{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:17:36Z","timestamp":1791778656513,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070868"],"award-info":[{"award-number":["82070868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500631"],"award-info":[{"award-number":["81500631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370853"],"award-info":[{"award-number":["82370853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200918"],"award-info":[{"award-number":["82200918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QC111"],"award-info":[{"award-number":["ZR2021QC111"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05710-w","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T09:01:59Z","timestamp":1728637319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing"],"prefix":"10.1186","volume":"22","author":[{"given":"Yujing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qincheng","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tixiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-1007","authenticated-orcid":false,"given":"Ruxing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"issue":"8","key":"5710_CR1","doi-asserted-by":"publisher","first-page":"e28993","DOI":"10.1002\/jmv.28993","volume":"95","author":"T Briese","year":"2023","unstructured":"Briese T, et al. A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis\/chronic fatigue syndrome. J Med Virol. 2023;95(8):e28993.","journal-title":"J Med Virol"},{"key":"5710_CR2","doi-asserted-by":"publisher","first-page":"1386607","DOI":"10.3389\/fimmu.2024.1386607","volume":"15","author":"HE Arron","year":"2024","unstructured":"Arron HE, et al. Myalgic Encephalomyelitis\/Chronic fatigue syndrome: the biology of a neglected disease. Front Immunol. 2024;15:1386607.","journal-title":"Front Immunol"},{"issue":"2","key":"5710_CR3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.chom.2023.01.001","volume":"31","author":"R Xiong","year":"2023","unstructured":"Xiong R, et al. Multi-\u2018omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis\/chronic fatigue syndrome patients. Cell Host Microbe. 2023;31(2):273\u2013e2875.","journal-title":"Cell Host Microbe"},{"issue":"34","key":"5710_CR4","doi-asserted-by":"publisher","first-page":"e2302738120","DOI":"10.1073\/pnas.2302738120","volume":"120","author":"PY Wang","year":"2023","unstructured":"Wang PY, et al. WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis\/chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2023;120(34):e2302738120.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"5710_CR5","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/s41591-022-01810-6","volume":"28","author":"J Choutka","year":"2022","unstructured":"Choutka J, et al. Unexplained post-acute infection syndromes. Nat Med. 2022;28(5):911\u201323.","journal-title":"Nat Med"},{"issue":"12","key":"5710_CR6","doi-asserted-by":"publisher","first-page":"841","DOI":"10.7326\/M15-0114","volume":"162","author":"ME Smith","year":"2015","unstructured":"Smith ME, et al. Treatment of myalgic Encephalomyelitis\/Chronic fatigue syndrome: a Systematic Review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015;162(12):841\u201350.","journal-title":"Ann Intern Med"},{"key":"5710_CR7","doi-asserted-by":"crossref","unstructured":"Fluge O, Tronstad KJ, Mella O. Pathomechanisms and possible interventions in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). J Clin Invest, 2021. 131(14).","DOI":"10.1172\/JCI150377"},{"key":"5710_CR8","doi-asserted-by":"publisher","first-page":"1294758","DOI":"10.3389\/fimmu.2023.1294758","volume":"14","author":"U Berkis","year":"2023","unstructured":"Berkis U, et al. Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME\/CFS progression. Front Immunol. 2023;14:1294758.","journal-title":"Front Immunol"},{"issue":"6","key":"5710_CR9","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/pm\/pnab308","volume":"23","author":"EE Barhorst","year":"2022","unstructured":"Barhorst EE, et al. Pain-related post-exertional malaise in myalgic encephalomyelitis \/ chronic fatigue syndrome (ME\/CFS) and Fibromyalgia: a systematic review and three-level Meta-analysis. Pain Med. 2022;23(6):1144\u201357.","journal-title":"Pain Med"},{"issue":"10","key":"5710_CR10","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.mayocp.2023.07.032","volume":"98","author":"SL Grach","year":"2023","unstructured":"Grach SL, et al. Diagnosis and management of myalgic Encephalomyelitis\/Chronic fatigue syndrome. Mayo Clin Proc. 2023;98(10):1544\u201351.","journal-title":"Mayo Clin Proc"},{"issue":"8","key":"5710_CR11","doi-asserted-by":"publisher","first-page":"e1011523","DOI":"10.1371\/journal.ppat.1011523","volume":"19","author":"MR Hanson","year":"2023","unstructured":"Hanson MR. The viral origin of myalgic encephalomyelitis\/chronic fatigue syndrome. PLoS Pathog. 2023;19(8):e1011523.","journal-title":"PLoS Pathog"},{"key":"5710_CR12","doi-asserted-by":"publisher","first-page":"1187163","DOI":"10.3389\/fmed.2023.1187163","volume":"10","author":"AL Komaroff","year":"2023","unstructured":"Komaroff AL, Lipkin WI. ME\/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature. Front Med (Lausanne). 2023;10:1187163.","journal-title":"Front Med (Lausanne)"},{"key":"5710_CR13","doi-asserted-by":"crossref","unstructured":"Deumer US et al. Myalgic Encephalomyelitis\/Chronic fatigue syndrome (ME\/CFS): an overview. J Clin Med, 2021. 10(20).","DOI":"10.3390\/jcm10204786"},{"issue":"5","key":"5710_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.molmed.2024.02.003","volume":"30","author":"SJ Annesley","year":"2024","unstructured":"Annesley SJ, et al. Unravelling shared mechanisms: insights from recent ME\/CFS research to illuminate long COVID pathologies. Trends Mol Med. 2024;30(5):443\u201358.","journal-title":"Trends Mol Med"},{"issue":"2","key":"5710_CR15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.chom.2023.01.004","volume":"31","author":"C Guo","year":"2023","unstructured":"Guo C, et al. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME\/CFS. Cell Host Microbe. 2023;31(2):288\u2013e3048.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"5710_CR16","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1186\/s12967-023-04515-7","volume":"21","author":"M Ruiz-Pablos","year":"2023","unstructured":"Ruiz-Pablos M, Paiva B, Zabaleta A. Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID? J Transl Med. 2023;21(1):633.","journal-title":"J Transl Med"},{"key":"5710_CR17","doi-asserted-by":"crossref","unstructured":"Maya J. Surveying the metabolic and dysfunctional profiles of T cells and NK Cells in myalgic Encephalomyelitis\/Chronic fatigue syndrome. Int J Mol Sci, 2023. 24(15).","DOI":"10.3390\/ijms241511937"},{"issue":"1","key":"5710_CR18","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41392-023-01640-z","volume":"8","author":"J Li","year":"2023","unstructured":"Li J, et al. The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID. Signal Transduct Target Ther. 2023;8(1):416.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"5710_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13027-023-00505-y","volume":"18","author":"CG Gottschalk","year":"2023","unstructured":"Gottschalk CG, et al. Correction: potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases. Infect Agent Cancer. 2023;18(1):23.","journal-title":"Infect Agent Cancer"},{"issue":"1","key":"5710_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13027-023-00485-z","volume":"18","author":"CG Gottschalk","year":"2023","unstructured":"Gottschalk CG, et al. Potential molecular mechanisms of chronic fatigue in long haul COVID and other viral diseases. Infect Agent Cancer. 2023;18(1):7.","journal-title":"Infect Agent Cancer"},{"key":"5710_CR21","doi-asserted-by":"crossref","unstructured":"Tate WP et al. Towards a better understanding of the complexities of myalgic Encephalomyelitis\/Chronic fatigue syndrome and Long COVID. Int J Mol Sci, 2023. 24(6).","DOI":"10.3390\/ijms24065124"},{"key":"5710_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbi.2021.03.023","volume":"95","author":"W Sato","year":"2021","unstructured":"Sato W, et al. Skewing of the B cell receptor repertoire in myalgic encephalomyelitis\/chronic fatigue syndrome. Brain Behav Immun. 2021;95:245\u201355.","journal-title":"Brain Behav Immun"},{"key":"5710_CR23","doi-asserted-by":"crossref","unstructured":"Jensen MA et al. Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome. Biochemistry, 2023.","DOI":"10.1021\/acs.biochem.3c00433"},{"issue":"1","key":"5710_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1021\/acs.biochem.3c00433","volume":"63","author":"MA Jensen","year":"2024","unstructured":"Jensen MA, et al. Catalytic Antibodies May Contribute to demyelination in myalgic Encephalomyelitis\/Chronic fatigue syndrome. Biochemistry. 2024;63(1):9\u201318.","journal-title":"Biochemistry"},{"issue":"9","key":"5710_CR25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.7326\/M18-1451","volume":"170","author":"O Fluge","year":"2019","unstructured":"Fluge O, et al. B-Lymphocyte depletion in patients with myalgic Encephalomyelitis\/Chronic fatigue syndrome: a Randomized, Double-Blind, placebo-controlled trial. Ann Intern Med. 2019;170(9):585\u201393.","journal-title":"Ann Intern Med"},{"key":"5710_CR26","doi-asserted-by":"publisher","first-page":"928945","DOI":"10.3389\/fimmu.2022.928945","volume":"13","author":"S Gravelsina","year":"2022","unstructured":"Gravelsina S, et al. Biomarkers in the diagnostic algorithm of myalgic encephalomyelitis\/chronic fatigue syndrome. Front Immunol. 2022;13:928945.","journal-title":"Front Immunol"},{"issue":"1","key":"5710_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12916-023-02893-9","volume":"21","author":"R Maksoud","year":"2023","unstructured":"Maksoud R, et al. Biomarkers for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS): a systematic review. BMC Med. 2023;21(1):189.","journal-title":"BMC Med"},{"issue":"1","key":"5710_CR28","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1186\/s12967-023-04295-0","volume":"21","author":"A Taccori","year":"2023","unstructured":"Taccori A, et al. A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). J Transl Med. 2023;21(1):440.","journal-title":"J Transl Med"},{"issue":"1","key":"5710_CR29","doi-asserted-by":"publisher","first-page":"101373","DOI":"10.1016\/j.xcrm.2023.101373","volume":"5","author":"LT Vu","year":"2024","unstructured":"Vu LT, et al. Single-cell transcriptomics of the immune system in ME\/CFS at baseline and following symptom provocation. Cell Rep Med. 2024;5(1):101373.","journal-title":"Cell Rep Med"},{"issue":"12","key":"5710_CR30","doi-asserted-by":"publisher","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","volume":"121","author":"K Fukuda","year":"1994","unstructured":"Fukuda K, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International chronic fatigue syndrome Study Group. Ann Intern Med. 1994;121(12):953\u20139.","journal-title":"Ann Intern Med"},{"issue":"2","key":"5710_CR31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1136\/jcp.2006.042754","volume":"60","author":"BM Carruthers","year":"2007","unstructured":"Carruthers BM. Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works. J Clin Pathol. 2007;60(2):117\u20139.","journal-title":"J Clin Pathol"},{"key":"5710_CR32","unstructured":"Medicine C. .t.D.C.f.M.E.C.F.S.B.o.t.H.o.S.P.I.o. Beyond myalgic Encephalomyelitis\/Chronic fatigue syndrome: redefining an illness, in Beyond myalgic Encephalomyelitis\/Chronic fatigue syndrome: redefining an illness. Washington (DC); 2015."},{"issue":"1","key":"5710_CR33","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1207\/S15324826AN0801_7","volume":"8","author":"R Patarca-Montero","year":"2001","unstructured":"Patarca-Montero R, et al. Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors. Appl Neuropsychol. 2001;8(1):51\u201364.","journal-title":"Appl Neuropsychol"},{"issue":"10","key":"5710_CR34","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/s41590-022-01309-9","volume":"23","author":"L Bonaguro","year":"2022","unstructured":"Bonaguro L, et al. A guide to systems-level immunomics. Nat Immunol. 2022;23(10):1412\u201323.","journal-title":"Nat Immunol"},{"key":"5710_CR35","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.3389\/fimmu.2019.01355","volume":"10","author":"AL Roy","year":"2019","unstructured":"Roy AL. Transcriptional regulation in the Immune System: one cell at a time. Front Immunol. 2019;10:1355.","journal-title":"Front Immunol"},{"key":"5710_CR36","doi-asserted-by":"crossref","unstructured":"Ahmed F et al. Single-cell transcriptomics of the immune system in ME\/CFS at baseline and following symptom provocation 2022.","DOI":"10.1101\/2022.10.13.512091"},{"issue":"3","key":"5710_CR37","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.immuni.2023.01.016","volume":"56","author":"IS Schuster","year":"2023","unstructured":"Schuster IS, et al. Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity. 2023;56(3):531\u2013e5466.","journal-title":"Immunity"},{"key":"5710_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.semcdb.2023.08.002","volume":"156","author":"R Kandel","year":"2024","unstructured":"Kandel R, Jung J, Neal S. Proteotoxic stress and the ubiquitin proteasome system. Semin Cell Dev Biol. 2024;156:107\u201320.","journal-title":"Semin Cell Dev Biol"},{"issue":"20","key":"5710_CR39","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1080\/15384101.2023.2287929","volume":"22","author":"A Kumar","year":"2023","unstructured":"Kumar A, Thirumurugan K. Understanding cellular senescence: pathways involved, therapeutics and longevity aiding. Cell Cycle. 2023;22(20):2324\u201345.","journal-title":"Cell Cycle"},{"key":"5710_CR40","doi-asserted-by":"crossref","unstructured":"Witham MD et al. New Horizons in cellular senescence for clinicians. Age Ageing, 2023. 52(7).","DOI":"10.1093\/ageing\/afad127"},{"issue":"3","key":"5710_CR41","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1172\/JCI132185","volume":"130","author":"AH Mandarano","year":"2020","unstructured":"Mandarano AH, et al. Myalgic encephalomyelitis\/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. J Clin Invest. 2020;130(3):1491\u2013505.","journal-title":"J Clin Invest"},{"key":"5710_CR42","doi-asserted-by":"crossref","unstructured":"Cortes Rivera M et al. Myalgic Encephalomyelitis\/Chronic fatigue syndrome: a Comprehensive Review. Diagnostics (Basel), 2019. 9(3).","DOI":"10.3390\/diagnostics9030091"},{"issue":"11","key":"5710_CR43","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1038\/s41423-021-00757-x","volume":"18","author":"I Galea","year":"2021","unstructured":"Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol. 2021;18(11):2489\u2013501.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"5710_CR44","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","volume":"8","author":"C Gao","year":"2023","unstructured":"Gao C, et al. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduct Target Ther. 2023;8(1):359.","journal-title":"Signal Transduct Target Ther"},{"issue":"6 Pt A","key":"5710_CR45","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.bbamcr.2016.03.026","volume":"1863","author":"B Schroder","year":"2016","unstructured":"Schroder B. The multifaceted roles of the invariant chain CD74\u2013More than just a chaperone. Biochim Biophys Acta. 2016;1863(6 Pt A):1269\u201381.","journal-title":"Biochim Biophys Acta"},{"key":"5710_CR46","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1750-1326-4-41","volume":"4","author":"S Matsuda","year":"2009","unstructured":"Matsuda S, Matsuda Y, D\u2019Adamio L. CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener. 2009;4:41.","journal-title":"Mol Neurodegener"},{"key":"5710_CR47","doi-asserted-by":"publisher","first-page":"1328979","DOI":"10.3389\/fcell.2023.1328979","volume":"11","author":"X Xu","year":"2023","unstructured":"Xu X, et al. Single-cell transcriptome profiling highlights the role of APP in blood vessels in assessing the risk of patients with proliferative diabetic retinopathy developing Alzheimer\u2019s disease. Front Cell Dev Biol. 2023;11:1328979.","journal-title":"Front Cell Dev Biol"},{"key":"5710_CR48","doi-asserted-by":"crossref","unstructured":"Ma C et al. Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM. Biochim Biophys Acta Mol Basis Dis, 2024: p. 167449.","DOI":"10.1016\/j.bbadis.2024.167449"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05710-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05710-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05710-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T21:03:23Z","timestamp":1728680603000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05710-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5710"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05710-w","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,11]]},"assertion":[{"value":"15 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"925"}}