{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:36:01Z","timestamp":1788287761561,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(General Program"],"award-info":[{"award-number":["(General Program"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273233); Natural Science Foundation of Shanghai (22ZR1408900); National Natural Science Foundation of China (General Program"],"award-info":[{"award-number":["82273233); Natural Science Foundation of Shanghai (22ZR1408900); National Natural Science Foundation of China (General Program"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772777); Clinical Research Plan of SHDC (No. SHDC2020CR4079); Shanghai \"Rising Stars of Medical Talent\" Youth Development Program-Outstanding Youth Medical Talents (SHWJRS2021-99)"],"award-info":[{"award-number":["81772777); Clinical Research Plan of SHDC (No. SHDC2020CR4079); Shanghai \"Rising Stars of Medical Talent\" Youth Development Program-Outstanding Youth Medical Talents (SHWJRS2021-99)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Shanghai Science"],"award-info":[{"award-number":["Shanghai Science"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["technology committee medical guidance program (18411963700)."],"award-info":[{"award-number":["technology committee medical guidance program (18411963700)."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-05977-z","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:30:48Z","timestamp":1736155848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Tianyou","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongbo","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"issue":"5","key":"5977_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100633","volume":"46","author":"A Chao","year":"2023","unstructured":"Chao A, Wu RC, Lin CY, et al. Small cell neuroendocrine carcinoma of the cervix: from molecular basis to therapeutic advances. Biomed J. 2023;46(5): 100633.","journal-title":"Biomed J"},{"issue":"6","key":"5977_CR2","first-page":"545","volume":"32","author":"Society of Neuroendocrine Neoplasm of China Anti-Cancer Association","year":"2022","unstructured":"Society of Neuroendocrine Neoplasm of China Anti-Cancer Association. China Anti-Cancer Association guideline for diagnosis and treatment of neuroendocrine neoplasm (2022 edition). China Oncol. 2022;32(6):545\u201379.","journal-title":"China Oncol."},{"issue":"12","key":"5977_CR3","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1002\/1878-0261.13057","volume":"15","author":"H Mahdi","year":"2021","unstructured":"Mahdi H, Joehlin-Price A, Elishaev E, et al. Genomic analyses of high-grade neuroendocrine gynecological malignancies reveal a unique mutational landscape and therapeutic vulnerabilities. Mol Oncol. 2021;15(12):3545\u201358.","journal-title":"Mol Oncol"},{"issue":"6","key":"5977_CR4","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13394","volume":"36","author":"P Saraei","year":"2024","unstructured":"Saraei P, Heshmati A, Hosseini S. Small-cell neuroendocrine carcinoma of the female genital tract: a comprehensive overview. J Neuroendocrinol. 2024;36(6): e13394.","journal-title":"J Neuroendocrinol"},{"key":"5977_CR5","doi-asserted-by":"crossref","unstructured":"Lyu YH, Liu HX, Han X, et al. Clinicopathologic characteristics and prognostic factors of patients with surgically treated high-grade neuroendocrine carcinoma of the cervix: a multicenter retrospective study. Int J Gynaecol Obstet. 2024.","DOI":"10.21203\/rs.3.rs-3961481\/v1"},{"issue":"3","key":"5977_CR6","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/path.6290","volume":"263","author":"B Pan","year":"2024","unstructured":"Pan B, Yan S, Yuan L, et al. Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix. J Pathol. 2024;263(3):372\u201385.","journal-title":"J Pathol"},{"issue":"17","key":"5977_CR7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2321898121","volume":"121","author":"S Bellone","year":"2024","unstructured":"Bellone S, Jeong K, Halle MK, et al. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. Proc Natl Acad Sci U S A. 2024;121(17): e2321898121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5977_CR8","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2021. https:\/\/www.R-project.org\/."},{"issue":"11","key":"5977_CR9","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"4","key":"5977_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","volume":"8","author":"SL Wolock","year":"2019","unstructured":"Wolock SL, Lopez R, Klein AM. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Syst. 2019;8(4):281-291.e289.","journal-title":"Cell Syst"},{"key":"5977_CR11","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.1093\/bioinformatics\/btaa1011","volume":"36","author":"DG Bunis","year":"2020","unstructured":"Bunis DG, Andrews J, Fragiadakis GK, Burt TD, Sirota M. dittoSeq: universal user-friendly single-cell and bulk RNA sequencing visualization toolkit. Bioinformatics. 2020;36:5535\u20136. https:\/\/doi.org\/10.1093\/bioinformatics\/btaa1011.","journal-title":"Bioinformatics"},{"issue":"2","key":"5977_CR12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, Looney AP, Liu L, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20(2):163\u201372.","journal-title":"Nat Immunol"},{"issue":"1","key":"5977_CR13","doi-asserted-by":"publisher","first-page":"vbad029","DOI":"10.1093\/bioadv\/vbad029","volume":"3","author":"R Li","year":"2023","unstructured":"Li R, Zhang J, Li Z. EasyCellType: marker-based cell-type annotation by automatically querying multiple databases. Bioinform Adv. 2023;3(1):vbad029.","journal-title":"Bioinform Adv"},{"issue":"12","key":"5977_CR14","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1016\/j.ccell.2023.10.009","volume":"41","author":"CC Chen","year":"2023","unstructured":"Chen CC, Tran W, Song K, et al. Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation. Cancer Cell. 2023;41(12):2066-2082 e2069.","journal-title":"Cancer Cell"},{"issue":"29","key":"5977_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203040","volume":"9","author":"Z Ou","year":"2022","unstructured":"Ou Z, Lin S, Qiu J, et al. Single-nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma. Adv Sci (Weinh). 2022;9(29): e2203040.","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"5977_CR16","doi-asserted-by":"publisher","first-page":"eadd8977","DOI":"10.1126\/sciadv.add8977","volume":"9","author":"C Liu","year":"2023","unstructured":"Liu C, Zhang M, Yan X, et al. Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression. Sci Adv. 2023;9(4):eadd8977.","journal-title":"Sci Adv"},{"issue":"12","key":"5977_CR17","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.jtho.2020.09.009","volume":"15","author":"MK Baine","year":"2020","unstructured":"Baine MK, Hsieh MS, Lai WV, et al. SCLC subtypes defined by ASCL1, NEUROD1, POU2F3, and YAP1: a comprehensive immunohistochemical and histopathologic characterization. J Thorac Oncol. 2020;15(12):1823\u201335.","journal-title":"J Thorac Oncol"},{"issue":"6","key":"5977_CR18","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1038\/s41596-021-00534-0","volume":"16","author":"ZA Clarke","year":"2021","unstructured":"Clarke ZA, Andrews TS, Atif J, et al. Tutorial: guidelines for annotating single-cell transcriptomic maps using automated and manual methods. Nat Protoc. 2021;16(6):2749\u201364.","journal-title":"Nat Protoc"},{"issue":"D1","key":"5977_CR19","doi-asserted-by":"publisher","first-page":"D870","DOI":"10.1093\/nar\/gkac947","volume":"51","author":"C Hu","year":"2023","unstructured":"Hu C, Li T, Xu Y, et al. Cell Marker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 2023;51(D1):D870-d876.","journal-title":"Nucleic Acids Res"},{"key":"5977_CR20","unstructured":"inferCNV of the Trinity CTAT Project. https:\/\/github.com\/broadinstitute\/inferCNV."},{"issue":"9","key":"5977_CR21","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/s41422-019-0195-y","volume":"29","author":"J Peng","year":"2019","unstructured":"Peng J, Sun BF, Chen CY, et al. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Res. 2019;29(9):725\u201338.","journal-title":"Cell Res"},{"key":"5977_CR22","doi-asserted-by":"crossref","unstructured":"Gu, Z. Complex Heatmap Visualization. iMeta 2022.","DOI":"10.1002\/imt2.43"},{"issue":"3","key":"5977_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nmeth.4150","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Hill A, Packer J, et al. Single-cell mRNA quantification and differential analysis with Census. Nat Methods. 2017;14(3):309\u201315.","journal-title":"Nat Methods"},{"issue":"1","key":"5977_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25(1):25\u20139.","journal-title":"Nat Genet"},{"issue":"9","key":"5977_CR25","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1089\/cmb.2020.0564","volume":"28","author":"S Wang","year":"2021","unstructured":"Wang S, Zhong Y, Cheng J, et al. EnrichVisBox: a versatile and powerful web toolbox for visualizing complex functional enrichment results of omics data. J Comput Biol. 2021;28(9):922\u201330.","journal-title":"J Comput Biol"},{"key":"5977_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy083","author":"L Zappia","year":"2018","unstructured":"Zappia L, Oshlack A. Clustering trees: a visualization for evaluating clusterings at multiple resolutions. Gigascience. 2018. https:\/\/doi.org\/10.1093\/gigascience\/giy083.","journal-title":"Gigascience"},{"issue":"6","key":"5977_CR27","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41591-023-02371-y","volume":"29","author":"Y Chu","year":"2023","unstructured":"Chu Y, Dai E, Li Y, et al. Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance. Nat Med. 2023;29(6):1550\u201362.","journal-title":"Nat Med"},{"issue":"7735","key":"5977_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","volume":"564","author":"L Zhang","year":"2018","unstructured":"Zhang L, Yu X, Zheng L, et al. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature. 2018;564(7735):268\u201372.","journal-title":"Nature"},{"issue":"1","key":"5977_CR29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s40364-020-00245-w","volume":"8","author":"C Han","year":"2020","unstructured":"Han C, Liu T, Yin R. Biomarkers for cancer-associated fibroblasts. Biomark Res. 2020;8(1):64.","journal-title":"Biomark Res"},{"issue":"6","key":"5977_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsd\u00f3ttir H, et al. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417\u201325.","journal-title":"Cell Syst"},{"issue":"12","key":"5977_CR31","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon A, Subramanian A, Pinchback R, et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics. 2011;27(12):1739\u201340.","journal-title":"Bioinformatics"},{"issue":"43","key":"5977_CR32","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"5977_CR33","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar S, Gonz\u00e1lez-Blas CB, Moerman T, et al. SCENIC: single-cell regulatory network inference and clustering. Nat Methods. 2017;14(11):1083\u20136.","journal-title":"Nat Methods"},{"issue":"1","key":"5977_CR34","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using Cell Chat. Nat Commun. 2021;12(1):1088.","journal-title":"Nat Commun"},{"issue":"7563","key":"5977_CR35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature14664","volume":"524","author":"J George","year":"2015","unstructured":"George J, Lim JS, Jang SJ, et al. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015;524(7563):47\u201353.","journal-title":"Nature"},{"issue":"5","key":"5977_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401\u20134.","journal-title":"Cancer Discov"},{"issue":"269","key":"5977_CR37","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6(269):pl1.","journal-title":"Sci Signal"},{"issue":"23","key":"5977_CR38","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","volume":"83","author":"I de Bruijn","year":"2023","unstructured":"de Bruijn I, Kundra R, Mastrogiacomo B, et al. Analysis and visualization of longitudinal genomic and clinical data from the AACR Project GENIE biopharma collaborative in cBioPortal. Cancer Res. 2023;83(23):3861\u20137.","journal-title":"Cancer Res"},{"key":"5977_CR39","unstructured":"Kassambara A, Kosinski M, Biecek P. survminer: Drawing Survival Curves using 'ggplot2'. R package version 0.4.9. 2021. https:\/\/CRAN.R-project.org\/package=survminer."},{"key":"5977_CR40","unstructured":"Therneau T. A Package for Survival Analysis in R. R package version 3.5\u20137, 2023. https:\/\/CRAN.R-project.org\/package=survival."},{"key":"5977_CR41","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a004978","author":"M Rao","year":"2020","unstructured":"Rao M, Oh K, Moffitt R, et al. Comparative single-cell RNA sequencing (scRNA-seq) reveals liver metastasis-specific targets in a patient with small intestinal neuroendocrine cancer. Cold Spring Harb Mol Case Stud. 2020. https:\/\/doi.org\/10.1101\/mcs.a004978.","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"13","key":"5977_CR42","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao Y, Hao S, Andersen-Nissen E, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184(13):3573-3587.e3529.","journal-title":"Cell"},{"issue":"2","key":"5977_CR43","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","volume":"181","author":"L Zhang","year":"2020","unstructured":"Zhang L, Li Z, Skrzypczynska KM, et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell. 2020;181(2):442\u2013459429.","journal-title":"Cell"},{"key":"5977_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122637","volume":"346","author":"Y Ju","year":"2024","unstructured":"Ju Y, Fang S, Liu L, et al. The function of the ELF3 gene and its mechanism in cancers. Life Sci. 2024;346: 122637.","journal-title":"Life Sci"},{"key":"5977_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092191","author":"IY Luk","year":"2018","unstructured":"Luk IY, Reehorst CM, Mariadason JM. ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer. Molecules. 2018. https:\/\/doi.org\/10.3390\/molecules23092191.","journal-title":"Molecules"},{"issue":"6","key":"5977_CR46","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1111\/cas.15764","volume":"114","author":"M Horie","year":"2023","unstructured":"Horie M, Tanaka H, Suzuki M, et al. An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1-positive neuroendocrine carcinoma. Cancer Sci. 2023;114(6):2596\u2013608.","journal-title":"Cancer Sci"},{"issue":"8","key":"5977_CR47","first-page":"941","volume":"53","author":"TONG Lu","year":"2022","unstructured":"Lu TONG, Shan LI, Zheng P. Expression of ELF3 in cervical cancer and its effect on the proliferation of HeLa cells. J Shanxi Med Univ. 2022;53(8):941\u20139.","journal-title":"J Shanxi Med Univ"},{"issue":"7488","key":"5977_CR48","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature12881","volume":"506","author":"AI Ojesina","year":"2014","unstructured":"Ojesina AI, Lichtenstein L, Freeman SS, et al. Landscape of genomic alterations in cervical carcinomas. Nature. 2014;506(7488):371\u20135.","journal-title":"Nature"},{"issue":"1","key":"5977_CR49","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1038\/s41467-023-37377-0","volume":"14","author":"MC Bedard","year":"2023","unstructured":"Bedard MC, Chihanga T, Carlile A, et al. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nat Commun. 2023;14(1):1975.","journal-title":"Nat Commun"},{"key":"5977_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14050462","author":"Y Wang","year":"2024","unstructured":"Wang Y, Qiu H, Lin R, et al. Advancements in the understanding of small-cell neuroendocrine cervical cancer: where we stand and what lies ahead. J Pers Med. 2024. https:\/\/doi.org\/10.3390\/jpm14050462.","journal-title":"J Pers Med"},{"key":"5977_CR51","doi-asserted-by":"publisher","first-page":"557","DOI":"10.2147\/OTT.S460465","volume":"17","author":"Y Liu","year":"2024","unstructured":"Liu Y, Li M, Liu Y, et al. Liquid-based cytology of small cell carcinoma of the cervix: a multicenter retrospective study. Onco Targets Ther. 2024;17:557\u201365.","journal-title":"Onco Targets Ther"},{"key":"5977_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042287","author":"A Laskou","year":"2024","unstructured":"Laskou A, Znalesniak EB, Harder S, et al. Different forms of TFF3 in the human endocervix, including a complex with IgG Fc binding protein (FCGBP), and further aspects of the cervico-vaginal innate immune barrier. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25042287.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5977_CR53","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13046-022-02259-8","volume":"41","author":"E Fina","year":"2022","unstructured":"Fina E, Cleris L, Dugo M, et al. Gene signatures of circulating breast cancer cell models are a source of novel molecular determinants of metastasis and improve circulating tumor cell detection in patients. J Exp Clin Cancer Res. 2022;41(1):78.","journal-title":"J Exp Clin Cancer Res"},{"key":"5977_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076853","author":"A Lorenz","year":"2023","unstructured":"Lorenz A, Lenkiewicz S, Kozlowski M, et al. Neuroendocrine neoplasms of the gastrointestinal tract versus neuroendocrine neoplasms of the gynaecological tract-comparison of the risk factors and non-surgical treatment efficacy. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24076853.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5977_CR55","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.annonc.2019.11.003","volume":"31","author":"K Oberg","year":"2020","unstructured":"Oberg K, Califano A, Strosberg JR, et al. A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood. Ann Oncol. 2020;31(2):202\u201312.","journal-title":"Ann Oncol"},{"issue":"6","key":"5977_CR56","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1111\/cas.15327","volume":"113","author":"Y Ichikawa","year":"2022","unstructured":"Ichikawa Y, Kobayashi N, Takano S, et al. Neuroendocrine tumor theranostics. Cancer Sci. 2022;113(6):1930\u20138.","journal-title":"Cancer Sci"},{"issue":"3","key":"5977_CR57","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/PAS.0000000000002155","volume":"48","author":"G Kim","year":"2024","unstructured":"Kim G, Kim M, Nam EJ, et al. Application of small cell lung cancer molecular subtyping markers to small cell neuroendocrine carcinoma of the cervix: NEUROD1 as a poor prognostic factor. Am J Surg Pathol. 2024;48(3):364\u201372.","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"5977_CR58","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.cell.2019.09.010","volume":"179","author":"Y Ouadah","year":"2019","unstructured":"Ouadah Y, Rojas ER, Riordan DP, et al. Rare pulmonary neuroendocrine cells are stem cells regulated by Rb, p53, and Notch. Cell. 2019;179(2):403\u2013416423.","journal-title":"Cell"},{"issue":"Pt B","key":"5977_CR59","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.semcdb.2023.05.008","volume":"155","author":"S Kaur","year":"2024","unstructured":"Kaur S, Roberts DD. Emerging functions of thrombospondin-1 in immunity. Semin Cell Dev Biol. 2024;155(Pt B):22\u201331.","journal-title":"Semin Cell Dev Biol"},{"key":"5977_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094570","author":"S Kaur","year":"2021","unstructured":"Kaur S, Bronson SM, Pal-Nath D, et al. Functions of thrombospondin-1 in the tumor microenvironment. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22094570.","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05977-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-05977-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-05977-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T22:02:32Z","timestamp":1736200952000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-05977-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5977"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-05977-z","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"4 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Obstetrics and Gynecology Hospital of Fudan University(2024-113). Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the patient to publish this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}