{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:26:43Z","timestamp":1790807203056,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2023-NHLHCRF-PY-06"],"award-info":[{"award-number":["2023-NHLHCRF-PY-06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05848-7","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T04:45:32Z","timestamp":1738817132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis"],"prefix":"10.1186","volume":"23","author":[{"given":"Xiaoxue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"8","key":"5848_CR1","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/ajh.26590","volume":"97","author":"SV Rajkumar","year":"2022","unstructured":"Rajkumar SV. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022;97(8):1086\u2013107.","journal-title":"Am J Hematol"},{"issue":"1","key":"5848_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1186\/s12885-021-08280-y","volume":"21","author":"L Zhou","year":"2021","unstructured":"Zhou L, Yu Q, Wei G, Wang L, Huang H. Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019. BMC Cancer. 2021;21(1):606.","journal-title":"BMC Cancer"},{"issue":"5","key":"5848_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1001\/jama.2022.0003","volume":"327","author":"AJ Cowan","year":"2022","unstructured":"Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, et al. Diagnosis and management of multiple myeloma: a review. JAMA. 2022;327(5):464\u201377.","journal-title":"JAMA"},{"issue":"1","key":"5848_CR4","first-page":"3","volume":"9","author":"SA Padala","year":"2021","unstructured":"Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, et al. Epidemiology, staging, and management of multiple myeloma. Med Sci (Basel). 2021;9(1):3.","journal-title":"Med Sci (Basel)"},{"issue":"12","key":"5848_CR5","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/ijc.33762","volume":"149","author":"K Hemminki","year":"2021","unstructured":"Hemminki K, F\u00f6rsti A, Houlston R, Sud A. Epidemiology, genetics and treatment of multiple myeloma and precursor diseases. Int J Cancer. 2021;149(12):1980\u201396.","journal-title":"Int J Cancer"},{"issue":"17","key":"5848_CR6","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.3390\/cancers14174082","volume":"14","author":"D Dima","year":"2022","unstructured":"Dima D, Jiang D, Singh DJ, Hasipek M, Shah HS, Ullah F, et al. Multiple myeloma therapy: emerging trends and challenges. Cancers (Basel). 2022;14(17):4082.","journal-title":"Cancers (Basel)"},{"key":"5848_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.maturitas.2020.04.015","volume":"138","author":"D Fotiou","year":"2020","unstructured":"Fotiou D, Ntanasis-Stathopoulos I, Gavriatopoulou M, Dimopoulos MA. Multiple myeloma: current and future management in the aging population. Maturitas. 2020;138:8\u201313.","journal-title":"Maturitas"},{"key":"5848_CR8","doi-asserted-by":"crossref","unstructured":"Chen S, Zhou M, Yang J, Cheng YR, Li Y, Lu K et al. Significance of common blood test indexes in the diagnosis and prognosis of multiple myeloma. Clin Lab. 2022;68(4).","DOI":"10.7754\/Clin.Lab.2021.210716"},{"issue":"5","key":"5848_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41408-022-00679-5","volume":"12","author":"P Hagen","year":"2022","unstructured":"Hagen P, Zhang J, Barton K. High-risk disease in newly diagnosed multiple myeloma: beyond the R-ISS and IMWG definitions. Blood Cancer J. 2022;12(5):83.","journal-title":"Blood Cancer J"},{"issue":"20","key":"5848_CR10","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1182\/blood-2014-09-568915","volume":"125","author":"P Moreau","year":"2015","unstructured":"Moreau P, Attal M, Facon T. Frontline therapy of multiple myeloma. Blood. 2015;125(20):3076\u201384.","journal-title":"Blood"},{"issue":"5","key":"5848_CR11","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1586\/17474086.2015.1078236","volume":"8","author":"MJ Cejalvo","year":"2015","unstructured":"Cejalvo MJ, de la Rubia J. Clinical treatment of newly diagnosed multiple myeloma. Expert Rev Hematol. 2015;8(5):595\u2013611.","journal-title":"Expert Rev Hematol"},{"issue":"4","key":"5848_CR12","first-page":"260","volume":"18","author":"Z Kovacs","year":"2018","unstructured":"Kovacs Z, Guttman A. Utilization of analytical omics tools in the molecular diagnostics of multiple myeloma. Curr Mol Med. 2018;18(4):260\u201372.","journal-title":"Curr Mol Med"},{"issue":"4","key":"5848_CR13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.23736\/S0031-0808.18.03542-5","volume":"60","author":"MA Aljama","year":"2018","unstructured":"Aljama MA, Sidiqi MH, Dingli D. Therapy for relapsed multiple myeloma. Panminerva Med. 2018;60(4):174\u201384.","journal-title":"Panminerva Med"},{"key":"5848_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/bs.acc.2019.11.002","volume":"96","author":"B Rubio-Jurado","year":"2020","unstructured":"Rubio-Jurado B, Sosa-Quintero LS, Carrasco-Martinez IL, Norato-Delgado A, Garcia-Luna E, Guzm\u00e1n-Silahua S, et al. New biomarkers in non-hodgkin lymphoma and acute leukemias. Adv Clin Chem. 2020;96:19\u201353.","journal-title":"Adv Clin Chem"},{"issue":"5","key":"5848_CR15","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3390\/diagnostics13050861","volume":"13","author":"A Alfaifi","year":"2023","unstructured":"Alfaifi A, Refai MY, Alsaadi M, Bahashwan S, Malhan H, Al-Kahiry W, et al. Metabolomics: a new era in the diagnosis or prognosis of b-cell non-hodgkin\u2019s lymphoma. Diagnostics (Basel). 2023;13(5):861.","journal-title":"Diagnostics (Basel)"},{"issue":"30","key":"5848_CR16","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.2174\/1568026619666181130111202","volume":"18","author":"V Chanukuppa","year":"2018","unstructured":"Chanukuppa V, Taware R, Chatterjee T, Sharma S, More TH, Taunk K, et al. Current understanding of the potential of proteomics and metabolomics approaches in cancer chemoresistance: a focus on multiple myeloma. Curr Top Med Chem. 2018;18(30):2584\u201398.","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"5848_CR17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s00005-022-00665-6","volume":"70","author":"A Kozio\u0142","year":"2022","unstructured":"Kozio\u0142 A, Pupek M. Application of metabolomics in childhood leukemia diagnostics. Arch Immunol Ther Exp (Warsz). 2022;70(1):28.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"12","key":"5848_CR18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41575-021-00502-9","volume":"18","author":"M Masoodi","year":"2021","unstructured":"Masoodi M, Gastaldelli A, Hy\u00f6tyl\u00e4inen T, Arretxe E, Alonso C, Gaggini M, et al. Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nat Rev Gastroenterol Hepatol. 2021;18(12):835\u201356.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"5848_CR19","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/med.21883","volume":"42","author":"PR Pereira","year":"2022","unstructured":"Pereira PR, Carrageta DF, Oliveira PF, Rodrigues A, Alves MG, Monteiro MP. Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease. Med Res Rev. 2022;42(4):1518\u201344.","journal-title":"Med Res Rev"},{"issue":"11","key":"5848_CR20","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.3390\/cells10112832","volume":"10","author":"Q Jin","year":"2021","unstructured":"Jin Q, Ma RCW. Metabolomics in Diabetes and Diabetic complications: insights from Epidemiological studies. Cells. 2021;10(11):2832.","journal-title":"Cells"},{"issue":"15","key":"5848_CR21","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1016\/j.cell.2022.06.029","volume":"185","author":"RJ DeBerardinis","year":"2022","unstructured":"DeBerardinis RJ, Keshari KR. Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell. 2022;185(15):2678\u201389.","journal-title":"Cell"},{"issue":"17","key":"5848_CR22","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.1158\/1078-0432.CCR-12-2917","volume":"19","author":"L Puchades-Carrasco","year":"2013","unstructured":"Puchades-Carrasco L, Lecumberri R, Mart\u00ednez-L\u00f3pez J, Lahuerta JJ, Mateos MV, Pr\u00f3sper F, et al. Multiple myeloma patients have a specific serum metabolomic profile that changes after achieving complete remission. Clin Cancer Res. 2013;19(17):4770\u20139.","journal-title":"Clin Cancer Res"},{"key":"5848_CR23","doi-asserted-by":"publisher","first-page":"e12918","DOI":"10.7717\/peerj.12918","volume":"10","author":"L Yue","year":"2022","unstructured":"Yue L, Zeng P, Li Y, Chai Y, Wu C, Gao B. Nontargeted and targeted metabolomics approaches reveal the key amino acid alterations involved in multiple myeloma. PeerJ. 2022;10:e12918.","journal-title":"PeerJ"},{"issue":"51","key":"5848_CR24","doi-asserted-by":"publisher","first-page":"29522","DOI":"10.1039\/C9RA04458B","volume":"9","author":"V Chanukuppa","year":"2019","unstructured":"Chanukuppa V, More TH, Taunk K, Taware R, Chatterjee T, Sharma S, et al. Serum metabolomic alterations in multiple myeloma revealed by targeted and untargeted metabolomics approaches: a pilot study. RSC Adv. 2019;9(51):29522\u201332.","journal-title":"RSC Adv"},{"key":"5848_CR25","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3389\/fphar.2018.00884","volume":"9","author":"H Du","year":"2018","unstructured":"Du H, Wang L, Liu B, Wang J, Su H, Zhang T, Huang Z. Analysis of the metabolic characteristics of serum samples in patients with multiple myeloma. Front Pharmacol. 2018;9:884.","journal-title":"Front Pharmacol"},{"key":"5848_CR26","doi-asserted-by":"publisher","first-page":"808290","DOI":"10.3389\/fonc.2022.808290","volume":"12","author":"Y Wei","year":"2022","unstructured":"Wei Y, Wang J, Chen F, Li X, Zhang J, Shen M, et al. Serum abnormal metabolites for evaluating therapeutic response and prognosis of patients with multiple myeloma. Front Oncol. 2022;12:808290.","journal-title":"Front Oncol"},{"issue":"24","key":"5848_CR27","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1021\/acs.jafc.7b01015","volume":"65","author":"G Shen","year":"2017","unstructured":"Shen G, Zhou L, Liu W, Cui Y, Xie W, Chen H, et al. Di(2-ethylhexyl)phthalate alters the synthesis and \u03b2-oxidation of fatty acids and hinders ATP supply in mouse testes via uplc-q-exactive orbitrap ms-based metabonomics study. J Agric Food Chem. 2017;65(24):5056\u201363.","journal-title":"J Agric Food Chem"},{"issue":"6","key":"5848_CR28","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1021\/acs.chemrestox.9b00503","volume":"33","author":"H Ji","year":"2020","unstructured":"Ji H, Song N, Ren J, Li W, Zhang L, Xu B, et al. Systems toxicology approaches reveal the mechanisms of hepatotoxicity induced by diosbulbin b in male mice. Chem Res Toxicol. 2020;33(6):1389\u2013402.","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"5848_CR29","doi-asserted-by":"publisher","first-page":"101152","DOI":"10.1016\/j.beha.2020.101152","volume":"33","author":"C Kunacheewa","year":"2020","unstructured":"Kunacheewa C, Manasanch EE. High-risk smoldering myeloma versus early detection of multiple myeloma: current models, goals of therapy, and clinical implications. Best Pract Res Clin Haematol. 2020;33(1):101152.","journal-title":"Best Pract Res Clin Haematol"},{"key":"5848_CR30","doi-asserted-by":"publisher","first-page":"118852","DOI":"10.1016\/j.lfs.2020.118852","volume":"265","author":"F Fei","year":"2021","unstructured":"Fei F, Ma T, Zhou X, Zheng M, Cao B, Li J. Metabolic markers for diagnosis and risk-prediction of multiple myeloma. Life Sci. 2021;265:118852.","journal-title":"Life Sci"},{"issue":"1","key":"5848_CR31","doi-asserted-by":"publisher","first-page":"10250","DOI":"10.1038\/s41598-020-67105-3","volume":"10","author":"WI Gonsalves","year":"2020","unstructured":"Gonsalves WI, Broniowska K, Jessen E, Petterson XM, Bush AG, Gransee J, Lacy MQ, Hitosugi T, Kumar SK. Metabolomic and lipidomic profiling of bone marrow plasma differentiates patients with monoclonal gammopathy of undetermined significance from multiple myeloma. Sci Rep. 2020;10(1):10250.","journal-title":"Sci Rep"},{"issue":"6","key":"5848_CR32","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1113\/JP278810","volume":"599","author":"P Vaupel","year":"2021","unstructured":"Vaupel P, Multhoff G. Revisiting the Warburg effect: historical dogma versus current understanding. J Physiol. 2021;599(6):1745\u201357.","journal-title":"J Physiol"},{"issue":"3","key":"5848_CR33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1053\/j.seminoncol.2017.10.004","volume":"44","author":"L Wilde","year":"2017","unstructured":"Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U. Metabolic coupling and the Reverse Warburg Effect in cancer: implications for novel biomarker and anticancer agent development. Semin Oncol. 2017;44(3):198\u2013203.","journal-title":"Semin Oncol"},{"key":"5848_CR34","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40164-015-0008-z","volume":"4","author":"S Fujiwara","year":"2015","unstructured":"Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, et al. Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1. Exp Hematol Oncol. 2015;4:12.","journal-title":"Exp Hematol Oncol"},{"issue":"6","key":"5848_CR35","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1159\/000506174","volume":"143","author":"H Lee","year":"2020","unstructured":"Lee H, Jimenez-Zepeda VH. The prognostic role of lactate dehydrogenase at first relapse of multiple myeloma. Acta Haematol. 2020;143(6):516\u20137.","journal-title":"Acta Haematol"},{"issue":"2","key":"5848_CR36","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1600-0609.2010.01466.x","volume":"85","author":"E Terpos","year":"2010","unstructured":"Terpos E, Katodritou E, Roussou M, Pouli A, Michalis E, Delimpasi S, et al. High serum lactate dehydrogenase adds prognostic value to the international myeloma staging system even in the era of novel agents. Eur J Haematol. 2010;85(2):114\u20139.","journal-title":"Eur J Haematol"},{"key":"5848_CR37","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.exphem.2021.02.007","volume":"97","author":"L Veskovski","year":"2021","unstructured":"Veskovski L, Andersson PO, Turesson I, Malmodin D, Pedersen A, Mellqvist UH. Serum metabolomic profiling correlated with ISS and clinical outcome for multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation. Exp Hematol. 2021;97:79\u2013e888.","journal-title":"Exp Hematol"},{"issue":"1","key":"5848_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12935-023-03007-4","volume":"23","author":"Z Yu","year":"2023","unstructured":"Yu Z, Qiu B, Zhou H, Li L, Niu T. Characterization and application of a lactate and branched chain amino acid metabolism related gene signature in a prognosis risk model for multiple myeloma. Cancer Cell Int. 2023;23(1):169.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"5848_CR39","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Mart\u00ednez-Reyes","year":"2020","unstructured":"Mart\u00ednez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11(1):102.","journal-title":"Nat Commun"},{"issue":"6","key":"5848_CR40","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.3390\/cancers12061394","volume":"12","author":"C Mesguich","year":"2020","unstructured":"Mesguich C, Hulin C, Lascaux A, Bordenave L, Marit G, Hindi\u00e9 E. Choline PET\/CT in multiple myeloma. Cancers (Basel). 2020;12(6):1394.","journal-title":"Cancers (Basel)"},{"issue":"1","key":"5848_CR41","doi-asserted-by":"publisher","first-page":"21836","DOI":"10.1038\/s41598-020-75862-4","volume":"10","author":"IDCG da Silva","year":"2020","unstructured":"da Silva IDCG, de Castro Levatti EV, Pedroso AP, Marchioni DML, Carioca AAF, Colleoni GWB. Biochemical phenotyping of multiple myeloma patients at diagnosis reveals a disorder of mitochondrial complexes I and II and a hartnup-like disturbance as underlying conditions, also influencing different stages of the disease. Sci Rep. 2020;10(1):21836.","journal-title":"Sci Rep"},{"key":"5848_CR42","doi-asserted-by":"publisher","first-page":"925807","DOI":"10.3389\/fonc.2022.925807","volume":"12","author":"DN Petrusca","year":"2022","unstructured":"Petrusca DN, Lee KP, Galson DL. Role of sphingolipids in multiple myeloma progression, drug resistance, and their potential as therapeutic targets. Front Oncol. 2022;12:925807.","journal-title":"Front Oncol"},{"key":"5848_CR43","doi-asserted-by":"publisher","first-page":"e9146","DOI":"10.7717\/peerj.9146","volume":"8","author":"M Bai","year":"2020","unstructured":"Bai M, Che Y, Lu K, Fu L. Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis. PeerJ. 2020;8:e9146.","journal-title":"PeerJ"},{"issue":"1","key":"5848_CR44","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1038\/s41467-020-15058-6","volume":"11","author":"R Boon","year":"2020","unstructured":"Boon R, Kumar M, Tricot T, Elia I, Ordovas L, Jacobs F, et al. Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines. Nat Commun. 2020;11(1):1393.","journal-title":"Nat Commun"},{"issue":"2","key":"5848_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ccell.2019.12.011","volume":"37","author":"S Sivanand","year":"2020","unstructured":"Sivanand S, Vander Heiden MG. Emerging roles for branched-chain amino acid metabolism in cancer. Cancer Cell. 2020;37(2):147\u201356.","journal-title":"Cancer Cell"},{"issue":"7","key":"5848_CR46","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00277-006-0095-3","volume":"85","author":"M Umeda","year":"2006","unstructured":"Umeda M, Okuda S, Izumi H, Nagase D, Fujimoto Y, Sugasawa Y, et al. Prognostic significance of the serum phosphorus level and its relationship with other prognostic factors in multiple myeloma. Ann Hematol. 2006;85(7):469\u201373.","journal-title":"Ann Hematol"},{"issue":"11","key":"5848_CR47","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/ajh.24528","volume":"91","author":"TV Kourelis","year":"2016","unstructured":"Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, et al. Outcomes of patients with renal monoclonal immunoglobulin deposition disease. Am J Hematol. 2016;91(11):1123\u20138.","journal-title":"Am J Hematol"},{"issue":"2","key":"5848_CR48","doi-asserted-by":"publisher","first-page":"e56422","DOI":"10.1371\/journal.pone.0056422","volume":"8","author":"A Lodi","year":"2013","unstructured":"Lodi A, Tiziani S, Khanim FL, G\u00fcnther UL, Viant MR, Morgan GJ, et al. Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. PLoS ONE. 2013;8(2):e56422.","journal-title":"PLoS ONE"},{"issue":"9\u201310","key":"5848_CR49","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/S1567-5769(01)00105-9","volume":"1","author":"I Athanassakis","year":"2001","unstructured":"Athanassakis I, Mouratidou M, Sakka P, Evangeliou A, Spilioti M, Vassiliadis S. L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment. Int Immunopharmacol. 2001;1(9\u201310):1813\u201322.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"5848_CR50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ymben.2009.02.001","volume":"11","author":"SH Khoo","year":"2009","unstructured":"Khoo SH, Al-Rubeai M. Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line. Metab Eng. 2009;11(3):199\u2013211.","journal-title":"Metab Eng"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05848-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05848-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05848-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:33:51Z","timestamp":1738820031000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05848-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5848"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05848-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4805854\/v1","asserted-by":"object"}]},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"26 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the guidelines of the Declaration of Helsinki and was approved by the Ethics Committee of Beijing Chao-yang Hospital, Capital Medical University, and informed written consent was obtained from all patients and healthy individuals. (No. 2019-4-15-4).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all study participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"163"}}