{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:42:08Z","timestamp":1792618928375,"version":"4.5.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C2005966(50698-2023)"],"award-info":[{"award-number":["NRF-2021R1A2C2005966(50698-2023)"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF-2017M2A2A7A01018542(50035-2019)"],"award-info":[{"award-number":["NRF-2017M2A2A7A01018542(50035-2019)"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["50531-2024"],"award-info":[{"award-number":["50531-2024"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05797-1","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T14:02:38Z","timestamp":1730210558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["miR-1226-5p is involved in radioresistance of colorectal cancer by activating M2 macrophages through suppressing IRF1"],"prefix":"10.1186","volume":"22","author":[{"given":"Jae Yeon","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Seok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhye","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ui Sup","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Incheol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-349X","authenticated-orcid":false,"given":"In Hwa","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"5797_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071732","author":"MS Hossain","year":"2022","unstructured":"Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi J, John A, et al. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers (Basel). 2022. https:\/\/doi.org\/10.3390\/cancers14071732.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"5797_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","volume":"5","author":"YH Xie","year":"2020","unstructured":"Xie YH, Chen YX, Fang JY. Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther. 2020;5(1):22.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"5797_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.4240\/wjgs.v15.i4.495","volume":"15","author":"A Kumar","year":"2023","unstructured":"Kumar A, Gautam V, Sandhu A, Rawat K, Sharma A, Saha L. Current and emerging therapeutic approaches for colorectal cancer: a comprehensive review. World J Gastrointest Surg. 2023;15(4):495\u2013519.","journal-title":"World J Gastrointest Surg"},{"issue":"5","key":"5797_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41575-019-0247-2","volume":"17","author":"AM Buckley","year":"2020","unstructured":"Buckley AM, Lynam-Lennon N, O\u2019Neill H, O\u2019Sullivan J. Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers. Nat Rev Gastroenterol Hepatol. 2020;17(5):298\u2013313.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"5797_CR5","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/2211-5463.13137","volume":"11","author":"Y Jin","year":"2021","unstructured":"Jin Y, Chen Z, Dong J, Wang B, Fan S, Yang X, et al. SREBP1\/FASN\/cholesterol axis facilitates radioresistance in colorectal cancer. FEBS Open Bio. 2021;11(5):1343\u201352.","journal-title":"FEBS Open Bio"},{"key":"5797_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071651","author":"MA Olivares-Urbano","year":"2020","unstructured":"Olivares-Urbano MA, Grinan-Lison C, Marchal JA, Nunez MI. CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9071651.","journal-title":"Cells"},{"issue":"6","key":"5797_CR7","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s12276-021-00640-9","volume":"53","author":"T Suwa","year":"2021","unstructured":"Suwa T, Kobayashi M, Nam JM, Harada H. Tumor microenvironment and radioresistance. Exp Mol Med. 2021;53(6):1029\u201335.","journal-title":"Exp Mol Med"},{"issue":"3","key":"5797_CR8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","volume":"121","author":"A Orimo","year":"2005","unstructured":"Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion. Cell. 2005;121(3):335\u201348.","journal-title":"Cell"},{"key":"5797_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ctrv.2018.02.004","volume":"65","author":"C Belli","year":"2018","unstructured":"Belli C, Trapani D, Viale G, D\u2019Amico P, Duso BA, Della Vigna P, et al. Targeting the microenvironment in solid tumors. Cancer Treat Rev. 2018;65:22\u201332.","journal-title":"Cancer Treat Rev"},{"key":"5797_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.coph.2017.04.007","volume":"35","author":"N Dehne","year":"2017","unstructured":"Dehne N, Mora J, Namgaladze D, Weigert A, Brune B. Cancer cell and macrophage cross-talk in the tumor microenvironment. Curr Opin Pharmacol. 2017;35:12\u20139.","journal-title":"Curr Opin Pharmacol"},{"key":"5797_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685978","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Zhao Y, Li Q, Wang Y. Macrophages, as a promising strategy to targeted treatment for colorectal cancer metastasis in tumor immune microenvironment. Front Immunol. 2021;12: 685978.","journal-title":"Front Immunol"},{"key":"5797_CR12","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.2147\/CMAR.S199832","volume":"11","author":"L Cao","year":"2019","unstructured":"Cao L, Che X, Qiu X, Li Z, Yang B, Wang S, et al. M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer. Cancer Manag Res. 2019;11:6125\u201338.","journal-title":"Cancer Manag Res"},{"issue":"1","key":"5797_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12935-021-02089-2","volume":"21","author":"J Liu","year":"2021","unstructured":"Liu J, Geng X, Hou J, Wu G. New insights into M1\/M2 macrophages: key modulators in cancer progression. Cancer Cell Int. 2021;21(1):389.","journal-title":"Cancer Cell Int"},{"key":"5797_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136995","author":"AJ Boutilier","year":"2021","unstructured":"Boutilier AJ, Elsawa SF. Macrophage polarization states in the tumor microenvironment. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22136995.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5797_CR15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.semcancer.2008.03.004","volume":"18","author":"A Sica","year":"2008","unstructured":"Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, et al. Macrophage polarization in tumour progression. Semin Cancer Biol. 2008;18(5):349\u201355.","journal-title":"Semin Cancer Biol"},{"key":"5797_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111099","volume":"134","author":"N Zhang","year":"2021","unstructured":"Zhang N, Hu X, Du Y, Du J. The role of miRNAs in colorectal cancer progression and chemoradiotherapy. Biomed Pharmacother. 2021;134: 111099.","journal-title":"Biomed Pharmacother"},{"key":"5797_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyae097","author":"A Pedroza-Torres","year":"2024","unstructured":"Pedroza-Torres A, Romero-Cordoba SL, Montano S, Peralta-Zaragoza O, Velez-Uriza DE, Arriaga-Canon C, et al. Radio-miRs: a comprehensive view of radioresistance-related microRNAs. Genetics. 2024. https:\/\/doi.org\/10.1093\/genetics\/iyae097.","journal-title":"Genetics"},{"key":"5797_CR18","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3389\/fgene.2019.00626","volume":"10","author":"M Cui","year":"2019","unstructured":"Cui M, Wang H, Yao X, Zhang D, Xie Y, Cui R, et al. Circulating microRNAs in cancer: potential and challenge. Front Genet. 2019;10:626.","journal-title":"Front Genet"},{"key":"5797_CR19","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3389\/fimmu.2019.00799","volume":"10","author":"G Curtale","year":"2019","unstructured":"Curtale G, Rubino M, Locati M. MicroRNAs as molecular switches in macrophage activation. Front Immunol. 2019;10:799.","journal-title":"Front Immunol"},{"key":"5797_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116082","author":"LR Gao","year":"2024","unstructured":"Gao LR, Zhang J, Huang N, Deng W, Ni W, Xiao Z, et al. Tumor-derived exosomal miR-143-3p induces macrophage M2 polarization to cause radiation resistance in locally advanced esophageal squamous cell carcinoma. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25116082.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"5797_CR21","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1016\/j.ymthe.2021.02.006","volume":"29","author":"C Yang","year":"2021","unstructured":"Yang C, Dou R, Wei C, Liu K, Shi D, Zhang C, et al. Tumor-derived exosomal microRNA-106b-5p activates EMT-cancer cell and M2-subtype TAM interaction to facilitate CRC metastasis. Mol Ther. 2021;29(6):2088\u2013107.","journal-title":"Mol Ther"},{"key":"5797_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/biology10060500","author":"J Lee","year":"2021","unstructured":"Lee J, Kwon J, Kim D, Park M, Kim K, Bae I, et al. Gene expression profiles associated with radio-responsiveness in locally advanced rectal cancer. Biology (Basel). 2021. https:\/\/doi.org\/10.3390\/biology10060500.","journal-title":"Biology (Basel)"},{"issue":"1","key":"5797_CR23","first-page":"9","volume":"14","author":"F Wang","year":"2021","unstructured":"Wang F, Sun G, Peng C, Chen J, Quan J, Wu C, et al. ZEB1 promotes colorectal cancer cell invasion and disease progression by enhanced LOXL2 transcription. Int J Clin Exp Pathol. 2021;14(1):9\u201323.","journal-title":"Int J Clin Exp Pathol"},{"key":"5797_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.832916","volume":"9","author":"CF Jungers","year":"2022","unstructured":"Jungers CF, Djuranovic S. Modulation of miRISC-mediated gene silencing in eukaryotes. Front Mol Biosci. 2022;9: 832916.","journal-title":"Front Mol Biosci"},{"key":"5797_CR25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-981-13-1426-1_6","volume":"1087","author":"AC Panda","year":"2018","unstructured":"Panda AC. Circular RNAs act as miRNA sponges. Adv Exp Med Biol. 2018;1087:67\u201379.","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"5797_CR26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/15476286.2019.1600395","volume":"16","author":"M Liu","year":"2019","unstructured":"Liu M, Wang Q, Shen J, Yang BB, Ding X. Circbank: a comprehensive database for circRNA with standard nomenclature. RNA Biol. 2019;16(7):899\u2013905.","journal-title":"RNA Biol"},{"issue":"1","key":"5797_CR27","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s13046-023-02816-9","volume":"42","author":"C Wang","year":"2023","unstructured":"Wang C, Zhang M, Liu Y, Cui D, Gao L, Jiang Y. CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs. J Exp Clin Cancer Res. 2023;42(1):242.","journal-title":"J Exp Clin Cancer Res"},{"issue":"26","key":"5797_CR28","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.3748\/wjg.v28.i26.3027","volume":"28","author":"MB Novoa Diaz","year":"2022","unstructured":"Novoa Diaz MB, Martin MJ, Gentili C. Tumor microenvironment involvement in colorectal cancer progression via Wnt\/beta-catenin pathway: providing understanding of the complex mechanisms of chemoresistance. World J Gastroenterol. 2022;28(26):3027\u201346.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"5797_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13045-019-0760-3","volume":"12","author":"Y Lin","year":"2019","unstructured":"Lin Y, Xu J, Lan H. Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications. J Hematol Oncol. 2019;12(1):76.","journal-title":"J Hematol Oncol"},{"key":"5797_CR30","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","volume":"5","author":"N Wang","year":"2014","unstructured":"Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1\u2013m2 polarization balance. Front Immunol. 2014;5:614.","journal-title":"Front Immunol"},{"issue":"1","key":"5797_CR31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12957-022-02706-y","volume":"20","author":"J Jin","year":"2022","unstructured":"Jin J, Yu G. Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1. World J Surg Oncol. 2022;20(1):241.","journal-title":"World J Surg Oncol"},{"issue":"2","key":"5797_CR32","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.bbcan.2017.06.006","volume":"1868","author":"S Goossens","year":"2017","unstructured":"Goossens S, Vandamme N, Van Vlierberghe P, Berx G. EMT transcription factors in cancer development re-evaluated: beyond EMT and MET. Biochim Biophys Acta Rev Cancer. 2017;1868(2):584\u201391.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"5","key":"5797_CR33","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/ncb3513","volume":"19","author":"AM Krebs","year":"2017","unstructured":"Krebs AM, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, et al. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nat Cell Biol. 2017;19(5):518\u201329.","journal-title":"Nat Cell Biol"},{"issue":"4","key":"5797_CR34","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.3892\/ijo.2017.4099","volume":"51","author":"Z Wang","year":"2017","unstructured":"Wang Z, Chen Y, Lin Y, Wang X, Cui X, Zhang Z, et al. Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma. Int J Oncol. 2017;51(4):1239\u201348.","journal-title":"Int J Oncol"},{"issue":"9","key":"5797_CR35","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/ncb3013","volume":"16","author":"P Zhang","year":"2014","unstructured":"Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16(9):864\u201375.","journal-title":"Nat Cell Biol"},{"issue":"5","key":"5797_CR36","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20209700","volume":"54","author":"Y Huang","year":"2021","unstructured":"Huang Y, Zhang M, Li Y, Luo J, Wang Y, Geng W, et al. miR-183 promotes radioresistance of lung adenocarcinoma H1299 cells via epithelial-mesenchymal transition. Braz J Med Biol Res. 2021;54(5): e9700.","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"5797_CR37","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3858\/emm.2010.42.4.032","volume":"42","author":"H Min","year":"2010","unstructured":"Min H, Yoon S. Got target? Computational methods for microRNA target prediction and their extension. Exp Mol Med. 2010;42(4):233\u201344.","journal-title":"Exp Mol Med"},{"issue":"1","key":"5797_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2023.113733","volume":"431","author":"Y Chen","year":"2023","unstructured":"Chen Y, Lin B, Yang S, Huang J. IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis. Exp Cell Res. 2023;431(1): 113733.","journal-title":"Exp Cell Res"},{"issue":"9","key":"5797_CR39","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1093\/carcin\/bgi113","volume":"26","author":"KB Bouker","year":"2005","unstructured":"Bouker KB, Skaar TC, Riggins RB, Harburger DS, Fernandez DR, Zwart A, et al. Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis. 2005;26(9):1527\u201335.","journal-title":"Carcinogenesis"},{"issue":"4","key":"5797_CR40","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/cdd.2009.156","volume":"17","author":"J Gao","year":"2010","unstructured":"Gao J, Senthil M, Ren B, Yan J, Xing Q, Yu J, et al. IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells. Cell Death Differ. 2010;17(4):699\u2013709.","journal-title":"Cell Death Differ"},{"issue":"6","key":"5797_CR41","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/15592294.2015.1048953","volume":"10","author":"X Chen","year":"2015","unstructured":"Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, et al. Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics. 2015;10(6):545\u201361.","journal-title":"Epigenetics"},{"key":"5797_CR42","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4937","author":"X Xu","year":"2021","unstructured":"Xu X, Wu Y, Yi K, Hu Y, Ding W, Xing C. IRF1 regulates the progression of colorectal cancer via interferon-induced proteins. Int J Mol Med. 2021. https:\/\/doi.org\/10.3892\/ijmm.2021.4937.","journal-title":"Int J Mol Med"},{"issue":"2","key":"5797_CR43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ijrobp.2009.05.056","volume":"75","author":"S Eschrich","year":"2009","unstructured":"Eschrich S, Zhang H, Zhao H, Boulware D, Lee JH, Bloom G, et al. Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. Int J Radiat Oncol Biol Phys. 2009;75(2):497\u2013505.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"5797_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007468","volume":"15","author":"C Zhao","year":"2019","unstructured":"Zhao C, Mirando AC, Sove RJ, Medeiros TX, Annex BH, Popel AS. A mechanistic integrative computational model of macrophage polarization: implications in human pathophysiology. PLoS Comput Biol. 2019;15(11): e1007468.","journal-title":"PLoS Comput Biol"},{"key":"5797_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113194","author":"K Kashfi","year":"2021","unstructured":"Kashfi K, Kannikal J, Nath N. Macrophage reprogramming and cancer therapeutics: role of iNOS-derived NO. Cells. 2021. https:\/\/doi.org\/10.3390\/cells10113194.","journal-title":"Cells"},{"key":"5797_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063463","author":"G Recchia Luciani","year":"2024","unstructured":"Recchia Luciani G, Barilli A, Visigalli R, Sala R, Dall\u2019Asta V, Rotoli BM. IRF1 mediates growth arrest and the induction of a secretory phenotype in alveolar epithelial cells in response to inflammatory cytokines IFNgamma\/TNFalpha. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25063463.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5797_CR47","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41392-021-00569-5","volume":"6","author":"AT He","year":"2021","unstructured":"He AT, Liu J, Li F, Yang BB. Targeting circular RNAs as a therapeutic approach: current strategies and challenges. Signal Transduct Target Ther. 2021;6(1):185.","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"5797_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003777","volume":"9","author":"J Salzman","year":"2013","unstructured":"Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. Cell-type specific features of circular RNA expression. PLoS Genet. 2013;9(9): e1003777.","journal-title":"PLoS Genet"},{"key":"5797_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-020-01184-8","volume":"19","author":"K Han","year":"2020","unstructured":"Han K, Wang F-W, Cao C-H, Ling H, Chen J-W, Chen R-X, et al. CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17. Mol Cancer. 2020;19:1\u201318.","journal-title":"Mol Cancer"},{"issue":"11","key":"5797_CR50","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","volume":"21","author":"A Mantovani","year":"2022","unstructured":"Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21(11):799\u2013820.","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"5797_CR51","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/SHK.0000000000000604","volume":"46","author":"K Essandoh","year":"2016","unstructured":"Essandoh K, Li Y, Huo J, Fan GC. MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response. Shock. 2016;46(2):122\u201331.","journal-title":"Shock"},{"issue":"2","key":"5797_CR52","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3892\/or.2020.7628","volume":"44","author":"E Fu","year":"2020","unstructured":"Fu E, Liu T, Yu S, Chen X, Song L, Lou H, et al. M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB-EGF. Oncol Rep. 2020;44(2):698\u2013710.","journal-title":"Oncol Rep"},{"key":"5797_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051620","author":"Y Sheng","year":"2023","unstructured":"Sheng Y, Zhang B, Xing B, Liu Z, Chang Y, Wu G, et al. Cancer-associated fibroblasts exposed to high-dose ionizing radiation promote M2 polarization of macrophages, which induce radiosensitivity in cervical cancer. Cancers (Basel). 2023. https:\/\/doi.org\/10.3390\/cancers15051620.","journal-title":"Cancers (Basel)"},{"issue":"7","key":"5797_CR54","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1053\/j.gastro.2016.02.070","volume":"150","author":"L Seifert","year":"2016","unstructured":"Seifert L, Werba G, Tiwari S, Giao Ly NN, Nguy S, Alothman S, et al. Radiation therapy induces macrophages to suppress T-cell responses against pancreatic tumors in mice. Gastroenterology. 2016;150(7):1659-1672.e1655.","journal-title":"Gastroenterology"},{"key":"5797_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112767","author":"Y Hao","year":"2019","unstructured":"Hao Y, Baker D, Ten Dijke P. TGF-beta-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20112767.","journal-title":"Int J Mol Sci"},{"key":"5797_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155709","volume":"148","author":"J Wang","year":"2021","unstructured":"Wang J, Xu Z, Wang Z, Du G, Lun L. TGF-beta signaling in cancer radiotherapy. Cytokine. 2021;148: 155709.","journal-title":"Cytokine"},{"key":"5797_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104745","volume":"155","author":"B Farhood","year":"2020","unstructured":"Farhood B, Hoseini-Ghahfarokhi M, Motevaseli E, Mirtavoos-Mahyari H, Musa AE, Najafi M. TGF-\u03b2 in radiotherapy: mechanisms of tumor resistance and normal tissues injury. Pharmacol Res. 2020;155: 104745.","journal-title":"Pharmacol Res"},{"key":"5797_CR58","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3389\/fonc.2020.00874","volume":"10","author":"J Chen","year":"2020","unstructured":"Chen J, Liu X, Zeng Z, Li J, Luo Y, Sun W, et al. Immunomodulation of NK cells by ionizing radiation. Front Oncol. 2020;10:874.","journal-title":"Front Oncol"},{"issue":"8","key":"5797_CR59","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nri2808","volume":"10","author":"RA Flavell","year":"2010","unstructured":"Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limon P. The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol. 2010;10(8):554\u201367.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"5797_CR60","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1158\/0008-5472.CAN-14-3511","volume":"75","author":"C Vanpouille-Box","year":"2015","unstructured":"Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, et al. TGFbeta Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity. Cancer Res. 2015;75(11):2232\u201342.","journal-title":"Cancer Res"},{"key":"5797_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/genes14071375","author":"A Chakrabortty","year":"2023","unstructured":"Chakrabortty A, Patton DJ, Smith BF, Agarwal P. miRNAs: potential as biomarkers and therapeutic targets for cancer. Genes (Basel). 2023. https:\/\/doi.org\/10.3390\/genes14071375.","journal-title":"Genes (Basel)"},{"key":"5797_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.723609","volume":"12","author":"L Meng","year":"2021","unstructured":"Meng L, Xu J, Ye Y, Wang Y, Luo S, Gong X. The combination of radiotherapy with immunotherapy and potential predictive biomarkers for treatment of non-small cell lung cancer patients. Front Immunol. 2021;12: 723609.","journal-title":"Front Immunol"},{"issue":"2","key":"5797_CR63","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.canlet.2015.09.013","volume":"369","author":"L Chang","year":"2015","unstructured":"Chang L, Graham P, Hao J, Bucci J, Malouf D, Gillatt D, et al. Proteomics discovery of radioresistant cancer biomarkers for radiotherapy. Cancer Lett. 2015;369(2):289\u201397.","journal-title":"Cancer Lett"},{"key":"5797_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051358","author":"IP Yang","year":"2023","unstructured":"Yang IP, Yip KL, Chang YT, Chen YC, Huang CW, Tsai HL, et al. MicroRNAs as predictive biomarkers in patients with colorectal cancer receiving chemotherapy or chemoradiotherapy: a narrative literature review. Cancers (Basel). 2023. https:\/\/doi.org\/10.3390\/cancers15051358.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"5797_CR65","first-page":"545","volume":"5","author":"XD Yang","year":"2015","unstructured":"Yang XD, Xu XH, Zhang SY, Wu Y, Xing CG, Ru G, et al. Role of miR-100 in the radioresistance of colorectal cancer cells. Am J Cancer Res. 2015;5(2):545\u201359.","journal-title":"Am J Cancer Res"},{"issue":"8","key":"5797_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133870","volume":"10","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Yu J, Liu H, Ma W, Yan L, Wang J, et al. Novel epigenetic CREB-miR-630 signaling axis regulates radiosensitivity in colorectal cancer. PLoS One. 2015;10(8): e0133870.","journal-title":"PLoS One"},{"key":"5797_CR67","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12967-015-0592-z","volume":"13","author":"L Zheng","year":"2015","unstructured":"Zheng L, Zhang Y, Liu Y, Zhou M, Lu Y, Yuan L, et al. MiR-106b induces cell radioresistance via the PTEN\/PI3K\/AKT pathways and p21 in colorectal cancer. J Transl Med. 2015;13:252.","journal-title":"J Transl Med"},{"issue":"18","key":"5797_CR68","doi-asserted-by":"publisher","first-page":"15984","DOI":"10.18632\/oncotarget.3762","volume":"6","author":"W Ma","year":"2015","unstructured":"Ma W, Yu J, Qi X, Liang L, Zhang Y, Ding Y, et al. Radiation-induced microRNA-622 causes radioresistance in colorectal cancer cells by down-regulating Rb. Oncotarget. 2015;6(18):15984\u201394.","journal-title":"Oncotarget"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05797-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05797-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05797-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:26:11Z","timestamp":1730294771000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05797-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5797"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05797-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"18 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human lung tissue and plasma from lung cancer patients were Institutional Review Board (IRB) approved in Korea Institute of Radiological and Medical Sciences (KIRAMS).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors involved in this study agreed to this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"980"}}