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Males demonstrated overall larger benefits than premenopausal females from the VLEKT in terms of weight loss (\u0394%\u2009= \u2212\u00a011.63\u2009\u00b1\u20091.76 <jats:italic>vs <\/jats:italic>\u2212\u00a08.95\u2009\u00b1\u20091.65\u00a0kg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), fat mass (\u0394%\u2009= \u2212\u00a030.84\u2009\u00b1\u200912.00 <jats:italic>vs<\/jats:italic> -21.36\u2009\u00b1\u20094.65\u00a0kg, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and hs-CRP levels (\u0394%\u2009= \u2212\u00a041.42\u2009\u00b1\u200921.35 <jats:italic>vs <\/jats:italic>\u2212\u00a022.38\u2009\u00b1\u200917.30\u00a0mg\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Of interest, in males phase angle values are statistically improved compared to female (\u0394%\u2009=\u200917.11\u2009\u00b1\u20099.00 <jats:italic>vs<\/jats:italic> 7.05\u2009\u00b1\u20093.30\u00b0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These findings underscore the importance of considering sex-specific responses in personalized obesity treatment strategies, particularly dietary interventions like VLEKTs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12967-024-05733-3","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:02:21Z","timestamp":1729328541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter?"],"prefix":"10.1186","volume":"22","author":[{"given":"Giovanna","family":"Muscogiuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Frias-Toral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Reytor-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Annunziata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Progan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Savastano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Simancas-Racines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-456X","authenticated-orcid":false,"given":"Luigi","family":"Barrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"5733_CR1","unstructured":"Organization WH. 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