{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:14:00Z","timestamp":1784740440323,"version":"3.55.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004432"],"award-info":[{"award-number":["82004432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06074-5","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:19:04Z","timestamp":1737458344000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Zhen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"issue":"4","key":"6074_CR1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","volume":"5","author":"AS Monzel","year":"2023","unstructured":"Monzel AS, Enriquez JA, Picard M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat Metab. 2023;5(4):546\u201362.","journal-title":"Nat Metab"},{"issue":"6","key":"6074_CR2","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.molcel.2023.02.015","volume":"83","author":"JA Schafer","year":"2023","unstructured":"Schafer JA, Sutandy FXR, Munch C. Omics-based approaches for the systematic profiling of mitochondrial biology. Mol Cell. 2023;83(6):911\u201326.","journal-title":"Mol Cell"},{"issue":"5","key":"6074_CR3","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41556-024-01410-1","volume":"26","author":"M Granath-Panelo","year":"2024","unstructured":"Granath-Panelo M, Kajimura S. Mitochondrial heterogeneity and adaptations to cellular needs. Nat Cell Biol. 2024;26(5):674\u201386.","journal-title":"Nat Cell Biol"},{"issue":"1","key":"6074_CR4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41580-023-00650-7","volume":"25","author":"ZN Baker","year":"2024","unstructured":"Baker ZN, Forny P, Pagliarini DJ. Mitochondrial proteome research: the road ahead. Nat Rev Mol Cell Biol. 2024;25(1):65\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"6074_CR5","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1038\/s42255-023-00885-w","volume":"5","author":"RJ Mailloux","year":"2023","unstructured":"Mailloux RJ, Treberg J, Grayson C, et al. Mitochondrial function and phenotype are defined by bioenergetics. Nat Metab. 2023;5(10):1641.","journal-title":"Nat Metab"},{"issue":"1","key":"6074_CR6","first-page":"32","volume":"11","author":"BH Liu","year":"2024","unstructured":"Liu BH, Xu CZ, Liu Y, et al. Mitochondrial quality control in human health and disease. Mil Med Res. 2024;11(1):32.","journal-title":"Mil Med Res"},{"key":"6074_CR7","doi-asserted-by":"crossref","unstructured":"Lisowski P, Kannan P, Mlody B et al. Mitochondria and the dynamic control of stem cell homeostasis. EMBO Rep. 2018;19(5).","DOI":"10.15252\/embr.201745432"},{"issue":"3","key":"6074_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/JP271301","volume":"594","author":"C Vasquez-Trincado","year":"2016","unstructured":"Vasquez-Trincado C, Garcia-Carvajal I, Pennanen C, et al. Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 2016;594(3):509\u201325.","journal-title":"J Physiol"},{"issue":"2","key":"6074_CR9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/jcmm.17116","volume":"26","author":"P Narongkiatikhun","year":"2022","unstructured":"Narongkiatikhun P, Chattipakorn SC, Chattipakorn N. Mitochondrial dynamics and diabetic kidney disease: missing pieces for the puzzle of therapeutic approaches. J Cell Mol Med. 2022;26(2):249\u201373.","journal-title":"J Cell Mol Med"},{"key":"6074_CR10","doi-asserted-by":"publisher","first-page":"1035755","DOI":"10.3389\/fphar.2022.1035755","volume":"13","author":"Y Song","year":"2022","unstructured":"Song Y, Yu H, Sun Q, et al. Grape seed proanthocyanidin extract targets p66Shc to regulate mitochondrial biogenesis and dynamics in diabetic kidney disease. Front Pharmacol. 2022;13:1035755.","journal-title":"Front Pharmacol"},{"issue":"2","key":"6074_CR11","doi-asserted-by":"publisher","first-page":"156","DOI":"10.33594\/000000011","volume":"52","author":"H Jiang","year":"2019","unstructured":"Jiang H, Shao X, Jia S, et al. The Mitochondria-targeted metabolic tubular Injury in Diabetic kidney disease. Cell Physiol Biochem. 2019;52(2):156\u201371.","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"6074_CR12","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s12020-011-9555-1","volume":"41","author":"WX Tang","year":"2012","unstructured":"Tang WX, Wu WH, Zeng XX, et al. Early protective effect of mitofusion 2 overexpression in STZ-induced diabetic rat kidney. Endocrine. 2012;41(2):236\u201347.","journal-title":"Endocrine"},{"key":"6074_CR13","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ebiom.2019.04.044","volume":"43","author":"M Yang","year":"2019","unstructured":"Yang M, Zhao L, Gao P, et al. DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity. EBioMedicine. 2019;43:607\u201319.","journal-title":"EBioMedicine"},{"issue":"12","key":"6074_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nrd.2018.174","volume":"17","author":"MP Murphy","year":"2018","unstructured":"Murphy MP, Hartley RC. Mitochondria as a therapeutic target for common pathologies. Nat Rev Drug Discov. 2018;17(12):865\u201386.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"6074_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","volume":"9","author":"Y Zong","year":"2024","unstructured":"Zong Y, Li H, Liao P, et al. Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther. 2024;9(1):124.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"6074_CR16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","volume":"8","author":"S Wang","year":"2023","unstructured":"Wang S, Long H, Hou L, et al. The mitophagy pathway and its implications in human diseases. Signal Transduct Target Ther. 2023;8(1):304.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"6074_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41580-023-00661-4","volume":"25","author":"BG Tan","year":"2024","unstructured":"Tan BG, Gustafsson CM, Falkenberg M. Mechanisms and regulation of human mitochondrial transcription. Nat Rev Mol Cell Biol. 2024;25(2):119\u201332.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"6074_CR18","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1681\/ASN.2008070759","volume":"20","author":"AM Hall","year":"2009","unstructured":"Hall AM, Unwin RJ, Parker N, et al. Multiphoton imaging reveals differences in mitochondrial function between nephron segments. J Am Soc Nephrology: JASN. 2009;20(6):1293\u2013302.","journal-title":"J Am Soc Nephrology: JASN"},{"key":"6074_CR19","doi-asserted-by":"crossref","unstructured":"Mohandes S, Doke T, Hu H et al. Molecular pathways that drive diabetic kidney disease. J Clin Invest. 2023;133(4).","DOI":"10.1172\/JCI165654"},{"issue":"2","key":"6074_CR20","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1124\/pharmrev.122.000560","volume":"75","author":"KH Cleveland","year":"2023","unstructured":"Cleveland KH, Schnellmann RG. Pharmacological targeting of Mitochondria in Diabetic kidney disease. Pharmacol Rev. 2023;75(2):250\u201362.","journal-title":"Pharmacol Rev"},{"issue":"29","key":"6074_CR21","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.2174\/0929867324666170509121003","volume":"24","author":"S Yang","year":"2017","unstructured":"Yang S, Han Y, Liu J, et al. Mitochondria: a Novel Therapeutic Target in Diabetic Nephropathy. Curr Med Chem. 2017;24(29):3185\u2013202.","journal-title":"Curr Med Chem"},{"issue":"14","key":"6074_CR22","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.2174\/0929867327666201006152656","volume":"28","author":"M Yang","year":"2021","unstructured":"Yang M, Li C, Yang S, et al. Mitophagy: a Novel Therapeutic Target for treating DN. Curr Med Chem. 2021;28(14):2717\u201328.","journal-title":"Curr Med Chem"},{"key":"6074_CR23","doi-asserted-by":"publisher","first-page":"154890","DOI":"10.1016\/j.metabol.2021.154890","volume":"124","author":"CA Ricciardi","year":"2021","unstructured":"Ricciardi CA, Gnudi L. Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies. Metabolism. 2021;124:154890.","journal-title":"Metabolism"},{"issue":"3","key":"6074_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41581-023-00782-1","volume":"20","author":"R Correa-Rotter","year":"2024","unstructured":"Correa-Rotter R, Maple-Brown LJ, Sahay R, et al. New and emerging therapies for diabetic kidney disease. Nat Rev Nephrol. 2024;20(3):156\u201360.","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"6074_CR25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41581-024-00827-z","volume":"20","author":"DH van Raalte","year":"2024","unstructured":"van Raalte DH, Bjornstad P, Cherney DZI, et al. Combination therapy for kidney disease in people with diabetes mellitus. Nat Rev Nephrol. 2024;20(7):433\u201346.","journal-title":"Nat Rev Nephrol"},{"issue":"9","key":"6074_CR26","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.2337\/dci23-0030","volume":"46","author":"SC Naaman","year":"2023","unstructured":"Naaman SC, Bakris GL. Diabetic Nephropathy: Update on pillars of Therapy slowing progression. Diabetes Care. 2023;46(9):1574\u201386.","journal-title":"Diabetes Care"},{"issue":"3","key":"6074_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1185\/030079903125003107","volume":"20","author":"B Rayner","year":"2004","unstructured":"Rayner B. Advances in the treatment of diabetic renal disease: focus on losartan. Curr Med Res Opin. 2004;20(3):333\u201340.","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"6074_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0053-x","volume":"50","author":"D Dorotea","year":"2018","unstructured":"Dorotea D, Cho A, Lee G, et al. Orally active, species-independent novel A(3) adenosine receptor antagonist protects against kidney injury in db\/db mice. Exp Mol Med. 2018;50(4):1\u201314.","journal-title":"Exp Mol Med"},{"issue":"2","key":"6074_CR29","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/j.1523-1755.2005.00450.x","volume":"68","author":"A Deng","year":"2005","unstructured":"Deng A, Miracle CM, Suarez JM, et al. Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II. Kidney Int. 2005;68(2):723\u201330.","journal-title":"Kidney Int"},{"issue":"3","key":"6074_CR30","doi-asserted-by":"publisher","first-page":"517","DOI":"10.5301\/jn.5000176","volume":"26","author":"QL Fan","year":"2013","unstructured":"Fan QL, Yang G, Liu XD, et al. Effect of losartan on the glomerular protein expression profile of type 2 diabetic KKAy mice. J Nephrol. 2013;26(3):517\u201326.","journal-title":"J Nephrol"},{"key":"6074_CR31","doi-asserted-by":"publisher","first-page":"638422","DOI":"10.3389\/fphar.2021.638422","volume":"12","author":"J Su","year":"2021","unstructured":"Su J, Gao C, Xie L, et al. Astragaloside II ameliorated Podocyte Injury and mitochondrial dysfunction in Streptozotocin-Induced Diabetic rats. Front Pharmacol. 2021;12:638422.","journal-title":"Front Pharmacol"},{"key":"6074_CR32","doi-asserted-by":"publisher","first-page":"154975","DOI":"10.1016\/j.phymed.2023.154975","volume":"119","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Luan G, Peng S, et al. Huangkui capsule attenuates diabetic kidney disease through the induction of mitophagy mediated by STING1\/PINK1 signaling in tubular cells. Phytomedicine. 2023;119:154975.","journal-title":"Phytomedicine"},{"issue":"1","key":"6074_CR33","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.1038\/s41467-023-41994-0","volume":"14","author":"H Mumme","year":"2023","unstructured":"Mumme H, Thomas BE, Bhasin SS, et al. Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia. Nat Commun. 2023;14(1):6209.","journal-title":"Nat Commun"},{"issue":"7900","key":"6074_CR34","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41586-022-04461-2","volume":"603","author":"R Palovics","year":"2022","unstructured":"Palovics R, Keller A, Schaum N, et al. Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature. 2022;603(7900):309\u201314.","journal-title":"Nature"},{"issue":"6","key":"6074_CR35","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41573-023-00688-4","volume":"22","author":"B Van de Sande","year":"2023","unstructured":"Van de Sande B, Lee JS, Mutasa-Gottgens E, et al. Applications of single-cell RNA sequencing in drug discovery and development. Nat Rev Drug Discov. 2023;22(6):496\u2013520.","journal-title":"Nat Rev Drug Discov"},{"key":"6074_CR36","doi-asserted-by":"publisher","first-page":"1053850","DOI":"10.3389\/fphys.2022.1053850","volume":"13","author":"ZH Mao","year":"2022","unstructured":"Mao ZH, Gao ZX, Liu Y, et al. Single-cell transcriptomics: a new tool for studying diabetic kidney disease. Front Physiol. 2022;13:1053850.","journal-title":"Front Physiol"},{"issue":"1","key":"6074_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s10020-023-00693-8","volume":"29","author":"J Zhu","year":"2023","unstructured":"Zhu J, Lu J, Weng H. Single-cell RNA sequencing for the study of kidney disease. Mol Med. 2023;29(1):85.","journal-title":"Mol Med"},{"issue":"1","key":"6074_CR38","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1038\/s41467-019-10861-2","volume":"10","author":"BB Lake","year":"2019","unstructured":"Lake BB, Chen S, Hoshi M, et al. A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys. Nat Commun. 2019;10(1):2832.","journal-title":"Nat Commun"},{"issue":"4","key":"6074_CR39","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1681\/ASN.2018090896","volume":"30","author":"J Fu","year":"2019","unstructured":"Fu J, Akat KM, Sun Z, et al. Single-cell RNA profiling of glomerular cells shows dynamic changes in experimental diabetic kidney disease. J Am Soc Nephrol. 2019;30(4):533\u201345.","journal-title":"J Am Soc Nephrol"},{"issue":"6390","key":"6074_CR40","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1126\/science.aar2131","volume":"360","author":"J Park","year":"2018","unstructured":"Park J, Shrestha R, Qiu C, et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science. 2018;360(6390):758\u201363.","journal-title":"Science"},{"issue":"39","key":"6074_CR41","doi-asserted-by":"publisher","first-page":"19619","DOI":"10.1073\/pnas.1908706116","volume":"116","author":"PC Wilson","year":"2019","unstructured":"Wilson PC, Wu H, Kirita Y, et al. The single-cell transcriptomic landscape of early human diabetic nephropathy. Proc Natl Acad Sci USA. 2019;116(39):19619\u201325.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8011","key":"6074_CR42","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41586-024-07332-0","volume":"629","author":"AV Kotrys","year":"2024","unstructured":"Kotrys AV, Durham TJ, Guo XA, et al. Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature. 2024;629(8011):458\u201366.","journal-title":"Nature"},{"issue":"6","key":"6074_CR43","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.cell.2019.01.022","volume":"176","author":"LS Ludwig","year":"2019","unstructured":"Ludwig LS, Lareau CA, Ulirsch JC, et al. Lineage tracing in humans enabled by mitochondrial mutations and single-cell Genomics. Cell. 2019;176(6):1325\u201339. e1322.","journal-title":"Cell"},{"issue":"5","key":"6074_CR44","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.cmet.2020.10.005","volume":"32","author":"MC Ludikhuize","year":"2020","unstructured":"Ludikhuize MC, Meerlo M, Gallego MP, et al. Mitochondria define intestinal stem cell differentiation downstream of a FOXO\/Notch Axis. Cell Metab. 2020;32(5):889\u2013e900887.","journal-title":"Cell Metab"},{"issue":"7817","key":"6074_CR45","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41586-020-2499-y","volume":"583","author":"N Schaum","year":"2020","unstructured":"Schaum N, Lehallier B, Hahn O, et al. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020;583(7817):596\u2013602.","journal-title":"Nature"},{"issue":"1","key":"6074_CR46","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-023-02982-9","volume":"20","author":"Z Yang","year":"2023","unstructured":"Yang Z, Liu Y, Chen X, et al. Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury. J Neuroinflammation. 2023;20(1):296.","journal-title":"J Neuroinflammation"},{"key":"6074_CR47","doi-asserted-by":"crossref","unstructured":"Wu J, Sun Z, Yang S, et al. Kidney single-cell transcriptome prole reveals distinct response of proximal tubule cells to SGLT2i and ARB treatment in diabetic mice. Mol Ther.  2022 Apr 6;30(4):1741-1753.","DOI":"10.1016\/j.ymthe.2021.10.013"},{"issue":"7","key":"6074_CR48","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cmet.2022.05.010","volume":"34","author":"H Wu","year":"2022","unstructured":"Wu H, Gonzalez Villalobos R, Yao X, et al. Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies. Cell Metab. 2022;34(7):1064\u2013e10781066.","journal-title":"Cell Metab"},{"issue":"4","key":"6074_CR49","doi-asserted-by":"publisher","first-page":"100992","DOI":"10.1016\/j.xcrm.2023.100992","volume":"4","author":"MS Balzer","year":"2023","unstructured":"Balzer MS, Pavkovic M, Frederick J, et al. Treatment effects of soluble guanylate cyclase modulation on diabetic kidney disease at single-cell resolution. Cell Rep Med. 2023;4(4):100992.","journal-title":"Cell Rep Med"},{"key":"6074_CR50","doi-asserted-by":"crossref","unstructured":"Wu C, Song Y, Yu Y et al. Single-Cell Transcriptional Landscape Reveals the Regulatory Network and its heterogeneity of renal mitochondrial damages in Diabetic kidney disease. Int J Mol Sci. 2023;24(17).","DOI":"10.3390\/ijms241713502"},{"issue":"5","key":"6074_CR51","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1038\/s41596-022-00795-3","volume":"18","author":"CA Lareau","year":"2023","unstructured":"Lareau CA, Liu V, Muus C, et al. Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility. Nat Protoc. 2023;18(5):1416\u201340.","journal-title":"Nat Protoc"},{"issue":"7","key":"6074_CR52","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41588-024-01794-8","volume":"56","author":"L Nitsch","year":"2024","unstructured":"Nitsch L, Lareau CA, Ludwig LS. Mitochondrial genetics through the lens of single-cell multi-omics. Nat Genet. 2024;56(7):1355\u201365.","journal-title":"Nat Genet"},{"issue":"4","key":"6074_CR53","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41587-020-0645-6","volume":"39","author":"CA Lareau","year":"2021","unstructured":"Lareau CA, Ludwig LS, Muus C, et al. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nat Biotechnol. 2021;39(4):451\u201361.","journal-title":"Nat Biotechnol"},{"key":"6074_CR54","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1126\/scitranslmed.aaw2050","volume":"11","author":"P Gao","year":"2019","unstructured":"Gao P, Li L, Yang L, et al. Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFbeta1. Sci Transl Med. 2019;11:510.","journal-title":"Sci Transl Med"},{"issue":"3","key":"6074_CR55","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/path.2961","volume":"225","author":"L Sun","year":"2011","unstructured":"Sun L, Zhang D, Liu F, et al. Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192. J Pathol. 2011;225(3):364\u201377.","journal-title":"J Pathol"},{"key":"6074_CR56","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","volume":"11","author":"L Xiao","year":"2017","unstructured":"Xiao L, Xu X, Zhang F, et al. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1. Redox Biol. 2017;11:297\u2013311.","journal-title":"Redox Biol"},{"issue":"10","key":"6074_CR57","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.2337\/dc14-1296","volume":"37","author":"KR Tuttle","year":"2014","unstructured":"Tuttle KR, Bakris GL, Bilous RW, et al. Diabetic kidney disease: a report from an ADA Consensus Conference. Diabetes Care. 2014;37(10):2864\u201383.","journal-title":"Diabetes Care"},{"issue":"1","key":"6074_CR58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41387-018-0061-x","volume":"8","author":"Y Sun","year":"2018","unstructured":"Sun Y, Jin C, Zhang X, et al. Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice. Nutr Diabetes. 2018;8(1):53.","journal-title":"Nutr Diabetes"},{"key":"6074_CR59","doi-asserted-by":"crossref","unstructured":"Hex N, Bartlett C, Wright D et al. Estimating the current and future costs of type 1 and type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet Med. 2012;29.","DOI":"10.1111\/j.1464-5491.2012.03698.x"},{"key":"6074_CR60","doi-asserted-by":"crossref","unstructured":"Li A, Yi B, Han H, et al. Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubularepithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway. Autophagy. 2022 Apr;18(4):877-890.","DOI":"10.1080\/15548627.2021.1962681"},{"issue":"1","key":"6074_CR61","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/MNH.0b013e32835abb52","volume":"22","author":"LJ Hale","year":"2013","unstructured":"Hale LJ, Coward RJM. The insulin receptor and the kidney. Curr Opin Nephrol Hypertens. 2013;22(1):100\u20136.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"6074_CR62","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1053\/j.ajkd.2015.03.032","volume":"66","author":"E Schutte","year":"2015","unstructured":"Schutte E, Lambers Heerspink HJ, Lutgers HL, et al. Serum bicarbonate and kidney Disease Progression and Cardiovascular Outcome in patients with Diabetic Nephropathy: a Post Hoc Analysis of the RENAAL (reduction of end points in Non-insulin-dependent Diabetes with the angiotensin II antagonist Losartan) Study and IDNT (Irbesartan Diabetic Nephropathy Trial). Am J Kidney Dis. 2015;66(3):450\u20138.","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"6074_CR63","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1056\/NEJMoa011161","volume":"345","author":"BM Brenner","year":"2001","unstructured":"Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001;345(12):861\u20139.","journal-title":"N Engl J Med"},{"key":"6074_CR64","doi-asserted-by":"publisher","first-page":"107112","DOI":"10.1016\/j.vph.2022.107112","volume":"147","author":"E Sauge","year":"2022","unstructured":"Sauge E, Pechkovsky D, Atmuri NDP, et al. Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties. Vascul Pharmacol. 2022;147:107112.","journal-title":"Vascul Pharmacol"},{"issue":"9","key":"6074_CR65","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1093\/ndt\/gfae021","volume":"39","author":"H Nagasawa","year":"2024","unstructured":"Nagasawa H, Ueda S, Suzuki H, et al. Sparsentan is superior to losartan in the gddY mouse model of IgA nephropathy. Nephrol Dial Transpl. 2024;39(9):1494\u2013503.","journal-title":"Nephrol Dial Transpl"},{"issue":"7","key":"6074_CR66","doi-asserted-by":"publisher","first-page":"e014996","DOI":"10.1161\/JAHA.119.014996","volume":"9","author":"P Wu","year":"2020","unstructured":"Wu P, Gao ZX, Zhang DD, et al. Effect of angiotensin II on ENaC in the Distal Convoluted Tubule and in the cortical Collecting Duct of Mineralocorticoid receptor deficient mice. J Am Heart Assoc. 2020;9(7):e014996.","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"6074_CR67","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1161\/HYPERTENSIONAHA.117.10471","volume":"71","author":"P Wu","year":"2018","unstructured":"Wu P, Gao ZX, Duan XP, et al. AT2R (angiotensin II type 2 Receptor)-Mediated regulation of NCC (Na-Cl cotransporter) and renal K excretion depends on the K Channel, Kir4.1. Hypertension. 2018;71(4):622\u201330.","journal-title":"Hypertension"},{"issue":"8","key":"6074_CR68","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1248\/yakushi.125.653","volume":"125","author":"P Vijayapandi","year":"2005","unstructured":"Vijayapandi P, Nagappa AN. Biphasic effects of losartan potassium on immobility in mice. Yakugaku Zasshi. 2005;125(8):653\u20137.","journal-title":"Yakugaku Zasshi"},{"issue":"5","key":"6074_CR69","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nrneph.2018.9","volume":"14","author":"JM Forbes","year":"2018","unstructured":"Forbes JM, Thorburn DR. Mitochondrial dysfunction in diabetic kidney disease. Nat Rev Nephrol. 2018;14(5):291\u2013312.","journal-title":"Nat Rev Nephrol"},{"key":"6074_CR70","doi-asserted-by":"crossref","unstructured":"Flemming N, Pernoud L, Forbes J et al. Mitochondrial dysfunction in individuals with Diabetic kidney disease: a systematic review. Cells. 2022;11(16).","DOI":"10.3390\/cells11162481"},{"key":"6074_CR71","doi-asserted-by":"crossref","unstructured":"Yang Y, Liu J, Shi Q et al. Roles of mitochondrial dysfunction in Diabetic kidney disease: new perspectives from mechanism to Therapy. Biomolecules. 2024;14(6).","DOI":"10.3390\/biom14060733"},{"key":"6074_CR72","doi-asserted-by":"publisher","first-page":"706832","DOI":"10.3389\/fcell.2021.706832","volume":"9","author":"W Dai","year":"2021","unstructured":"Dai W, Lu H, Chen Y, et al. The loss of mitochondrial Quality Control in Diabetic kidney disease. Front Cell Dev Biol. 2021;9:706832.","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"6074_CR73","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","volume":"15","author":"X Fan","year":"2024","unstructured":"Fan X, Yang M, Lang Y, et al. Mitochondrial metabolic reprogramming in diabetic kidney disease. Cell Death Dis. 2024;15(6):442.","journal-title":"Cell Death Dis"},{"key":"6074_CR74","doi-asserted-by":"publisher","first-page":"155195","DOI":"10.1016\/j.metabol.2022.155195","volume":"131","author":"L Yao","year":"2022","unstructured":"Yao L, Liang X, Qiao Y, et al. Mitochondrial dysfunction in diabetic tubulopathy. Metabolism. 2022;131:155195.","journal-title":"Metabolism"},{"key":"6074_CR75","doi-asserted-by":"publisher","first-page":"1394486","DOI":"10.1155\/2021\/1394486","volume":"2021","author":"Z Zhu","year":"2021","unstructured":"Zhu Z, Liang W, Chen Z, et al. Mitoquinone protects podocytes from Angiotensin II-Induced mitochondrial dysfunction and Injury via the Keap1-Nrf2 signaling pathway. Oxid Med Cell Longev. 2021;2021:1394486.","journal-title":"Oxid Med Cell Longev"},{"key":"6074_CR76","doi-asserted-by":"crossref","unstructured":"Marshall AS, Jones NS. Discovering Cellular mitochondrial heteroplasmy heterogeneity with single cell RNA and ATAC sequencing. Biology (Basel). 2021;10(6).","DOI":"10.3390\/biology10060503"},{"issue":"6","key":"6074_CR77","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s41587-020-0465-8","volume":"38","author":"J Ding","year":"2020","unstructured":"Ding J, Adiconis X, Simmons SK, et al. Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nat Biotechnol. 2020;38(6):737\u201346.","journal-title":"Nat Biotechnol"},{"issue":"6","key":"6074_CR78","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1681\/ASN.2014050457","volume":"26","author":"M Zhan","year":"2015","unstructured":"Zhan M, Usman IM, Sun L, et al. Disruption of renal tubular mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic kidney disease. J Am Soc Nephrol. 2015;26(6):1304\u201321.","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"6074_CR79","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1016\/j.apsb.2020.12.020","volume":"11","author":"G Tang","year":"2021","unstructured":"Tang G, Li S, Zhang C, et al. Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management. Acta Pharm Sin B. 2021;11(9):2749\u201367.","journal-title":"Acta Pharm Sin B"},{"key":"6074_CR80","doi-asserted-by":"publisher","first-page":"104373","DOI":"10.1016\/j.jbi.2023.104373","volume":"142","author":"F Ahmed","year":"2023","unstructured":"Ahmed F, Samantasinghar A, Soomro AM, et al. A systematic review of computational approaches to understand cancer biology for informed drug repurposing. J Biomed Inf. 2023;142:104373.","journal-title":"J Biomed Inf"},{"key":"6074_CR81","doi-asserted-by":"publisher","first-page":"113350","DOI":"10.1016\/j.biopha.2022.113350","volume":"153","author":"F Ahmed","year":"2022","unstructured":"Ahmed F, Soomro AM, Chethikkattuveli Salih AR, et al. A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19. Biomed Pharmacother. 2022;153:113350.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"6074_CR82","doi-asserted-by":"publisher","first-page":"e28693","DOI":"10.1002\/jmv.28693","volume":"95","author":"F Ahmed","year":"2023","unstructured":"Ahmed F, Kang IS, Kim KH, et al. Drug repurposing for viral cancers: a paradigm of machine learning, deep learning, and virtual screening-based approaches. J Med Virol. 2023;95(4):e28693.","journal-title":"J Med Virol"},{"key":"6074_CR83","doi-asserted-by":"crossref","unstructured":"Wang Z, Xie X, Liu S et al. scFseCluster: a feature selection-enhanced clustering for single-cell RNA-seq data. Life Sci Alliance. 2023;6(12).","DOI":"10.26508\/lsa.202302103"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06074-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06074-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06074-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T23:08:09Z","timestamp":1737500889000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06074-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6074"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06074-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures in mice adhered to the \u201cAnimal Research: Reporting of In Vivo Experiments\u201d (ARRIVE) standards and were approved by the Sixth People\u2019s Hospital Ethics Committee guidelines (approval no.: 2020-022). In accordance with local and national laws, ethics approval and consent to participate were exempted due to the retrospective\/observational and non-interventional nature of the human study. However, all patients involved in this study provided written informed consent before undergoing treatment administration and molecular assessments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}