{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:31:16Z","timestamp":1774074676335,"version":"3.50.1"},"reference-count":269,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005309","name":"Alzheimer Society of B.C.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>This review discusses findings related to neurological disorders, gut microbiota, and bariatric surgery, focusing on neurotransmitters, neuroendocrine, the pathophysiology of bacteria contributing to disorders, and possible therapeutic interventions. Research on neurotransmitters suggests that their levels are heavily influenced by gut microbiota, which may link them to neurological disorders such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Depression, and Autism spectrum disorder. The pathophysiology of bacteria that reach and influence the central nervous system has been documented. Trends in microbiota are often observed in specific neurological disorders, with a prominence of pro-inflammatory bacteria and a reduction in anti-inflammatory types. Furthermore, bariatric surgery has been shown to alter microbiota profiles similar to those observed in neurological disorders. Therapeutic interventions, including fecal microbiota transplants and probiotics, have shown potential to alleviate neurological symptoms. We suggest a framework for future studies that integrates knowledge from diverse research areas, employs rigorous methodologies, and includes long-trial clinical control groups.<\/jats:p>","DOI":"10.1186\/s12967-025-06201-2","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T17:35:16Z","timestamp":1740418516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Beyond weight loss: exploring the neurological ramifications of altered gut microbiota post-bariatric surgery"],"prefix":"10.1186","volume":"23","author":[{"given":"Rashed T.","family":"Almheiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baraa","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif M. I.","family":"Alkhaaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rabeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Aljoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-1975","authenticated-orcid":false,"given":"Khaled S.","family":"Abd-Elrahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdan","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"issue":"4","key":"6201_CR1","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The microbiota-gut-brain axis. Physiol Rev. 2019;99(4):1877\u20132013.","journal-title":"Physiol Rev"},{"key":"6201_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103908","volume":"77","author":"L Liu","year":"2022","unstructured":"Liu L, Huh JR, Shah K. Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS. EBioMedicine. 2022;77: 103908.","journal-title":"EBioMedicine"},{"issue":"4","key":"6201_CR3","first-page":"308","volume":"9","author":"AC Gomes","year":"2018","unstructured":"Gomes AC, Hoffmann C, Mota JF. The human gut microbiota: metabolism and perspective in obesity. Gut Microbes. 2018;9(4):308\u201325.","journal-title":"Gut Microbes"},{"issue":"10","key":"6201_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S2468-1253(17)30147-4","volume":"2","author":"C Torres-Fuentes","year":"2017","unstructured":"Torres-Fuentes C, Schellekens H, Dinan TG, Cryan JF. The microbiota\u2013gut\u2013brain axis in obesity. Lancet Gastroenterol Hepatol. 2017;2(10):747\u201356.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"9","key":"6201_CR5","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1111\/obr.12889","volume":"20","author":"T Semlitsch","year":"2019","unstructured":"Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care-A systematic overview of international evidence-based guidelines. Obes Rev. 2019;20(9):1218\u201330.","journal-title":"Obes Rev"},{"issue":"46","key":"6201_CR6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008632","volume":"96","author":"JH Kang","year":"2017","unstructured":"Kang JH, Le QA. Effectiveness of bariatric surgical procedures: a systematic review and network meta-analysis of randomized controlled trials. Medicine. 2017;96(46): e8632.","journal-title":"Medicine"},{"issue":"8","key":"6201_CR7","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/obr.12541","volume":"18","author":"FB Seganfredo","year":"2017","unstructured":"Seganfredo FB, Blume CA, Moehlecke M, Giongo A, Casagrande DS, Spolidoro JVN, et al. Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review. Obes Rev. 2017;18(8):832\u201351.","journal-title":"Obes Rev"},{"issue":"2","key":"6201_CR8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.chom.2019.01.017","volume":"25","author":"AN Shkoporov","year":"2019","unstructured":"Shkoporov AN, Hill C. Bacteriophages of the human gut: the \u201cknown unknown\u201d of the microbiome. Cell Host Microbe. 2019;25(2):195\u2013209.","journal-title":"Cell Host Microbe"},{"issue":"7346","key":"6201_CR9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","volume":"473","author":"M Arumugam","year":"2011","unstructured":"Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174\u201380.","journal-title":"Nature"},{"key":"6201_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.csbj.2021.12.035","volume":"20","author":"S Piquer-Esteban","year":"2022","unstructured":"Piquer-Esteban S, Ruiz-Ruiz S, Arnau V, Diaz W, Moya A. Exploring the universal healthy human gut microbiota around the World. Comput Struct Biotechnol J. 2022;20:421\u201333.","journal-title":"Comput Struct Biotechnol J"},{"issue":"1","key":"6201_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/microorganisms7010014","volume":"7","author":"E Rinninella","year":"2019","unstructured":"Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms. 2019;7(1):210.","journal-title":"Microorganisms"},{"issue":"8","key":"6201_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255446","volume":"16","author":"M Duan","year":"2021","unstructured":"Duan M, Wang Y, Zhang Q, Zou R, Guo M, Zheng H. Characteristics of gut microbiota in people with obesity. PLoS ONE. 2021;16(8): e0255446.","journal-title":"PLoS ONE"},{"issue":"1","key":"6201_CR13","doi-asserted-by":"publisher","first-page":"19417","DOI":"10.1038\/s41598-020-76474-8","volume":"10","author":"M-H Kim","year":"2020","unstructured":"Kim M-H, Yun KE, Kim J, Park E, Chang Y, Ryu S, et al. Gut microbiota and metabolic health among overweight and obese individuals. Sci Rep. 2020;10(1):19417.","journal-title":"Sci Rep"},{"issue":"1","key":"6201_CR14","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.1038\/s41598-019-47332-z","volume":"9","author":"FL Paganelli","year":"2019","unstructured":"Paganelli FL, Luyer M, Hazelbag CM, Uh H-W, Rogers MRC, Adriaans D, et al. Roux-Y gastric bypass and sleeve gastrectomy directly change gut microbiota composition independent of surgery type. Sci Rep. 2019;9(1):10979.","journal-title":"Sci Rep"},{"issue":"8","key":"6201_CR15","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/ejcn.2012.17","volume":"66","author":"VR da Silva","year":"2012","unstructured":"da Silva VR, Moreira EA, Wilhelm-Filho D, de Miranda JX, Beninc\u00e1 JP, Vigil SV, et al. Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up. Eur J Clin Nutr. 2012;66(8):891\u20139.","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"6201_CR16","first-page":"942","volume":"11","author":"C Guti\u00e9rrez-Repiso","year":"2019","unstructured":"Guti\u00e9rrez-Repiso C, Moreno-Indias I, de Hollanda A, Mart\u00edn-N\u00fa\u00f1ez GM, Vidal J, Tinahones FJ. Gut microbiota specific signatures are related to the successful rate of bariatric surgery. Am J Transl Res. 2019;11(2):942\u201352.","journal-title":"Am J Transl Res"},{"issue":"8","key":"6201_CR17","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1007\/s00394-020-02190-8","volume":"59","author":"J Rossell","year":"2020","unstructured":"Rossell J, Brindefalk B, Baena-Fustegueras JA, Peinado-Onsurbe J, Udekwu KI. Diet change affects intestinal microbiota restoration and improves vertical sleeve gastrectomy outcome in diet-induced obese rats. Eur J Nutr. 2020;59(8):3555\u201364.","journal-title":"Eur J Nutr"},{"issue":"4","key":"6201_CR18","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s11695-016-2399-2","volume":"27","author":"R Murphy","year":"2017","unstructured":"Murphy R, Tsai P, J\u00fcllig M, Liu A, Plank L, Booth M. Differential changes in gut microbiota after gastric bypass and sleeve gastrectomy bariatric surgery vary according to diabetes remission. Obes Surg. 2017;27(4):917\u201325.","journal-title":"Obes Surg"},{"issue":"4","key":"6201_CR19","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.soard.2019.01.033","volume":"15","author":"NK Davies","year":"2019","unstructured":"Davies NK, O\u2019Sullivan JM, Plank LD, Murphy R. Altered gut microbiome after bariatric surgery and its association with metabolic benefits: a systematic review. Surg Obes Relat Dis. 2019;15(4):656\u201365.","journal-title":"Surg Obes Relat Dis"},{"key":"6201_CR20","doi-asserted-by":"publisher","first-page":"9351507","DOI":"10.1155\/2017\/9351507","volume":"2017","author":"G Rizzatti","year":"2017","unstructured":"Rizzatti G, Lopetuso LR, Gibiino G, Binda C, Gasbarrini A. Proteobacteria: a common factor in human diseases. Biomed Res Int. 2017;2017:9351507.","journal-title":"Biomed Res Int"},{"issue":"8","key":"6201_CR21","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.soard.2019.05.038","volume":"15","author":"N Shen","year":"2019","unstructured":"Shen N, Caix\u00e0s A, Ahlers M, Patel K, Gao Z, Dutia R, et al. Longitudinal changes of microbiome composition and microbial metabolomics after surgical weight loss in individuals with obesity. Surg Obes Relat Dis. 2019;15(8):1367\u201373.","journal-title":"Surg Obes Relat Dis"},{"issue":"2","key":"6201_CR22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cmet.2015.07.009","volume":"22","author":"V Tremaroli","year":"2015","unstructured":"Tremaroli V, Karlsson F, Werling M, St\u00e5hlman M, Kovatcheva-Datchary P, Olbers T, et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab. 2015;22(2):228\u201338.","journal-title":"Cell Metab"},{"issue":"1","key":"6201_CR23","doi-asserted-by":"publisher","first-page":"2050636","DOI":"10.1080\/19490976.2022.2050636","volume":"14","author":"JT Dang","year":"2022","unstructured":"Dang JT, Mocanu V, Park H, Laffin M, Hotte N, Karmali S, et al. Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways. Gut Microbes. 2022;14(1):2050636.","journal-title":"Gut Microbes"},{"issue":"1","key":"6201_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s40168-021-01086-x","volume":"9","author":"JV Li","year":"2021","unstructured":"Li JV, Ashrafian H, Sarafian M, Homola D, Rushton L, Barker G, et al. Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype. Microbiome. 2021;9(1):139.","journal-title":"Microbiome"},{"issue":"4","key":"6201_CR25","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s11154-021-09676-8","volume":"22","author":"C Guti\u00e9rrez-Repiso","year":"2021","unstructured":"Guti\u00e9rrez-Repiso C, Moreno-Indias I, Tinahones FJ. Shifts in gut microbiota and their metabolites induced by bariatric surgery Impact of factors shaping gut microbiota on bariatric surgery outcomes. Rev Endocr Metab Disord. 2021;22(4):1137\u201356.","journal-title":"Rev Endocr Metab Disord"},{"issue":"5","key":"6201_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101051","volume":"4","author":"J Yadav","year":"2023","unstructured":"Yadav J, Liang T, Qin T, Nathan N, Schwenger KJP, Pickel L, et al. Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure. Cell Rep Med. 2023;4(5): 101051.","journal-title":"Cell Rep Med"},{"issue":"4","key":"6201_CR27","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/oby.23107","volume":"29","author":"YJ Kim","year":"2021","unstructured":"Kim YJ, Womble JT, Gunsch CK, Ingram JL. The gut\/lung microbiome axis in obesity, asthma, and bariatric surgery: a literature review. Obesity (Silver Spring). 2021;29(4):636\u201344.","journal-title":"Obesity (Silver Spring)"},{"issue":"11","key":"6201_CR28","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.soard.2019.08.551","volume":"15","author":"L S\u00e1nchez-Alcoholado","year":"2019","unstructured":"S\u00e1nchez-Alcoholado L, Guti\u00e9rrez-Repiso C, G\u00f3mez-P\u00e9rez AM, Garc\u00eda-Fuentes E, Tinahones FJ, Moreno-Indias I. Gut microbiota adaptation after weight loss by Roux-en-Y gastric bypass or sleeve gastrectomy bariatric surgeries. Surg Obes Relat Dis. 2019;15(11):1888\u201395.","journal-title":"Surg Obes Relat Dis"},{"issue":"3","key":"6201_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4291\/wjgp.v13.i3.59","volume":"13","author":"K Georgiou","year":"2022","unstructured":"Georgiou K, Belev NA, Koutouratsas T, Katifelis H, Gazouli M. Gut microbiome: Linking together obesity, bariatric surgery and associated clinical outcomes under a single focus. World J Gastrointest Pathophysiol. 2022;13(3):59\u201372.","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"6","key":"6201_CR30","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3390\/metabo11060353","volume":"11","author":"J Hoozemans","year":"2021","unstructured":"Hoozemans J, de Brauw M, Nieuwdorp M, Gerdes V. Gut microbiome and metabolites in patients with NAFLD and after bariatric surgery: a comprehensive review. Metabolites. 2021;11(6):353.","journal-title":"Metabolites"},{"issue":"3","key":"6201_CR31","first-page":"235","volume":"10","author":"AK McGavigan","year":"2017","unstructured":"McGavigan AK, Henseler ZM, Garibay D, Butler SD, Jayasinghe S, Ley RE, et al. Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice. Dis Model Mech. 2017;10(3):235\u201343.","journal-title":"Dis Model Mech"},{"issue":"2","key":"6201_CR32","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s11695-016-2297-7","volume":"27","author":"Y Shao","year":"2017","unstructured":"Shao Y, Ding R, Xu B, Hua R, Shen Q, He K, et al. Alterations of gut microbiota after roux-en-Y gastric bypass and sleeve gastrectomy in sprague-dawley rats. Obes Surg. 2017;27(2):295\u2013302.","journal-title":"Obes Surg"},{"issue":"7","key":"6201_CR33","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1073\/pnas.0812600106","volume":"106","author":"H Zhang","year":"2009","unstructured":"Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA. 2009;106(7):2365\u201370.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"6201_CR34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s12974-022-02510-1","volume":"19","author":"P Sittipo","year":"2022","unstructured":"Sittipo P, Choi J, Lee S, Lee YK. The function of gut microbiota in immune-related neurological disorders: a review. J Neuroinflammation. 2022;19(1):154.","journal-title":"J Neuroinflammation"},{"key":"6201_CR35","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3389\/fnins.2019.01365","volume":"13","author":"H Kaur","year":"2019","unstructured":"Kaur H, Bose C, Mande SS. Tryptophan metabolism by gut microbiome and gut-brain-axis: an in silico analysis. Front Neurosci. 2019;13:1365.","journal-title":"Front Neurosci"},{"issue":"2","key":"6201_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13178","volume":"30","author":"M Jennis","year":"2018","unstructured":"Jennis M, Cavanaugh CR, Leo GC, Mabus JR, Lenhard J, Hornby PJ. Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo. Neurogastroenterol Motil. 2018;30(2): e13178.","journal-title":"Neurogastroenterol Motil"},{"issue":"12","key":"6201_CR37","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1517\/17425255.2012.722757","volume":"8","author":"DR Brocks","year":"2012","unstructured":"Brocks DR, Ben-Eltriki M, Gabr RQ, Padwal RS. The effects of gastric bypass surgery on drug absorption and pharmacokinetics. Expert Opin Drug Metab Toxicol. 2012;8(12):1505\u201319.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"4","key":"6201_CR38","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/00000441-200604000-00009","volume":"331","author":"SS Malinowski","year":"2006","unstructured":"Malinowski SS. Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006;331(4):219\u201325.","journal-title":"Am J Med Sci"},{"issue":"4","key":"6201_CR39","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/femsre\/fuu010","volume":"39","author":"H Neuman","year":"2015","unstructured":"Neuman H, Debelius JW, Knight R, Koren O. Microbial endocrinology: the interplay between the microbiota and the endocrine system. FEMS Microbiol Rev. 2015;39(4):509\u201321.","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"6201_CR40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.12938\/bmfh.18-018","volume":"38","author":"\u0130 Ulker","year":"2019","unstructured":"Ulker \u0130, Yildiran H. The effects of bariatric surgery on gut microbiota in patients with obesity: a review of the literature. Biosci Microbiota Food Health. 2019;38(1):3\u20139.","journal-title":"Biosci Microbiota Food Health"},{"issue":"Suppl 1","key":"6201_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/dom.13129","volume":"20","author":"MA Nauck","year":"2018","unstructured":"Nauck MA, Meier JJ. Incretin hormones: their role in health and disease. Diabetes Obes Metab. 2018;20(Suppl 1):5\u201321.","journal-title":"Diabetes Obes Metab"},{"issue":"1\u20132","key":"6201_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.2040-1124.2010.00022.x","volume":"1","author":"Y Seino","year":"2010","unstructured":"Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: similarities and differences. J Diabetes Investig. 2010;1(1\u20132):8\u201323.","journal-title":"J Diabetes Investig"},{"issue":"1","key":"6201_CR43","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.soard.2022.08.020","volume":"19","author":"F Feris","year":"2023","unstructured":"Feris F, McRae A, Kellogg TA, McKenzie T, Ghanem O, Acosta A. Mucosal and hormonal adaptations after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2023;19(1):37\u201349.","journal-title":"Surg Obes Relat Dis"},{"issue":"12","key":"6201_CR44","doi-asserted-by":"publisher","first-page":"4139","DOI":"10.1210\/en.2017-00564","volume":"158","author":"CR Hutch","year":"2017","unstructured":"Hutch CR, Sandoval D. The role of GLP-1 in the metabolic success of bariatric surgery. Endocrinology. 2017;158(12):4139\u201351.","journal-title":"Endocrinology"},{"issue":"3","key":"6201_CR45","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1210\/js.2018-00213","volume":"3","author":"A Georgia","year":"2019","unstructured":"Georgia A, Asnis MCC, Febres G, Tsang A, Bessler M, Korner J. Roux-en-Y gastric bypass is associated with hyperinsulinemia but not increased maximal \u03b2-cell function. J Endocr Soc. 2019;3(3):632\u201342.","journal-title":"J Endocr Soc"},{"issue":"3","key":"6201_CR46","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1053\/j.gastro.2014.01.038","volume":"146","author":"ME Patti","year":"2014","unstructured":"Patti ME, Goldfine AB. Hypoglycemia after gastric bypass: the dark side of GLP-1. Gastroenterology. 2014;146(3):605\u20138.","journal-title":"Gastroenterology"},{"issue":"3","key":"6201_CR47","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1053\/j.gastro.2013.11.044","volume":"146","author":"M Salehi","year":"2014","unstructured":"Salehi M, Gastaldelli A, D\u2019Alessio DA. Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass. Gastroenterology. 2014;146(3):669-80.e2.","journal-title":"Gastroenterology"},{"issue":"2","key":"6201_CR48","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00423-021-02341-3","volume":"407","author":"C Carvalho","year":"2022","unstructured":"Carvalho C, de Souza AL, Batista GA, Duran LFT, Fernandes DP, Molina VBC, et al. GLP-1: 10-year follow-up after Roux-en-Y gastric bypass. Langenbecks Arch Surg. 2022;407(2):559\u201368.","journal-title":"Langenbecks Arch Surg"},{"issue":"3","key":"6201_CR49","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.dsx.2018.03.002","volume":"12","author":"I Yildirim Simsir","year":"2018","unstructured":"Yildirim Simsir I, Soyaltin UE, Cetinkalp S. Glucagon like peptide-1 (GLP-1) likes Alzheimer\u2019s disease. Diabetes Metab Syndr. 2018;12(3):469\u201375.","journal-title":"Diabetes Metab Syndr"},{"issue":"8","key":"6201_CR50","doi-asserted-by":"publisher","first-page":"741","DOI":"10.2174\/1567205016666190913155950","volume":"16","author":"RJ Mullins","year":"2019","unstructured":"Mullins RJ, Mustapic M, Chia CW, Carlson O, Gulyani S, Tran J, et al. A pilot study of exenatide actions in Alzheimer\u2019s disease. Curr Alzheimer Res. 2019;16(8):741\u201352.","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"6201_CR51","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1113\/jphysiol.2008.164269","volume":"587","author":"E Karra","year":"2009","unstructured":"Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol. 2009;587(1):19\u201325.","journal-title":"J Physiol"},{"issue":"4","key":"6201_CR52","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41574-019-0168-8","volume":"15","author":"FM Gribble","year":"2019","unstructured":"Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol. 2019;15(4):226\u201337.","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"6201_CR53","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.npep.2012.08.005","volume":"46","author":"P Holzer","year":"2012","unstructured":"Holzer P, Reichmann F, Farzi A, Neuropeptide Y. peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides. 2012;46(6):261\u201374.","journal-title":"Neuropeptides"},{"issue":"12","key":"6201_CR54","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.3390\/nu11122862","volume":"11","author":"ER Leeming","year":"2019","unstructured":"Leeming ER, Johnson AJ, Spector TD, Le Roy CI. Effect of diet on the gut microbiota: rethinking intervention duration. Nutrients. 2019;11(12):2862.","journal-title":"Nutrients"},{"issue":"1","key":"6201_CR55","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s40200-024-01418-2","volume":"23","author":"U Vijayashankar","year":"2024","unstructured":"Vijayashankar U, Ramashetty R, Rajeshekara M, Vishwanath N, Yadav AK, Prashant A, et al. Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus. J Diabetes Metab Disord. 2024;23(1):427\u201340.","journal-title":"J Diabetes Metab Disord"},{"issue":"7","key":"6201_CR56","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3390\/nu16071071","volume":"16","author":"S Hamamah","year":"2024","unstructured":"Hamamah S, Hajnal A, Covasa M. Influence of bariatric surgery on gut microbiota composition and its implication on brain and peripheral targets. Nutrients. 2024;16(7):1071.","journal-title":"Nutrients"},{"issue":"4","key":"6201_CR57","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s10787-017-0360-1","volume":"25","author":"BL Slomiany","year":"2017","unstructured":"Slomiany BL, Slomiany A. Role of LPS-elicited signaling in triggering gastric mucosal inflammatory responses to H pylori modulatory effect of ghrelin. Inflammopharmacology. 2017;25(4):415\u201329.","journal-title":"Inflammopharmacology"},{"key":"6201_CR58","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neubiorev.2016.12.010","volume":"73","author":"Q Jiao","year":"2017","unstructured":"Jiao Q, Du X, Li Y, Gong B, Shi L, Tang T, et al. The neurological effects of ghrelin in brain diseases: Beyond metabolic functions. Neurosci Biobehav Rev. 2017;73:98\u2013111.","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"6201_CR59","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1007\/s12035-016-9729-1","volume":"54","author":"L Shi","year":"2017","unstructured":"Shi L, Du X, Jiang H, Xie J. Ghrelin and neurodegenerative disorders-a review. Mol Neurobiol. 2017;54(2):1144\u201355.","journal-title":"Mol Neurobiol"},{"key":"6201_CR60","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbi.2022.09.010","volume":"107","author":"M Regensburger","year":"2023","unstructured":"Regensburger M, Rasul Chaudhry S, Yasin H, Zhao Y, Stadlbauer A, Buchfelder M, et al. Emerging roles of leptin in Parkinson\u2019s disease: chronic inflammation, neuroprotection and more? Brain Behav Immun. 2023;107:53\u201361.","journal-title":"Brain Behav Immun"},{"key":"6201_CR61","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3389\/fnins.2019.00828","volume":"13","author":"Y Fujita","year":"2019","unstructured":"Fujita Y, Yamashita T. The effects of leptin on glial cells in neurological diseases. Front Neurosci. 2019;13:828.","journal-title":"Front Neurosci"},{"issue":"11","key":"6201_CR62","volume":"15","author":"E Slouha","year":"2023","unstructured":"Slouha E, Elkersh EM, Shay A, Ghosh S, Mahmood A, Gorantla VR. Significance of hormone alteration following bariatric surgery. Cureus. 2023;15(11): e49053.","journal-title":"Cureus"},{"issue":"9","key":"6201_CR63","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/j.bbadis.2015.06.019","volume":"1852","author":"Y Yang","year":"2015","unstructured":"Yang Y, Hu W, Jiang S, Wang B, Li Y, Fan C, et al. The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases. Biochim Biophys Acta. 2015;1852(9):1887\u201394.","journal-title":"Biochim Biophys Acta"},{"key":"6201_CR64","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3389\/fnins.2018.01027","volume":"12","author":"L Forny-Germano","year":"2018","unstructured":"Forny-Germano L, De Felice FG, Vieira M. The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer\u2019s Disease. Front Neurosci. 2018;12:1027.","journal-title":"Front Neurosci"},{"issue":"4","key":"6201_CR65","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","volume":"21","author":"SL Collins","year":"2023","unstructured":"Collins SL, Stine JG, Bisanz JE, Okafor CD, Patterson AD. Bile acids and the gut microbiota: metabolic interactions and impacts on disease. Nat Rev Microbiol. 2023;21(4):236\u201347.","journal-title":"Nat Rev Microbiol"},{"key":"6201_CR66","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5604\/01.3001.0010.5672","volume":"16","author":"O Ram\u00edrez-P\u00e9rez","year":"2017","unstructured":"Ram\u00edrez-P\u00e9rez O, Cruz-Ram\u00f3n V, Chinchilla-L\u00f3pez P, M\u00e9ndez-S\u00e1nchez N. The role of the gut microbiota in bile acid metabolism. Ann Hepatol. 2017;16:15\u201320.","journal-title":"Ann Hepatol"},{"issue":"2","key":"6201_CR67","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","volume":"47","author":"JM Ridlon","year":"2006","unstructured":"Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47(2):241\u201359.","journal-title":"J Lipid Res"},{"issue":"9","key":"6201_CR68","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1038\/oby.2009.102","volume":"17","author":"ME Patti","year":"2009","unstructured":"Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity. 2009;17(9):1671\u20137.","journal-title":"Obesity"},{"issue":"3","key":"6201_CR69","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023939","volume":"100","author":"C Zhang","year":"2021","unstructured":"Zhang C, Zhang J, Zhou Z. Changes in fasting bile acid profiles after Roux-en-Y gastric bypass and sleeve gastrectomy. Medicine. 2021;100(3): e23939.","journal-title":"Medicine"},{"key":"6201_CR70","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3389\/fphys.2019.00374","volume":"10","author":"W Wang","year":"2019","unstructured":"Wang W, Cheng Z, Wang Y, Dai Y, Zhang X, Hu S. Role of bile acids in bariatric surgery. Front Physiol. 2019;10:374.","journal-title":"Front Physiol"},{"key":"6201_CR71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.mam.2017.04.001","volume":"56","author":"VL Albaugh","year":"2017","unstructured":"Albaugh VL, Banan B, Ajouz H, Abumrad NN, Flynn CR. Bile acids and bariatric surgery. Mol Aspects Med. 2017;56:75\u201389.","journal-title":"Mol Aspects Med"},{"issue":"1","key":"6201_CR72","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40168-020-0788-1","volume":"8","author":"SB Haange","year":"2020","unstructured":"Haange SB, Jehmlich N, Kr\u00fcgel U, Hintschich C, Wehrmann D, Hankir M, et al. Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss. Microbiome. 2020;8(1):13.","journal-title":"Microbiome"},{"key":"6201_CR73","doi-asserted-by":"publisher","first-page":"1021924","DOI":"10.3389\/fimmu.2022.1021924","volume":"13","author":"N Calzadilla","year":"2022","unstructured":"Calzadilla N, Comiskey SM, Dudeja PK, Saksena S, Gill RK, Alrefai WA. Bile acids as inflammatory mediators and modulators of intestinal permeability. Front Immunol. 2022;13:1021924.","journal-title":"Front Immunol"},{"issue":"1","key":"6201_CR74","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40035-022-00307-z","volume":"11","author":"K Khalaf","year":"2022","unstructured":"Khalaf K, Tornese P, Cocco A, Albanese A. Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases. Transl Neurodegener. 2022;11(1):33.","journal-title":"Transl Neurodegener"},{"issue":"12","key":"6201_CR75","doi-asserted-by":"publisher","first-page":"9139","DOI":"10.1007\/s12035-018-1062-4","volume":"55","author":"AI Rosa","year":"2018","unstructured":"Rosa AI, Duarte-Silva S, Silva-Fernandes A, Nunes MJ, Carvalho AN, Rodrigues E, et al. Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson\u2019s disease. Mol Neurobiol. 2018;55(12):9139\u201355.","journal-title":"Mol Neurobiol"},{"issue":"7","key":"6201_CR76","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1172\/JCI129401","volume":"130","author":"P Bhargava","year":"2020","unstructured":"Bhargava P, Smith MD, Mische L, Harrington E, Fitzgerald KC, Martin K, et al. Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation. J Clin Invest. 2020;130(7):3467\u201382.","journal-title":"J Clin Invest"},{"issue":"2","key":"6201_CR77","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/oby.20548","volume":"22","author":"A Myronovych","year":"2014","unstructured":"Myronovych A, Kirby M, Ryan KK, Zhang W, Jha P, Setchell KD, et al. Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obesity (Silver Spring). 2014;22(2):390\u2013400.","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"6201_CR78","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1097\/SLA.0000000000001552","volume":"264","author":"C Jahansouz","year":"2016","unstructured":"Jahansouz C, Xu H, Hertzel AV, Serrot FJ, Kvalheim N, Cole A, et al. Bile acids increase independently from hypocaloric restriction after bariatric surgery. Ann Surg. 2016;264(6):1022\u20138.","journal-title":"Ann Surg"},{"issue":"1","key":"6201_CR79","doi-asserted-by":"publisher","first-page":"23813","DOI":"10.1038\/s41598-021-03396-4","volume":"11","author":"JT Dang","year":"2021","unstructured":"Dang JT, Mocanu V, Park H, Laffin M, Tran C, Hotte N, et al. Ileal microbial shifts after Roux-en-Y gastric bypass orchestrate changes in glucose metabolism through modulation of bile acids and L-cell adaptation. Sci Rep. 2021;11(1):23813.","journal-title":"Sci Rep"},{"issue":"20","key":"6201_CR80","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.3390\/nu14204243","volume":"14","author":"JL Meijer","year":"2022","unstructured":"Meijer JL, Roderka MN, Chinburg EL, Renier TJ, McClure AC, Rothstein RI, et al. Alterations in fecal short-chain fatty acids after bariatric surgery: relationship with dietary intake and weight loss. Nutrients. 2022;14(20):4243.","journal-title":"Nutrients"},{"issue":"7","key":"6201_CR81","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.soard.2022.12.041","volume":"19","author":"MA Mart\u00ednez-S\u00e1nchez","year":"2023","unstructured":"Mart\u00ednez-S\u00e1nchez MA, Balaguer-Rom\u00e1n A, Fern\u00e1ndez-Ruiz VE, Almansa-Saura S, Garc\u00eda-Zafra V, Ferrer-G\u00f3mez M, et al. Plasma short-chain fatty acid changes after bariatric surgery in patients with severe obesity. Surg Obes Relat Dis. 2023;19(7):727\u201334.","journal-title":"Surg Obes Relat Dis"},{"issue":"3","key":"6201_CR82","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3390\/nu12030802","volume":"12","author":"PG Farup","year":"2020","unstructured":"Farup PG, Valeur J. Changes in faecal short-chain fatty acids after weight-loss interventions in subjects with morbid obesity. Nutrients. 2020;12(3):802.","journal-title":"Nutrients"},{"issue":"8","key":"6201_CR83","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","volume":"24","author":"ER Mann","year":"2024","unstructured":"Mann ER, Lam YK, Uhlig HH. Short-chain fatty acids: linking diet, the microbiome and immunity. Nat Rev Immunol. 2024;24(8):577\u201395.","journal-title":"Nat Rev Immunol"},{"key":"6201_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111661","volume":"139","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R, Bouzari B, Hosseini-Fard SR, Mazaheri M, Ahmadyousefi Y, Abdi M, et al. Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomed Pharmacother. 2021;139: 111661.","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"6201_CR85","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14440","volume":"34","author":"K Michel","year":"2022","unstructured":"Michel K, Kuch B, Dengler S, Demir IE, Zeller F, Schemann M. How big is the little brain in the gut? Neuronal numbers in the enteric nervous system of mice, Guinea pig, and human. Neurogastroenterol Motil. 2022;34(12): e14440.","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"6201_CR86","first-page":"203","volume":"28","author":"M Carabotti","year":"2015","unstructured":"Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203\u20139.","journal-title":"Ann Gastroenterol"},{"issue":"10","key":"6201_CR87","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13(10):701\u201312.","journal-title":"Nat Rev Neurosci"},{"key":"6201_CR88","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fnint.2018.00033","volume":"12","author":"S Liang","year":"2018","unstructured":"Liang S, Wu X, Jin F. Gut-brain psychology: rethinking psychology from the microbiota-gut-brain axis. Front Integr Neurosci. 2018;12:33.","journal-title":"Front Integr Neurosci"},{"key":"6201_CR89","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","volume":"235","author":"C Saraiva","year":"2016","unstructured":"Saraiva C, Pra\u00e7a C, Ferreira R, Santos T, Ferreira L, Bernardino L. Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. J Control Release. 2016;235:34\u201347.","journal-title":"J Control Release"},{"issue":"9","key":"6201_CR90","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/microorganisms10091838","volume":"10","author":"LMT Dicks","year":"2022","unstructured":"Dicks LMT. Gut bacteria and neurotransmitters. Microorganisms. 2022;10(9):1838.","journal-title":"Microorganisms"},{"issue":"38","key":"6201_CR91","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","volume":"108","author":"JA Bravo","year":"2011","unstructured":"Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA. 2011;108(38):16050\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"6201_CR92","doi-asserted-by":"publisher","first-page":"T41","DOI":"10.1530\/JOE-15-0113","volume":"226","author":"TM Plant","year":"2015","unstructured":"Plant TM. 60 years of neuroendocrinology: the hypothalamo-pituitary-gonadal axis. J Endocrinol. 2015;226(2):T41-54.","journal-title":"J Endocrinol"},{"issue":"1","key":"6201_CR93","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1530\/EC-19-0522","volume":"9","author":"L Zhou","year":"2020","unstructured":"Zhou L, Ni Z, Cheng W, Yu J, Sun S, Zhai D, et al. Characteristic gut microbiota and predicted metabolic functions in women with PCOS. Endocr Connect. 2020;9(1):63\u201373.","journal-title":"Endocr Connect"},{"issue":"1","key":"6201_CR94","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12978-021-01203-x","volume":"18","author":"N Sarahian","year":"2021","unstructured":"Sarahian N, Sarvazad H, Sajadi E, Rahnejat N, Eskandari RN. Investigation of common risk factors between polycystic ovary syndrome and Alzheimer\u2019s disease: a narrative review. Reprod Health. 2021;18(1):156.","journal-title":"Reprod Health"},{"issue":"3","key":"6201_CR95","doi-asserted-by":"publisher","first-page":"e899","DOI":"10.1210\/clinem\/dgab757","volume":"107","author":"T Zhu","year":"2022","unstructured":"Zhu T, Goodarzi MO. Causes and consequences of polycystic ovary syndrome: insights from mendelian randomization. J Clin Endocrinol Metab. 2022;107(3):e899\u2013911.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"6201_CR96","doi-asserted-by":"publisher","first-page":"7128","DOI":"10.1038\/s41467-022-34502-3","volume":"13","author":"D Radjabzadeh","year":"2022","unstructured":"Radjabzadeh D, Bosch JA, Uitterlinden AG, Zwinderman AH, Ikram MA, van Meurs JBJ, et al. Gut microbiome-wide association study of depressive symptoms. Nat Commun. 2022;13(1):7128.","journal-title":"Nat Commun"},{"key":"6201_CR97","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.yfrne.2018.04.002","volume":"51","author":"S Cussotto","year":"2018","unstructured":"Cussotto S, Sandhu KV, Dinan TG, Cryan JF. The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective. Front Neuroendocrinol. 2018;51:80\u2013101.","journal-title":"Front Neuroendocrinol"},{"key":"6201_CR98","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnagi.2019.00043","volume":"11","author":"S Ouanes","year":"2019","unstructured":"Ouanes S, Popp J. High cortisol and the risk of dementia and Alzheimer\u2019s disease: a review of the literature. Front Aging Neurosci. 2019;11:43.","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"6201_CR99","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40359-022-00744-5","volume":"10","author":"L Veiga","year":"2022","unstructured":"Veiga L, Carolino E, Santos I, Ver\u00edssimo C, Almeida A, Grilo A, et al. Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students. BMC Psychol. 2022;10(1):36.","journal-title":"BMC Psychol"},{"key":"6201_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2023.100205","volume":"16","author":"BJ Varian","year":"2023","unstructured":"Varian BJ, Weber KT, Erdman SE. Oxytocin and the microbiome. Comprehensive Psychoneuroendocrinol. 2023;16: 100205.","journal-title":"Comprehensive Psychoneuroendocrinol"},{"issue":"6","key":"6201_CR101","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.3390\/nu12061769","volume":"12","author":"J Knezevic","year":"2020","unstructured":"Knezevic J, Starchl C, Tmava Berisha A, Amrein K. Thyroid-gut-axis: how does the microbiota influence thyroid function? Nutrients. 2020;12(6):1769.","journal-title":"Nutrients"},{"issue":"7","key":"6201_CR102","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1007\/s10571-023-01392-y","volume":"43","author":"FH AlAnazi","year":"2023","unstructured":"AlAnazi FH, Al-kuraishy HM, Alexiou A, Papadakis M, Ashour MHM, Alnaaim SA, et al. Primary hypothyroidism and Alzheimer\u2019s disease: a tale of two. Cell Mol Neurobiol. 2023;43(7):3405\u201316.","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"6201_CR103","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1007\/s12035-018-1270-y","volume":"56","author":"P Salazar","year":"2019","unstructured":"Salazar P, Cisternas P, Martinez M, Inestrosa NC. Hypothyroidism and cognitive disorders during development and adulthood: implications in the central nervous system. Mol Neurobiol. 2019;56(4):2952\u201363.","journal-title":"Mol Neurobiol"},{"issue":"7","key":"6201_CR104","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"D Erny","year":"2015","unstructured":"Erny D, Hrab\u011b de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015;18(7):965\u201377.","journal-title":"Nat Neurosci"},{"issue":"8","key":"6201_CR105","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nri.2017.38","volume":"17","author":"JM Kinder","year":"2017","unstructured":"Kinder JM, Stelzer IA, Arck PC, Way SS. Immunological implications of pregnancy-induced microchimerism. Nat Rev Immunol. 2017;17(8):483\u201394.","journal-title":"Nat Rev Immunol"},{"issue":"6012","key":"6201_CR106","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1126\/science.1195568","volume":"330","author":"YK Lee","year":"2010","unstructured":"Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010;330(6012):1768\u201373.","journal-title":"Science"},{"key":"6201_CR107","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.coi.2013.10.016","volume":"26","author":"CA Thaiss","year":"2014","unstructured":"Thaiss CA, Levy M, Suez J, Elinav E. The interplay between the innate immune system and the microbiota. Curr Opin Immunol. 2014;26:41\u20138.","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"6201_CR108","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.pathophys.2013.11.007","volume":"21","author":"P Lu","year":"2014","unstructured":"Lu P, Sodhi CP, Hackam DJ. Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology. 2014;21(1):81\u201393.","journal-title":"Pathophysiology"},{"key":"6201_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100248","volume":"14","author":"CB Quave","year":"2021","unstructured":"Quave CB, Nieto SJ, Haile CN, Kosten TA. Immune receptor toll-like receptor 4 contributes to stress-induced affective responses in a sex-specific manner. Brain Behav Immun Health. 2021;14: 100248.","journal-title":"Brain Behav Immun Health"},{"key":"6201_CR110","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.603445","volume":"11","author":"R Wu","year":"2020","unstructured":"Wu R, Li JX. Toll-like receptor 4 signaling and drug addiction. Front Pharmacol. 2020;11: 603445.","journal-title":"Front Pharmacol"},{"issue":"6285","key":"6201_CR111","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1126\/science.aad9378","volume":"352","author":"T Gensollen","year":"2016","unstructured":"Gensollen T, Iyer SS, Kasper DL, Blumberg RS. How colonization by microbiota in early life shapes the immune system. Science. 2016;352(6285):539\u201344.","journal-title":"Science"},{"issue":"4","key":"6201_CR112","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.immuni.2008.03.004","volume":"28","author":"W Ouyang","year":"2008","unstructured":"Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008;28(4):454\u201367.","journal-title":"Immunity"},{"issue":"263","key":"6201_CR113","doi-asserted-by":"publisher","first-page":"263ra158","DOI":"10.1126\/scitranslmed.3009759","volume":"6","author":"V Braniste","year":"2014","unstructured":"Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, T\u00f3th M, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6(263):263ra158.","journal-title":"Sci Transl Med"},{"key":"6201_CR114","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3389\/fncel.2015.00392","volume":"9","author":"JR Kelly","year":"2015","unstructured":"Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci. 2015;9:392.","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"6201_CR115","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4291\/wjgp.v2.i6.123","volume":"2","author":"SF Assimakopoulos","year":"2011","unstructured":"Assimakopoulos SF, Papageorgiou I, Charonis A. Enterocytes\u2019 tight junctions: from molecules to diseases. World J Gastrointest Pathophysiol. 2011;2(6):123\u201337.","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"2","key":"6201_CR116","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","volume":"161","author":"JM Yano","year":"2015","unstructured":"Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264\u201376.","journal-title":"Cell"},{"issue":"6","key":"6201_CR117","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"A Agus","year":"2018","unstructured":"Agus A, Planchais J, Sokol H. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe. 2018;23(6):716\u201324.","journal-title":"Cell Host Microbe"},{"issue":"4","key":"6201_CR118","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jcmgh.2019.01.004","volume":"7","author":"YH Kwon","year":"2019","unstructured":"Kwon YH, Wang H, Denou E, Ghia JE, Rossi L, Fontes ME, et al. Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis. Cell Mol Gastroenterol Hepatol. 2019;7(4):709\u201328.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"6","key":"6201_CR119","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.3390\/nu13062099","volume":"13","author":"Y Chen","year":"2021","unstructured":"Chen Y, Xu J, Chen Y. Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients. 2021;13(6):2099.","journal-title":"Nutrients"},{"issue":"2","key":"6201_CR120","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.celrep.2017.12.058","volume":"22","author":"A Luqman","year":"2018","unstructured":"Luqman A, Nega M, Nguyen MT, Ebner P, G\u00f6tz F. SadA-expressing staphylococci in the human gut show increased cell adherence and internalization. Cell Rep. 2018;22(2):535\u201345.","journal-title":"Cell Rep"},{"key":"6201_CR121","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fpsyt.2019.00034","volume":"10","author":"SG Cheung","year":"2019","unstructured":"Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic review of gut microbiota and major depression. Front Psychiatry. 2019;10:34.","journal-title":"Front Psychiatry"},{"issue":"6","key":"6201_CR122","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1002\/ana.26084","volume":"89","author":"LM Cox","year":"2021","unstructured":"Cox LM, Maghzi AH, Liu S, Tankou SK, Dhang FH, Willocq V, et al. Gut microbiome in progressive multiple sclerosis. Ann Neurol. 2021;89(6):1195\u2013211.","journal-title":"Ann Neurol"},{"issue":"1","key":"6201_CR123","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41398-023-02556-6","volume":"13","author":"S Zuffa","year":"2023","unstructured":"Zuffa S, Schimmel P, Gonzalez-Santana A, Belzer C, Knol J, B\u00f6lte S, et al. Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder. Transl Psychiatry. 2023;13(1):257.","journal-title":"Transl Psychiatry"},{"key":"6201_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.967747","volume":"14","author":"M Feng","year":"2022","unstructured":"Feng M, Hou T, Zhou M, Cen Q, Yi T, Bai J, et al. Gut microbiota may be involved in Alzheimer\u2019s disease pathology by dysregulating pyrimidine metabolism in APP\/PS1 mice. Front Aging Neurosci. 2022;14: 967747.","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"6201_CR125","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1073\/pnas.262796399","volume":"100","author":"WJ Gao","year":"2003","unstructured":"Gao WJ, Goldman-Rakic PS. Selective modulation of excitatory and inhibitory microcircuits by dopamine. Proc Natl Acad Sci USA. 2003;100(5):2836\u201341.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"6201_CR126","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/ijnp\/pyx056","volume":"20","author":"P Belujon","year":"2017","unstructured":"Belujon P, Grace AA. Dopamine system dysregulation in major depressive disorders. Int J Neuropsychopharmacol. 2017;20(12):1036\u201346.","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"6201_CR127","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40035-023-00378-6","volume":"12","author":"ZD Zhou","year":"2023","unstructured":"Zhou ZD, Yi LX, Wang DQ, Lim TM, Tan EK. Role of dopamine in the pathophysiology of Parkinson\u2019s disease. Transl Neurodegener. 2023;12(1):44.","journal-title":"Transl Neurodegener"},{"issue":"10","key":"6201_CR128","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1021\/cr200296t","volume":"111","author":"PE Selvy","year":"2011","unstructured":"Selvy PE, Lavieri RR, Lindsley CW, Brown HA. Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev. 2011;111(10):6064\u2013119.","journal-title":"Chem Rev"},{"issue":"7","key":"6201_CR129","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/brain\/awy132","volume":"141","author":"H Hampel","year":"2018","unstructured":"Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease. Brain. 2018;141(7):1917\u201333.","journal-title":"Brain"},{"key":"6201_CR130","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115733","volume":"168","author":"N Rabeh","year":"2023","unstructured":"Rabeh N, Hajjar B, Maraka JO, Sammanasunathan AF, Khan M, Alkhaaldi SMI, et al. Targeting mGluR group III for the treatment of neurodegenerative diseases. Biomed Pharmacother. 2023;168: 115733.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"6201_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1897212","volume":"13","author":"A Nogal","year":"2021","unstructured":"Nogal A, Valdes AM, Menni C. The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. Gut Microbes. 2021;13(1):1\u201324.","journal-title":"Gut Microbes"},{"issue":"8","key":"6201_CR132","first-page":"1707","volume":"18","author":"R Pluta","year":"2023","unstructured":"Pluta R, Januszewski S. Gut microbiota neurotransmitters: influence on risk and outcome of ischemic stroke. Neural Regen Res. 2023;18(8):1707\u20138.","journal-title":"Neural Regen Res"},{"issue":"3","key":"6201_CR133","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jphs.2020.07.011","volume":"144","author":"L Iovino","year":"2020","unstructured":"Iovino L, Tremblay ME, Civiero L. Glutamate-induced excitotoxicity in Parkinson\u2019s disease: the role of glial cells. J Pharmacol Sci. 2020;144(3):151\u201364.","journal-title":"J Pharmacol Sci"},{"issue":"4","key":"6201_CR134","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3233\/JAD-160763","volume":"57","author":"R Wang","year":"2017","unstructured":"Wang R, Reddy PH. Role of glutamate and NMDA receptors in Alzheimer\u2019s disease. J Alzheimers Dis. 2017;57(4):1041\u20138.","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"6201_CR135","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nm.4358","volume":"23","author":"R Liu","year":"2017","unstructured":"Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859\u201368.","journal-title":"Nat Med"},{"key":"6201_CR136","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.exger.2018.12.005","volume":"115","author":"D Abraham","year":"2019","unstructured":"Abraham D, Feher J, Scuderi GL, Szabo D, Dobolyi A, Cservenak M, et al. Exercise and probiotics attenuate the development of Alzheimer\u2019s disease in transgenic mice: Role of microbiome. Exp Gerontol. 2019;115:122\u201331.","journal-title":"Exp Gerontol"},{"key":"6201_CR137","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jad.2022.08.059","volume":"318","author":"X Fan","year":"2022","unstructured":"Fan X, Deng H, Qiu J, Ji H, Shen X. Antibiotics-induced depression in mice via the microbiota-gut-brain axis. J Affect Disord. 2022;318:152\u20138.","journal-title":"J Affect Disord"},{"issue":"1","key":"6201_CR138","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12934-018-1029-1","volume":"17","author":"C Lyu","year":"2018","unstructured":"Lyu C, Zhao W, Peng C, Hu S, Fang H, Hua Y, et al. Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and \u03b3-aminobutyric acid production. Microb Cell Fact. 2018;17(1):180.","journal-title":"Microb Cell Fact"},{"issue":"2","key":"6201_CR139","doi-asserted-by":"publisher","first-page":"lxac066","DOI":"10.1093\/jambio\/lxac066","volume":"134","author":"A Monteagudo-Mera","year":"2023","unstructured":"Monteagudo-Mera A, Fanti V, Rodriguez-Sobstel C, Gibson G, Wijeyesekera A, Karatzas KA, et al. Gamma aminobutyric acid production by commercially available probiotic strains. J Appl Microbiol. 2023;134(2):lxac066.","journal-title":"J Appl Microbiol"},{"issue":"1","key":"6201_CR140","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41538-024-00253-2","volume":"8","author":"JD Braga","year":"2024","unstructured":"Braga JD, Thongngam M, Kumrungsee T. Gamma-aminobutyric acid as a potential postbiotic mediator in the gut\u2013brain axis. npj Sci Food. 2024;8(1):16.","journal-title":"npj Sci Food"},{"key":"6201_CR141","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.clnesp.2022.09.458","volume":"54","author":"AP Prudencio","year":"2023","unstructured":"Prudencio AP, Fonseca DC, Cardinelli C, Machado NM, Ferreira B, Sala P, et al. Increased fecal serotonin after gastric bypass is unrelated to tryptophan intake. Clinical Nutrition ESPEN. 2023;54:614.","journal-title":"Clinical Nutrition ESPEN"},{"issue":"1","key":"6201_CR142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1875108","volume":"13","author":"F Seyfried","year":"2021","unstructured":"Seyfried F, Phetcharaburanin J, Glymenaki M, Nordbeck A, Hankir M, Nicholson JK, et al. Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss. Gut Microbes. 2021;13(1):1\u201320.","journal-title":"Gut Microbes"},{"issue":"9","key":"6201_CR143","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1136\/gut.2010.234708","volume":"60","author":"JV Li","year":"2011","unstructured":"Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW, et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 2011;60(9):1214\u201323.","journal-title":"Gut"},{"issue":"14","key":"6201_CR144","doi-asserted-by":"publisher","first-page":"7503","DOI":"10.3390\/ijms23147503","volume":"23","author":"S Hamamah","year":"2022","unstructured":"Hamamah S, Hajnal A, Covasa M. Impact of nutrition, microbiota transplant and weight loss surgery on dopaminergic alterations in Parkinson\u2019s disease and obesity. Int J Mol Sci. 2022;23(14):7503.","journal-title":"Int J Mol Sci"},{"key":"6201_CR145","doi-asserted-by":"publisher","DOI":"10.1002\/syn.22058","volume":"72","author":"J Hamilton","year":"2018","unstructured":"Hamilton J, Swenson S, Hajnal A, Thanos PK. Roux-en-Y gastric bypass surgery normalizes dopamine D1, D2, and DAT levels. Synapse. 2018;72: e22058.","journal-title":"Synapse"},{"key":"6201_CR146","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113053","volume":"224","author":"M McGregor","year":"2020","unstructured":"McGregor M, Hamilton J, Hajnal A, Thanos PK. Roux-en-Y gastric bypass increases GABA-A receptor levels in regions of the rat brain involved in object recognition memory and perceptual acuity. Physiol Behav. 2020;224: 113053.","journal-title":"Physiol Behav"},{"issue":"4","key":"6201_CR147","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1007\/s10620-019-05714-3","volume":"65","author":"W Abidi","year":"2020","unstructured":"Abidi W, Nestoridi E, Feldman H, Stefater M, Clish C, Thompson CC, et al. Differential metabolomic signatures in patients with weight regain and sustained weight loss after gastric bypass surgery: a pilot study. Dig Dis Sci. 2020;65(4):1144\u201354.","journal-title":"Dig Dis Sci"},{"issue":"1\u20132","key":"6201_CR148","doi-asserted-by":"publisher","DOI":"10.4161\/21688370.2014.982426","volume":"3","author":"S Cornick","year":"2015","unstructured":"Cornick S, Tawiah A, Chadee K. Roles and regulation of the mucus barrier in the gut. Tissue Barriers. 2015;3(1\u20132): e982426.","journal-title":"Tissue Barriers"},{"issue":"12","key":"6201_CR149","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","volume":"69","author":"P Paone","year":"2020","unstructured":"Paone P, Cani PD. Mucus barrier, mucins and gut microbiota: the expected slimy partners? Gut. 2020;69(12):2232\u201343.","journal-title":"Gut"},{"issue":"2","key":"6201_CR150","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s11695-014-1485-6","volume":"25","author":"M Torriani","year":"2015","unstructured":"Torriani M, Oliveira AL, Azevedo DC, Bredella MA, Yu EW. Effects of Roux-en-Y gastric bypass surgery on visceral and subcutaneous fat density by computed tomography. Obes Surg. 2015;25(2):381\u20135.","journal-title":"Obes Surg"},{"key":"6201_CR151","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101214","volume":"48","author":"J Chen","year":"2021","unstructured":"Chen J, Haase N, Haange SB, Sucher R, M\u00fcnzker J, J\u00e4ger E, et al. Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk. Mol Metab. 2021;48: 101214.","journal-title":"Mol Metab"},{"issue":"4","key":"6201_CR152","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033118","volume":"10","author":"MG Erkkinen","year":"2018","unstructured":"Erkkinen MG, Kim MO, Geschwind MD. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb Perspect Biol. 2018;10(4): a033118.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"6201_CR153","doi-asserted-by":"publisher","first-page":"1448377","DOI":"10.3389\/fneur.2024.1448377","volume":"15","author":"S Safiri","year":"2024","unstructured":"Safiri S, Ghaffari Jolfayi A, Mousavi SE, Nejadghaderi SA, Sullman MJM, Kolahi AA. Global burden of multiple sclerosis and its attributable risk factors, 1990\u20132019. Front Neurol. 2024;15:1448377.","journal-title":"Front Neurol"},{"issue":"2","key":"6201_CR154","first-page":"149","volume":"70","author":"J Dumurgier","year":"2020","unstructured":"Dumurgier J, Sabia S. Epidemiology of Alzheimer\u2019s disease: latest trends. Rev Prat. 2020;70(2):149\u201351.","journal-title":"Rev Prat"},{"issue":"1","key":"6201_CR155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9758\/cpn.2017.15.1.1","volume":"15","author":"S Kocahan","year":"2017","unstructured":"Kocahan S, Do\u011fan Z. Mechanisms of Alzheimer\u2019s disease pathogenesis and prevention: the brain, neural pathology, N-methyl-D-aspartate receptors, Tau protein and other risk factors. Clin Psychopharmacol Neurosci. 2017;15(1):1\u20138.","journal-title":"Clin Psychopharmacol Neurosci"},{"issue":"5","key":"6201_CR156","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3390\/biomedicines11051398","volume":"11","author":"Y Ratan","year":"2023","unstructured":"Ratan Y, Rajput A, Maleysm S, Pareek A, Jain V, Pareek A, et al. An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer\u2019s disease. Biomedicines. 2023;11(5):1398.","journal-title":"Biomedicines"},{"issue":"1","key":"6201_CR157","doi-asserted-by":"publisher","first-page":"2167172","DOI":"10.1080\/19490976.2023.2167172","volume":"15","author":"J Jin","year":"2023","unstructured":"Jin J, Xu Z, Zhang L, Zhang C, Zhao X, Mao Y, et al. Gut-derived \u03b2-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer\u2019s pathogenesis. Gut Microbes. 2023;15(1):2167172.","journal-title":"Gut Microbes"},{"issue":"1","key":"6201_CR158","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13024-023-00595-7","volume":"18","author":"S Chandra","year":"2023","unstructured":"Chandra S, Sisodia SS, Vassar RJ. The gut microbiome in Alzheimer\u2019s disease: what we know and what remains to be explored. Mol Neurodegener. 2023;18(1):9.","journal-title":"Mol Neurodegener"},{"issue":"6","key":"6201_CR159","doi-asserted-by":"publisher","first-page":"369","DOI":"10.5607\/en.2017.26.6.369","volume":"26","author":"JY Park","year":"2017","unstructured":"Park JY, Choi J, Lee Y, Lee JE, Lee EH, Kwon HJ, et al. Metagenome analysis of bodily microbiota in a mouse model of Alzheimer disease using bacteria-derived membrane vesicles in blood. Exp Neurobiol. 2017;26(6):369\u201379.","journal-title":"Exp Neurobiol"},{"issue":"21","key":"6201_CR160","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.3390\/ijms232113574","volume":"23","author":"S Park","year":"2022","unstructured":"Park S, Wu X. Modulation of the gut microbiota in memory impairment and Alzheimer\u2019s disease via the inhibition of the parasympathetic nervous system. Int J Mol Sci. 2022;23(21):13574.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6201_CR161","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12866-021-02286-z","volume":"21","author":"J Xi","year":"2021","unstructured":"Xi J, Ding D, Zhu H, Wang R, Su F, Wu W, et al. Disturbed microbial ecology in Alzheimer\u2019s disease: evidence from the gut microbiota and fecal metabolome. BMC Microbiol. 2021;21(1):226.","journal-title":"BMC Microbiol"},{"issue":"18","key":"6201_CR162","doi-asserted-by":"publisher","first-page":"2001299","DOI":"10.1002\/advs.202001299","volume":"7","author":"I Javed","year":"2020","unstructured":"Javed I, Zhang Z, Adamcik J, Andrikopoulos N, Li Y, Otzen DE, et al. accelerated amyloid beta pathogenesis by bacterial amyloid FapC. Adv Sci (Weinh). 2020;7(18):2001299.","journal-title":"Adv Sci (Weinh)"},{"issue":"9","key":"6201_CR163","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.3390\/genes13091564","volume":"13","author":"V D'Argenio","year":"2022","unstructured":"D\u2019Argenio V, Veneruso I, Gong C, Cecarini V, Bonfili L, Eleuteri AM. Gut Microbiome and mycobiome alterations in an in vivo model of Alzheimer\u2019s disease. Genes (Basel). 2022;13(9):1564.","journal-title":"Genes (Basel)"},{"issue":"10","key":"6201_CR164","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.jalz.2019.07.002","volume":"15","author":"B Li","year":"2019","unstructured":"Li B, He Y, Ma J, Huang P, Du J, Cao L, et al. Mild cognitive impairment has similar alterations as Alzheimer\u2019s disease in gut microbiota. Alzheimers Dement. 2019;15(10):1357\u201366.","journal-title":"Alzheimers Dement"},{"issue":"3","key":"6201_CR165","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/arclin\/acac008","volume":"37","author":"ER Murray","year":"2022","unstructured":"Murray ER, Kemp M, Nguyen TT. The microbiota-gut-brain axis in alzheimer\u2019s disease: a review of taxonomic alterations and potential avenues for interventions. Arch Clin Neuropsychol. 2022;37(3):595\u2013607.","journal-title":"Arch Clin Neuropsychol"},{"issue":"2","key":"6201_CR166","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000526947","volume":"22","author":"P Wanapaisan","year":"2022","unstructured":"Wanapaisan P, Chuansangeam M, Nopnipa S, Mathuranyanon R, Nonthabenjawan N, Ngamsombat C, et al. Association between gut microbiota with mild cognitive impairment and Alzheimer\u2019s disease in a Thai population. Neurodegener Dis. 2022;22(2):43\u201354.","journal-title":"Neurodegener Dis"},{"issue":"3","key":"6201_CR167","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s12263-010-0206-6","volume":"6","author":"K Pokusaeva","year":"2011","unstructured":"Pokusaeva K, Fitzgerald GF, van Sinderen D. Carbohydrate metabolism in Bifidobacteria. Genes Nutr. 2011;6(3):285\u2013306.","journal-title":"Genes Nutr"},{"issue":"1","key":"6201_CR168","doi-asserted-by":"publisher","first-page":"15115","DOI":"10.1038\/s41598-022-19393-0","volume":"12","author":"A Kaiyrlykyzy","year":"2022","unstructured":"Kaiyrlykyzy A, Kozhakhmetov S, Babenko D, Zholdasbekova G, Alzhanova D, Olzhayev F, et al. Study of gut microbiota alterations in Alzheimer\u2019s dementia patients from Kazakhstan. Sci Rep. 2022;12(1):15115.","journal-title":"Sci Rep"},{"issue":"1","key":"6201_CR169","doi-asserted-by":"publisher","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","volume":"7","author":"NM Vogt","year":"2017","unstructured":"Vogt NM, Kerby RL, Dill-McFarland KA, Harding SJ, Merluzzi AP, Johnson SC, et al. Gut microbiome alterations in Alzheimer\u2019s disease. Sci Rep. 2017;7(1):13537.","journal-title":"Sci Rep"},{"key":"6201_CR170","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.972982","volume":"14","author":"SS Wang","year":"2022","unstructured":"Wang SS, Li XH, Liu P, Li J, Liu L. The relationship between Alzheimer\u2019s disease and intestinal microflora structure and inflammatory factors. Front Aging Neurosci. 2022;14: 972982.","journal-title":"Front Aging Neurosci"},{"issue":"11","key":"6201_CR171","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","volume":"50","author":"PD Cani","year":"2007","unstructured":"Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007;50(11):2374\u201383.","journal-title":"Diabetologia"},{"issue":"12","key":"6201_CR172","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.3390\/nu14122543","volume":"14","author":"M Abdelhamid","year":"2022","unstructured":"Abdelhamid M, Zhou C, Jung CG, Michikawa M. Probiotic bifidobacterium breve MCC1274 mitigates Alzheimer\u2019s disease-related pathologies in wild-type mice. Nutrients. 2022;14(12):2543.","journal-title":"Nutrients"},{"key":"6201_CR173","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.537847","volume":"8","author":"K Arora","year":"2020","unstructured":"Arora K, Green M, Prakash S. The microbiome and alzheimer\u2019s disease: potential and limitations of prebiotic, synbiotic, and probiotic formulations. Front Bioeng Biotechnol. 2020;8: 537847.","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"6201_CR174","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1038\/s41598-023-31730-5","volume":"13","author":"D Cammann","year":"2023","unstructured":"Cammann D, Lu Y, Cummings MJ, Zhang ML, Cue JM, Do J, et al. Genetic correlations between Alzheimer\u2019s disease and gut microbiome genera. Sci Rep. 2023;13(1):5258.","journal-title":"Sci Rep"},{"issue":"22","key":"6201_CR175","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","volume":"110","author":"A Everard","year":"2013","unstructured":"Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA. 2013;110(22):9066\u201371.","journal-title":"Proc Natl Acad Sci USA"},{"key":"6201_CR176","doi-asserted-by":"publisher","first-page":"1191445","DOI":"10.3389\/fmicb.2023.1191445","volume":"14","author":"F Zhang","year":"2023","unstructured":"Zhang F, Wang D. Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseases. Front Microbiol. 2023;14:1191445.","journal-title":"Front Microbiol"},{"key":"6201_CR177","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952161","volume":"10","author":"C Ding","year":"2022","unstructured":"Ding C, Wu Y, Chen X, Chen Y, Wu Z, Lin Z, et al. Global, regional, and national burden and attributable risk factors of neurological disorders: the global burden of disease study 1990\u20132019. Front Public Health. 2022;10: 952161.","journal-title":"Front Public Health"},{"key":"6201_CR178","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.666737","volume":"12","author":"AN MacMahon Copas","year":"2021","unstructured":"MacMahon Copas AN, McComish SF, Fletcher JM, Caldwell MA. The pathogenesis of Parkinson\u2019s disease: a complex interplay between astrocytes, microglia, and T lymphocytes? Front Neurol. 2021;12: 666737.","journal-title":"Front Neurol"},{"issue":"1","key":"6201_CR179","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/mds.25032","volume":"28","author":"EC Hirsch","year":"2013","unstructured":"Hirsch EC, Jenner P, Przedborski S. Pathogenesis of Parkinson\u2019s disease. Mov Disord. 2013;28(1):24\u201330.","journal-title":"Mov Disord"},{"issue":"10","key":"6201_CR180","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/mds.26307","volume":"30","author":"A Keshavarzian","year":"2015","unstructured":"Keshavarzian A, Green SJ, Engen PA, Voigt RM, Naqib A, Forsyth CB, et al. Colonic bacterial composition in Parkinson\u2019s disease. Mov Disord. 2015;30(10):1351\u201360.","journal-title":"Mov Disord"},{"issue":"1","key":"6201_CR181","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13073-017-0428-y","volume":"9","author":"JR Bedarf","year":"2017","unstructured":"Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F, et al. Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-na\u00efve Parkinson\u2019s disease patients. Genome Med. 2017;9(1):39.","journal-title":"Genome Med"},{"issue":"12","key":"6201_CR182","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s11910-017-0802-6","volume":"17","author":"EMM Quigley","year":"2017","unstructured":"Quigley EMM. Microbiota-brain-gut axis and neurodegenerative diseases. Curr Neurol Neurosci Rep. 2017;17(12):94.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"3","key":"6201_CR183","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/mds.26069","volume":"30","author":"F Scheperjans","year":"2015","unstructured":"Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E, et al. Gut microbiota are related to Parkinson\u2019s disease and clinical phenotype. Mov Disord. 2015;30(3):350\u20138.","journal-title":"Mov Disord"},{"issue":"2","key":"6201_CR184","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3390\/biomedicines10020436","volume":"10","author":"S Hamamah","year":"2022","unstructured":"Hamamah S, Aghazarian A, Nazaryan A, Hajnal A, Covasa M. Role of microbiota-gut-brain axis in regulating dopaminergic signaling. Biomedicines. 2022;10(2):436.","journal-title":"Biomedicines"},{"issue":"1","key":"6201_CR185","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1038\/s41598-023-29219-2","volume":"13","author":"K Nakahara","year":"2023","unstructured":"Nakahara K, Nakane S, Ishii K, Ikeda T, Ando Y. Gut microbiota of Parkinson\u2019s disease in an appendectomy cohort: a preliminary study. Sci Rep. 2023;13(1):2210.","journal-title":"Sci Rep"},{"issue":"29","key":"6201_CR186","doi-asserted-by":"publisher","first-page":"26880","DOI":"10.1074\/jbc.M502031200","volume":"280","author":"S Bieler","year":"2005","unstructured":"Bieler S, Estrada L, Lagos R, Baeza M, Castilla J, Soto C. Amyloid formation modulates the biological activity of a bacterial protein. J Biol Chem. 2005;280(29):26880\u20135.","journal-title":"J Biol Chem"},{"key":"6201_CR187","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.728479","volume":"12","author":"L Mao","year":"2021","unstructured":"Mao L, Zhang Y, Tian J, Sang M, Zhang G, Zhou Y, et al. Cross-sectional study on the gut microbiome of Parkinson\u2019s disease patients in central China. Front Microbiol. 2021;12: 728479.","journal-title":"Front Microbiol"},{"issue":"1","key":"6201_CR188","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41531-022-00328-5","volume":"8","author":"H Nishiwaki","year":"2022","unstructured":"Nishiwaki H, Ito M, Hamaguchi T, Maeda T, Kashihara K, Tsuboi Y, et al. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson\u2019s disease. NPJ Parkinsons Dis. 2022;8(1):65.","journal-title":"NPJ Parkinsons Dis"},{"issue":"5","key":"6201_CR189","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/mds.26942","volume":"32","author":"EM Hill-Burns","year":"2017","unstructured":"Hill-Burns EM, Debelius JW, Morton JT, Wissemann WT, Lewis MR, Wallen ZD, et al. Parkinson\u2019s disease and Parkinson\u2019s disease medications have distinct signatures of the gut microbiome. Mov Disord. 2017;32(5):739\u201349.","journal-title":"Mov Disord"},{"issue":"1","key":"6201_CR190","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/cns.13990","volume":"29","author":"Z Li","year":"2023","unstructured":"Li Z, Liang H, Hu Y, Lu L, Zheng C, Fan Y, et al. Gut bacterial profiles in Parkinson\u2019s disease: a systematic review. CNS Neurosci Ther. 2023;29(1):140\u201357.","journal-title":"CNS Neurosci Ther"},{"issue":"6","key":"6201_CR191","doi-asserted-by":"publisher","first-page":"00431","DOI":"10.1128\/msphere.00431-23","volume":"8","author":"C Cui","year":"2023","unstructured":"Cui C, Song H, Han Y, Yu H, Li H, Yang Y, et al. Gut microbiota-associated taurine metabolism dysregulation in a mouse model of Parkinson\u2019s disease. mSphere. 2023;8(6):00431\u201323.","journal-title":"mSphere"},{"issue":"1","key":"6201_CR192","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s100720170061","volume":"22","author":"M Pierantozzi","year":"2001","unstructured":"Pierantozzi M, Pietroiusti A, Sancesario G, Lunardi G, Fedele E, Giacomini P, et al. Reduced L-dopa absorption and increased clinical fluctuations in Helicobacter pylori-infected Parkinson\u2019s disease patients. Neurol Sci. 2001;22(1):89\u201391.","journal-title":"Neurol Sci"},{"issue":"5","key":"6201_CR193","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12398","volume":"22","author":"X Shen","year":"2017","unstructured":"Shen X, Yang H, Wu Y, Zhang D, Jiang H. Meta-analysis: association of helicobacter pylori infection with Parkinson\u2019s diseases. Helicobacter. 2017;22(5): e12398.","journal-title":"Helicobacter"},{"issue":"2","key":"6201_CR194","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14383","volume":"30","author":"X Hu","year":"2024","unstructured":"Hu X, Yu L, Li Y, Li X, Zhao Y, Xiong L, et al. Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson\u2019s disease by suppressing gut bacterial tyrosine decarboxylase. CNS Neurosci Ther. 2024;30(2): e14383.","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"6201_CR195","doi-asserted-by":"publisher","first-page":"19155","DOI":"10.1038\/s41598-023-45953-z","volume":"13","author":"MS Cirstea","year":"2023","unstructured":"Cirstea MS, Creus-Cuadros A, Lo C, Yu AC, Serapio-Palacios A, Neilson S, et al. A novel pathway of levodopa metabolism by commensal Bifidobacteria. Sci Rep. 2023;13(1):19155.","journal-title":"Sci Rep"},{"key":"6201_CR196","doi-asserted-by":"publisher","first-page":"1046910","DOI":"10.3389\/fneur.2023.1046910","volume":"14","author":"Z Zhong","year":"2023","unstructured":"Zhong Z, Ye M, Yan F. A review of studies on gut microbiota and levodopa metabolism. Front Neurol. 2023;14:1046910.","journal-title":"Front Neurol"},{"issue":"11","key":"6201_CR197","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s11427-016-9001-4","volume":"60","author":"W Li","year":"2017","unstructured":"Li W, Wu X, Hu X, Wang T, Liang S, Duan Y, et al. Structural changes of gut microbiota in Parkinson\u2019s disease and its correlation with clinical features. Sci China Life Sci. 2017;60(11):1223\u201333.","journal-title":"Sci China Life Sci"},{"key":"6201_CR198","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3389\/fnins.2019.00839","volume":"13","author":"AM Gorecki","year":"2019","unstructured":"Gorecki AM, Preskey L, Bakeberg MC, Kenna JE, Gildenhuys C, MacDougall G, et al. Altered gut microbiome in Parkinson\u2019s disease and the influence of lipopolysaccharide in a human \u03b1-synuclein over-expressing mouse model. Front Neurosci. 2019;13:839.","journal-title":"Front Neurosci"},{"issue":"2","key":"6201_CR199","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3390\/neurolint15020047","volume":"15","author":"AC Proano","year":"2023","unstructured":"Proano AC, Viteri JA, Orozco EN, Calle MA, Costa SC, Reyes DV, et al. Gut microbiota and its repercussion in parkinson\u2019s disease: a systematic review in occidental patients. Neurol Int. 2023;15(2):750\u201363.","journal-title":"Neurol Int"},{"key":"6201_CR200","doi-asserted-by":"publisher","first-page":"1224155","DOI":"10.3389\/fcimb.2023.1224155","volume":"13","author":"W Lei","year":"2023","unstructured":"Lei W, Cheng Y, Gao J, Liu X, Shao L, Kong Q, et al. Akkermansia muciniphila in neuropsychiatric disorders: friend or foe? Front Cell Infect Microbiol. 2023;13:1224155.","journal-title":"Front Cell Infect Microbiol"},{"issue":"178","key":"6201_CR201","doi-asserted-by":"publisher","first-page":"178ra41","DOI":"10.1126\/scitranslmed.3005687","volume":"5","author":"AP Liou","year":"2013","unstructured":"Liou AP, Paziuk M, Luevano JM Jr, Machineni S, Turnbaugh PJ, Kaplan LM. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med. 2013;5(178):178ra41.","journal-title":"Sci Transl Med"},{"issue":"3","key":"6201_CR202","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2174\/157015911796557911","volume":"9","author":"I Loma","year":"2011","unstructured":"Loma I, Heyman R. Multiple sclerosis: pathogenesis and treatment. Curr Neuropharmacol. 2011;9(3):409\u201316.","journal-title":"Curr Neuropharmacol"},{"issue":"14","key":"6201_CR203","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","volume":"26","author":"C Walton","year":"2020","unstructured":"Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS third. Mult Scler. 2020;26(14):1816\u201321.","journal-title":"Mult Scler."},{"issue":"1","key":"6201_CR204","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cei\/uxad075","volume":"214","author":"JM van Noort","year":"2023","unstructured":"van Noort JM, Baker D, Kipp M, Amor S. The pathogenesis of multiple sclerosis: a series of unfortunate events. Clin Exp Immunol. 2023;214(1):1\u201317.","journal-title":"Clin Exp Immunol"},{"issue":"19","key":"6201_CR205","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1016\/j.cell.2022.08.021","volume":"185","author":"X Zhou","year":"2022","unstructured":"Zhou X, Baumann R, Gao X, Mendoza M, Singh S, Katz Sand I, et al. Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell. 2022;185(19):3467-86.e16.","journal-title":"Cell"},{"issue":"5","key":"6201_CR206","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.3390\/ijerph20054624","volume":"20","author":"A Ordo\u00f1ez-Rodriguez","year":"2023","unstructured":"Ordo\u00f1ez-Rodriguez A, Roman P, Rueda-Ruzafa L, Campos-Rios A, Cardona D. Changes in gut microbiota and multiple sclerosis: a systematic review. Int J Environ Res Public Health. 2023;20(5):4624.","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"6201_CR207","doi-asserted-by":"publisher","first-page":"2020068","DOI":"10.1080\/19490976.2021.2020068","volume":"14","author":"DA Koutoukidis","year":"2022","unstructured":"Koutoukidis DA, Jebb SA, Zimmerman M, Otunla A, Henry JA, Ferrey A, et al. The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysis. Gut Microbes. 2022;14(1):2020068.","journal-title":"Gut Microbes"},{"issue":"1\u20132","key":"6201_CR208","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0165-5728(03)00274-1","volume":"144","author":"LE Hughes","year":"2003","unstructured":"Hughes LE, Smith PA, Bonell S, Natt RS, Wilson C, Rashid T, et al. Cross-reactivity between related sequences found in Acinetobacter sp Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol. 2003;144(1\u20132):105\u201315.","journal-title":"J Neuroimmunol."},{"issue":"1","key":"6201_CR209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","volume":"13","author":"X Liu","year":"2021","unstructured":"Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, et al. Blautia-a new functional genus with potential probiotic properties? Gut Microbes. 2021;13(1):1\u201321.","journal-title":"Gut Microbes"},{"key":"6201_CR210","doi-asserted-by":"publisher","first-page":"28484","DOI":"10.1038\/srep28484","volume":"6","author":"J Chen","year":"2016","unstructured":"Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Paz Soldan MM, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484.","journal-title":"Sci Rep"},{"issue":"12","key":"6201_CR211","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1177\/0963689719873890","volume":"28","author":"G Schepici","year":"2019","unstructured":"Schepici G, Silvestro S, Bramanti P, Mazzon E. The gut microbiota in multiple sclerosis: an overview of clinical trials. Cell Transplant. 2019;28(12):1507\u201327.","journal-title":"Cell Transplant"},{"issue":"3","key":"6201_CR212","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/gutjnl-2022-328185","volume":"72","author":"FF Anh\u00ea","year":"2023","unstructured":"Anh\u00ea FF, Zlitni S, Zhang SY, Choi BS, Chen CY, Foley KP, et al. Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. Gut. 2023;72(3):460\u201371.","journal-title":"Gut"},{"issue":"1","key":"6201_CR213","doi-asserted-by":"publisher","first-page":"7","DOI":"10.31887\/DCNS.2002.4.1\/bbondy","volume":"4","author":"B Brigitta","year":"2002","unstructured":"Brigitta B. Pathophysiology of depression and mechanisms of treatment. Dialogues Clin Neurosci. 2002;4(1):7\u201320.","journal-title":"Dialogues Clin Neurosci"},{"key":"6201_CR214","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","volume":"2","author":"C Otte","year":"2016","unstructured":"Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, et al. Major depressive disorder. Nat Rev Dis Primers. 2016;2:16065.","journal-title":"Nat Rev Dis Primers"},{"key":"6201_CR215","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.neubiorev.2021.10.041","volume":"132","author":"N Abdoli","year":"2022","unstructured":"Abdoli N, Salari N, Darvishi N, Jafarpour S, Solaymani M, Mohammadi M, et al. The global prevalence of major depressive disorder (MDD) among the elderly: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2022;132:1067\u201373.","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"6201_CR216","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/bjc.12333","volume":"61","author":"S Shorey","year":"2022","unstructured":"Shorey S, Ng ED, Wong CHJ. Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis. Br J Clin Psychol. 2022;61(2):287\u2013305.","journal-title":"Br J Clin Psychol"},{"key":"6201_CR217","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainresbull.2022.02.004","volume":"182","author":"L Chang","year":"2022","unstructured":"Chang L, Wei Y, Hashimoto K. Brain-gut-microbiota axis in depression: a historical overview and future directions. Brain Res Bull. 2022;182:44\u201356.","journal-title":"Brain Res Bull"},{"key":"6201_CR218","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","volume":"321","author":"C M\u00e9nard","year":"2016","unstructured":"M\u00e9nard C, Hodes GE, Russo SJ. Pathogenesis of depression: Insights from human and rodent studies. Neuroscience. 2016;321:138\u201362.","journal-title":"Neuroscience"},{"issue":"7","key":"6201_CR219","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/da.20262","volume":"24","author":"AV Kalueff","year":"2007","unstructured":"Kalueff AV, Nutt DJ. Role of GABA in anxiety and depression. Depress Anxiety. 2007;24(7):495\u2013517.","journal-title":"Depress Anxiety"},{"issue":"2","key":"6201_CR220","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1089\/bioe.2021.0012","volume":"3","author":"SJ Quillin","year":"2021","unstructured":"Quillin SJ, Tran P, Prindle A. Potential roles for gamma-aminobutyric acid signaling in bacterial communities. Bioelectricity. 2021;3(2):120\u20135.","journal-title":"Bioelectricity"},{"issue":"3","key":"6201_CR221","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","volume":"4","author":"P Strandwitz","year":"2019","unstructured":"Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, et al. GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2019;4(3):396\u2013403.","journal-title":"Nat Microbiol"},{"key":"6201_CR222","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jad.2016.05.038","volume":"202","author":"E Aizawa","year":"2016","unstructured":"Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S, et al. Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. J Affect Disord. 2016;202:254\u20137.","journal-title":"J Affect Disord"},{"key":"6201_CR223","doi-asserted-by":"publisher","first-page":"1034839","DOI":"10.3389\/fmicb.2022.1034839","volume":"13","author":"J Yang","year":"2022","unstructured":"Yang J, Chen L, Shang XY, Chen YL, Zhao SS, Jin S, et al. Roux-en-Y gastric bypass-induced perturbative changes in microbial communities and metabolic pathways in rats. Front Microbiol. 2022;13:1034839.","journal-title":"Front Microbiol"},{"issue":"8","key":"6201_CR224","doi-asserted-by":"publisher","first-page":"949","DOI":"10.2174\/1381612822666151214104826","volume":"22","author":"L Dell'Osso","year":"2016","unstructured":"Dell\u2019Osso L, Carmassi C, Mucci F, Marazziti D. Depression, serotonin and tryptophan. Curr Pharm Des. 2016;22(8):949\u201354.","journal-title":"Curr Pharm Des"},{"key":"6201_CR225","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.852506","volume":"16","author":"A Eltokhi","year":"2022","unstructured":"Eltokhi A, Sommer IE. A reciprocal link between gut microbiota, inflammation and depression: a place for probiotics? Front Neurosci. 2022;16: 852506.","journal-title":"Front Neurosci"},{"issue":"1","key":"6201_CR226","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","volume":"13","author":"B Guo","year":"2023","unstructured":"Guo B, Zhang M, Hao W, Wang Y, Zhang T, Liu C. Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression. Transl Psychiatry. 2023;13(1):5.","journal-title":"Transl Psychiatry"},{"issue":"1","key":"6201_CR227","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/ejn.14720","volume":"53","author":"R Troubat","year":"2021","unstructured":"Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, et al. Neuroinflammation and depression: a review. Eur J Neurosci. 2021;53(1):151\u201371.","journal-title":"Eur J Neurosci"},{"issue":"1","key":"6201_CR228","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1192\/bjp.2018.66","volume":"214","author":"SR Chamberlain","year":"2019","unstructured":"Chamberlain SR, Cavanagh J, de Boer P, Mondelli V, Jones DNC, Drevets WC, et al. Treatment-resistant depression and peripheral C-reactive protein. Br J Psychiatry. 2019;214(1):11\u20139.","journal-title":"Br J Psychiatry"},{"issue":"12","key":"6201_CR229","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/mp.2016.3","volume":"21","author":"DR Goldsmith","year":"2016","unstructured":"Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016;21(12):1696\u2013709.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"6201_CR230","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/schbul\/sbx035","volume":"44","author":"AK Wang","year":"2018","unstructured":"Wang AK, Miller BJ. Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder, and depression. Schizophr Bull. 2018;44(1):75\u201383.","journal-title":"Schizophr Bull"},{"key":"6201_CR231","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","volume":"48","author":"H Jiang","year":"2015","unstructured":"Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 2015;48:186\u201394.","journal-title":"Brain Behav Immun"},{"issue":"35","key":"6201_CR232","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203707","volume":"9","author":"L Liu","year":"2022","unstructured":"Liu L, Wang H, Zhang H, Chen X, Zhang Y, Wu J, et al. Toward a deeper understanding of gut microbiome in depression: the promise of clinical applicability. Adv Sci (Weinh). 2022;9(35): e2203707.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"6201_CR233","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/ejn.14631","volume":"53","author":"AS Carlessi","year":"2021","unstructured":"Carlessi AS, Borba LA, Zugno AI, Quevedo J, R\u00e9us GZ. Gut microbiota-brain axis in depression: the role of neuroinflammation. Eur J Neurosci. 2021;53(1):222\u201335.","journal-title":"Eur J Neurosci"},{"issue":"11","key":"6201_CR234","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.soard.2020.06.032","volume":"16","author":"D Yu","year":"2020","unstructured":"Yu D, Shu XO, Howard EF, Long J, English WJ, Flynn CR. Fecal metagenomics and metabolomics reveal gut microbial changes after bariatric surgery. Surg Obes Relat Dis. 2020;16(11):1772\u201382.","journal-title":"Surg Obes Relat Dis"},{"issue":"10","key":"6201_CR235","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/bjs.10258","volume":"103","author":"O Backman","year":"2016","unstructured":"Backman O, Stockeld D, Rasmussen F, N\u00e4slund E, Marsk R. Alcohol and substance abuse, depression and suicide attempts after Roux-en-Y gastric bypass surgery. Br J Surg. 2016;103(10):1336\u201342.","journal-title":"Br J Surg"},{"issue":"12","key":"6201_CR236","first-page":"972","volume":"94","author":"KE Sanchack","year":"2016","unstructured":"Sanchack KE, Thomas CA. Autism spectrum disorder: primary care principles. Am Fam Physician. 2016;94(12):972\u20139.","journal-title":"Am Fam Physician"},{"issue":"5","key":"6201_CR237","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/aur.2696","volume":"15","author":"J Zeidan","year":"2022","unstructured":"Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, et al. Global prevalence of autism: a systematic review update. Autism Res. 2022;15(5):778\u201390.","journal-title":"Autism Res"},{"issue":"3","key":"6201_CR238","doi-asserted-by":"publisher","first-page":"281","DOI":"10.31887\/DCNS.2012.14.3\/pchaste","volume":"14","author":"P Chaste","year":"2012","unstructured":"Chaste P, Leboyer M. Autism risk factors: genes, environment, and gene-environment interactions. Dialogues Clin Neurosci. 2012;14(3):281\u201392.","journal-title":"Dialogues Clin Neurosci"},{"issue":"1","key":"6201_CR239","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3748\/wjg.v22.i1.361","volume":"22","author":"F Mangiola","year":"2016","unstructured":"Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A. Gut microbiota in autism and mood disorders. World J Gastroenterol. 2016;22(1):361\u20138.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"6201_CR240","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3390\/nu11030521","volume":"11","author":"A Fattorusso","year":"2019","unstructured":"Fattorusso A, Di Genova L, Dell\u2019Isola GB, Mencaroni E, Esposito S. Autism spectrum disorders and the gut microbiota. Nutrients. 2019;11(3):521.","journal-title":"Nutrients"},{"issue":"11","key":"6201_CR241","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11910-018-0887-6","volume":"18","author":"HK Hughes","year":"2018","unstructured":"Hughes HK, Rose D, Ashwood P. The gut microbiota and dysbiosis in autism spectrum disorders. Curr Neurol Neurosci Rep. 2018;18(11):81.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"6201_CR242","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.871086","volume":"13","author":"P Vernocchi","year":"2022","unstructured":"Vernocchi P, Ristori MV, Guerrera S, Guarrasi V, Conte F, Russo A, et al. Gut Microbiota ecology and inferred functions in children with ASD compared to neurotypical subjects. Front Microbiol. 2022;13: 871086.","journal-title":"Front Microbiol"},{"issue":"1","key":"6201_CR243","doi-asserted-by":"publisher","first-page":"18218","DOI":"10.1038\/s41598-023-45534-0","volume":"13","author":"M Chamtouri","year":"2023","unstructured":"Chamtouri M, Gaddour N, Merghni A, Mastouri M, Arboleya S. Age and severity-dependent gut microbiota alterations in Tunisian children with autism spectrum disorder. Sci Rep. 2023;13(1):18218.","journal-title":"Sci Rep"},{"key":"6201_CR244","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2018.03.020","volume":"132","author":"N Israelyan","year":"2018","unstructured":"Israelyan N, Margolis KG. Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders. Pharmacol Res. 2018;132:1\u20136.","journal-title":"Pharmacol Res"},{"issue":"6","key":"6201_CR245","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/aur.2718","volume":"15","author":"X Xie","year":"2022","unstructured":"Xie X, Li L, Wu X, Hou F, Chen Y, Shi L, et al. Alteration of the fecal microbiota in Chinese children with autism spectrum disorder. Autism Res. 2022;15(6):996\u20131007.","journal-title":"Autism Res"},{"issue":"9","key":"6201_CR246","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1002\/aur.2358","volume":"13","author":"R Zou","year":"2020","unstructured":"Zou R, Xu F, Wang Y, Duan M, Guo M, Zhang Q, et al. Changes in the gut microbiota of children with autism spectrum disorder. Autism Res. 2020;13(9):1614\u201325.","journal-title":"Autism Res"},{"issue":"5","key":"6201_CR247","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3892\/etm.2024.12719","volume":"28","author":"D Abuljadayel","year":"2024","unstructured":"Abuljadayel D, Alotibi A, Algothmi K, Basingab F, Alhazmi S, Almuhammadi A, et al. Gut microbiota of children with autism spectrum disorder and healthy siblings: a comparative study. Exp Ther Med. 2024;28(5):430.","journal-title":"Exp Ther Med"},{"issue":"11","key":"6201_CR248","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.3390\/nu11112812","volume":"11","author":"MV Ristori","year":"2019","unstructured":"Ristori MV, Quagliariello A, Reddel S, Ianiro G, Vicari S, Gasbarrini A, et al. Autism, gastrointestinal symptoms and modulation of gut microbiota by nutritional interventions. Nutrients. 2019;11(11):2812.","journal-title":"Nutrients"},{"issue":"9","key":"6201_CR249","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.3390\/ijms20092115","volume":"20","author":"P Srikantha","year":"2019","unstructured":"Srikantha P, Mohajeri MH. The possible role of the microbiota-gut-brain-axis in autism spectrum disorder. Int J Mol Sci. 2019;20(9):2115.","journal-title":"Int J Mol Sci"},{"key":"6201_CR250","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2022.100023","volume":"3","author":"SE Cuda","year":"2022","unstructured":"Cuda SE, Pratt JSA, Santos M, Browne A. Obesity pillars roundtable: metabolic and bariatric surgery in children and adolescents. Obes Pillars. 2022;3: 100023.","journal-title":"Obes Pillars"},{"issue":"2","key":"6201_CR251","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1001\/jama.2021.23619","volume":"327","author":"DM Rubino","year":"2022","unstructured":"Rubino DM, Greenway FL, Khalid U, O\u2019Neil PM, Rosenstock J, S\u00f8rrig R, et al. Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial. JAMA. 2022;327(2):138\u201350.","journal-title":"JAMA"},{"issue":"24","key":"6201_CR252","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1056\/NEJMoa2208601","volume":"387","author":"D Weghuber","year":"2022","unstructured":"Weghuber D, Barrett T, Barrientos-P\u00e9rez M, Gies I, Hesse D, Jeppesen OK, et al. Once-weekly semaglutide in adolescents with obesity. N Engl J Med. 2022;387(24):2245\u201357.","journal-title":"N Engl J Med"},{"issue":"1","key":"6201_CR253","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12933-022-01604-7","volume":"21","author":"MA Nauck","year":"2022","unstructured":"Nauck MA, D\u2019Alessio DA. Tirzepatide, a dual GIP\/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction. Cardiovasc Diabetol. 2022;21(1):169.","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"6201_CR254","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jagp.2023.08.010","volume":"32","author":"X Chen","year":"2024","unstructured":"Chen X, Zhao P, Wang W, Guo L, Pan Q. The antidepressant effects of GLP-1 receptor agonists: a systematic review and meta-analysis. Am J Geriatr Psychiatry. 2024;32(1):117\u201327.","journal-title":"Am J Geriatr Psychiatry"},{"key":"6201_CR255","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jpsychires.2023.05.041","volume":"164","author":"DH Cooper","year":"2023","unstructured":"Cooper DH, Ramachandra R, Ceban F, Di Vincenzo JD, Rhee TG, Mansur RB, et al. Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: a systematic review. J Psychiatr Res. 2023;164:80\u20139.","journal-title":"J Psychiatr Res"},{"key":"6201_CR256","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17891","volume":"12","author":"J Feng","year":"2024","unstructured":"Feng J, Teng Z, Yang Y, Liu J, Chen S. Effects of semaglutide on gut microbiota, cognitive function and inflammation in obese mice. PeerJ. 2024;12: e17891.","journal-title":"PeerJ"},{"key":"6201_CR257","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176440","volume":"969","author":"X Duan","year":"2024","unstructured":"Duan X, Zhang L, Liao Y, Lin Z, Guo C, Luo S, et al. Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet. Eur J Pharmacol. 2024;969: 176440.","journal-title":"Eur J Pharmacol"},{"key":"6201_CR258","doi-asserted-by":"publisher","first-page":"204201882312223","DOI":"10.1177\/20420188231222367","volume":"15","author":"SH Alharbi","year":"2024","unstructured":"Alharbi SH. Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications. Ther Adv Endocrinol Metab. 2024;15:20420188231222370.","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"7","key":"6201_CR259","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.3390\/ijms25073812","volume":"25","author":"K Kalinderi","year":"2024","unstructured":"Kalinderi K, Papaliagkas V, Fidani L. GLP-1 receptor agonists: a new treatment in Parkinson\u2019s disease. Int J Mol Sci. 2024;25(7):3812.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"6201_CR260","doi-asserted-by":"publisher","first-page":"5929","DOI":"10.3390\/cimb46060354","volume":"46","author":"AD Meca","year":"2024","unstructured":"Meca AD, Boboc IKS, Mititelu-Tartau L, Bogdan M. Unlocking the potential: semaglutide\u2019s impact on Alzheimer\u2019s and Parkinson\u2019s disease in animal models. Curr Issues Mol Biol. 2024;46(6):5929\u201349.","journal-title":"Curr Issues Mol Biol"},{"key":"6201_CR261","first-page":"1428817","volume":"2022","author":"L Zhang","year":"2022","unstructured":"Zhang L, Li C, Zhang Z, Zhang Z, Jin QQ, Li L, et al. DA5-CH and semaglutide protect against neurodegeneration and reduce \u03b1-synuclein levels in the 6-OHDA Parkinson\u2019s disease rat model. Parkinsons Dis. 2022;2022:1428817.","journal-title":"Parkinsons Dis"},{"key":"6201_CR262","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109647","volume":"115","author":"MA Sadek","year":"2023","unstructured":"Sadek MA, Kandil EA, El Sayed NS, Sayed HM, Rabie MA. Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K\/Akt\/GSK-3\u03b2 pathway. Int Immunopharmacol. 2023;115: 109647.","journal-title":"Int Immunopharmacol"},{"key":"6201_CR263","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104784","volume":"157","author":"Y Wang","year":"2020","unstructured":"Wang Y, Li N, Yang JJ, Zhao DM, Chen B, Zhang GQ, et al. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacol Res. 2020;157: 104784.","journal-title":"Pharmacol Res"},{"key":"6201_CR264","doi-asserted-by":"publisher","first-page":"1481390","DOI":"10.3389\/fnins.2024.1481390","volume":"18","author":"KJ Park","year":"2024","unstructured":"Park KJ, Gao Y. Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials. Front Neurosci. 2024;18:1481390.","journal-title":"Front Neurosci"},{"issue":"3","key":"6201_CR265","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.clnu.2018.05.018","volume":"38","author":"OR Tamtaji","year":"2019","unstructured":"Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R, Kouchaki E, Bahmani F, Borzabadi S, et al. Clinical and metabolic response to probiotic administration in people with Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019;38(3):1031\u20135.","journal-title":"Clin Nutr"},{"issue":"2","key":"6201_CR266","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/gutjnl-2018-317431","volume":"69","author":"MS Kim","year":"2020","unstructured":"Kim MS, Kim Y, Choi H, Kim W, Park S, Lee D, et al. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer\u2019s disease animal model. Gut. 2020;69(2):283\u201394.","journal-title":"Gut"},{"issue":"1","key":"6201_CR267","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","volume":"9","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Ning J, Bao XQ, Shang M, Ma J, Li G, et al. Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome. 2021;9(1):226.","journal-title":"Microbiome"},{"issue":"6","key":"6201_CR268","volume":"16","author":"J Sanzone","year":"2024","unstructured":"Sanzone J, Life M, Reiss D, May D, Hartley B, Spiddle P, et al. Uses of fecal microbiota transplantation in neurodegenerative disease: a scoping review. Cureus. 2024;16(6): e62265.","journal-title":"Cureus"},{"key":"6201_CR269","doi-asserted-by":"publisher","first-page":"1104759","DOI":"10.3389\/fneur.2023.1104759","volume":"14","author":"HL DuPont","year":"2023","unstructured":"DuPont HL, Suescun J, Jiang ZD, Brown EL, Essigmann HT, Alexander AS, et al. Fecal microbiota transplantation in Parkinson\u2019s disease-a randomized repeat-dose, placebo-controlled clinical pilot study. Front Neurol. 2023;14:1104759.","journal-title":"Front Neurol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06201-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06201-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06201-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T17:47:27Z","timestamp":1740419247000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06201-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":269,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6201"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06201-2","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All methods were conducted in accordance with institution-specific regulations. This review synthesized previously published, publicly available, and de-identified data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no known financial conflicts of interest or personal relationships that could have influenced the work reported in this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"223"}}