{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:52:51Z","timestamp":1780379571133,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05857-6","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:56:07Z","timestamp":1731588967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression"],"prefix":"10.1186","volume":"22","author":[{"given":"Zhenchao","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canliang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"5857_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2147\/IJGM.S186854","volume":"12","author":"M Alsaleh","year":"2019","unstructured":"Alsaleh M, Leftley Z, Barbera TA, Sithithaworn P, Khuntikeo N, Loilome W, Yongvanit P, Cox IJ, Chamodol N, Syms RR, et al. Cholangiocarcinoma: a guide for the nonspecialist. Int J Gen Med. 2019;12:13\u201323. https:\/\/doi.org\/10.2147\/IJGM.S186854.","journal-title":"Int J Gen Med"},{"key":"5857_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1159\/000453013","volume":"32","author":"MM Kirstein","year":"2016","unstructured":"Kirstein MM, Vogel A. Epidemiology and risk factors of Cholangiocarcinoma. Visc Med. 2016;32:395\u2013400. https:\/\/doi.org\/10.1159\/000453013.","journal-title":"Visc Med"},{"key":"5857_CR3","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.jhep.2022.07.022","volume":"77","author":"M Vithayathil","year":"2022","unstructured":"Vithayathil M, Khan SA. Current epidemiology of cholangiocarcinoma in western countries. J Hepatol. 2022;77:1690\u20138. https:\/\/doi.org\/10.1016\/j.jhep.2022.07.022.","journal-title":"J Hepatol"},{"key":"5857_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","volume":"17","author":"JM Banales","year":"2020","unstructured":"Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol. 2020;17:557\u201388. https:\/\/doi.org\/10.1038\/s41575-020-0310-z.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5857_CR5","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.4254\/wjh.v13.i9.1003","volume":"13","author":"AG Zori","year":"2021","unstructured":"Zori AG, Yang D, Draganov PV, Cabrera R. Advances in the management of cholangiocarcinoma. World J Hepatol. 2021;13:1003\u201318. https:\/\/doi.org\/10.4254\/wjh.v13.i9.1003.","journal-title":"World J Hepatol"},{"key":"5857_CR6","doi-asserted-by":"publisher","unstructured":"Sahin TK, Rizzo A, Aksoy S, Guven DC. Prognostic significance of the Royal Marsden Hospital (RMH) score in patients with Cancer: a systematic review and Meta-analysis. Cancers (Basel). 2024;16. https:\/\/doi.org\/10.3390\/cancers16101835.","DOI":"10.3390\/cancers16101835"},{"key":"5857_CR7","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1007\/s00520-023-08083-w","volume":"31","author":"DC Guven","year":"2023","unstructured":"Guven DC, Erul E, Kaygusuz Y, Akagunduz B, Kilickap S, De Luca R, Rizzo A. Immune checkpoint inhibitor-related hearing loss: a systematic review and analysis of individual patient data. Support Care Cancer. 2023;31:624. https:\/\/doi.org\/10.1007\/s00520-023-08083-w.","journal-title":"Support Care Cancer"},{"key":"5857_CR8","doi-asserted-by":"publisher","first-page":"107327482094804","DOI":"10.1177\/1073274820948047","volume":"27","author":"AD Ricci","year":"2020","unstructured":"Ricci AD, Rizzo A, Brandi G. Immunotherapy in biliary Tract Cancer: Worthy of a second look. Cancer Control. 2020;27:1073274820948047. https:\/\/doi.org\/10.1177\/1073274820948047.","journal-title":"Cancer Control"},{"key":"5857_CR9","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1080\/17425255.2021.2029405","volume":"17","author":"A Rizzo","year":"2021","unstructured":"Rizzo A, Santoni M, Mollica V, Logullo F, Rosellini M, Marchetti A, Faloppi L, Battelli N, Massari F. Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: the MOUSEION-02 study. Expert Opin Drug Metab Toxicol. 2021;17:1455\u201366. https:\/\/doi.org\/10.1080\/17425255.2021.2029405.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"5857_CR10","doi-asserted-by":"publisher","first-page":"e001042","DOI":"10.1136\/esmoopen-2020-001042","volume":"5","author":"AD Ricci","year":"2020","unstructured":"Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora\u2019s box? ESMO Open. 2020;5:e001042. https:\/\/doi.org\/10.1136\/esmoopen-2020-001042.","journal-title":"ESMO Open"},{"key":"5857_CR11","doi-asserted-by":"publisher","first-page":"114491","DOI":"10.1016\/j.biopha.2023.114491","volume":"161","author":"P Pandey","year":"2023","unstructured":"Pandey P, Khan F, Upadhyay TK, Seungjoon M, Park MN, Kim B. New insights about the PDGF\/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies. Biomed Pharmacother. 2023;161:114491. https:\/\/doi.org\/10.1016\/j.biopha.2023.114491.","journal-title":"Biomed Pharmacother"},{"key":"5857_CR12","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ijbiomac.2022.01.113","volume":"202","author":"X Zou","year":"2022","unstructured":"Zou X, Tang XY, Qu ZY, Sun ZW, Ji CF, Li YJ, Guo SD. Targeting the PDGF\/PDGFR signaling pathway for cancer therapy: a review. Int J Biol Macromol. 2022;202:539\u201357. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.01.113.","journal-title":"Int J Biol Macromol"},{"key":"5857_CR13","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1101\/gad.1653708","volume":"22","author":"J Andrae","year":"2008","unstructured":"Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22:1276\u2013312. https:\/\/doi.org\/10.1101\/gad.1653708.","journal-title":"Genes Dev"},{"key":"5857_CR14","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/modpathol.3880109","volume":"13","author":"I Sulzbacher","year":"2000","unstructured":"Sulzbacher I, Traxler M, Mosberger I, Lang S, Chott A. Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and\/or paracrine loop in osteosarcoma. Mod Pathol. 2000;13:632\u20137. https:\/\/doi.org\/10.1038\/modpathol.3880109.","journal-title":"Mod Pathol"},{"key":"5857_CR15","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1073\/pnas.89.9.3942","volume":"89","author":"HN Antoniades","year":"1992","unstructured":"Antoniades HN, Galanopoulos T, Neville-Golden J, O\u2019Hara CJ. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc Natl Acad Sci U S A. 1992;89:3942\u20136. https:\/\/doi.org\/10.1073\/pnas.89.9.3942.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5857_CR16","first-page":"3729","volume":"62","author":"NA Lokker","year":"2002","unstructured":"Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 2002;62:3729\u201335.","journal-title":"Cancer Res"},{"key":"5857_CR17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/ijc.2910600206","volume":"60","author":"A Guha","year":"1995","unstructured":"Guha A, Dashner K, Black PM, Wagner JA, Stiles CD. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer. 1995;60:168\u201373. https:\/\/doi.org\/10.1002\/ijc.2910600206.","journal-title":"Int J Cancer"},{"key":"5857_CR18","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/s0006-291x(02)00917-8","volume":"296","author":"J Andrae","year":"2002","unstructured":"Andrae J, Molander C, Smits A, Funa K, Nister M. Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells. Biochem Biophys Res Commun. 2002;296:604\u201311. https:\/\/doi.org\/10.1016\/s0006-291x(02)00917-8.","journal-title":"Biochem Biophys Res Commun"},{"key":"5857_CR19","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s43018-023-00525-y","volume":"4","author":"FK Turrell","year":"2023","unstructured":"Turrell FK, Orha R, Guppy NJ, Gillespie A, Guelbert M, Starling C, Haider S, Isacke CM. Age-associated microenvironmental changes highlight the role of PDGF-C in ER(+) breast cancer metastatic relapse. Nat Cancer. 2023;4:468\u201384. https:\/\/doi.org\/10.1038\/s43018-023-00525-y.","journal-title":"Nat Cancer"},{"key":"5857_CR20","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.1074\/jbc.M113.508994","volume":"289","author":"D Son","year":"2014","unstructured":"Son D, Na YR, Hwang ES, Seok SH. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through akt and bad phosphorylation. J Biol Chem. 2014;289:6225\u201335. https:\/\/doi.org\/10.1074\/jbc.M113.508994.","journal-title":"J Biol Chem"},{"key":"5857_CR21","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1038\/s41418-021-00823-x","volume":"28","author":"S Uxa","year":"2021","unstructured":"Uxa S, Castillo-Binder P, Kohler R, Stangner K, Muller GA, Engeland K. Ki-67 gene expression. Cell Death Differ. 2021;28:3357\u201370. https:\/\/doi.org\/10.1038\/s41418-021-00823-x.","journal-title":"Cell Death Differ"},{"key":"5857_CR22","doi-asserted-by":"publisher","unstructured":"Shin DW, Moon SH, Kim JH. Diagnosis of Cholangiocarcinoma. Diagnostics (Basel). 2023;13. https:\/\/doi.org\/10.3390\/diagnostics13020233.","DOI":"10.3390\/diagnostics13020233"},{"key":"5857_CR23","doi-asserted-by":"publisher","unstructured":"Khosla D, Misra S, Chu PL, Guan P, Nada R, Gupta R, Kaewnarin K, Ko TK, Heng HL, Srinivasalu VK, et al. Cholangiocarcinoma: recent advances in Molecular Pathobiology and therapeutic approaches. Cancers (Basel). 2024;16. https:\/\/doi.org\/10.3390\/cancers16040801.","DOI":"10.3390\/cancers16040801"},{"key":"5857_CR24","doi-asserted-by":"publisher","first-page":"e3000133","DOI":"10.1371\/journal.pbio.3000133","volume":"17","author":"H Li","year":"2019","unstructured":"Li H, Mao Y, Bouaziz M, Yu H, Qu X, Wang F, Feng GS, Shawber C, Zhang X. Lens differentiation is controlled by the balance between PDGF and FGF signaling. PLoS Biol. 2019;17:e3000133. https:\/\/doi.org\/10.1371\/journal.pbio.3000133.","journal-title":"PLoS Biol"},{"key":"5857_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.pharmthera.2016.07.016","volume":"167","author":"SA Lewandowski","year":"2016","unstructured":"Lewandowski SA, Fredriksson L, Lawrence DA, Eriksson U. Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders. Pharmacol Ther. 2016;167:108\u201319. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.07.016.","journal-title":"Pharmacol Ther"},{"key":"5857_CR26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.5732\/cjc.011.10300","volume":"30","author":"KW Liu","year":"2011","unstructured":"Liu KW, Hu B, Cheng SY. Platelet-derived growth factor signaling in human malignancies. Chin J Cancer. 2011;30:581\u20134. https:\/\/doi.org\/10.5732\/cjc.011.10300.","journal-title":"Chin J Cancer"},{"key":"5857_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/cbf.3120","volume":"33","author":"AA Farooqi","year":"2015","unstructured":"Farooqi AA, Siddik ZH. Platelet-derived growth factor (PDGF) signalling in cancer: rapidly emerging signalling landscape. Cell Biochem Funct. 2015;33:257\u201365. https:\/\/doi.org\/10.1002\/cbf.3120.","journal-title":"Cell Biochem Funct"},{"key":"5857_CR28","doi-asserted-by":"publisher","first-page":"e1537691","DOI":"10.1080\/2162402X.2018.1537691","volume":"8","author":"S Jabeen","year":"2019","unstructured":"Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Luders T, Engebraaten O, Borresen-Dale AL, Kyte JA, et al. Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics. Oncoimmunology. 2019;8:e1537691. https:\/\/doi.org\/10.1080\/2162402X.2018.1537691.","journal-title":"Oncoimmunology"},{"key":"5857_CR29","doi-asserted-by":"publisher","unstructured":"Lin LH, Lin JS, Yang CC, Cheng HW, Chang KW, Liu CJ. Overexpression of platelet-derived growth factor and its receptor are correlated with oral tumorigenesis and poor prognosis in oral squamous cell carcinoma. Int J Mol Sci. 2020;21. https:\/\/doi.org\/10.3390\/ijms21072360.","DOI":"10.3390\/ijms21072360"},{"key":"5857_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3892\/or.2020.7859","volume":"45","author":"T Li","year":"2021","unstructured":"Li T, Guo T, Liu H, Jiang H, Wang Y. Platelet\u2013derived growth factor\u2013BB mediates pancreatic cancer malignancy via regulation of the Hippo\/Yes\u2013associated protein signaling pathway. Oncol Rep. 2021;45:83\u201394. https:\/\/doi.org\/10.3892\/or.2020.7859.","journal-title":"Oncol Rep"},{"key":"5857_CR31","doi-asserted-by":"publisher","unstructured":"Kozlowski M, Borzyszkowska D, Mirko J, Turon-Skrzypinska A, Piotrowska K, Toloczko-Grabarek A, Kwiatkowski S, Tarnowski M, Rotter I, Cymbaluk-Ploska A. Preoperative Serum Levels of PDGF-AB, PDGF-BB, TGF-alpha, EGF and ANG-2 in the diagnosis of Endometrial Cancer. Cancers (Basel). 2023;15. https:\/\/doi.org\/10.3390\/cancers15194815.","DOI":"10.3390\/cancers15194815"},{"key":"5857_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1146\/annurev-med-062913-051343","volume":"67","author":"IA Mayer","year":"2016","unstructured":"Mayer IA, Arteaga CL. The PI3K\/AKT pathway as a target for Cancer Treatment. Annu Rev Med. 2016;67:11\u201328. https:\/\/doi.org\/10.1146\/annurev-med-062913-051343.","journal-title":"Annu Rev Med"},{"key":"5857_CR33","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","volume":"36","author":"MC Mendoza","year":"2011","unstructured":"Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci. 2011;36:320\u20138. https:\/\/doi.org\/10.1016\/j.tibs.2011.03.006.","journal-title":"Trends Biochem Sci"},{"key":"5857_CR34","doi-asserted-by":"publisher","first-page":"16192","DOI":"10.1038\/s41598-017-16443-w","volume":"7","author":"Y Saito","year":"2017","unstructured":"Saito Y, Chikenji T, Ozasa Y, Fujimiya M, Yamashita T, Gingery A, Iba K. PDGFR Signaling mediates hyperproliferation and fibrotic responses of Subsynovial Connective tissue cells in idiopathic carpal tunnel syndrome. Sci Rep. 2017;7:16192. https:\/\/doi.org\/10.1038\/s41598-017-16443-w.","journal-title":"Sci Rep"},{"key":"5857_CR35","doi-asserted-by":"publisher","first-page":"77902","DOI":"10.18632\/oncotarget.12843","volume":"7","author":"L Zheng","year":"2016","unstructured":"Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, et al. PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently. Oncotarget. 2016;7:77902\u201315. https:\/\/doi.org\/10.18632\/oncotarget.12843.","journal-title":"Oncotarget"},{"key":"5857_CR36","doi-asserted-by":"publisher","first-page":"12216","DOI":"10.1073\/pnas.1004143107","volume":"107","author":"X Hou","year":"2010","unstructured":"Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, et al. PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci U S A. 2010;107:12216\u201321. https:\/\/doi.org\/10.1073\/pnas.1004143107.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5857_CR37","doi-asserted-by":"publisher","unstructured":"Duangdara J, Boonsri B, Sayinta A, Supradit K, Thintharua P, Kumkate S, Suriyonplengsaeng C, Larbcharoensub N, Mingphruedhi S, Rungsakulkij N, et al. CP-673451, a selective platelet-derived growth factor receptor tyrosine kinase inhibitor, induces apoptosis in Opisthorchis viverrini-Associated Cholangiocarcinoma via Nrf2 suppression and enhanced ROS. Pharmaceuticals (Basel). 2023;17. https:\/\/doi.org\/10.3390\/ph17010009.","DOI":"10.3390\/ph17010009"},{"key":"5857_CR38","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1016\/j.bbapap.2012.10.015","volume":"1834","author":"PH Chen","year":"2013","unstructured":"Chen PH, Chen X, He X. Platelet-derived growth factors and their receptors: structural and functional perspectives. Biochim Biophys Acta. 2013;1834:2176\u201386. https:\/\/doi.org\/10.1016\/j.bbapap.2012.10.015.","journal-title":"Biochim Biophys Acta"},{"key":"5857_CR39","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1478-3231.2011.02687.x","volume":"32","author":"CD Fingas","year":"2012","unstructured":"Fingas CD, Mertens JC, Razumilava N, Bronk SF, Sirica AE, Gores GJ. Targeting PDGFR-beta in Cholangiocarcinoma. Liver Int. 2012;32:400\u20139. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02687.x.","journal-title":"Liver Int"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05857-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05857-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05857-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:04:15Z","timestamp":1731589455000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05857-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5857"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05857-6","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"29 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Sun Yat- sen Memorial Hospital (permit number: SYSKY-2023-156-01). Each participant signed informed consent before participating in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1023"}}