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The project was approved by the Ethics Committee of Qilu Hospital of Shandong University (approval number: 2018-023) with the title \u201cEffectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury\u201d on August 1st, 2018. The study was registered on the U.S. National Institutes of Health sponsored website, , under the identification number, NCT03955497, before any subjects were enrolled. 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