{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:13:20Z","timestamp":1792800800238,"version":"4.5.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270933"],"award-info":[{"award-number":["32270933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071758"],"award-info":[{"award-number":["82071758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R&D Program of Beijing Municipal Education Commission","award":["KZ202210025035"],"award-info":[{"award-number":["KZ202210025035"]}],"id":[{"id":"https:\/\/ror.org\/04bpn6s66","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Chinese Institutes for Medical Research, Beijing","award":["CX24PY07"],"award-info":[{"award-number":["CX24PY07"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-024-06015-8","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:25:25Z","timestamp":1738221925000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis"],"prefix":"10.1186","volume":"23","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaizhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-2458","authenticated-orcid":false,"given":"Guoming","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-3334","authenticated-orcid":false,"given":"Renxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"issue":"9997","key":"6015_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","volume":"386","author":"WH Boehncke","year":"2015","unstructured":"Boehncke WH, Schon MP. Psoriasis. Lancet. 2015;386(9997):983\u201394.","journal-title":"Lancet"},{"issue":"Suppl 2","key":"6015_CR2","doi-asserted-by":"publisher","first-page":"ii18","DOI":"10.1136\/ard.2004.033217","volume":"64","author":"RG Langley","year":"2005","unstructured":"Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis. 2005;64(Suppl 2):ii18-23 (discussion ii4-5).","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"6015_CR3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.7861\/clinmed.2021-0257","volume":"21","author":"A Raharja","year":"2021","unstructured":"Raharja A, Mahil SK, Barker JN. Psoriasis: a brief overview. Clin Med (Lond). 2021;21(3):170\u20133.","journal-title":"Clin Med (Lond)"},{"issue":"6","key":"6015_CR4","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","volume":"20","author":"A Rendon","year":"2019","unstructured":"Rendon A, Schakel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6):1475.","journal-title":"Int J Mol Sci"},{"issue":"18","key":"6015_CR5","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.3390\/ijms20184347","volume":"20","author":"K Kamiya","year":"2019","unstructured":"Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk factors for the development of psoriasis. Int J Mol Sci. 2019;20(18):4347.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"6015_CR6","doi-asserted-by":"publisher","first-page":"adv00030","DOI":"10.2340\/00015555-3384","volume":"100","author":"N Dand","year":"2020","unstructured":"Dand N, Mahil SK, Capon F, Smith CH, Simpson MA, Barker JN. Psoriasis and genetics. Acta Derm Venereol. 2020;100(3):adv00030.","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"6015_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.311","volume":"41","author":"RP Nair","year":"2009","unstructured":"Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009;41(2):199\u2013204.","journal-title":"Nat Genet"},{"issue":"11","key":"6015_CR8","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ng.689","volume":"42","author":"E Ellinghaus","year":"2010","unstructured":"Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 2010;42(11):991\u20135.","journal-title":"Nat Genet"},{"issue":"6","key":"6015_CR9","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ajhg.2015.10.019","volume":"97","author":"PE Stuart","year":"2015","unstructured":"Stuart PE, Nair RP, Tsoi LC, Tejasvi T, Das S, Kang HM, et al. Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture. Am J Hum Genet. 2015;97(6):816\u201336.","journal-title":"Am J Hum Genet"},{"issue":"11","key":"6015_CR10","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ng.694","volume":"42","author":"A Strange","year":"2010","unstructured":"Genetic Analysis of Psoriasis C, the Wellcome Trust Case Control C, Strange A, Capon F, Spencer CC, Knight J, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 2010;42(11):985\u201390.","journal-title":"Nat Genet"},{"key":"6015_CR11","doi-asserted-by":"publisher","first-page":"15382","DOI":"10.1038\/ncomms15382","volume":"8","author":"LC Tsoi","year":"2017","unstructured":"Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, et al. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat Commun. 2017;8:15382.","journal-title":"Nat Commun"},{"issue":"12","key":"6015_CR12","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ng.2467","volume":"44","author":"LC Tsoi","year":"2012","unstructured":"Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 2012;44(12):1341\u20138.","journal-title":"Nat Genet"},{"issue":"1","key":"6015_CR13","first-page":"100069","volume":"3","author":"PE Stuart","year":"2022","unstructured":"Stuart PE, Tsoi LC, Nair RP, Ghosh M, Kabra M, Shaiq PA, et al. Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide. HGG Adv. 2022;3(1):100069.","journal-title":"HGG Adv"},{"issue":"10","key":"6015_CR14","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","volume":"53","author":"S Sakaue","year":"2021","unstructured":"Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021;53(10):1415\u201324.","journal-title":"Nat Genet"},{"issue":"5","key":"6015_CR15","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/nprot.2014.071","volume":"9","author":"TW Winkler","year":"2014","unstructured":"Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Magi R, et al. Quality control and conduct of genome-wide association meta-analyses. Nat Protoc. 2014;9(5):1192\u2013212.","journal-title":"Nat Protoc"},{"issue":"17","key":"6015_CR16","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190\u20131.","journal-title":"Bioinformatics"},{"issue":"18","key":"6015_CR17","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1093\/hmg\/ddx280","volume":"26","author":"R Magi","year":"2017","unstructured":"Magi R, Horikoshi M, Sofer T, Mahajan A, Kitajima H, Franceschini N, et al. Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Hum Mol Genet. 2017;26(18):3639\u201350.","journal-title":"Hum Mol Genet"},{"issue":"7","key":"6015_CR18","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1038\/s41380-023-02089-w","volume":"28","author":"J Lake","year":"2023","unstructured":"Lake J, Warly Solsberg C, Kim JJ, Acosta-Uribe J, Makarious MB, Li Z, et al. Multi-ancestry meta-analysis and fine-mapping in Alzheimer\u2019s disease. Mol Psychiatry. 2023;28(7):3121\u201332.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"6015_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41588-023-01584-8","volume":"56","author":"JJ Kim","year":"2024","unstructured":"Kim JJ, Vitale D, Otani DV, Lian MM, Heilbron K, Me Research T, et al. Multi-ancestry genome-wide association meta-analysis of Parkinson\u2019s disease. Nat Genet. 2024;56(1):27\u201336.","journal-title":"Nat Genet"},{"issue":"25","key":"6015_CR20","doi-asserted-by":"publisher","first-page":"731","DOI":"10.21105\/joss.00731","volume":"3","author":"SD Turner","year":"2018","unstructured":"Turner SD. qqman: an R package for visualizing GWAS results using Q-Q and Manhattan plots. J Open Source Softw. 2018;3(25):731.","journal-title":"J Open Source Softw"},{"issue":"1","key":"6015_CR21","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe K, Taskesen E, van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun. 2017;8(1):1826.","journal-title":"Nat Commun"},{"issue":"16","key":"6015_CR22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38(16): e164.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"6015_CR23","doi-asserted-by":"publisher","first-page":"D886","DOI":"10.1093\/nar\/gky1016","volume":"47","author":"P Rentzsch","year":"2019","unstructured":"Rentzsch P, Witten D, Cooper GM, Shendure J, Kircher M. CADD: predicting the deleteriousness of variants throughout the human genome. Nucleic Acids Res. 2019;47(D1):D886\u201394.","journal-title":"Nucleic Acids Res"},{"issue":"7539","key":"6015_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature14248","volume":"518","author":"C Roadmap Epigenomics","year":"2015","unstructured":"Roadmap Epigenomics C, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518(7539):317\u201330.","journal-title":"Nature"},{"issue":"3","key":"6015_CR25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nmeth.1906","volume":"9","author":"J Ernst","year":"2012","unstructured":"Ernst J, Kellis M. ChromHMM: automating chromatin-state discovery and characterization. Nat Methods. 2012;9(3):215\u20136.","journal-title":"Nat Methods"},{"issue":"5","key":"6015_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41588-023-01365-3","volume":"55","author":"S Dong","year":"2023","unstructured":"Dong S, Zhao N, Spragins E, Kagda MS, Li M, Assis P, et al. Annotating and prioritizing human non-coding variants with RegulomeDB vol 2. Nat Genet. 2023;55(5):724\u20136.","journal-title":"Nat Genet"},{"issue":"6235","key":"6015_CR27","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"Consortium GT","year":"2015","unstructured":"Consortium GT. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348(6235):648\u201360.","journal-title":"Science"},{"issue":"D1","key":"6015_CR28","doi-asserted-by":"publisher","first-page":"D950","DOI":"10.1093\/nar\/gkab1008","volume":"50","author":"C Quan","year":"2022","unstructured":"Quan C, Ping J, Lu H, Zhou G, Lu Y. 3DSNP 2.0: update and expansion of the noncoding genomic variant annotation database. Nucleic Acids Res. 2022;50(D1):D950\u20135.","journal-title":"Nucleic Acids Res"},{"issue":"383","key":"6015_CR29","doi-asserted-by":"publisher","first-page":"eaag1166","DOI":"10.1126\/scitranslmed.aag1166","volume":"9","author":"C Finan","year":"2017","unstructured":"Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J, et al. The druggable genome and support for target identification and validation in drug development. Sci Transl Med. 2017;9(383):eaag1166.","journal-title":"Sci Transl Med"},{"issue":"D1","key":"6015_CR30","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkaa1084","volume":"49","author":"SL Freshour","year":"2021","unstructured":"Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ, et al. Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):D1144\u201351.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"6015_CR31","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46(D1):D1074\u201382.","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"6015_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219","volume":"11","author":"CA de Leeuw","year":"2015","unstructured":"de Leeuw CA, Mooij JM, Heskes T, Posthuma D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol. 2015;11(4): e1004219.","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"6015_CR33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","volume":"48","author":"A Gusev","year":"2016","unstructured":"Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016;48(3):245\u201352.","journal-title":"Nat Genet"},{"issue":"5","key":"6015_CR34","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48(5):481\u20137.","journal-title":"Nat Genet"},{"issue":"8","key":"6015_CR35","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/s41588-023-01443-6","volume":"55","author":"EM Weeks","year":"2023","unstructured":"Weeks EM, Ulirsch JC, Cheng NY, Trippe BL, Fine RS, Miao J, et al. Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases. Nat Genet. 2023;55(8):1267\u201376.","journal-title":"Nat Genet"},{"issue":"7675","key":"6015_CR36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","volume":"550","author":"Consortium GT","year":"2017","unstructured":"Consortium GT, Laboratory DA, Coordinating Center-Analysis Working G, Statistical Methods groups-Analysis Working G, Enhancing Gg, Fund NIHC, et al. Genetic effects on gene expression across human tissues. Nature. 2017;550(7675):204\u201313.","journal-title":"Nature"},{"issue":"9","key":"6015_CR37","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1038\/s41588-023-01485-w","volume":"55","author":"International League Against Epilepsy Consortium on Complex E","year":"2023","unstructured":"International League Against Epilepsy Consortium on Complex E. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nat Genet. 2023;55(9):1471\u201382.","journal-title":"Nat Genet"},{"issue":"1","key":"6015_CR38","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1038\/s41467-018-07524-z","volume":"9","author":"International League Against Epilepsy Consortium on Complex E","year":"2018","unstructured":"International League Against Epilepsy Consortium on Complex E. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nat Commun. 2018;9(1):5269.","journal-title":"Nat Commun"},{"issue":"7488","key":"6015_CR39","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature12873","volume":"506","author":"Y Okada","year":"2014","unstructured":"Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014;506(7488):376\u201381.","journal-title":"Nature"},{"issue":"3","key":"6015_CR40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics C, et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015;47(3):291\u20135.","journal-title":"Nat Genet"},{"issue":"2","key":"6015_CR41","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41588-018-0279-5","volume":"51","author":"D Speed","year":"2019","unstructured":"Speed D, Balding DJ. SumHer better estimates the SNP heritability of complex traits from summary statistics. Nat Genet. 2019;51(2):277\u201384.","journal-title":"Nat Genet"},{"issue":"4","key":"6015_CR42","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41588-020-0600-y","volume":"52","author":"D Speed","year":"2020","unstructured":"Speed D, Holmes J, Balding DJ. Evaluating and improving heritability models using summary statistics. Nat Genet. 2020;52(4):458\u201362.","journal-title":"Nat Genet"},{"issue":"5","key":"6015_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008612","volume":"16","author":"D Holland","year":"2020","unstructured":"Holland D, Frei O, Desikan R, Fan CC, Shadrin AA, Smeland OB, et al. Beyond SNP heritability: polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. PLoS Genet. 2020;16(5): e1008612.","journal-title":"PLoS Genet"},{"issue":"4","key":"6015_CR44","doi-asserted-by":"publisher","first-page":"fcab287","DOI":"10.1093\/braincomms\/fcab287","volume":"3","author":"N Mirza","year":"2021","unstructured":"Mirza N, Stevelink R, Taweel B, Koeleman BPC, Marson AG, International League Against Epilepsy Consortium on Complex E. Using common genetic variants to find drugs for common epilepsies. Brain Commun. 2021;3(4):fcab287.","journal-title":"Brain Commun."},{"issue":"3","key":"6015_CR45","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","volume":"46","author":"M Kircher","year":"2014","unstructured":"Kircher M, Witten DM, Jain P, O\u2019Roak BJ, Cooper GM, Shendure J. A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 2014;46(3):310\u20135.","journal-title":"Nat Genet"},{"issue":"5","key":"6015_CR46","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s40291-022-00603-4","volume":"26","author":"SS Ho","year":"2022","unstructured":"Ho SS, Tsai TF. Associations between HLA-Cw1 and systemic treatment response of asian psoriasis patients. Mol Diagn Ther. 2022;26(5):541\u20139.","journal-title":"Mol Diagn Ther"},{"issue":"2","key":"6015_CR47","doi-asserted-by":"publisher","first-page":"jkaa056","DOI":"10.1093\/g3journal\/jkaa056","volume":"11","author":"Z Chen","year":"2021","unstructured":"Chen Z, Boehnke M, Wen X, Mukherjee B. Revisiting the genome-wide significance threshold for common variant GWAS. G3 (Bethesda). 2021;11(2):jkaa056.","journal-title":"G3 (Bethesda)"},{"issue":"5","key":"6015_CR48","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41588-024-01714-w","volume":"56","author":"JM Keaton","year":"2024","unstructured":"Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, et al. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat Genet. 2024;56(5):778\u201391.","journal-title":"Nat Genet"},{"issue":"11","key":"6015_CR49","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1038\/s41588-024-01951-z","volume":"56","author":"LM Garcia-Marin","year":"2024","unstructured":"Garcia-Marin LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, et al. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nat Genet. 2024;56(11):2333\u201344.","journal-title":"Nat Genet"},{"issue":"1","key":"6015_CR50","doi-asserted-by":"publisher","first-page":"8629","DOI":"10.1038\/s41467-024-52129-4","volume":"15","author":"BR Gorman","year":"2024","unstructured":"Gorman BR, Ji SG, Francis M, Sendamarai AK, Shi Y, Devineni P, et al. Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. Nat Commun. 2024;15(1):8629.","journal-title":"Nat Commun"},{"issue":"11","key":"6015_CR51","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/ng.693","volume":"42","author":"PE Stuart","year":"2010","unstructured":"Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, et al. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet. 2010;42(11):1000\u20134.","journal-title":"Nat Genet"},{"issue":"2","key":"6015_CR52","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/ng.313","volume":"41","author":"R de Cid","year":"2009","unstructured":"de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet. 2009;41(2):211\u20135.","journal-title":"Nat Genet"},{"issue":"13","key":"6015_CR53","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1093\/hmg\/ddn091","volume":"17","author":"F Capon","year":"2008","unstructured":"Capon F, Bijlmakers MJ, Wolf N, Quaranta M, Huffmeier U, Allen M, et al. Identification of ZNF313\/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet. 2008;17(13):1938\u201345.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"6015_CR54","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1086\/511051","volume":"80","author":"M Cargill","year":"2007","unstructured":"Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80(2):273\u201390.","journal-title":"Am J Hum Genet"},{"issue":"10","key":"6015_CR55","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1038\/jid.2012.191","volume":"132","author":"PE Stuart","year":"2012","unstructured":"Stuart PE, Huffmeier U, Nair RP, Palla R, Tejasvi T, Schalkwijk J, et al. Association of beta-defensin copy number and psoriasis in three cohorts of European origin. J Invest Dermatol. 2012;132(10):2407\u201313.","journal-title":"J Invest Dermatol"},{"key":"6015_CR56","doi-asserted-by":"publisher","first-page":"1387875","DOI":"10.3389\/fgene.2024.1387875","volume":"15","author":"S He","year":"2024","unstructured":"He S, Liu L, Long X, Ge M, Cai M, Zhang J. Single-cell analysis and machine learning identify psoriasis-associated CD8(+) T cells serve as biomarker for psoriasis. Front Genet. 2024;15:1387875.","journal-title":"Front Genet"},{"key":"6015_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.104985","volume":"100","author":"BH Lee","year":"2024","unstructured":"Lee BH, Bang YJ, Lim SH, Kang SJ, Kim SH, Kim-Schulze S, et al. High-dimensional profiling of regulatory T cells in psoriasis reveals an impaired skin-trafficking property. EBioMedicine. 2024;100: 104985.","journal-title":"EBioMedicine"},{"issue":"6","key":"6015_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31266","volume":"239","author":"AAM Noor","year":"2024","unstructured":"Noor AAM, Nor A, Redzwan NM. The immunological understanding on germinal center B cells in psoriasis. J Cell Physiol. 2024;239(6): e31266.","journal-title":"J Cell Physiol"},{"issue":"9","key":"6015_CR59","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.autrev.2017.07.011","volume":"16","author":"JC Prinz","year":"2017","unstructured":"Prinz JC. Autoimmune aspects of psoriasis: heritability and autoantigens. Autoimmun Rev. 2017;16(9):970\u20139.","journal-title":"Autoimmun Rev"},{"issue":"6","key":"6015_CR60","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/1523-1747.ep12476080","volume":"100","author":"M Schmitt-Egenolf","year":"1993","unstructured":"Schmitt-Egenolf M, Boehncke WH, Stander M, Eiermann TH, Sterry W. Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB1*0701\/2, -DQA1*0201, -DQB1*0303 extended haplotype. J Invest Dermatol. 1993;100(6):749\u201352.","journal-title":"J Invest Dermatol"},{"issue":"5","key":"6015_CR61","first-page":"263","volume":"15","author":"JH Yen","year":"1999","unstructured":"Yen JH, Tsai WC, Tsai JJ, Chen CJ, Lin CH, Ou TT, et al. HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases. Kaohsiung J Med Sci. 1999;15(5):263\u20137.","journal-title":"Kaohsiung J Med Sci"},{"issue":"3","key":"6015_CR62","first-page":"159","volume":"15","author":"CB Cardoso","year":"2005","unstructured":"Cardoso CB, Uthida-Tanaka AM, Magalhaes RF, Magna LA, Kraemer MH. Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis. Eur J Dermatol. 2005;15(3):159\u201363.","journal-title":"Eur J Dermatol"},{"issue":"5","key":"6015_CR63","doi-asserted-by":"publisher","first-page":"497","DOI":"10.4103\/0019-5154.87128","volume":"56","author":"S Umapathy","year":"2011","unstructured":"Umapathy S, Pawar A, Mitra R, Khuperkar D, Devaraj JP, Ghosh K, et al. Hla-a and hla-B alleles associated in psoriasis patients from mumbai. Western India Indian J Dermatol. 2011;56(5):497\u2013500.","journal-title":"Western India Indian J Dermatol"},{"issue":"11","key":"6015_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023089","volume":"6","author":"KJ Zhu","year":"2011","unstructured":"Zhu KJ, Lv YM, Yin XY, Wang ZX, Sun LD, He SM, et al. Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. PLoS ONE. 2011;6(11): e23089.","journal-title":"PLoS ONE"},{"issue":"5","key":"6015_CR65","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.1007\/s11033-011-1407-9","volume":"39","author":"YH Lee","year":"2012","unstructured":"Lee YH, Choi SJ, Ji JD, Song GG. Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet\u2019s disease. Mol Biol Rep. 2012;39(5):5953\u20139.","journal-title":"Mol Biol Rep"},{"issue":"9\u201310","key":"6015_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2961","volume":"19","author":"H Guo","year":"2017","unstructured":"Guo H, Huang Y, Wu J, Zheng X, Ye L, Huang H, et al. Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population. J Gene Med. 2017;19(9\u201310): e2961.","journal-title":"J Gene Med"},{"issue":"3","key":"6015_CR67","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.jid.2017.10.001","volume":"138","author":"J Hirata","year":"2018","unstructured":"Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, et al. Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese. J Invest Dermatol. 2018;138(3):542\u20138.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"6015_CR68","first-page":"62","volume":"157","author":"M Bieniek-Kobuszewska","year":"2022","unstructured":"Bieniek-Kobuszewska M, Owczarczyk-Saczonek A, Maciejewska-Radomska A, Wojtacha P, Placek W. Analysis of key markers: IL-10\/sHLA-G in psoriasis patients and the identification of 14-bp INDEL in the HLA-G gene. Ital J Dermatol Venerol. 2022;157(1):62\u20138.","journal-title":"Ital J Dermatol Venerol"},{"issue":"1","key":"6015_CR69","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.1038\/s41467-024-49782-0","volume":"15","author":"L Yang","year":"2024","unstructured":"Yang L, Ou YN, Wu BS, Liu WS, Deng YT, He XY, et al. Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults. Nat Commun. 2024;15(1):5924.","journal-title":"Nat Commun"},{"issue":"8","key":"6015_CR70","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.humimm.2020.07.002","volume":"81","author":"C Li","year":"2020","unstructured":"Li C, Dai S, Yan Z, Zhang X, Liu S, Wang X, et al. Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting system are associated with cervical cancer in a Chinese Han population. Hum Immunol. 2020;81(8):445\u201351.","journal-title":"Hum Immunol"},{"issue":"5","key":"6015_CR71","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.4049\/jimmunol.1101003","volume":"187","author":"DM Zaiss","year":"2011","unstructured":"Zaiss DM, Bekker CP, Grone A, Lie BA, Sijts AJ. Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases. J Immunol. 2011;187(5):2302\u20139.","journal-title":"J Immunol"},{"key":"6015_CR72","doi-asserted-by":"publisher","first-page":"10031","DOI":"10.2147\/IJGM.S341079","volume":"14","author":"AH Mufti","year":"2021","unstructured":"Mufti AH, AlJahdali IA, Elhawary NA, Ekram SN, Abumansour I, Sindi IA, et al. Variations in TAP1 and PSMB9 genes involved in antigen processing and presentation increase the risk of vitiligo in the saudi community. Int J Gen Med. 2021;14:10031\u201344.","journal-title":"Int J Gen Med"},{"issue":"2","key":"6015_CR73","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ni.2203","volume":"13","author":"EZ Kincaid","year":"2011","unstructured":"Kincaid EZ, Che JW, York I, Escobar H, Reyes-Vargas E, Delgado JC, et al. Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol. 2011;13(2):129\u201335.","journal-title":"Nat Immunol"},{"issue":"1","key":"6015_CR74","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.coi.2012.11.004","volume":"25","author":"M Basler","year":"2013","unstructured":"Basler M, Kirk CJ, Groettrup M. The immunoproteasome in antigen processing and other immunological functions. Curr Opin Immunol. 2013;25(1):74\u201380.","journal-title":"Curr Opin Immunol"},{"issue":"19","key":"6015_CR75","doi-asserted-by":"publisher","first-page":"10841","DOI":"10.3390\/ijms221910841","volume":"22","author":"A Orsmond","year":"2021","unstructured":"Orsmond A, Bereza-Malcolm L, Lynch T, March L, Xue M. Skin barrier dysregulation in psoriasis. Int J Mol Sci. 2021;22(19):10841.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"6015_CR76","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12945","volume":"92","author":"LL Ten Bergen","year":"2020","unstructured":"Ten Bergen LL, Petrovic A, Aarebrot AK, Appel S. Current knowledge on autoantigens and autoantibodies in psoriasis. Scand J Immunol. 2020;92(4): e12945.","journal-title":"Scand J Immunol"},{"key":"6015_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.788940","volume":"12","author":"P Hu","year":"2021","unstructured":"Hu P, Wang M, Gao H, Zheng A, Li J, Mu D, et al. The role of helper T cells in psoriasis. Front Immunol. 2021;12: 788940.","journal-title":"Front Immunol"},{"issue":"6","key":"6015_CR78","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204\u201318.","journal-title":"Oncotarget"},{"issue":"4","key":"6015_CR79","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.humimm.2018.02.003","volume":"79","author":"A Bojko","year":"2018","unstructured":"Bojko A, Ostasz R, Bialecka M, Klimowicz A, Malinowski D, Budawski R, et al. IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment. Hum Immunol. 2018;79(4):213\u20137.","journal-title":"Hum Immunol"},{"key":"6015_CR80","first-page":"1","volume":"8","author":"C Fotiadou","year":"2018","unstructured":"Fotiadou C, Lazaridou E, Sotiriou E, Ioannides D. Targeting IL-23 in psoriasis: current perspectives. Psoriasis (Auckl). 2018;8:1\u20135.","journal-title":"Psoriasis (Auckl)"},{"issue":"9","key":"6015_CR81","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41419-023-06134-y","volume":"14","author":"Z Fang","year":"2023","unstructured":"Fang Z, Wang Y, Huang B, Chen X, Jiang R, Yin M. Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte. Cell Death Dis. 2023;14(9):627.","journal-title":"Cell Death Dis"},{"issue":"4","key":"6015_CR82","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/ar1203","volume":"6","author":"ME Alarcon-Riquelme","year":"2004","unstructured":"Alarcon-Riquelme ME. Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus. Arthritis Res Ther. 2004;6(4):169\u201373.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"6015_CR83","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1084\/jem.20021200","volume":"198","author":"O Komine","year":"2003","unstructured":"Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, et al. The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression. J Exp Med. 2003;198(1):51\u201361.","journal-title":"J Exp Med"},{"key":"6015_CR84","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-3-030-92616-8_4","volume":"1367","author":"E Trovato","year":"2022","unstructured":"Trovato E, Rubegni P, Cinotti E. The immunogenetics of psoriasis. Adv Exp Med Biol. 2022;1367:105\u201317.","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"6015_CR85","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","volume":"21","author":"JJ Hu","year":"2020","unstructured":"Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020;21(7):736\u201345.","journal-title":"Nat Immunol"},{"issue":"9","key":"6015_CR86","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41419-023-06094-3","volume":"14","author":"N Lian","year":"2023","unstructured":"Lian N, Chen Y, Chen S, Zhang Y, Chen H, Yang Y, et al. Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. Cell Death Dis. 2023;14(9):595.","journal-title":"Cell Death Dis"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-06015-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-024-06015-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-024-06015-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:25:34Z","timestamp":1738221934000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-024-06015-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6015"],"URL":"https:\/\/doi.org\/10.1186\/s12967-024-06015-8","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"25 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Beijing Institute of Brain Disorders in Capital Medical University and the ethical code number is AEEI-2021-077.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that there are no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"133"}}