{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:14:54Z","timestamp":1792872894613,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101884"],"award-info":[{"award-number":["82101884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171770"],"award-info":[{"award-number":["82171770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971519"],"award-info":[{"award-number":["81971519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M693661"],"award-info":[{"award-number":["2021M693661"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05951-9","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:06:00Z","timestamp":1734937560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells"],"prefix":"10.1186","volume":"22","author":[{"given":"Yimei","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2624-5658","authenticated-orcid":false,"given":"Niansheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-7220","authenticated-orcid":false,"given":"Mianjing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"issue":"17","key":"5951_CR1","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1001\/jama.2024.2315","volume":"331","author":"CH Siegel","year":"2024","unstructured":"Siegel CH, Sammaritano LR. Systemic lupus erythematosus: a review. JAMA. 2024;331(17):1480\u201391.","journal-title":"JAMA"},{"issue":"1","key":"5951_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41572-019-0141-9","volume":"6","author":"HJ Anders","year":"2020","unstructured":"Anders HJ, Saxena R, Zhao MH, Parodis I, Salmon JE, Mohan C. Lupus nephritis. Nat Rev Dis Primers. 2020;6(1):7.","journal-title":"Nat Rev Dis Primers"},{"key":"5951_CR3","doi-asserted-by":"publisher","first-page":"102871","DOI":"10.1016\/j.jaut.2022.102871","volume":"132","author":"C Yu","year":"2022","unstructured":"Yu C, Li P, Dang X, Zhang X, Mao Y, Chen X. Lupus nephritis: new progress in diagnosis and treatment. J Autoimmun. 2022;132:102871.","journal-title":"J Autoimmun"},{"issue":"7","key":"5951_CR4","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41590-023-01538-6","volume":"24","author":"M Buggert","year":"2023","unstructured":"Buggert M, Price DA, Mackay LK, Betts MR. Human circulating and tissue-resident memory CD8(+) T cells. Nat Immunol. 2023;24(7):1076\u201386.","journal-title":"Nat Immunol"},{"key":"5951_CR5","doi-asserted-by":"publisher","first-page":"1378359","DOI":"10.3389\/fimmu.2024.1378359","volume":"15","author":"G Liu","year":"2024","unstructured":"Liu G, Wang Z, Li S. Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review. Front Immunol. 2024;15:1378359.","journal-title":"Front Immunol"},{"issue":"7","key":"5951_CR6","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","volume":"192","author":"S Cheuk","year":"2014","unstructured":"Cheuk S, Wik\u00e9n M, Blomqvist L, Nyl\u00e9n S, Talme T, St\u00e5hle M, et al. Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis. J Immunol. 2014;192(7):3111\u201320.","journal-title":"J Immunol"},{"issue":"4","key":"5951_CR7","doi-asserted-by":"publisher","first-page":"109902","DOI":"10.1016\/j.celrep.2021.109902","volume":"37","author":"MH Chang","year":"2021","unstructured":"Chang MH, Levescot A, Nelson-Maney N, Blaustein RB, Winden KD, Morris A, et al. Arthritis flares mediated by tissue-resident memory T cells in the joint. Cell Rep. 2021;37(4):109902.","journal-title":"Cell Rep"},{"issue":"4","key":"5951_CR8","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jid.2018.10.032","volume":"139","author":"JM Richmond","year":"2019","unstructured":"Richmond JM, Strassner JP, Rashighi M, Agarwal P, Garg M, Essien KI, et al. Resident Memory and Recirculating Memory T Cells Cooperate to maintain Disease in a mouse model of Vitiligo. J Invest Dermatol. 2019;139(4):769\u201378.","journal-title":"J Invest Dermatol"},{"key":"5951_CR9","doi-asserted-by":"publisher","first-page":"102424","DOI":"10.1016\/j.jaut.2020.102424","volume":"109","author":"M Zhou","year":"2020","unstructured":"Zhou M, Guo C, Li X, Huang Y, Li M, Zhang T, et al. JAK\/STAT signaling controls the fate of CD8(+)CD103(+) tissue-resident memory T cell in lupus nephritis. J Autoimmun. 2020;109:102424.","journal-title":"J Autoimmun"},{"key":"5951_CR10","doi-asserted-by":"publisher","first-page":"116597","DOI":"10.1016\/j.biopha.2024.116597","volume":"174","author":"CL Liang","year":"2024","unstructured":"Liang CL, Wei YY, Chen Y, Luo Y, Qin F, Chen Y, et al. Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8(+) T cells via suppressing IL-15\/STAT3 pathway. Biomed Pharmacother. 2024;174:116597.","journal-title":"Biomed Pharmacother"},{"key":"5951_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu J, Wu H. Structural mechanisms of NLRP3 Inflammasome Assembly and Activation. Annu Rev Immunol. 2023;41:301\u201316.","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"5951_CR12","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18(9):2114\u201327.","journal-title":"Cell Mol Immunol"},{"issue":"6292","key":"5951_CR13","doi-asserted-by":"publisher","first-page":"aad1210","DOI":"10.1126\/science.aad1210","volume":"352","author":"G Arbore","year":"2016","unstructured":"Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4\u207a T cells. Sci (New York NY). 2016;352(6292):aad1210.","journal-title":"Sci (New York NY)"},{"issue":"7","key":"5951_CR14","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1136\/annrheumdis-2021-221985","volume":"81","author":"Z Zhao","year":"2022","unstructured":"Zhao Z, Xu B, Wang S, Zhou M, Huang Y, Guo C, et al. Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity. Ann Rheum Dis. 2022;81(7):1006\u201312.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"5951_CR15","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1038\/s41467-018-06706-z","volume":"9","author":"G Arbore","year":"2018","unstructured":"Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8(+) T cell effector function via fatty acid metabolism. Nat Commun. 2018;9(1):4186.","journal-title":"Nat Commun"},{"issue":"4","key":"5951_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.55563\/clinexprheumatol\/gfqlcz","volume":"39","author":"M Zhou","year":"2021","unstructured":"Zhou M, Li M, Guo C, Wang S, Li X, Zhao S, et al. Circulating TFH cells is correlated with disease activity in anti-MDA5 antibody positive idiopathic inflammatory myopathies. Clin Exp Rheumatol. 2021;39(4):804\u201310.","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"5951_CR17","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/ni.3202","volume":"16","author":"M Bruchard","year":"2015","unstructured":"Bruchard M, Reb\u00e9 C, Derang\u00e8re V, Togb\u00e9 D, Ryffel B, Boidot R, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16(8):859\u201370.","journal-title":"Nat Immunol"},{"issue":"47","key":"5951_CR18","doi-asserted-by":"publisher","first-page":"17951","DOI":"10.1074\/jbc.RA119.010545","volume":"294","author":"SH Park","year":"2019","unstructured":"Park SH, Ham S, Lee A, M\u00f6ller A, Kim TS. NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation. J Biol Chem. 2019;294(47):17951\u201361.","journal-title":"J Biol Chem"},{"issue":"5","key":"5951_CR19","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/ni.3389","volume":"17","author":"BN Martin","year":"2016","unstructured":"Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, et al. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016;17(5):583\u201392.","journal-title":"Nat Immunol"},{"key":"5951_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.clim.2018.09.007","volume":"197","author":"C Zhao","year":"2018","unstructured":"Zhao C, Gu Y, Zeng X, Wang J. NLRP3 inflammasome regulates Th17 differentiation in rheumatoid arthritis. Clin Immunol (Orlando Fla). 2018;197:154\u201360.","journal-title":"Clin Immunol (Orlando Fla)"},{"key":"5951_CR21","doi-asserted-by":"crossref","unstructured":"Oliveira CB, Lima CAD, Vajgel G, Sandrin-Garcia P. The role of NLRP3 inflammasome in Lupus Nephritis. Int J Mol Sci. 2021;22(22).","DOI":"10.3390\/ijms222212476"},{"issue":"8","key":"5951_CR22","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/art.40155","volume":"69","author":"R Fu","year":"2017","unstructured":"Fu R, Guo C, Wang S, Huang Y, Jin O, Hu H, et al. Podocyte activation of NLRP3 inflammasomes contributes to the development of Proteinuria in Lupus Nephritis. Arthritis Rheumatol. 2017;69(8):1636\u201346.","journal-title":"Arthritis Rheumatol"},{"key":"5951_CR23","doi-asserted-by":"publisher","first-page":"102286","DOI":"10.1016\/j.jaut.2019.05.014","volume":"103","author":"C Guo","year":"2019","unstructured":"Guo C, Fu R, Zhou M, Wang S, Huang Y, Hu H, et al. Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation. J Autoimmun. 2019;103:102286.","journal-title":"J Autoimmun"},{"issue":"12","key":"5951_CR24","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1136\/annrheumdis-2014-205496","volume":"74","author":"M Lech","year":"2015","unstructured":"Lech M, Lorenz G, Kulkarni OP, Grosser MO, Stigrot N, Darisipudi MN, et al. NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-\u03b2 receptor signalling. Ann Rheum Dis. 2015;74(12):2224\u201335.","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"5951_CR25","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40(9):1725.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"5951_CR26","first-page":"288","volume":"29","author":"DD Gladman","year":"2002","unstructured":"Gladman DD, Iba\u00f1ez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288\u201391.","journal-title":"J Rheumatol"},{"issue":"5","key":"5951_CR27","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.ymthe.2024.03.003","volume":"32","author":"B Ye","year":"2024","unstructured":"Ye B, Chen B, Guo C, Xiong N, Huang Y, Li M, et al. C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis. Mol Ther. 2024;32(5):1540\u201360.","journal-title":"Mol Ther"},{"issue":"5","key":"5951_CR28","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.cmet.2023.03.010","volume":"35","author":"Q Zeng","year":"2023","unstructured":"Zeng Q, Wang S, Li M, Wang S, Guo C, Ruan X, et al. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell Metab. 2023;35(5):837\u2013e548.","journal-title":"Cell Metab"},{"issue":"1","key":"5951_CR29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.celrep.2017.03.031","volume":"19","author":"T Bergsbaken","year":"2017","unstructured":"Bergsbaken T, Bevan MJ, Fink PJ. Local inflammatory cues regulate differentiation and persistence of CD8(+) tissue-Resident memory T cells. Cell Rep. 2017;19(1):114\u201324.","journal-title":"Cell Rep"},{"key":"5951_CR30","doi-asserted-by":"crossref","unstructured":"Qiu Z, Chu TH, Sheridan BS. TGF-\u03b2: many paths to CD103(+) CD8 T cell residency. Cells. 2021;10(5).","DOI":"10.3390\/cells10050989"},{"issue":"82","key":"5951_CR31","doi-asserted-by":"publisher","first-page":"eadd8454","DOI":"10.1126\/sciimmunol.add8454","volume":"8","author":"R Tieu","year":"2023","unstructured":"Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, et al. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. Sci Immunol. 2023;8(82):eadd8454.","journal-title":"Sci Immunol"},{"issue":"1","key":"5951_CR32","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.immuni.2020.10.022","volume":"54","author":"T Hirai","year":"2021","unstructured":"Hirai T, Yang Y, Zenke Y, Li H, Chaudhri VK, De La Cruz Diaz JS, et al. Competition for active TGF\u03b2 cytokine allows for Selective Retention of Antigen-Specific tissue- Resident memory T cells in the epidermal niche. Immunity. 2021;54(1):84\u2013e985.","journal-title":"Immunity"},{"issue":"8","key":"5951_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.63.8.15","volume":"63","author":"J Xu","year":"2022","unstructured":"Xu J, Chen P, Luan X, Yuan X, Wei S, Li Y, et al. The NLRP3 activation in infiltrating macrophages contributes to corneal fibrosis by inducing TGF-\u03b21 expression in the corneal epithelium. Invest Ophthalmol Vis Sci. 2022;63(8):15.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"5951_CR34","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1007\/s11010-022-04369-5","volume":"477","author":"H Kang","year":"2022","unstructured":"Kang H, Seo E, Oh YS, Jun HS. TGF-\u03b2 activates NLRP3 inflammasome by an autocrine production of TGF-\u03b2 in LX-2 human hepatic stellate cells. Mol Cell Biochem. 2022;477(5):1329\u201338.","journal-title":"Mol Cell Biochem"},{"key":"5951_CR35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fphys.2019.00117","volume":"10","author":"J Rex","year":"2019","unstructured":"Rex J, Lutz A, Faletti LE, Albrecht U, Thomas M, Bode JG, et al. IL-1\u03b2 and TNF\u03b1 differentially influence NF-\u03baB activity and FasL-Induced apoptosis in primary murine hepatocytes during LPS-Induced inflammation. Front Physiol. 2019;10:117.","journal-title":"Front Physiol"},{"issue":"23","key":"5951_CR36","doi-asserted-by":"publisher","first-page":"10466","DOI":"10.7150\/thno.45211","volume":"10","author":"Y Chen","year":"2020","unstructured":"Chen Y, Yan Y, Liu H, Qiu F, Liang CL, Zhang Q, et al. Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice. Theranostics. 2020;10(23):10466\u201382.","journal-title":"Theranostics"},{"issue":"8","key":"5951_CR37","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1016\/j.ymthe.2022.04.024","volume":"30","author":"L Li","year":"2022","unstructured":"Li L, Tang W, Zhang Y, Jia M, Wang L, Li Q, et al. Targeting tissue-resident memory CD8(+) T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis. Mol Ther. 2022;30(8):2746\u201359.","journal-title":"Mol Ther"},{"issue":"1","key":"5951_CR38","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-immunol-101320-020220","volume":"42","author":"SN Christo","year":"2024","unstructured":"Christo SN, Park SL, Mueller SN, Mackay LK. The multifaceted role of tissue-Resident memory T cells. Annu Rev Immunol. 2024;42(1):317\u201345.","journal-title":"Annu Rev Immunol"},{"key":"5951_CR39","doi-asserted-by":"publisher","first-page":"876054","DOI":"10.3389\/fcell.2022.876054","volume":"10","author":"C Huang","year":"2022","unstructured":"Huang C, Meng M, Li S, Liu S, Li L, Su Y, et al. Umbilical cord mesenchymal stem cells ameliorate kidney Injury in MRL\/Ipr mice through the TGF-\u03b21 pathway. Front Cell Dev Biol. 2022;10:876054.","journal-title":"Front Cell Dev Biol"},{"key":"5951_CR40","doi-asserted-by":"publisher","first-page":"105962","DOI":"10.1016\/j.phrs.2021.105962","volume":"176","author":"J Sun","year":"2022","unstructured":"Sun J, Ge X, Wang Y, Niu L, Tang L, Pan S. USF2 knockdown downregulates THBS1 to inhibit the TGF-\u03b2 signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury. Pharmacol Res. 2022;176:105962.","journal-title":"Pharmacol Res"},{"issue":"6","key":"5951_CR41","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","volume":"137","author":"S He","year":"2009","unstructured":"He S, Wang L, Miao L, Wang T, Du F, Zhao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137(6):1100\u201311.","journal-title":"Cell"},{"key":"5951_CR42","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1038\/ncomms7282","volume":"6","author":"KE Lawlor","year":"2015","unstructured":"Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D\u2019Cruz AA, et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun. 2015;6:6282.","journal-title":"Nat Commun"},{"issue":"12","key":"5951_CR43","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/ni.2745","volume":"14","author":"CN Skon","year":"2013","unstructured":"Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8\u2009+\u2009T cells. Nat Immunol. 2013;14(12):1285\u201393.","journal-title":"Nat Immunol"},{"key":"5951_CR44","doi-asserted-by":"publisher","first-page":"15402","DOI":"10.1038\/ncomms15402","volume":"8","author":"Y Yao","year":"2017","unstructured":"Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, et al. Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nat Commun. 2017;8:15402.","journal-title":"Nat Commun"},{"issue":"10","key":"5951_CR45","doi-asserted-by":"publisher","first-page":"6536","DOI":"10.4049\/jimmunol.179.10.6536","volume":"179","author":"DA Rao","year":"2007","unstructured":"Rao DA, Tracey KJ, Pober JS. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol. 2007;179(10):6536\u201346.","journal-title":"J Immunol"},{"issue":"12","key":"5951_CR46","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.4049\/jimmunol.1800906","volume":"201","author":"S Sarkar","year":"2018","unstructured":"Sarkar S, Yuzefpolskiy Y, Xiao H, Baumann FM, Yim S, Lee DJ, et al. Programming of CD8 T cell quantity and polyfunctionality by direct IL-1 signals. J Immunol. 2018;201(12):3641\u201350.","journal-title":"J Immunol"},{"key":"5951_CR47","doi-asserted-by":"crossref","unstructured":"Liang Y, Luo J, Yang N, Wang S, Ye M, Pan G. Activation of the IL-1\u03b2\/KLF2\/HSPH1 pathway promotes STAT3 phosphorylation in alveolar macrophages during LPS-induced acute lung injury. Biosci Rep. 2020;40(3).","DOI":"10.1042\/BSR20193572"},{"key":"5951_CR48","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.mce.2018.08.002","volume":"478","author":"M Wu","year":"2018","unstructured":"Wu M, Han W, Song S, Du Y, Liu C, Chen N, et al. NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice. Mol Cell Endocrinol. 2018;478:115\u201325.","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"5951_CR49","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1530\/JME-18-0069","volume":"61","author":"S Song","year":"2018","unstructured":"Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, et al. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. J Mol Endocrinol. 2018;61(3):101\u201313.","journal-title":"J Mol Endocrinol"},{"issue":"9","key":"5951_CR50","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1681\/ASN.2013010026","volume":"24","author":"M Lech","year":"2013","unstructured":"Lech M, Anders H-J. The pathogenesis of lupus nephritis. J Am Soc Nephrol. 2013;24(9):1357\u201366.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"5951_CR51","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.kint.2018.05.021","volume":"94","author":"M De Rosa","year":"2018","unstructured":"De Rosa M, Azzato F, Toblli JE, De Rosa G, Fuentes F, Nagaraja HN, et al. A prospective observational cohort study highlights kidney biopsy findings of lupus nephritis patients in remission who flare following withdrawal of maintenance therapy. Kidney Int. 2018;94(4):788\u201394.","journal-title":"Kidney Int"},{"issue":"5","key":"5951_CR52","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/art.33488","volume":"64","author":"R Winchester","year":"2012","unstructured":"Winchester R, Wiesendanger M, Zhang H-Z, Steshenko V, Peterson K, Geraldino-Pardilla L, et al. Immunologic characteristics of intrarenal T cells: trafficking of expanded CD8\u2009+\u2009T cell \u03b2-chain clonotypes in progressive lupus nephritis. Arthritis Rheum. 2012;64(5):1589\u2013600.","journal-title":"Arthritis Rheum"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05951-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05951-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05951-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T08:05:10Z","timestamp":1734941110000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05951-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5951"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05951-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethical review board of The First Affiliated Hospital, Sun Yat-sen University. All participants provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have agreed to the publication of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1139"}}