{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:30:36Z","timestamp":1787239836057,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation Key Program","award":["(82230032)"],"award-info":[{"award-number":["(82230032)"]}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(81930023)"],"award-info":[{"award-number":["(81930023)"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of Chongqing Science and Technology Bureau","award":["(CSTC2021jscx-gksb-N0010)"],"award-info":[{"award-number":["(CSTC2021jscx-gksb-N0010)"]}]},{"name":"Chongqing Outstanding Scientists Project","award":["(2019)"],"award-info":[{"award-number":["(2019)"]}]},{"name":"Chongqing Chief Medical Scientist Project","award":["(2018)"],"award-info":[{"award-number":["(2018)"]}]},{"name":"Chongqing Science and Technology Bureau Mountaineering Project","award":["(cyyy-xkdfjh-jcyj-202301"],"award-info":[{"award-number":["(cyyy-xkdfjh-jcyj-202301"]}]},{"name":"Chongqing Science and Technology Bureau Mountaineering Project","award":["cyyy-xkdfjh-lcyj-202303"],"award-info":[{"award-number":["cyyy-xkdfjh-lcyj-202303"]}]},{"name":"Chongqing Science and Technology Bureau Mountaineering Project","award":["cyyy-xkdfjh-cgzh202302)"],"award-info":[{"award-number":["cyyy-xkdfjh-cgzh202302)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05925-x","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:18:00Z","timestamp":1734679080000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study"],"prefix":"10.1186","volume":"22","author":[{"given":"Lingyu","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-6619","authenticated-orcid":false,"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"issue":"26","key":"5925_CR1","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1056\/NEJMra1406182","volume":"374","author":"JD Taurog","year":"2016","unstructured":"Taurog JD, Chhabra A, Colbert RA. Ankylosing spondylitis and axial spondyloarthritis. N Engl J Med. 2016;374(26):2563\u201374.","journal-title":"N Engl J Med"},{"issue":"12","key":"5925_CR2","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1136\/annrheumdis-2021-221035","volume":"80","author":"V Navarro-Comp\u00e1n","year":"2021","unstructured":"Navarro-Comp\u00e1n V, Sepriano A, El-Zorkany B, van der Heijde D. Axial spondyloarthritis. Ann Rheum Dis. 2021;80(12):1511\u201321.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"5925_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13075-015-0627-0","volume":"17","author":"S Exarchou","year":"2015","unstructured":"Exarchou S, Lindstr\u00f6m U, Askling J, et al. The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study. Arthritis Res Ther. 2015;17(1):118.","journal-title":"Arthritis Res Ther"},{"issue":"7539","key":"5925_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13835","volume":"518","author":"KK Farh","year":"2015","unstructured":"Farh KK, Marson A, Zhu J, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015;518(7539):337\u201343.","journal-title":"Nature"},{"issue":"4","key":"5925_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41584-022-00761-z","volume":"18","author":"A Danve","year":"2022","unstructured":"Danve A, Deodhar A. Treatment of axial spondyloarthritis: an update. Nat Rev Rheumatol. 2022;18(4):205\u201316.","journal-title":"Nat Rev Rheumatol"},{"key":"5925_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1753-6561-3-S7-S135","author":"HC Yang","year":"2009","unstructured":"Yang HC, Liang YJ, Chung CM, Chen JW, Pan WH. Genome-wide gene-based association study. BMC Proc. 2009. https:\/\/doi.org\/10.1186\/1753-6561-3-S7-S135.","journal-title":"BMC Proc"},{"key":"5925_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.990486","volume":"13","author":"A Yazdani","year":"2022","unstructured":"Yazdani A, Yazdani A, Mendez-Giraldez R, Samiei A, Kosorok MR, Schaid DJ. From classical mendelian randomization to causal networks for systematic integration of multi-omics. Front Genet. 2022;13: 990486.","journal-title":"Front Genet"},{"issue":"1","key":"5925_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s10038-020-00842-5","volume":"66","author":"M Akiyama","year":"2021","unstructured":"Akiyama M. Multi-omics study for interpretation of genome-wide association study. J Hum Genet. 2021;66(1):3\u201310.","journal-title":"J Hum Genet"},{"issue":"9","key":"5925_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101112","volume":"4","author":"MS Kim","year":"2023","unstructured":"Kim MS, Song M, Kim B, et al. Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis. Cell Rep Med. 2023;4(9): 101112.","journal-title":"Cell Rep Med"},{"issue":"5","key":"5925_CR10","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48(5):481\u20137.","journal-title":"Nat Genet"},{"issue":"1","key":"5925_CR11","doi-asserted-by":"publisher","first-page":"17605","DOI":"10.1038\/s41598-018-35871-w","volume":"8","author":"AF McRae","year":"2018","unstructured":"McRae AF, Marioni RE, Shah S, et al. Identification of 55,000 replicated DNA methylation QTL. Sci Rep. 2018;8(1):17605.","journal-title":"Sci Rep"},{"issue":"12","key":"5925_CR12","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA, et al. Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021;53(12):1712\u201321.","journal-title":"Nat Genet"},{"issue":"7571","key":"5925_CR13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Auton A, Brooks LD, Durbin RM, et al. A global reference for human genetic variation. Nature. 2015;526(7571):68\u201374.","journal-title":"Nature"},{"key":"5925_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104934","volume":"99","author":"J Chen","year":"2024","unstructured":"Chen J, Ruan X, Sun Y, et al. Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease. EBioMedicine. 2024;99: 104934.","journal-title":"EBioMedicine"},{"issue":"11","key":"5925_CR15","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1136\/jnnp-2023-331142","volume":"94","author":"WM Su","year":"2023","unstructured":"Su WM, Gu XJ, Dou M, et al. Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer\u2019s disease. J Neurol Neurosurg Psychiat. 2023;94(11):954\u201361.","journal-title":"J Neurol Neurosurg Psychiat"},{"issue":"1","key":"5925_CR16","doi-asserted-by":"publisher","first-page":"7342","DOI":"10.1038\/s41467-021-26280-1","volume":"12","author":"CS Storm","year":"2021","unstructured":"Storm CS, Kia DA, Almramhi MM, et al. Finding genetically-supported drug targets for Parkinson\u2019s disease using Mendelian randomization of the druggable genome. Nat Commun. 2021;12(1):7342.","journal-title":"Nat Commun"},{"issue":"18","key":"5925_CR17","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","volume":"31","author":"M Yoo","year":"2015","unstructured":"Yoo M, Shin J, Kim J, et al. DSigDB: drug signatures database for gene set analysis. Bioinformatics. 2015;31(18):3069\u201371.","journal-title":"Bioinformatics"},{"issue":"20","key":"5925_CR18","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1007\/s00018-019-03411-y","volume":"77","author":"S Medunjanin","year":"2020","unstructured":"Medunjanin S, Putzier M, N\u00f6then T, et al. DNA-PK: gatekeeper for IKK\u03b3\/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation. Cell Mol Life Sci. 2020;77(20):4133\u201342.","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"5925_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/ard.2010.133322","volume":"70","author":"SI Davidson","year":"2011","unstructured":"Davidson SI, Liu Y, Danoy PA, et al. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis. 2011;70(2):289\u201392.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"5925_CR20","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ng.2667","volume":"45","author":"A Cortes","year":"2013","unstructured":"Cortes A, Hadler J, Pointon JP, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet. 2013;45(7):730\u20138.","journal-title":"Nat Genet"},{"key":"5925_CR21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015306","volume":"296","author":"Y Hao","year":"2021","unstructured":"Hao Y, Cr\u00e9quer-Grandhomme A, Javier N, et al. Structures and mechanism of human glycosyltransferase \u03b21,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important player in immune homeostasis. J Biol Chem. 2021;296: 100042.","journal-title":"J Biol Chem"},{"issue":"7","key":"5925_CR22","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.jfma.2021.09.010","volume":"121","author":"CM Wang","year":"2022","unstructured":"Wang CM, Jan Wu YJ, Lin JC, Huang LY, Wu J, Chen JY. Genetic effects of B3GNT2 on ankylosing spondylitis susceptibility and clinical manifestations in Taiwanese. J Formos Med Assoc. 2022;121(7):1283\u201394.","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"5925_CR23","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.coi.2012.11.002","volume":"25","author":"S Keidel","year":"2013","unstructured":"Keidel S, Chen L, Pointon J, Wordsworth P. ERAP1 and ankylosing spondylitis. Curr Opin Immunol. 2013;25(1):97\u2013102.","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"5925_CR24","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.immuni.2019.02.006","volume":"50","author":"T Castro-Dopico","year":"2019","unstructured":"Castro-Dopico T, Dennison TW, Ferdinand JR, et al. Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis. Immunity. 2019;50(4):1099-114.e10.","journal-title":"Immunity"},{"issue":"5","key":"5925_CR25","first-page":"647","volume":"33","author":"YH Lee","year":"2015","unstructured":"Lee YH, Bae SC, Song GG. FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. Clin Exp Rheumatol. 2015;33(5):647\u201354.","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"5925_CR26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/ng.81","volume":"40","author":"JB Harley","year":"2008","unstructured":"Harley JB, Alarc\u00f3n-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40(2):204\u201310.","journal-title":"Nat Genet"},{"issue":"12","key":"5925_CR27","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/ng.981","volume":"43","author":"CC Khor","year":"2011","unstructured":"Khor CC, Davila S, Breunis WB, et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet. 2011;43(12):1241\u20136.","journal-title":"Nat Genet"},{"issue":"9","key":"5925_CR28","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/ng.3359","volume":"47","author":"JZ Liu","year":"2015","unstructured":"Liu JZ, van Sommeren S, Huang H, et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015;47(9):979\u201386.","journal-title":"Nat Genet"},{"issue":"1","key":"5925_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00296-018-4204-0","volume":"39","author":"M Ivanova","year":"2019","unstructured":"Ivanova M, Manolova I, Miteva L, Gancheva R, Stoilov R, Stanilova S. Genetic variations in the IL-12B gene in association with IL-23 and IL-12p40 serum levels in ankylosing spondylitis. Rheumatol Int. 2019;39(1):111\u20139.","journal-title":"Rheumatol Int"},{"issue":"1","key":"5925_CR30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3899\/jrheum.110613","volume":"39","author":"RH Wong","year":"2012","unstructured":"Wong RH, Wei JC, Huang CH, et al. Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis. J Rheumatol. 2012;39(1):135\u201340.","journal-title":"J Rheumatol"},{"issue":"7","key":"5925_CR31","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s00296-012-2637-4","volume":"33","author":"KJ Zhu","year":"2013","unstructured":"Zhu KJ, Zhu CY, Shi G, Fan YM. Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis. Rheumatol Int. 2013;33(7):1785\u201390.","journal-title":"Rheumatol Int"},{"key":"5925_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100866","volume":"80","author":"Z Zhong","year":"2021","unstructured":"Zhong Z, Su G, Kijlstra A, Yang P. Activation of the interleukin-23\/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. Prog Retin Eye Res. 2021;80: 100866.","journal-title":"Prog Retin Eye Res"},{"key":"5925_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3389\/fimmu.2019.00173","volume":"10","author":"DM Elizondo","year":"2019","unstructured":"Elizondo DM, Brandy NZD, da Silva RLL, et al. Allograft inflammatory factor-1 governs hematopoietic stem cell differentiation into cDC1 and monocyte-derived dendritic cells through IRF8 and RelB in vitro. Front Immunol. 2019;10:173.","journal-title":"Front Immunol"},{"key":"5925_CR34","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3389\/fimmu.2017.01502","volume":"8","author":"DM Elizondo","year":"2017","unstructured":"Elizondo DM, Andargie TE, Yang D, Kacsinta AD, Lipscomb MW. Inhibition of allograft inflammatory factor-1 in dendritic cells restrains CD4(+) T Cell effector responses and induces CD25(+)Foxp3(+) T regulatory subsets. Front Immunol. 2017;8:1502.","journal-title":"Front Immunol"},{"key":"5925_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071064","author":"K Piotrowska","year":"2020","unstructured":"Piotrowska K, S\u0142uczanowska-G\u0142abowska S, Kurzawski M, et al. Over-expression of allograft inflammatory factor-1 (AIF-1) in patients with rheumatoid arthritis. Biomolecules. 2020. https:\/\/doi.org\/10.3390\/biom10071064.","journal-title":"Biomolecules"},{"issue":"5","key":"5925_CR36","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.4049\/jimmunol.178.5.3316","volume":"178","author":"M Kimura","year":"2007","unstructured":"Kimura M, Kawahito Y, Obayashi H, et al. A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis. J Immunol. 2007;178(5):3316\u201322.","journal-title":"J Immunol"},{"issue":"8","key":"5925_CR37","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/rheumatology\/kem057","volume":"46","author":"F Alkassab","year":"2007","unstructured":"Alkassab F, Gourh P, Tan FK, et al. An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis. Rheumatology (Oxford). 2007;46(8):1248\u201351.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"5925_CR38","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s13075-015-0715-1","volume":"17","author":"W Zheng","year":"2015","unstructured":"Zheng W, Rao S. Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis. Arthritis Res Ther. 2015;17(1):202.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"5925_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s10038-007-0219-1","volume":"53","author":"Y Kamatani","year":"2008","unstructured":"Kamatani Y, Matsuda K, Ohishi T, et al. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. J Hum Genet. 2008;53(1):64\u201373.","journal-title":"J Hum Genet"},{"issue":"7560","key":"5925_CR40","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nature14462","volume":"523","author":"VA Blaho","year":"2015","unstructured":"Blaho VA, Galvani S, Engelbrecht E, et al. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. 2015;523(7560):342\u20136.","journal-title":"Nature"},{"key":"5925_CR41","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41413-019-0057-8","volume":"7","author":"W Zhu","year":"2019","unstructured":"Zhu W, He X, Cheng K, et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res. 2019;7:22.","journal-title":"Bone Res"},{"issue":"1","key":"5925_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1517\/14728214.2015.993378","volume":"20","author":"J Braun","year":"2015","unstructured":"Braun J, Kiltz U, Heldmann F, Baraliakos X. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. Expert Opin Emerg Drugs. 2015;20(1):1\u201314.","journal-title":"Expert Opin Emerg Drugs"},{"issue":"4","key":"5925_CR43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.21037\/atm-23-195","volume":"11","author":"C Tian","year":"2023","unstructured":"Tian C, Shu J, Shao W, Zhou Z, Guo H, Wang J. Efficacy and safety of IL inhibitors, TNF-\u03b1 inhibitors, and JAK inhibitors in patients with ankylosing spondylitis: a systematic review and Bayesian network meta-analysis. Ann Transl Med. 2023;11(4):178.","journal-title":"Ann Transl Med"},{"issue":"5","key":"5925_CR44","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1002\/art.33503","volume":"64","author":"JD Reveille","year":"2012","unstructured":"Reveille JD, Hirsch R, Dillon CF, Carroll MD, Weisman MH. The prevalence of HLA-B27 in the US: data from the US national health and nutrition examination survey, 2009. Arthritis Rheum. 2012;64(5):1407\u201311.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"5925_CR45","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cell.2020.08.036","volume":"183","author":"L Jiang","year":"2020","unstructured":"Jiang L, Wang M, Lin S, et al. A quantitative proteome map of the human body. Cell. 2020;183(1):269-83.e19.","journal-title":"Cell"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05925-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05925-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05925-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T08:03:50Z","timestamp":1734681830000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05925-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5925"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05925-x","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"24 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All data in this study were obtained from public databases approved by the corresponding ethical review boards. Informed written consent was obtained from all subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1115"}}