{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:33:14Z","timestamp":1791516794315,"version":"4.3.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation Regional Innovation and Development Joint Fund","award":["U23A6011"],"award-info":[{"award-number":["U23A6011"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070434\/H0214"],"award-info":[{"award-number":["82070434\/H0214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072717"],"award-info":[{"award-number":["82072717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Strengthening Plan Project","award":["2023-JCJQ-JJ-0704"],"award-info":[{"award-number":["2023-JCJQ-JJ-0704"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC3600100"],"award-info":[{"award-number":["2022YFC3600100"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2023-1"],"award-info":[{"award-number":["2023-1"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["BJ-2024-219"],"award-info":[{"award-number":["BJ-2024-219"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723897"],"award-info":[{"award-number":["2022M723897"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160787"],"award-info":[{"award-number":["2023T160787"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z191100001119020"],"award-info":[{"award-number":["Z191100001119020"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05887-0","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:09:09Z","timestamp":1732810149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress"],"prefix":"10.1186","volume":"22","author":[{"given":"Haijing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weini","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-5723","authenticated-orcid":false,"given":"Yuqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"5887_CR1","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/CIRCRESAHA.118.311378","volume":"123","author":"Z Ungvari","year":"2018","unstructured":"Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of vascular aging. Circ Res. 2018;123:849\u201367.","journal-title":"Circ Res"},{"key":"5887_CR2","doi-asserted-by":"publisher","first-page":"H292","DOI":"10.1152\/ajpheart.00307.2014","volume":"307","author":"A Csiszar","year":"2014","unstructured":"Csiszar A, Gautam T, Sosnowska D, Tarantini S, Banki E, Tucsek Z, Toth P, Losonczy G, Koller A, Reglodi D, et al. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. Am J Physiol Heart Circ Physiol. 2014;307:H292-306.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5887_CR3","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1186\/s12967-023-04361-7","volume":"21","author":"Q Yan","year":"2023","unstructured":"Yan Q, Liu S, Sun Y, Chen C, Yang S, Lin M, Long J, Yao J, Lin Y, Yi F, et al. Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease. J Transl Med. 2023;21:519.","journal-title":"J Transl Med"},{"key":"5887_CR4","doi-asserted-by":"publisher","first-page":"H647","DOI":"10.1152\/ajpheart.01271.2010","volume":"301","author":"NS Zinkevich","year":"2011","unstructured":"Zinkevich NS, Gutterman DD. ROS-induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol. 2011;301:H647-653.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5887_CR5","first-page":"3","volume":"44","author":"RZ Zhao","year":"2019","unstructured":"Zhao RZ, Jiang S, Zhang L, Yu ZB. Mitochondrial electron transport chain, ROS generation and uncoupling (review). Int J Mol Med. 2019;44:3\u201315.","journal-title":"Int J Mol Med"},{"key":"5887_CR6","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","volume":"17","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nat Rev Cardiol. 2020;17:170\u201394.","journal-title":"Nat Rev Cardiol"},{"key":"5887_CR7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2024.03.001","volume":"216","author":"X Mu","year":"2024","unstructured":"Mu X, Liu SJ, Zheng LY, Ouyang C, Abdalla AME, Wang XX, Chen K, Yang FF, Meng N. The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-\/-) mice. Free Radic Biol Med. 2024;216:106\u201317.","journal-title":"Free Radic Biol Med"},{"key":"5887_CR8","doi-asserted-by":"publisher","first-page":"5245308","DOI":"10.1155\/2020\/5245308","volume":"2020","author":"C Khatana","year":"2020","unstructured":"Khatana C, Saini NK, Chakrabarti S, Saini V, Sharma A, Saini RV, Saini AK. Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis. Oxid Med Cell Longev. 2020;2020:5245308.","journal-title":"Oxid Med Cell Longev"},{"key":"5887_CR9","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3109\/10408363.2014.992063","volume":"52","author":"A Trpkovic","year":"2015","unstructured":"Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa SA, Cenic-Milosevic D, Jevremovic D, Isenovic ER. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2015;52:70\u201385.","journal-title":"Crit Rev Clin Lab Sci"},{"key":"5887_CR10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12950-023-00366-7","volume":"20","author":"H Zhou","year":"2023","unstructured":"Zhou H, Khan D, Hussain SM, Gerdes N, Hagenbeck C, Rana M, Cornelius JF, Muhammad S. Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-\u03baB and MAPKs: implications in vascular diseases. J Inflamm (Lond). 2023;20:41.","journal-title":"J Inflamm (Lond)"},{"key":"5887_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","volume":"52","author":"T de Lange","year":"2018","unstructured":"de Lange T. Shelterin-mediated telomere protection. Annu Rev Genet. 2018;52:223\u201347.","journal-title":"Annu Rev Genet"},{"key":"5887_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fcvm.2019.00031","volume":"6","author":"K Ait-Aissa","year":"2019","unstructured":"Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM. Telomerase deficiency predisposes to heart failure and ischemia-reperfusion injury. Front Cardiovasc Med. 2019;6:31.","journal-title":"Front Cardiovasc Med"},{"key":"5887_CR13","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1161\/CIRCULATIONAHA.120.051923","volume":"144","author":"N Ale-Agha","year":"2021","unstructured":"Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, et al. Mitochondrial telomerase reverse transcriptase protects from myocardial ischemia\/reperfusion injury by improving complex I composition and function. Circulation. 2021;144:1876\u201390.","journal-title":"Circulation"},{"key":"5887_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115576","volume":"167","author":"X Wang","year":"2023","unstructured":"Wang X, Guo Y, Cui T, Zhang T, Hu W, Liu R, Yin C. Telomerase reverse transcriptase restores pancreatic microcirculation profiles and attenuates endothelial dysfunction by inhibiting mitochondrial superoxide production: a potential target for acute pancreatitis therapy. Biomed Pharmacother. 2023;167: 115576.","journal-title":"Biomed Pharmacother"},{"key":"5887_CR15","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/ATVBAHA.109.185546","volume":"29","author":"J Haendeler","year":"2009","unstructured":"Haendeler J, Dr\u00f6se S, B\u00fcchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol. 2009;29:929\u201335.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5887_CR16","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.1182\/blood-2010-08-297390","volume":"117","author":"E Nitta","year":"2011","unstructured":"Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T. Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism. Blood. 2011;117:4169\u201380.","journal-title":"Blood"},{"key":"5887_CR17","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.18632\/aging.101089","volume":"8","author":"S Miwa","year":"2016","unstructured":"Miwa S, Czapiewski R, Wan T, Bell A, Hill KN, von Zglinicki T, Saretzki G. Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria. Aging (Albany NY). 2016;8:2551\u201367.","journal-title":"Aging (Albany NY)"},{"key":"5887_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.896782","volume":"9","author":"H Huang","year":"2022","unstructured":"Huang H, Huang W. Regulation of endothelial progenitor cell functions in ischemic heart disease: new therapeutic targets for cardiac remodeling and repair. Front Cardiovasc Med. 2022;9: 896782.","journal-title":"Front Cardiovasc Med"},{"key":"5887_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512298","author":"M Mart\u00edn-B\u00f3rnez","year":"2023","unstructured":"Mart\u00edn-B\u00f3rnez M, Falc\u00f3n D, Morrugares R, Siegfried G, Khatib AM, Rosado JA, Galeano-Otero I, Smani T. New insights into the reparative angiogenesis after myocardial infarction. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241512298.","journal-title":"Int J Mol Sci"},{"key":"5887_CR20","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1002\/stem.745","volume":"29","author":"T Asahara","year":"2011","unstructured":"Asahara T, Kawamoto A, Masuda H. Concise review: circulating endothelial progenitor cells for vascular medicine. Stem Cells. 2011;29:1650\u20135.","journal-title":"Stem Cells"},{"key":"5887_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/FJC.0000000000000166","volume":"65","author":"J Peng","year":"2015","unstructured":"Peng J, Liu B, Ma QL, Luo XJ. Dysfunctional endothelial progenitor cells in cardiovascular diseases: role of NADPH oxidase. J Cardiovasc Pharmacol. 2015;65:80\u20137.","journal-title":"J Cardiovasc Pharmacol"},{"key":"5887_CR22","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1038\/s41596-019-0213-z","volume":"14","author":"RA Wimmer","year":"2019","unstructured":"Wimmer RA, Leopoldi A, Aichinger M, Kerjaschki D, Penninger JM. Generation of blood vessel organoids from human pluripotent stem cells. Nat Protoc. 2019;14:3082\u2013100.","journal-title":"Nat Protoc"},{"key":"5887_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41586-018-0858-8","volume":"565","author":"RA Wimmer","year":"2019","unstructured":"Wimmer RA, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, Taubenschmid J, H\u00e4mmerle M, Esk C, Bagley JA, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505\u201310.","journal-title":"Nature"},{"key":"5887_CR24","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","volume":"165","author":"H Clevers","year":"2016","unstructured":"Clevers H. Modeling development and disease with organoids. Cell. 2016;165:1586\u201397.","journal-title":"Cell"},{"key":"5887_CR25","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.cell.2020.04.004","volume":"181","author":"V Monteil","year":"2020","unstructured":"Monteil V, Kwon H, Prado P, Hagelkr\u00fcys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, et al. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell. 2020;181:905-913.e907.","journal-title":"Cell"},{"key":"5887_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13729","volume":"21","author":"R Jin","year":"2022","unstructured":"Jin R, Niu C, Wu F, Zhou S, Han T, Zhang Z, Li E, Zhang X, Xu S, Wang J, et al. DNA damage contributes to age-associated differences in SARS-CoV-2 infection. Aging Cell. 2022;21: e13729.","journal-title":"Aging Cell"},{"key":"5887_CR27","doi-asserted-by":"publisher","first-page":"eaav1090","DOI":"10.1126\/sciadv.aav1090","volume":"5","author":"L Cheng","year":"2019","unstructured":"Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, et al. PES1 is a critical component of telomerase assembly and regulates cellular senescence. Sci Adv. 2019;5:eaav1090.","journal-title":"Sci Adv"},{"key":"5887_CR28","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10522-023-10076-5","volume":"25","author":"J Harley","year":"2024","unstructured":"Harley J, Santosa MM, Ng CY, Grinchuk OV, Hor JH, Liang Y, Lim VJ, Tee WW, Ong DST, Ng SY. Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes. Biogerontology. 2024;25:341\u201360.","journal-title":"Biogerontology"},{"key":"5887_CR29","first-page":"4600","volume":"15","author":"AM Polonio","year":"2023","unstructured":"Polonio AM, Medrano M, Chico-Sordo L, C\u00f3rdova-Oriz I, Cozzolino M, Montans J, Herraiz S, Seli E, Pellicer A, Garc\u00eda-Velasco JA, Varela E. Impaired telomere pathway and fertility in senescence-accelerated mice prone 8 females with reproductive senescence. Aging (Albany NY). 2023;15:4600\u201324.","journal-title":"Aging (Albany NY)"},{"key":"5887_CR30","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s00018-024-05239-7","volume":"81","author":"S Chatterjee","year":"2024","unstructured":"Chatterjee S, Leach-Mehrwald M, Huang CK, Xiao K, Fuchs M, Otto M, Lu D, Dang V, Winkler T, Dunbar CE, et al. Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes. Cell Mol Life Sci. 2024;81:196.","journal-title":"Cell Mol Life Sci"},{"key":"5887_CR31","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1093\/jnci\/djn213","volume":"100","author":"J Xing","year":"2008","unstructured":"Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, et al. Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst. 2008;100:1104\u201312.","journal-title":"J Natl Cancer Inst"},{"key":"5887_CR32","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1007\/s00125-007-0818-6","volume":"50","author":"M Kaaman","year":"2007","unstructured":"Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sj\u00f6lin E, Dahlman I, Arner P. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia. 2007;50:2526\u201333.","journal-title":"Diabetologia"},{"key":"5887_CR33","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106283","volume":"40","author":"L Shu","year":"2021","unstructured":"Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z. ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA. Embo j. 2021;40: e106283.","journal-title":"Embo j"},{"key":"5887_CR34","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.ymeth.2010.01.033","volume":"51","author":"SE Hunter","year":"2010","unstructured":"Hunter SE, Jung D, Di Giulio RT, Meyer JN. The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. Methods. 2010;51:444\u201351.","journal-title":"Methods"},{"key":"5887_CR35","first-page":"2036","volume":"10","author":"MT Nikolova","year":"2022","unstructured":"Nikolova MT, He Z, Wimmer RA, Seimiya M, Nikoloff JM, Penninger JM, Camp JG, Treutlein B. Fate and state transitions during human bloodvessel organoid development. bioRxiv. 2022;10:2036.","journal-title":"bioRxiv"},{"key":"5887_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ijcard.2010.04.018","volume":"144","author":"BR Everaert","year":"2010","unstructured":"Everaert BR, Van Craenenbroeck EM, Hoymans VY, Haine SE, Van Nassauw L, Conraads VM, Timmermans JP, Vrints CJ. Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: focus on PI3K\/AKT\/eNOS pathway. Int J Cardiol. 2010;144:350\u201366.","journal-title":"Int J Cardiol"},{"key":"5887_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","volume":"19","author":"AJ Kattoor","year":"2017","unstructured":"Kattoor AJ, Pothineni NVK, Palagiri D, Mehta JL. Oxidative stress in atherosclerosis. Curr Atheroscler Rep. 2017;19:42.","journal-title":"Curr Atheroscler Rep"},{"key":"5887_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1747-1028-2-10","volume":"2","author":"A Takahashi","year":"2007","unstructured":"Takahashi A, Ohtani N, Hara E. Irreversibility of cellular senescence: dual roles of p16INK4a\/Rb-pathway in cell cycle control. Cell Div. 2007;2:10.","journal-title":"Cell Div"},{"key":"5887_CR39","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1093\/nar\/gkp100","volume":"37","author":"I Shokolenko","year":"2009","unstructured":"Shokolenko I, Venediktova N, Bochkareva A, Wilson GL, Alexeyev MF. Oxidative stress induces degradation of mitochondrial DNA. Nucleic Acids Res. 2009;37:2539\u201348.","journal-title":"Nucleic Acids Res"},{"key":"5887_CR40","doi-asserted-by":"publisher","first-page":"32195","DOI":"10.1021\/acsomega.0c03581","volume":"5","author":"R Liu","year":"2020","unstructured":"Liu R, Cheng F, Zeng K, Li W, Lan J. GPR120 agonist GW9508 ameliorated cellular senescence induced by ox-LDL. ACS Omega. 2020;5:32195\u2013202.","journal-title":"ACS Omega"},{"key":"5887_CR41","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/902842","volume":"2014","author":"R Liu","year":"2014","unstructured":"Liu R, Liu H, Ha Y, Tilton RG, Zhang W. Oxidative stress induces endothelial cell senescence via downregulation of Sirt6. Biomed Res Int. 2014;2014: 902842.","journal-title":"Biomed Res Int"},{"key":"5887_CR42","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1074\/jbc.M112.416792","volume":"288","author":"HY Jung","year":"2013","unstructured":"Jung HY, Wang X, Jun S, Park JI. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem. 2013;288:7252\u201362.","journal-title":"J Biol Chem"},{"key":"5887_CR43","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.cell.2008.01.019","volume":"132","author":"AS Venteicher","year":"2008","unstructured":"Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell. 2008;132:945\u201357.","journal-title":"Cell"},{"key":"5887_CR44","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/cr.2011.16","volume":"21","author":"J Huang","year":"2011","unstructured":"Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, et al. Association of telomere length with authentic pluripotency of ES\/iPS cells. Cell Res. 2011;21:779\u201392.","journal-title":"Cell Res"},{"key":"5887_CR45","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1080\/15476286.2015.1134413","volume":"13","author":"JH Teichroeb","year":"2016","unstructured":"Teichroeb JH, Kim J, Betts DH. The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance. RNA Biol. 2016;13:707\u201319.","journal-title":"RNA Biol"},{"key":"5887_CR46","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/nprot.2014.102","volume":"9","author":"VV Orlova","year":"2014","unstructured":"Orlova VV, van den Hil FE, Petrus-Reurer S, Drabsch Y, Ten Dijke P, Mummery CL. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells. Nat Protoc. 2014;9:1514\u201331.","journal-title":"Nat Protoc"},{"key":"5887_CR47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/ATVBAHA.113.302598","volume":"34","author":"VV Orlova","year":"2014","unstructured":"Orlova VV, Drabsch Y, Freund C, Petrus-Reurer S, van den Hil FE, Muenthaisong S, Dijke PT, Mummery CL. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler Thromb Vasc Biol. 2014;34:177\u201386.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5887_CR48","first-page":"127","volume":"14","author":"J Yu","year":"2021","unstructured":"Yu J. Vascularized organoids: a more complete model. Int J Stem Cells. 2021;14:127\u201337.","journal-title":"Int J Stem Cells"},{"key":"5887_CR49","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1038\/s41467-023-41326-2","volume":"14","author":"SG Romeo","year":"2023","unstructured":"Romeo SG, Secco I, Schneider E, Reumiller CM, Santos CXC, Zoccarato A, Musale V, Pooni A, Yin X, Theofilatos K, et al. Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity. Nat Commun. 2023;14:5552.","journal-title":"Nat Commun"},{"key":"5887_CR50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cardiores.2006.01.002","volume":"70","author":"T Thum","year":"2006","unstructured":"Thum T, Fraccarollo D, Galuppo P, Tsikas D, Frantz S, Ertl G, Bauersachs J. Bone marrow molecular alterations after myocardial infarction: impact on endothelial progenitor cells. Cardiovasc Res. 2006;70:50\u201360.","journal-title":"Cardiovasc Res"},{"key":"5887_CR51","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.atherosclerosis.2012.05.003","volume":"223","author":"J Turgeon","year":"2012","unstructured":"Turgeon J, Haddad P, Dussault S, Groleau J, Maingrette F, Perez G, Rivard A. Protection against vascular aging in Nox2-deficient mice: impact on endothelial progenitor cells and reparative neovascularization. Atherosclerosis. 2012;223:122\u20139.","journal-title":"Atherosclerosis"},{"key":"5887_CR52","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.3390\/ijms20133338","volume":"20","author":"X Yuan","year":"2019","unstructured":"Yuan X, Xu D. Telomerase reverse transcriptase (TERT) in action: cross-talking with epigenetics. Int J Mol Sci. 2019;20:3338.","journal-title":"Int J Mol Sci"},{"key":"5887_CR53","first-page":"547","volume":"2","author":"H Takano","year":"2008","unstructured":"Takano H, Murasawa S, Asahara T. Functional and gene expression analysis of hTERT overexpressed endothelial cells. Biologics. 2008;2:547\u201354.","journal-title":"Biologics"},{"key":"5887_CR54","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1038\/sj.onc.1201933","volume":"16","author":"RA Greenberg","year":"1998","unstructured":"Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 1998;16:1723\u201330.","journal-title":"Oncogene"},{"key":"5887_CR55","doi-asserted-by":"publisher","first-page":"5863","DOI":"10.1038\/ncomms6863","volume":"5","author":"C B\u00e4r","year":"2014","unstructured":"B\u00e4r C, Bernardes de Jesus B, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, et al. Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. Nat Commun. 2014;5:5863.","journal-title":"Nat Commun"},{"key":"5887_CR56","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1161\/ATVBAHA.120.314944","volume":"41","author":"WE Hughes","year":"2021","unstructured":"Hughes WE, Chabowski DS, Ait-Aissa K, Fetterman JL, Hockenberry J, Beyer AM, Gutterman DD. Critical interaction between telomerase and autophagy in mediating flow-induced human arteriolar vasodilation. Arterioscler Thromb Vasc Biol. 2021;41:446\u201357.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5887_CR57","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1161\/01.ATV.0000069624.55424.61","volume":"23","author":"DJ Kurz","year":"2003","unstructured":"Kurz DJ, Hong Y, Trivier E, Huang HL, Decary S, Zang GH, L\u00fcscher TF, Erusalimsky JD. Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells. Arterioscler Thromb Vasc Biol. 2003;23:748\u201354.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5887_CR58","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/CIRCRESAHA.115.307918","volume":"118","author":"AM Beyer","year":"2016","unstructured":"Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, et al. Critical role for telomerase in the mechanism of flow-mediated dilation in the human microcirculation. Circ Res. 2016;118:856\u201366.","journal-title":"Circ Res"},{"key":"5887_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101543","volume":"34","author":"J Rosen","year":"2020","unstructured":"Rosen J, Jakobs P, Ale-Agha N, Altschmied J, Haendeler J. Non-canonical functions of telomerase reverse transcriptase\u2014impact on redox homeostasis. Redox Biol. 2020;34: 101543.","journal-title":"Redox Biol"},{"key":"5887_CR60","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1161\/ATVBAHA.116.307518","volume":"36","author":"MJ Durand","year":"2016","unstructured":"Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM. Vascular actions of angiotensin 1\u20137 in the human microcirculation: novel role for telomerase. Arterioscler Thromb Vasc Biol. 2016;36:1254\u201362.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5887_CR61","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.1128\/MCB.23.13.4598-4610.2003","volume":"23","author":"J Haendeler","year":"2003","unstructured":"Haendeler J, Hoffmann J, Brandes RP, Zeiher AM, Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol. 2003;23:4598\u2013610.","journal-title":"Mol Cell Biol"},{"key":"5887_CR62","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/cvr\/cvn182","volume":"80","author":"P Wenzel","year":"2008","unstructured":"Wenzel P, Schuhmacher S, Kienhofer J, Muller J, Hortmann M, Oelze M, Schulz E, Treiber N, Kawamoto T, Scharffetter-Kochanek K, et al. Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res. 2008;80:280\u20139.","journal-title":"Cardiovasc Res"},{"key":"5887_CR63","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1093\/gerona\/glu244","volume":"70","author":"Z Springo","year":"2015","unstructured":"Springo Z, Tarantini S, Toth P, Tucsek Z, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates pressure-induced mitochondrial oxidative stress in mouse cerebral arteries. J Gerontol A Biol Sci Med Sci. 2015;70:1355\u20139.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"5887_CR64","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/ijms20061509","volume":"20","author":"PD Green","year":"2019","unstructured":"Green PD, Sharma NK, Santos JH. Telomerase impinges on the cellular response to oxidative stress through mitochondrial ROS-mediated regulation of autophagy. Int J Mol Sci. 2019;20:1509.","journal-title":"Int J Mol Sci"},{"key":"5887_CR65","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1242\/jcs.019372","volume":"121","author":"S Ahmed","year":"2008","unstructured":"Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008;121:1046\u201353.","journal-title":"J Cell Sci"},{"key":"5887_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052989","volume":"8","author":"C Singhapol","year":"2013","unstructured":"Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS ONE. 2013;8: e52989.","journal-title":"PLoS ONE"},{"key":"5887_CR67","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1158\/0008-5472.CAN-10-1588","volume":"71","author":"IR Indran","year":"2011","unstructured":"Indran IR, Hande MP, Pervaiz S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res. 2011;71:266\u201376.","journal-title":"Cancer Res"},{"key":"5887_CR68","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/ncb1848","volume":"11","author":"S Maddika","year":"2009","unstructured":"Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009;11:409\u201319.","journal-title":"Nat Cell Biol"},{"key":"5887_CR69","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41418-020-00707-6","volume":"28","author":"SS Shah","year":"2021","unstructured":"Shah SS, Kumar S. Adaptors as the regulators of HECT ubiquitin ligases. Cell Death Differ. 2021;28:455\u201372.","journal-title":"Cell Death Differ"},{"key":"5887_CR70","doi-asserted-by":"publisher","first-page":"11804","DOI":"10.1074\/jbc.M117.785170","volume":"292","author":"JH Cho","year":"2017","unstructured":"Cho JH, Kim SA, Seo YS, Park SG, Park BC, Kim JH, Kim S. The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3. J Biol Chem. 2017;292:11804\u201314.","journal-title":"J Biol Chem"},{"key":"5887_CR71","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1158\/1541-7786.MCR-15-0383","volume":"13","author":"RF Shearer","year":"2015","unstructured":"Shearer RF, Iconomou M, Watts CK, Saunders DN. Functional roles of the E3 ubiquitin ligase UBR5 in cancer. Mol Cancer Res. 2015;13:1523\u201332.","journal-title":"Mol Cancer Res"},{"key":"5887_CR72","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/MNH.0000000000000580","volume":"29","author":"G Kokeny","year":"2020","unstructured":"Kokeny G, Calvier L, Legchenko E, Chouvarine P, Mozes MM, Hansmann G. PPARgamma is a gatekeeper for extracellular matrix and vascular cell homeostasis: beneficial role in pulmonary hypertension and renal\/cardiac\/pulmonary fibrosis. Curr Opin Nephrol Hypertens. 2020;29:171\u20139.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"5887_CR73","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1523\/JNEUROSCI.1631-18.2018","volume":"39","author":"Z Pan","year":"2019","unstructured":"Pan Z, Li GF, Sun ML, Xie L, Liu D, Zhang Q, Yang XX, Xia S, Liu X, Zhou H, et al. MicroRNA-1224 splicing circularRNA-Filip1l in an Ago2-dependent manner regulates chronic inflammatory pain via targeting Ubr5. J Neurosci. 2019;39:2125\u201343.","journal-title":"J Neurosci"},{"key":"5887_CR74","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2478\/jtim-2020-0012","volume":"8","author":"H Qian","year":"2020","unstructured":"Qian H, Zhang Y, Wu B, Wu S, You S, Zhang N, Sun Y. Structure and function of HECT E3 ubiquitin ligases and their role in oxidative stress. J Transl Int Med. 2020;8:71\u20139.","journal-title":"J Transl Int Med"},{"key":"5887_CR75","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.molcel.2011.04.028","volume":"43","author":"W Jiang","year":"2011","unstructured":"Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell. 2011;43:33\u201344.","journal-title":"Mol Cell"},{"issue":"1333\u20131343","key":"5887_CR76","volume":"26","author":"CG Li","year":"2019","unstructured":"Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, et al. PPARgamma interaction with UBR5\/ATMIN promotes DNA repair to maintain endothelial homeostasis. Cell Rep. 2019;26(1333\u20131343): e1337.","journal-title":"Cell Rep"},{"key":"5887_CR77","doi-asserted-by":"publisher","first-page":"10940","DOI":"10.1093\/nar\/gkaa756","volume":"48","author":"H Feng","year":"2020","unstructured":"Feng H, Lu J, Song X, Thongkum A, Zhang F, Lou L, Reizes O, Almasan A, Gong Z. CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication. Nucleic Acids Res. 2020;48:10940\u201352.","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05887-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05887-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05887-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T17:02:55Z","timestamp":1732813375000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05887-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5887"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05887-0","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"1 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript does not contain clinical studies, patient data, or animal studies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have declared that no competing interest exists.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1080"}}