{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:20:32Z","timestamp":1790277632480,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074471"],"award-info":[{"award-number":["82074471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81804117"],"award-info":[{"award-number":["81804117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Administration of Traditional Chinese Medicine","award":["MS202220"],"award-info":[{"award-number":["MS202220"]}]},{"name":"Jiangsu Provincial Medical Key Discipline(Laboratory)Cultivation Unit","award":["JSDW202252"],"award-info":[{"award-number":["JSDW202252"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05813-4","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:24:54Z","timestamp":1731295494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis"],"prefix":"10.1186","volume":"22","author":[{"given":"Mingbin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangquan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"issue":"2","key":"5813_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s12020-011-9580-0","volume":"41","author":"RS Weinstein","year":"2012","unstructured":"Weinstein RS. Glucocorticoid-induced osteonecrosis. Endocrine. 2012;41(2):183\u201390. https:\/\/doi.org\/10.1007\/s12020-011-9580-0.","journal-title":"Endocrine"},{"issue":"4","key":"5813_CR2","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3390\/life13040907","volume":"13","author":"S Muthu","year":"2023","unstructured":"Muthu S, Jeyaraman M, Selvaraj P, Jeyaraman N, Potty AG, Gupta A. Dose\u2013response Meta-analysis of Corticosteroid effects in SARS Outbreak: a model for risk stratification and screening strategy for osteonecrosis of femoral Head Post-corticosteroid Therapy for COVID-19. Life (Basel). 2023;13(4):907. https:\/\/doi.org\/10.3390\/life13040907.","journal-title":"Life (Basel)"},{"issue":"1","key":"5813_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMcp1012926","volume":"365","author":"RS Weinstein","year":"2011","unstructured":"Weinstein RS. Glucocorticoid-Induced Bone Disease. N Engl J Med. 2011;365(1):62\u201370. https:\/\/doi.org\/10.1056\/NEJMcp1012926.","journal-title":"N Engl J Med"},{"issue":"1","key":"5813_CR4","doi-asserted-by":"publisher","first-page":"29576","DOI":"10.1038\/srep29576","volume":"6","author":"W Sun","year":"2016","unstructured":"Sun W, Shi Z, Gao F, Wang B, Li Z. The pathogenesis of multifocal osteonecrosis. Sci Rep. 2016;6(1):29576. https:\/\/doi.org\/10.1038\/srep29576.","journal-title":"Sci Rep"},{"key":"5813_CR5","doi-asserted-by":"publisher","first-page":"102460","DOI":"10.1016\/j.jaut.2020.102460","volume":"110","author":"C Chang","year":"2020","unstructured":"Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun. 2020;110:102460. https:\/\/doi.org\/10.1016\/j.jaut.2020.102460.","journal-title":"J Autoimmun"},{"key":"5813_CR6","doi-asserted-by":"publisher","first-page":"110331","DOI":"10.1016\/j.foodres.2021.110331","volume":"144","author":"J Peng","year":"2021","unstructured":"Peng J, Yu XJ, Yu LL, et al. The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions. Food Res Int. 2021;144:110331. https:\/\/doi.org\/10.1016\/j.foodres.2021.110331.","journal-title":"Food Res Int"},{"issue":"3","key":"5813_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/term.3009","volume":"14","author":"A Shavandi","year":"2020","unstructured":"Shavandi A, Saeedi P, G\u00e9rard P, Jalalvandi E, Cannella D, Bekhit AE. The role of microbiota in tissue repair and regeneration. J Tissue Eng Regen Med. 2020;14(3):539\u201355. https:\/\/doi.org\/10.1002\/term.3009.","journal-title":"J Tissue Eng Regen Med"},{"issue":"2","key":"5813_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00774-023-01415-0","volume":"41","author":"RX Zhou","year":"2023","unstructured":"Zhou RX, Zhang YW, Cao MM, Liu CH, Rui YF, Li YJ. Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis. J Bone Min Metab. 2023;41(2):145\u201362. https:\/\/doi.org\/10.1007\/s00774-023-01415-0.","journal-title":"J Bone Min Metab"},{"issue":"15","key":"5813_CR9","doi-asserted-by":"publisher","first-page":"eabg8335","DOI":"10.1126\/sciadv.abg8335","volume":"8","author":"CY Chen","year":"2022","unstructured":"Chen CY, Rao SS, Yue T, et al. Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis. Sci Adv. 2022;8(15):eabg8335. https:\/\/doi.org\/10.1126\/sciadv.abg8335.","journal-title":"Sci Adv"},{"issue":"6","key":"5813_CR10","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/jbmr.1588","volume":"27","author":"K Sj\u00f6gren","year":"2012","unstructured":"Sj\u00f6gren K, Engdahl C, Henning P, et al. The gut microbiota regulates bone mass in mice. J Bone Min Res. 2012;27(6):1357\u201367. https:\/\/doi.org\/10.1002\/jbmr.1588.","journal-title":"J Bone Min Res"},{"issue":"3","key":"5813_CR11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5582\/irdr.2018.01055","volume":"7","author":"J Zhang","year":"2018","unstructured":"Zhang J, Lu Y, Wang Y, Ren X, Han J. The impact of the intestinal microbiome on bone health. Intractable Rare Dis Res. 2018;7(3):148\u201355. https:\/\/doi.org\/10.5582\/irdr.2018.01055.","journal-title":"Intractable Rare Dis Res"},{"key":"5813_CR12","doi-asserted-by":"publisher","first-page":"1007610","DOI":"10.3389\/fimmu.2022.1007610","volume":"13","author":"X Xu","year":"2022","unstructured":"Xu X, Wang M, Wang Z, et al. The bridge of the gut\u2013joint axis: gut microbial metabolites in rheumatoid arthritis. Front Immunol. 2022;13:1007610. https:\/\/doi.org\/10.3389\/fimmu.2022.1007610.","journal-title":"Front Immunol"},{"key":"5813_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","volume":"9","author":"S Lucas","year":"2018","unstructured":"Lucas S, Omata Y, Hofmann J, et al. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018;9:55. https:\/\/doi.org\/10.1038\/s41467-017-02490-4.","journal-title":"Nat Commun"},{"key":"5813_CR14","doi-asserted-by":"publisher","unstructured":"Yang KL, Mullins BJ, Lejeune A et al. Short Chain Fatty Acids Mitigate Osteoclast-Mediated Arthritic Bone Remodelling. Arthritis & Rheumatology. n\/a(n\/a)(https:\/\/doi.org\/10.1002\/art.42765).","DOI":"10.1002\/art.42765"},{"key":"5813_CR15","doi-asserted-by":"publisher","unstructured":"Zaiss MM, Jones RM, Schett G, Pacifici R. The gut-bone axis: how bacterial metabolites bridge the distance. J Clin Invest. 129(8):3018\u201328. https:\/\/doi.org\/10.1172\/JCI128521","DOI":"10.1172\/JCI128521"},{"issue":"19","key":"5813_CR16","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S, Mendelian Randomization. JAMA. 2017;318(19):1925\u20136. https:\/\/doi.org\/10.1001\/jama.2017.17219.","journal-title":"JAMA"},{"key":"5813_CR17","doi-asserted-by":"publisher","first-page":"n2233","DOI":"10.1136\/bmj.n2233","volume":"375","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR, et al. Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ. 2021;375:n2233. https:\/\/doi.org\/10.1136\/bmj.n2233.","journal-title":"BMJ"},{"issue":"2","key":"5813_CR18","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41588-020-00763-1","volume":"53","author":"A Kurilshikov","year":"2021","unstructured":"Kurilshikov A, Medina-Gomez C, Bacigalupe R, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156\u201365. https:\/\/doi.org\/10.1038\/s41588-020-00763-1.","journal-title":"Nat Genet"},{"issue":"7944","key":"5813_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508\u201318. https:\/\/doi.org\/10.1038\/s41586-022-05473-8.","journal-title":"Nature"},{"key":"5813_CR20","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","volume":"21","author":"D Zhao","year":"2020","unstructured":"Zhao D, Zhang F, Wang B, et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J Orthop Translation. 2020;21:100\u201310. https:\/\/doi.org\/10.1016\/j.jot.2019.12.004.","journal-title":"J Orthop Translation"},{"issue":"22","key":"5813_CR21","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","volume":"35","author":"MA Kamat","year":"2019","unstructured":"Kamat MA, Blackshaw JA, Young R, et al. PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations. Bioinformatics. 2019;35(22):4851\u20133. https:\/\/doi.org\/10.1093\/bioinformatics\/btz469.","journal-title":"Bioinformatics"},{"issue":"4","key":"5813_CR22","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/gepi.22295","volume":"44","author":"EAW Slob","year":"2020","unstructured":"Slob EAW, Burgess S. A comparison of robust mendelian randomization methods using summary data. Genet Epidemiol. 2020;44(4):313\u201329. https:\/\/doi.org\/10.1002\/gepi.22295.","journal-title":"Genet Epidemiol"},{"issue":"11","key":"5813_CR23","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.joca.2021.08.006","volume":"29","author":"T Floerkemeier","year":"2021","unstructured":"Floerkemeier T, Budde S, Willbold E, et al. Do biomarkers allow a differentiation between osteonecrosis of the femoral head and osteoarthritis of the hip? - a biochemical, histological and gene expression analysis. Osteoarthritis Cartilage. 2021;29(11):1614\u201323. https:\/\/doi.org\/10.1016\/j.joca.2021.08.006.","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"5813_CR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3390\/biom13010171","volume":"13","author":"Y Wang","year":"2023","unstructured":"Wang Y, Li D, Chen H, Li Z, Feng B, Weng X. Accumulation of Fat not responsible for femoral Head Necrosis, revealed by single-cell RNA sequencing: a preliminary study. Biomolecules. 2023;13(1):171. https:\/\/doi.org\/10.3390\/biom13010171.","journal-title":"Biomolecules"},{"key":"5813_CR25","doi-asserted-by":"publisher","unstructured":"He H, Li Z, Lu J, et al. Single-cell RNA\u2010seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma. Clin Translational Med. 2022;12(3). https:\/\/doi.org\/10.1002\/ctm2.757.","DOI":"10.1002\/ctm2.757"},{"issue":"6","key":"5813_CR26","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/biof.1565","volume":"45","author":"D Qiu","year":"2019","unstructured":"Qiu D, Xia Z, Deng J, Jiao X, Liu L, Li J. Glucorticoid-induced obesity individuals have distinct signatures of the gut microbiome. BioFactors. 2019;45(6):892\u2013901. https:\/\/doi.org\/10.1002\/biof.1565.","journal-title":"BioFactors"},{"key":"5813_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.lfs.2017.11.049","volume":"192","author":"T Wu","year":"2018","unstructured":"Wu T, Yang L, Jiang J, et al. Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats. Life Sci. 2018;192:173\u201382. https:\/\/doi.org\/10.1016\/j.lfs.2017.11.049.","journal-title":"Life Sci"},{"issue":"4","key":"5813_CR28","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/jbmr.3947","volume":"35","author":"JD Schepper","year":"2020","unstructured":"Schepper JD, Collins F, Rios-Arce ND, et al. Involvement of the gut microbiota and barrier function in glucocorticoid-Induced osteoporosis. J Bone Miner Res. 2020;35(4):801\u201320. https:\/\/doi.org\/10.1002\/jbmr.3947.","journal-title":"J Bone Miner Res"},{"issue":"S1","key":"5813_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.04882","volume":"34","author":"HJ Kang","year":"2020","unstructured":"Kang HJ, Schepper J, Vidal-Franco M, Parameswaran N, McCabe LR. Lactobacillus reuteri alleviates glucocorticoid induced avascular necrosis of femoral head. FASEB J. 2020;34(S1):1\u20131. https:\/\/doi.org\/10.1096\/fasebj.2020.34.s1.04882.","journal-title":"FASEB J"},{"issue":"7","key":"5813_CR30","doi-asserted-by":"publisher","first-page":"e21740","DOI":"10.1096\/fj.202100451R","volume":"35","author":"L Lu","year":"2021","unstructured":"Lu L, Chen X, Liu Y, Yu X. Gut microbiota and bone metabolism. FASEB J. 2021;35(7):e21740. https:\/\/doi.org\/10.1096\/fj.202100451R.","journal-title":"FASEB J"},{"key":"5813_CR31","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41467-019-14148-4","volume":"11","author":"M Yu","year":"2020","unstructured":"Yu M, Malik Tyagi A, Li JY, et al. PTH induces bone loss via microbial-dependent expansion of intestinal TNF\u2009+\u2009T cells and Th17 cells. Nat Commun. 2020;11:468. https:\/\/doi.org\/10.1038\/s41467-019-14148-4.","journal-title":"Nat Commun"},{"issue":"3","key":"5813_CR32","doi-asserted-by":"publisher","first-page":"629","DOI":"10.14336\/AD.2019.0613","volume":"11","author":"X Chen","year":"2019","unstructured":"Chen X, Zhang Z, Hu Y, et al. Lactulose suppresses osteoclastogenesis and ameliorates Estrogen Deficiency-Induced Bone loss in mice. Aging Dis. 2019;11(3):629\u201341. https:\/\/doi.org\/10.14336\/AD.2019.0613.","journal-title":"Aging Dis"},{"key":"5813_CR33","doi-asserted-by":"publisher","first-page":"1732638","DOI":"10.1155\/2017\/1732638","volume":"2017","author":"J Ma","year":"2017","unstructured":"Ma J, Guo W, Li Z, Wang B, Li S, Wang P. Hip osteonecrosis is Associated with increased plasma IL-33 level. Mediators Inflamm. 2017;2017:1732638. https:\/\/doi.org\/10.1155\/2017\/1732638.","journal-title":"Mediators Inflamm"},{"issue":"3","key":"5813_CR34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5603\/EP.a2018.0031","volume":"69","author":"D Zou","year":"2018","unstructured":"Zou D, Zhang K, Yang Y, et al. Th17 and IL-17 exhibit higher levels in osteonecrosis of the femoral head and have a positive correlation with severity of pain. Endokrynol Pol. 2018;69(3):283\u201390. https:\/\/doi.org\/10.5603\/EP.a2018.0031.","journal-title":"Endokrynol Pol"},{"issue":"3","key":"5813_CR35","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1177\/0394632015593228","volume":"28","author":"X Wu","year":"2015","unstructured":"Wu X, Xu W, Feng X, et al. TNF-a mediated inflammatory macrophage polarization contributes to the pathogenesis of steroid-induced osteonecrosis in mice. Int J Immunopathol Pharmacol. 2015;28(3):351\u201361. https:\/\/doi.org\/10.1177\/0394632015593228.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"5813_CR36","doi-asserted-by":"publisher","first-page":"879","DOI":"10.2147\/JIR.S401968","volume":"16","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Sun W, Li T, Liu F. Polarization behavior of bone macrophage as Well as Associated Osteoimmunity in Glucocorticoid-Induced osteonecrosis of the femoral head. JIR. 2023;16:879\u201394. https:\/\/doi.org\/10.2147\/JIR.S401968.","journal-title":"JIR"},{"key":"5813_CR37","doi-asserted-by":"publisher","first-page":"1064245","DOI":"10.3389\/fimmu.2022.1064245","volume":"13","author":"J Zheng","year":"2022","unstructured":"Zheng J, Yao Z, Xue L, Wang D, Tan Z. The role of immune cells in modulating chronic inflammation and osteonecrosis. Front Immunol. 2022;13:1064245. https:\/\/doi.org\/10.3389\/fimmu.2022.1064245.","journal-title":"Front Immunol"},{"key":"5813_CR38","doi-asserted-by":"publisher","first-page":"1324396","DOI":"10.3389\/fbioe.2023.1324396","volume":"11","author":"T Zaplana","year":"2024","unstructured":"Zaplana T, Miele S, Tolonen AC. Lachnospiraceae are emerging industrial biocatalysts and biotherapeutics. Front Bioeng Biotechnol. 2024;11:1324396. https:\/\/doi.org\/10.3389\/fbioe.2023.1324396.","journal-title":"Front Bioeng Biotechnol"},{"issue":"4","key":"5813_CR39","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1002\/imt2.58","volume":"1","author":"R Abdugheni","year":"2022","unstructured":"Abdugheni R, Wang WZ, Wang YJ, et al. Metabolite profiling of human-originated Lachnospiraceae at the strain level. iMeta. 2022;1(4):e58. https:\/\/doi.org\/10.1002\/imt2.58.","journal-title":"iMeta"},{"issue":"6","key":"5813_CR40","doi-asserted-by":"publisher","first-page":"eabm1511","DOI":"10.1126\/sciadv.abm1511","volume":"8","author":"J He","year":"2022","unstructured":"He J, Chu Y, Li J, et al. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis. Sci Adv. 2022;8(6):eabm1511. https:\/\/doi.org\/10.1126\/sciadv.abm1511.","journal-title":"Sci Adv"},{"issue":"11","key":"5813_CR41","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1093\/rheumatology\/ker277","volume":"50","author":"T Shigemura","year":"2011","unstructured":"Shigemura T, Nakamura J, Kishida S, et al. Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: prospective MRI study. Rheumatology. 2011;50(11):2023\u20138. https:\/\/doi.org\/10.1093\/rheumatology\/ker277.","journal-title":"Rheumatology"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05813-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05813-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05813-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T16:11:36Z","timestamp":1731341496000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05813-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5813"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05813-4","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"28 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Sample collection was approved by the Ethics Committee at Jiangsu Provincial Hospital of Traditional Chinese Medicine (No. 2023NL-037-01). All volunteers voluntarily donated their own discarded femoral head specimens, stools, blood and signed an informed consent form. All animal experiments were approved by the Animal Ethics Committee of Nanjing University of Chinese Medicine (202306A059), and were conducted according to the National Research Council Guide for Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No potential conflict of interest was reported by the author(s).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1015"}}