589_CR48","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1182\/blood.V96.2.671.014k24_671_675","volume":"96","author":"SJ Choi","year":"2000","unstructured":"Choi SJ, Cruz JC, Craig F, Chung H, Devlin RD, Roodman GD, Alsina M. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood. 2000;96(2):671\u20135.","journal-title":"Blood"},{"issue":"S20","key":"5589_CR49","doi-asserted-by":"publisher","first-page":"S149","DOI":"10.1111\/jcpe.12945","volume":"45","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Clin Periodontol. 2018;45(S20):S149\u201361. https:\/\/doi.org\/10.1111\/jcpe.12945.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"5589_CR50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2350-14-7","volume":"14","author":"JG Romero-Quintana","year":"2013","unstructured":"Romero-Quintana JG, Fr\u00edas-Castro LO, Ar\u00e1mbula-Meraz E, Aguilar-Medina M, Due\u00f1as-Arias JE, Melchor-Soto JD, et al. Identification of novel mutation in cathepsin C gene causing Papillon\u2013Lef\u00e8vre syndrome in Mexican patients. BMC Med Genet. 2013;14(1):7. https:\/\/doi.org\/10.1186\/1471-2350-14-7.","journal-title":"BMC Med Genet"},{"issue":"2","key":"5589_CR51","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/1098-1004(200102)17:2","volume":"17","author":"LM Allende","year":"2001","unstructured":"Allende LM, Garc\u00eda-P\u00e9rez MA, Moreno A, Corell A, Carasol M, Mart\u00ednez-Canut P, et al. Cathepsin C gene: first compound heterozygous patient with Papillon\u2013Lef\u00e8vre syndrome and a novel symptomless mutation. Hum Mutat. 2001;17(2):152\u20133. https:\/\/doi.org\/10.1002\/1098-1004(200102)17:2.","journal-title":"Hum Mutat"},{"issue":"1","key":"5589_CR52","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jdermsci.2008.07.006","volume":"53","author":"T Ochiai","year":"2009","unstructured":"Ochiai T, Nakano H, Rokunohe D, Akasaka E, Toyomaki Y, Mitsuhashi Y, et al. Novel p.M1T and recurrent p.G301S mutations in cathepsin C in a Japanese patient with Papillon-Lef\u00e8vre syndrome: implications for understanding the genotype\/phenotype relationship. J Dermatol Sci. 2009;53(1):73\u20135. https:\/\/doi.org\/10.1016\/j.jdermsci.2008.07.006.","journal-title":"J Dermatol Sci"},{"issue":"2","key":"5589_CR53","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1046\/j.1523-1747.2001.01244.x","volume":"116","author":"A Nakano","year":"2001","unstructured":"Nakano A, Nakano H, LaForgia S, Pulkkinen L, Uitto J, Nomura K, et al. Papillon\u2013Lef\u00e8vre Syndrome: mutations and polymorphisms in the cathepsin C gene. J Invest Dermatol. 2001;116(2):339\u201343. https:\/\/doi.org\/10.1046\/j.1523-1747.2001.01244.x.","journal-title":"J Invest Dermatol"},{"issue":"8","key":"5589_CR54","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/ijd.13297","volume":"55","author":"B Tekin","year":"2016","unstructured":"Tekin B, Yucelten D, Beleggia F, Sarig O, Sprecher E. Papillon\u2013Lef\u00e8vre syndrome: report of six patients and identification of a novel mutation. Int J Dermatol. 2016;55(8):898\u2013902. https:\/\/doi.org\/10.1111\/ijd.13297.","journal-title":"Int J Dermatol"},{"issue":"7","key":"5589_CR55","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s10038-019-0615-3","volume":"64","author":"A Molitor","year":"2019","unstructured":"Molitor A, Prud\u2019homme T, Miao Z, Conrad S, Bloch-Zupan A, Pichot A, et al. Exome sequencing identifies a novel missense variant in CTSC causing nonsyndromic aggressive periodontitis. J Hum Genet. 2019;64(7):689\u201394. https:\/\/doi.org\/10.1038\/s10038-019-0615-3.","journal-title":"J Hum Genet"},{"issue":"3","key":"5589_CR56","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/humu.10314","volume":"23","author":"C Hewitt","year":"2004","unstructured":"Hewitt C, McCormick D, Linden G, Turk D, Stern I, Wallace I, et al. The role of cathepsin C in Papillon\u2013Lef\u00e8vre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat. 2004;23(3):222\u20138. https:\/\/doi.org\/10.1002\/humu.10314.","journal-title":"Hum Mutat"},{"issue":"1","key":"5589_CR57","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/humu.9040","volume":"20","author":"Y Zhang","year":"2002","unstructured":"Zhang Y, Hart PS, Moretti AJ, Bouwsma OJ, Fisher EM, Dudlicek L, et al. Biochemical and mutational analyses of the cathepsin c gene (CTSC) in three North American families with Papillon Lef\u00e8vre syndrome. Hum Mutat. 2002;20(1):75. https:\/\/doi.org\/10.1002\/humu.9040.","journal-title":"Hum Mutat"},{"issue":"10","key":"5589_CR58","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1172\/jci76009","volume":"124","author":"OE S\u00f8rensen","year":"2014","unstructured":"S\u00f8rensen OE, Clemmensen SN, Dahl SL, \u00d8stergaard O, Heegaard NH, Glenth\u00f8j A, et al. Papillon\u2013Lef\u00e8vre syndrome patient reveals species-dependent requirements for neutrophil defenses. J Clin Invest. 2014;124(10):4539\u201348. https:\/\/doi.org\/10.1172\/jci76009.","journal-title":"J Clin Invest"},{"issue":"3","key":"5589_CR59","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1902\/jop.2002.73.3.307","volume":"73","author":"VF Cury","year":"2002","unstructured":"Cury VF, Costa JE, Gomez RS, Boson WL, Loures CG, De ML. A novel mutation of the cathepsin C gene in Papillon\u2013Lef\u00e8vre syndrome. J Periodontol. 2002;73(3):307\u201312. https:\/\/doi.org\/10.1902\/jop.2002.73.3.307.","journal-title":"J Periodontol"},{"issue":"5","key":"5589_CR60","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1111\/odi.13095","volume":"25","author":"Y Wu","year":"2019","unstructured":"Wu Y, Zhao L, Xu C, Wu Y. CTSC compound heterozygous mutations in two Chinese patients with Papillon\u2013Lef\u00e8vre syndrome. Oral Dis. 2019;25(5):1394\u2013402. https:\/\/doi.org\/10.1111\/odi.13095.","journal-title":"Oral Dis"},{"issue":"4","key":"5589_CR61","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/70525","volume":"23","author":"C Toomes","year":"1999","unstructured":"Toomes C, James J, Wood AJ, Wu CL, McCormick D, Lench N, et al. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat Genet. 1999;23(4):421\u20134. https:\/\/doi.org\/10.1038\/70525.","journal-title":"Nat Genet"},{"issue":"7","key":"5589_CR62","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1007\/s11033-020-05622-0","volume":"47","author":"S Meenu","year":"2020","unstructured":"Meenu S, Pradeep B, Ramalingam S, Sairam T, Rai R, Sankaran R. Papillon\u2013Lef\u00e8vre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and peptidase C1A domains of Cathepsin C gene. Mol Biol Rep. 2020;47(7):5681\u20137. https:\/\/doi.org\/10.1007\/s11033-020-05622-0.","journal-title":"Mol Biol Rep"},{"issue":"1","key":"5589_CR63","doi-asserted-by":"publisher","first-page":"31","DOI":"10.7518\/hxkq.2019.01.006","volume":"37","author":"T-T Hu","year":"2019","unstructured":"Hu T-T, Zou X-Y, Ye F. Gene mutational analyses of cathepsin C gene in a family with Papillon\u2013Lef\u00e8vre syndrome. Hua Xi Kou Qiang Yi Xue Za Zhi. 2019;37(1):31\u20136. https:\/\/doi.org\/10.7518\/hxkq.2019.01.006.","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"6","key":"5589_CR64","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.tripleo.2004.08.030","volume":"100","author":"FN Hattab","year":"2005","unstructured":"Hattab FN, Amin WM. Papillon\u2013Lef\u00e8vre syndrome with albinism: a review of the literature and report of 2 brothers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(6):709\u201316. https:\/\/doi.org\/10.1016\/j.tripleo.2004.08.030.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"2","key":"5589_CR65","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/s1096-7192(03)00070-2","volume":"79","author":"LM Allende","year":"2003","unstructured":"Allende LM, Moreno A, de Unamuno P. A genetic study of cathepsin C gene in two families with Papillon\u2013Lef\u00e8vre syndrome. Mol Genet Metab. 2003;79(2):146\u20138. https:\/\/doi.org\/10.1016\/s1096-7192(03)00070-2.","journal-title":"Mol Genet Metab"},{"issue":"3","key":"5589_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121351","volume":"10","author":"AM Erzurumluoglu","year":"2015","unstructured":"Erzurumluoglu AM, Alsaadi MM, Rodriguez S, Alotaibi TS, Guthrie PA, Lewis S, et al. Proxy molecular diagnosis from whole-exome sequencing reveals Papillon\u2013Lefevre syndrome caused by a missense mutation in CTSC. PLoS ONE. 2015;10(3): e0121351. https:\/\/doi.org\/10.1371\/journal.pone.0121351.","journal-title":"PLoS ONE"},{"issue":"4","key":"5589_CR67","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1365-2133.2008.08878.x","volume":"160","author":"M Castori","year":"2009","unstructured":"Castori M, Madonna S, Giannetti L, Floriddia G, Milioto M, Amato S, et al. Novel CTSC mutations in a patient with Papillon\u2013Lef\u00e8vre syndrome with recurrent pyoderma and minimal oral and palmoplantar involvement. Br J Dermatol. 2009;160(4):881\u20133. https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08878.x.","journal-title":"Br J Dermatol"},{"issue":"5","key":"5589_CR68","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1177\/154405910408300503","volume":"83","author":"B Noack","year":"2004","unstructured":"Noack B, G\u00f6rgens H, Hoffmann T, Fangh\u00e4nel J, Kocher T, Eickholz P, et al. Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon\u2013Lef\u00e8vre syndrome. J Dent Res. 2004;83(5):368\u201370. https:\/\/doi.org\/10.1177\/154405910408300503.","journal-title":"J Dent Res"},{"issue":"10","key":"5589_CR69","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/ajmg.a.61285","volume":"179","author":"RA Machado","year":"2019","unstructured":"Machado RA, Cuadra-Zelaya FJM, Martelli-J\u00fanior H, Miranda RT, Casarin RCV, Corr\u00eaa MG, et al. Clinical and molecular analysis in Papillon\u2013Lef\u00e8vre syndrome. Am J Med Genet A. 2019;179(10):2124\u201331. https:\/\/doi.org\/10.1002\/ajmg.a.61285.","journal-title":"Am J Med Genet A"},{"issue":"2","key":"5589_CR70","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/sj.jid.5700987","volume":"128","author":"T Jouary","year":"2008","unstructured":"Jouary T, Goizet C, Coupry I, Redonnet-Vernhet I, Levade T, Burgelin I, et al. Detection of an intragenic deletion expands the spectrum of CTSC mutations in Papillon\u2013Lef\u00e8vre syndrome. J Investig Dermatol. 2008;128(2):322\u20135. https:\/\/doi.org\/10.1038\/sj.jid.5700987.","journal-title":"J Investig Dermatol"},{"issue":"5","key":"5589_CR71","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/humu.9243","volume":"23","author":"SF de Haar","year":"2004","unstructured":"de Haar SF, Jansen DC, Schoenmaker T, De Vree H, Everts V, Beertsen W. Loss-of-function mutations in cathepsin C in two families with Papillon\u2013Lef\u00e8vre syndrome are associated with deficiency of serine proteinases in PMNs. Hum Mutat. 2004;23(5):524. https:\/\/doi.org\/10.1002\/humu.9243.","journal-title":"Hum Mutat"},{"issue":"11","key":"5589_CR72","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.scib.2019.12.006","volume":"65","author":"W Yin","year":"2020","unstructured":"Yin W, Dong M, Ye D, Liu Q, Liu S, Shi C, et al. Cathepsin C promotes the progression of periapical periodontitis. Sci Bull (Beijing). 2020;65(11):951\u20137. https:\/\/doi.org\/10.1016\/j.scib.2019.12.006.","journal-title":"Sci Bull (Beijing)"},{"issue":"3","key":"5589_CR73","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1902\/jop.2005.76.3.492","volume":"76","author":"H Nitta","year":"2005","unstructured":"Nitta H, Wara-Aswapati N, Lertsirivorakul J, Nakamura T, Yamamoto M, Izumi Y, et al. A novel mutation of the cathepsin C gene in a thai family with Papillon-Lefevre syndrome. J Periodontol. 2005;76(3):492\u20136. https:\/\/doi.org\/10.1902\/jop.2005.76.3.492.","journal-title":"J Periodontol"},{"issue":"8","key":"5589_CR74","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1111\/jdv.12265","volume":"28","author":"P Bull\u00f3n","year":"2014","unstructured":"Bull\u00f3n P, Morillo JM, Thakker N, Veeramachaneni R, Quiles JL, Ram\u00edrez-Tortosa MC, et al. Confirmation of oxidative stress and fatty acid disturbances in two further Papillon\u2013Lef\u00e8vre syndrome families with identification of a new mutation. J Eur Acad Dermatol Venereol. 2014;28(8):1049\u201356. https:\/\/doi.org\/10.1111\/jdv.12265.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"12","key":"5589_CR75","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1136\/jmg.36.12.881","volume":"36","author":"TC Hart","year":"1999","unstructured":"Hart TC, Hart PS, Bowden DW, Michalec MD, Callison SA, Walker SJ, et al. Mutations of the cathepsin C gene are responsible for Papillon\u2013Lef\u00e8vre syndrome. J Med Genet. 1999;36(12):881\u20137.","journal-title":"J Med Genet"},{"issue":"4","key":"5589_CR76","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.arcped.2017.01.013","volume":"24","author":"S Martinho","year":"2017","unstructured":"Martinho S, Levade T, Fergelot P, Stephan JL. Papillon\u2013Lef\u00e8vre syndrome: a new case. Arch Pediatr. 2017;24(4):360\u20132. https:\/\/doi.org\/10.1016\/j.arcped.2017.01.013.","journal-title":"Arch Pediatr"},{"issue":"8","key":"5589_CR77","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/j.1468-3083.2010.03575.x","volume":"24","author":"M Kurban","year":"2010","unstructured":"Kurban M, Cheng T, Wajid M, Kiuru M, Shimomura Y, Christiano AM. A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome. J Eur Acad Dermatol Venereol. 2010;24(8):967\u20139. https:\/\/doi.org\/10.1111\/j.1468-3083.2010.03575.x.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"5589_CR78","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.gene.2013.11.079","volume":"538","author":"M Moghaddasian","year":"2014","unstructured":"Moghaddasian M, Arab H, Dadkhah E, Boostani H, Babak AR, Abbaszadegan MR. Protein modeling of cathepsin C mutations found in Papillon\u2013Lef\u00e8vre syndrome. Gene. 2014;538(1):182\u20137. https:\/\/doi.org\/10.1016\/j.gene.2013.11.079.","journal-title":"Gene"},{"issue":"8","key":"5589_CR79","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1177\/154405910708600809","volume":"86","author":"Y Yang","year":"2007","unstructured":"Yang Y, Bai X, Liu H, Li L, Cao C, Ge L. Novel mutations of cathepsin C gene in two Chinese patients with Papillon\u2013Lef\u00e8vre syndrome. J Dent Res. 2007;86(8):735\u20138. https:\/\/doi.org\/10.1177\/154405910708600809.","journal-title":"J Dent Res"},{"issue":"1","key":"5589_CR80","first-page":"36","volume":"77","author":"D Pallos","year":"2010","unstructured":"Pallos D, Acevedo AC, Mestrinho HD, Cordeiro I, Hart TC. Novel cathepsin C mutation in a Brazilian family with Papillon\u2013Lef\u00e8vre syndrome: case report and mutation update. J Dent Child (Chic). 2010;77(1):36\u201341.","journal-title":"J Dent Child (Chic)"},{"issue":"6","key":"5589_CR81","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1046\/j.0022-202x.2001.01595.x","volume":"117","author":"C Lef\u00e8vre","year":"2001","unstructured":"Lef\u00e8vre C, Blanchet-Bardon C, Jobard F, Bouadjar B, Stalder JF, Cure S, et al. Novel point mutations, deletions, and polymorphisms in the cathepsin C gene in nine families from Europe and North Africa with Papillon\u2013Lef\u00e8vre syndrome. J Invest Dermatol. 2001;117(6):1657\u201361. https:\/\/doi.org\/10.1046\/j.0022-202x.2001.01595.x.","journal-title":"J Invest Dermatol"},{"issue":"2","key":"5589_CR82","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1902\/jop.2006.050124","volume":"77","author":"AA Wani","year":"2006","unstructured":"Wani AA, Devkar N, Patole MS, Shouche YS. Description of two new cathepsin C gene mutations in patients with Papillon\u2013Lef\u00e8vre syndrome. J Periodontol. 2006;77(2):233\u20137. https:\/\/doi.org\/10.1902\/jop.2006.050124.","journal-title":"J Periodontol"},{"issue":"4","key":"5589_CR83","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1111\/bjd.12429","volume":"169","author":"T Kobayashi","year":"2013","unstructured":"Kobayashi T, Sugiura K, Takeichi T, Akiyama M. The novel CTSC homozygous nonsense mutation p.Lys106X in a patient with Papillon\u2013Lef\u00e8vre syndrome with all permanent teeth remaining at over 40 years of age. Br J Dermatol. 2013;169(4):948\u201350. https:\/\/doi.org\/10.1111\/bjd.12429.","journal-title":"Br J Dermatol"},{"issue":"3","key":"5589_CR84","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000342509","volume":"225","author":"R Kosem","year":"2012","unstructured":"Kosem R, Debeljak M, Repi\u010d Lampret B, Kansky A, Battelino T, Trebu\u0161ak PK. Cathepsin C gene 5\u2019-untranslated region mutation in Papillon\u2013Lef\u00e8vre syndrome. Dermatology. 2012;225(3):193\u2013203. https:\/\/doi.org\/10.1159\/000342509.","journal-title":"Dermatology"},{"key":"5589_CR85","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2350-4-5","volume":"4","author":"V Selvaraju","year":"2003","unstructured":"Selvaraju V, Markandaya M, Prasad PV, Sathyan P, Sethuraman G, Srivastava SC, et al. Mutation analysis of the cathepsin C gene in Indian families with Papillon\u2013Lef\u00e8vre syndrome. BMC Med Genet. 2003;4:5. https:\/\/doi.org\/10.1186\/1471-2350-4-5.","journal-title":"BMC Med Genet"},{"issue":"3","key":"5589_CR86","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/jre.12317","volume":"51","author":"W Wu","year":"2016","unstructured":"Wu W, Chen B, Chen X, Chen L, Yi L, Wang Y, et al. A novel large deletion combined with a nonsense mutation in a Chinese child with Papillon\u2013Lef\u00e8vre syndrome. J Periodontal Res. 2016;51(3):376\u201380. https:\/\/doi.org\/10.1111\/jre.12317.","journal-title":"J Periodontal Res"},{"issue":"3","key":"5589_CR87","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ejmg.2014.12.003","volume":"58","author":"X Wang","year":"2015","unstructured":"Wang X, Liu Y, Liu Y, Dong G, Kenney EB, Liu Q, et al. Long-term change of disease behavior in Papillon\u2013Lef\u00e8vre syndrome: Seven years follow-up. Eur J Med Genet. 2015;58(3):184\u20137. https:\/\/doi.org\/10.1016\/j.ejmg.2014.12.003.","journal-title":"Eur J Med Genet"},{"issue":"4","key":"5589_CR88","doi-asserted-by":"publisher","first-page":"369","DOI":"10.5021\/ad.2021.33.4.369","volume":"33","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhang H, Feng S. Novel compound heterozygous mutations in CTSC Gene in a Chinese family with Papillon\u2013Lefevre syndrome. Ann Dermatol. 2021;33(4):369\u201372. https:\/\/doi.org\/10.5021\/ad.2021.33.4.369.","journal-title":"Ann Dermatol"},{"issue":"7","key":"5589_CR89","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1346-8138.2011.01474.x","volume":"39","author":"X Wen","year":"2012","unstructured":"Wen X, Wang X, Duan X. High immunoglobulin E in a Chinese Papillon\u2013Lef\u00e8vre syndrome patient with novel compound mutations of cathepsin C. J Dermatol. 2012;39(7):664\u20135. https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01474.x.","journal-title":"J Dermatol"},{"issue":"5","key":"5589_CR90","first-page":"502","volume":"25","author":"X Li","year":"2008","unstructured":"Li X, Zhang X, Zhang J, Chen Y. Mutational analysis of the cathepsin C gene in a family of Han nationality with Papillon-Lefevre syndrome. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25(5):502\u20135.","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"3","key":"5589_CR91","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jdermsci.2014.09.009","volume":"76","author":"Z Li","year":"2014","unstructured":"Li Z, Liu J, Fang S, Zhu H, Zhang X, Cai J, et al. Novel compound heterozygous mutations in CTSC gene cause Papillon\u2013Lef\u00e8vre syndrome with high serum immunoglobulin E. J Dermatol Sci. 2014;76(3):258\u201360. https:\/\/doi.org\/10.1016\/j.jdermsci.2014.09.009.","journal-title":"J Dermatol Sci"},{"issue":"8","key":"5589_CR92","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1111\/1346-8138.15412","volume":"47","author":"M Hayashi","year":"2020","unstructured":"Hayashi M, Nakano H, Sawamura D, Suzuki T. Japanese case of Papillon\u2013Lef\u00e8vre syndrome with novel compound heterozygous mutations. J Dermatol. 2020;47(8):e293\u20135. https:\/\/doi.org\/10.1111\/1346-8138.15412.","journal-title":"J Dermatol"},{"issue":"4","key":"5589_CR93","doi-asserted-by":"publisher","first-page":"346","DOI":"10.7518\/hxkq.2016.04.005","volume":"34","author":"C Yuanjiao","year":"2016","unstructured":"Yuanjiao C, Chen-Jun L. Gene mutational analyses of the cathepsin C gene in families with Papillon\u2013Lef\u00e8vre syndrome. Hua Xi Kou Qiang Yi Xue Za Zhi. 2016;34(4):346\u20139. https:\/\/doi.org\/10.7518\/hxkq.2016.04.005.","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"2","key":"5589_CR94","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1096-7192(02)00031-8","volume":"76","author":"PS Hart","year":"2002","unstructured":"Hart PS, Pallos D, Zhang Y, Sanchez J, Kavamura I, Brunoni D, et al. Identification of a novel cathepsin C mutation (p.W185X) in a Brazilian kindred with Papillon\u2013Lef\u00e8vre syndrome. Mol Genet Metab. 2002;76(2):145\u20137. https:\/\/doi.org\/10.1016\/S1096-7192(02)00031-8.","journal-title":"Mol Genet Metab"},{"issue":"2","key":"5589_CR95","doi-asserted-by":"publisher","first-page":"151","DOI":"10.18176\/jiaci.0467","volume":"30","author":"AL Moura","year":"2020","unstructured":"Moura AL, Regateiro FS, Peres Resende E, Coimbra Silva H, Gon\u00e7alo M, Todo Bom A, et al. A new terminal nonsense mutation of the cathepsin C gene in a patient with atypical Papillon-Lef\u00e8vre syndrome. J Investig Allergol Clin Immunol. 2020;30(2):151\u20133.","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"4","key":"5589_CR96","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/cre2.387","volume":"7","author":"M Ghanei","year":"2021","unstructured":"Ghanei M, Abbaszadegan MR, Forghanifard MM, Aarabi A, Arab H. A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome. Clin Exp Dent Res. 2021;7(4):568\u201373. https:\/\/doi.org\/10.1002\/cre2.387.","journal-title":"Clin Exp Dent Res"},{"issue":"5","key":"5589_CR97","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00403-013-1323-z","volume":"305","author":"K Farkas","year":"2013","unstructured":"Farkas K, Paschali E, Papp F, V\u00e1lyi P, Sz\u00e9ll M, Kem\u00e9ny L, et al. A novel seven-base deletion of the CTSC gene identified in a Hungarian family with Papillon\u2013Lef\u00e8vre syndrome. Arch Dermatol Res. 2013;305(5):453\u20135. https:\/\/doi.org\/10.1007\/s00403-013-1323-z.","journal-title":"Arch Dermatol Res"},{"issue":"7","key":"5589_CR98","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1365-4632.2012.05769.x","volume":"53","author":"HK Schackert","year":"2014","unstructured":"Schackert HK, Agha-Hosseini F, G\u00f6rgens H, Jatzwauk M, von Kannen S, Noack B, et al. Complete homozygous deletion of CTSC in an Iranian family with Papillon\u2013Lef\u00e8vre syndrome. Int J Dermatol. 2014;53(7):885\u20137. https:\/\/doi.org\/10.1111\/j.1365-4632.2012.05769.x.","journal-title":"Int J Dermatol"},{"issue":"2","key":"5589_CR99","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1136\/jmg.37.2.95","volume":"37","author":"TC Hart","year":"2000","unstructured":"Hart TC, Hart PS, Michalec MD, Zhang Y, Marazita ML, Cooper M, et al. Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. J Med Genet. 2000;37(2):95\u2013101. https:\/\/doi.org\/10.1136\/jmg.37.2.95.","journal-title":"J Med Genet"},{"issue":"2","key":"5589_CR100","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1600-051X.1998.tb02425.x","volume":"25","author":"\u00d8 Fardal","year":"1998","unstructured":"Fardal \u00d8, Drangsholt E, Olsen I. Palmar plantar keratosis and unusual periodontal findings. J Clin Periodontol. 1998;25(2):181\u20134. https:\/\/doi.org\/10.1111\/j.1600-051X.1998.tb02425.x.","journal-title":"J Clin Periodontol"},{"issue":"5","key":"5589_CR101","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1902\/jop.1993.64.5.379","volume":"64","author":"RS Brown","year":"1993","unstructured":"Brown RS, Hays GL, Flaitz CM, O\u2019Neill PA, Abramovitch K, White RR. A possible late onset variation of Papillon\u2013Lef\u00e8vre syndrome: report of 3 cases. J Periodontol. 1993;64(5):379\u201386. https:\/\/doi.org\/10.1902\/jop.1993.64.5.379.","journal-title":"J Periodontol"},{"key":"5589_CR102","doi-asserted-by":"publisher","first-page":"6139732","DOI":"10.1155\/2021\/6139732","volume":"2021","author":"J Dai","year":"2021","unstructured":"Dai J, Liu J, Zhang Q, An Y, Xia B, Wan C, et al. Cathepsin C is involved in macrophage M1 polarization via p38\/MAPK pathway in sudden cardiac death. Cardiovasc Ther. 2021;2021:6139732. https:\/\/doi.org\/10.1155\/2021\/6139732.","journal-title":"Cardiovasc Ther"},{"issue":"2","key":"5589_CR103","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1189\/jlb.5A1015-489R","volume":"100","author":"H Roberts","year":"2016","unstructured":"Roberts H, White P, Dias I, McKaig S, Veeramachaneni R, Thakker N, et al. Characterization of neutrophil function in Papillon\u2013Lef\u00e8vre syndrome. J Leukoc Biol. 2016;100(2):433\u201344. https:\/\/doi.org\/10.1189\/jlb.5A1015-489R.","journal-title":"J Leukoc Biol"},{"issue":"4","key":"5589_CR104","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.jaci.2018.01.018","volume":"142","author":"P Bull\u00f3n","year":"2018","unstructured":"Bull\u00f3n P, Castej\u00f3n-Vega B, Rom\u00e1n-Malo L, Jimenez-Guerrero MP, Cot\u00e1n D, Forbes-Hernandez TY, et al. Autophagic dysfunction in patients with Papillon\u2013Lef\u00e8vre syndrome is restored by recombinant cathepsin C treatment. J Allergy Clin Immunol. 2018;142(4):1131-43.e7. https:\/\/doi.org\/10.1016\/j.jaci.2018.01.018.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"5589_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","volume":"12","author":"DJ Klionsky","year":"2016","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1\u2013222. https:\/\/doi.org\/10.1080\/15548627.2015.1100356.","journal-title":"Autophagy"},{"issue":"50","key":"5589_CR106","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1038\/onc.2008.310","volume":"27","author":"P Boya","year":"2008","unstructured":"Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene. 2008;27(50):6434\u201351. https:\/\/doi.org\/10.1038\/onc.2008.310.","journal-title":"Oncogene"},{"issue":"2","key":"5589_CR107","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00784-011-0532-0","volume":"16","author":"CD Sadik","year":"2012","unstructured":"Sadik CD, Noack B, Schacher B, Pfeilschifter J, M\u00fchl H, Eickholz P. Cytokine production by leukocytes of Papillon\u2013Lef\u00e8vre syndrome patients in whole blood cultures. Clin Oral Investig. 2012;16(2):591\u20137. https:\/\/doi.org\/10.1007\/s00784-011-0532-0.","journal-title":"Clin Oral Investig"},{"issue":"Suppl 4","key":"5589_CR108","doi-asserted-by":"publisher","first-page":"S297","DOI":"10.1513\/AnnalsATS.201509-634KV","volume":"13","author":"C McCarthy","year":"2016","unstructured":"McCarthy C, Reeves EP, McElvaney NG. The role of neutrophils in alpha-1 antitrypsin deficiency. Ann Am Thorac Soc. 2016;13(Suppl 4):S297-304. https:\/\/doi.org\/10.1513\/AnnalsATS.201509-634KV.","journal-title":"Ann Am Thorac Soc"},{"issue":"22","key":"5589_CR109","doi-asserted-by":"publisher","first-page":"13258","DOI":"10.1021\/acs.jmedchem.0c00776","volume":"63","author":"B Korkmaz","year":"2020","unstructured":"Korkmaz B, Lesner A, Marchand-Adam S, Moss C, Jenne DE. Lung protection by cathepsin c inhibition: a new hope for COVID-19 and ARDS? J Med Chem. 2020;63(22):13258\u201365. https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00776.","journal-title":"J Med Chem"},{"issue":"6","key":"5589_CR110","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3390\/cells11061011","volume":"11","author":"M Fassan","year":"2022","unstructured":"Fassan M, Collesei A, Angerilli V, Sbaraglia M, Fortarezza F, Pezzuto F, et al. Multi-design differential expression profiling of COVID-19 lung autopsy specimens reveals significantly deregulated inflammatory pathways and SFTPC impaired transcription. Cells. 2022;11(6):1011. https:\/\/doi.org\/10.3390\/cells11061011.","journal-title":"Cells"},{"key":"5589_CR111","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cellsig.2018.02.017","volume":"46","author":"TP Khaket","year":"2018","unstructured":"Khaket TP, Singh MP, Khan I, Bhardwaj M, Kang SC. Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells. Cell Signal. 2018;46:92\u2013102. https:\/\/doi.org\/10.1016\/j.cellsig.2018.02.017.","journal-title":"Cell Signal"},{"issue":"1","key":"5589_CR112","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4143\/crt.2019.145","volume":"52","author":"GP Zhang","year":"2020","unstructured":"Zhang GP, Yue X, Li SQ. Cathepsin C interacts with TNF-\u03b1\/p38 MAPK signaling pathway to promote proliferation and metastasis in hepatocellular carcinoma. Cancer Res Treat. 2020;52(1):10\u201323. https:\/\/doi.org\/10.4143\/crt.2019.145.","journal-title":"Cancer Res Treat"},{"key":"5589_CR113","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0076-6879(08)03611-2","volume":"452","author":"T Ikenoue","year":"2009","unstructured":"Ikenoue T, Hong S, Inoki K. Monitoring mammalian target of rapamycin (mTOR) activity. Methods Enzymol. 2009;452:165\u201380. https:\/\/doi.org\/10.1016\/s0076-6879(08)03611-2.","journal-title":"Methods Enzymol"},{"issue":"3","key":"5589_CR114","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","volume":"39","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Cong M, Li J, He D, Wu Q, Tian P, et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell. 2021;39(3):423-37.e7. https:\/\/doi.org\/10.1016\/j.ccell.2020.12.012.","journal-title":"Cancer Cell"},{"issue":"12","key":"5589_CR115","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.4161\/cc.3.12.1289","volume":"3","author":"JA Joyce","year":"2004","unstructured":"Joyce JA, Hanahan D. Multiple roles for cysteine cathepsins in cancer. Cell Cycle. 2004;3(12):1516\u2013619. https:\/\/doi.org\/10.4161\/cc.3.12.1289.","journal-title":"Cell Cycle"},{"issue":"5","key":"5589_CR116","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1101\/gad.1407406","volume":"20","author":"V Gocheva","year":"2006","unstructured":"Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006;20(5):543\u201356. https:\/\/doi.org\/10.1101\/gad.1407406.","journal-title":"Genes Dev"},{"issue":"1","key":"5589_CR117","doi-asserted-by":"publisher","first-page":"60","DOI":"10.4161\/cc.6.1.3669","volume":"6","author":"V Gocheva","year":"2007","unstructured":"Gocheva V, Joyce JA. Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle. 2007;6(1):60\u20134. https:\/\/doi.org\/10.4161\/cc.6.1.3669.","journal-title":"Cell Cycle"},{"issue":"2","key":"5589_CR118","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/med.21531","volume":"39","author":"H Folkerts","year":"2019","unstructured":"Folkerts H, Hilgendorf S, Vellenga E, Bremer E, Wiersma VR. The multifaceted role of autophagy in cancer and the microenvironment. Med Res Rev. 2019;39(2):517\u201360. https:\/\/doi.org\/10.1002\/med.21531.","journal-title":"Med Res Rev"},{"issue":"19","key":"5589_CR119","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1101\/gad.224899.113","volume":"27","author":"B Ruffell","year":"2013","unstructured":"Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, DeNardo DG, et al. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev. 2013;27(19):2086\u201398. https:\/\/doi.org\/10.1101\/gad.224899.113.","journal-title":"Genes Dev"},{"key":"5589_CR120","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105156","volume":"161","author":"TP Khaket","year":"2020","unstructured":"Khaket TP, Singh MP, Khan I, Kang SC. In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells. Pharma Res. 2020;161: 105156. https:\/\/doi.org\/10.1016\/j.phrs.2020.105156.","journal-title":"Pharma Res"},{"issue":"4","key":"5589_CR121","first-page":"1304","volume":"11","author":"S Kim","year":"2021","unstructured":"Kim S, Lee SI, Kim N, Joo M, Lee KH, Lee MW, et al. Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C. Am J Cancer Res. 2021;11(4):1304\u201320.","journal-title":"Am J Cancer Res"},{"issue":"5","key":"5589_CR122","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1681\/asn.2021081112","volume":"33","author":"U Jerke","year":"2022","unstructured":"Jerke U, Eulenberg-Gustavus C, Rousselle A, Nicklin P, Kreideweiss S, Grundl MA, et al. Targeting cathepsin C in PR3-ANCA vasculitis. J Am Soc Nephrol. 2022;33(5):936\u201347. https:\/\/doi.org\/10.1681\/asn.2021081112.","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl_2","key":"5589_CR123","doi-asserted-by":"publisher","first-page":"kez061.11","DOI":"10.1093\/rheumatology\/kez061.011","volume":"58","author":"U Jerke","year":"2019","unstructured":"Jerke U, Eulenberg-Gustavus C, Rousselle A, Kreideweiss S, Grundl M, Eickholz P, et al. Characterization of cathepsin C as a treatment targent in anca-associated vasculitis. Rheumatology. 2019;58(Suppl_2):kez061.11. https:\/\/doi.org\/10.1093\/rheumatology\/kez061.011.","journal-title":"Rheumatology"},{"issue":"5","key":"5589_CR124","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1681\/asn.2022030309","volume":"33","author":"R Kain","year":"2022","unstructured":"Kain R, Nackenhorst MC. A view on cathepsin C as a target for therapy in AAV. J Am Soc Nephrol. 2022;33(5):875\u20138. https:\/\/doi.org\/10.1681\/asn.2022030309.","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"5589_CR125","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4049\/jimmunol.180.1.475","volume":"180","author":"W Beertsen","year":"2008","unstructured":"Beertsen W, Willenborg M, Everts V, Zirogianni A, Podschun R, Schr\u00f6der B, et al. Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice. J Immunol. 2008;180(1):475\u201382. https:\/\/doi.org\/10.4049\/jimmunol.180.1.475.","journal-title":"J Immunol"},{"issue":"1","key":"5589_CR126","doi-asserted-by":"publisher","first-page":"147","DOI":"10.31083\/j.rcm.2021.01.207","volume":"22","author":"A Kumar","year":"2021","unstructured":"Kumar A, Avishay DM, Jones CR, Shaikh JD, Kaur R, Aljadah M, et al. Sudden cardiac death: epidemiology, pathogenesis and management. Rev Cardiovasc Med. 2021;22(1):147\u201358. https:\/\/doi.org\/10.31083\/j.rcm.2021.01.207.","journal-title":"Rev Cardiovasc Med"},{"issue":"1","key":"5589_CR127","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12929-019-0535-8","volume":"26","author":"J Osman","year":"2019","unstructured":"Osman J, Tan SC, Lee PY, Low TY, Jamal R. Sudden Cardiac Death (SCD)\u2014risk stratification and prediction with molecular biomarkers. J Biomed Sci. 2019;26(1):39. https:\/\/doi.org\/10.1186\/s12929-019-0535-8.","journal-title":"J Biomed Sci"},{"issue":"8","key":"5589_CR128","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/circulationaha.111.023846","volume":"125","author":"RJ Myerburg","year":"2012","unstructured":"Myerburg RJ, Junttila MJ. Sudden cardiac death caused by coronary heart disease. Circulation. 2012;125(8):1043\u201352. https:\/\/doi.org\/10.1161\/circulationaha.111.023846.","journal-title":"Circulation"},{"issue":"12","key":"5589_CR129","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1161\/circresaha.116.304521","volume":"116","author":"M Hayashi","year":"2015","unstructured":"Hayashi M, Shimizu W, Albert CM. The spectrum of epidemiology underlying sudden cardiac death. Circ Res. 2015;116(12):1887\u2013906. https:\/\/doi.org\/10.1161\/circresaha.116.304521.","journal-title":"Circ Res"},{"issue":"1","key":"5589_CR130","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1161\/atvbaha.114.304292","volume":"35","author":"V Her\u00edas","year":"2015","unstructured":"Her\u00edas V, Biessen EA, Beckers C, Delsing D, Liao M, Daemen MJ, et al. Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses. Arterioscler Thromb Vasc Biol. 2015;35(1):79\u201386. https:\/\/doi.org\/10.1161\/atvbaha.114.304292.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"5589_CR131","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/ejn.12096","volume":"37","author":"M Koike","year":"2013","unstructured":"Koike M, Shibata M, Ezaki J, Peters C, Saftig P, Kominami E, et al. Differences in expression patterns of cathepsin C\/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur J Neurosci. 2013;37(5):816\u201330. https:\/\/doi.org\/10.1111\/ejn.12096.","journal-title":"Eur J Neurosci"},{"key":"5589_CR132","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fnmol.2016.00152","volume":"9","author":"J Liang","year":"2016","unstructured":"Liang J, Li N, Zhang Y, Hou C, Yang X, Shimizu T, et al. Disinhibition of cathepsin C caused by cystatin F deficiency Aggravates the demyelination in a cuprizone model. Front Mol Neurosci. 2016;9:152. https:\/\/doi.org\/10.3389\/fnmol.2016.00152.","journal-title":"Front Mol Neurosci"},{"key":"5589_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105107","volume":"148","author":"X Zhao","year":"2021","unstructured":"Zhao X, Liu S, Yang X, Liu Y, Liu G, Fan K, et al. Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion. Neurochem Int. 2021;148: 105107. https:\/\/doi.org\/10.1016\/j.neuint.2021.105107.","journal-title":"Neurochem Int"},{"issue":"12","key":"5589_CR134","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1111\/bcp.13398","volume":"83","author":"BE Miller","year":"2017","unstructured":"Miller BE, Mayer RJ, Goyal N, Bal J, Dallow N, Boyce M, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). Br J Clin Pharmacol. 2017;83(12):2813\u201320. https:\/\/doi.org\/10.1111\/bcp.13398.","journal-title":"Br J Clin Pharmacol"},{"key":"5589_CR135","doi-asserted-by":"publisher","DOI":"10.20517\/rdodj.2023.09","author":"M Stojkovska Docevska","year":"2023","unstructured":"Stojkovska Docevska M, Novinec M. Cathepsin C: structure, function, and pharmacological targeting. Rare Dis Orphan Drugs J. 2023. https:\/\/doi.org\/10.20517\/rdodj.2023.09.","journal-title":"Rare Dis Orphan Drugs J."},{"key":"5589_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114803","volume":"194","author":"B Korkmaz","year":"2021","unstructured":"Korkmaz B, Lamort A-S, Domain R, Beauvillain C, Gieldon A, Yildirim A\u00d6, et al. Cathepsin C inhibition as a potential treatment strategy in cancer. Biochem Pharmacol. 2021;194: 114803. https:\/\/doi.org\/10.1016\/j.bcp.2021.114803.","journal-title":"Biochem Pharmacol"},{"key":"5589_CR137","doi-asserted-by":"publisher","unstructured":"Wei H, Wee LWY, Born B, Seang S, Koh MJA, Yee R, Lin G, Rafi'ee K, Mey S, Tan EC. Palmoplantar keratoderma, oral involvement, and homozygous CTSC mutation in two brothers from Cambodia. Am J Med Genet A. 2020;182(2):296\u2013302. https:\/\/doi.org\/10.1002\/ajmg.a.61447.","DOI":"10.1002\/ajmg.a.61447"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05589-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05589-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05589-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T18:07:19Z","timestamp":1724177239000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05589-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":137,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5589"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05589-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"27 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"777"}}