{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T02:14:11Z","timestamp":1794536051997,"version":"4.9.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600862"],"award-info":[{"award-number":["81600862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860195"],"award-info":[{"award-number":["81860195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170939"],"award-info":[{"award-number":["82170939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010519"],"award-info":[{"award-number":["2023A1515010519"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["822CXTD534"],"award-info":[{"award-number":["822CXTD534"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2021SHFZ229"],"award-info":[{"award-number":["ZDYF2021SHFZ229"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06214-x","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:50:50Z","timestamp":1740131450000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Monocytic myeloid-derived suppressor cells contribute to the exacerbation of bone destruction in periodontitis"],"prefix":"10.1186","volume":"23","author":[{"given":"Zhaocai","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-0570","authenticated-orcid":false,"given":"Zhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"6214_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fneur.2019.00323","volume":"10","author":"PC Nascimento","year":"2019","unstructured":"Nascimento PC, Castro MML, Magno MB, et al. Association between periodontitis and cognitive impairment in adults: a systematic review. Front Neurol. 2019;10:323.","journal-title":"Front Neurol"},{"key":"6214_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12344","volume":"83","author":"RJ Genco","year":"2020","unstructured":"Genco RJ, Sanz M. Clinical and public health implications of periodontal and systemic diseases: an overview. Periodontol 2000. 2020;83:7\u201313.","journal-title":"Periodontol 2000"},{"key":"6214_CR3","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1177\/0022034521995157","volume":"100","author":"MG Balta","year":"2021","unstructured":"Balta MG, Papathanasiou E, Blix IJ, et al. Host modulation and treatment of periodontal disease. J Dent Res. 2021;100:798\u2013809.","journal-title":"J Dent Res"},{"key":"6214_CR4","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.apsb.2022.10.026","volume":"13","author":"J Luan","year":"2023","unstructured":"Luan J, Li R, Xu W, et al. Functional biomaterials for comprehensive periodontitis therapy. Acta Pharm Sin B. 2023;13:2310\u201333.","journal-title":"Acta Pharm Sin B"},{"key":"6214_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","volume":"9","author":"DI Gabrilovich","year":"2009","unstructured":"Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162\u201374.","journal-title":"Nat Rev Immunol"},{"key":"6214_CR6","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.coi.2010.01.021","volume":"22","author":"E Peranzoni","year":"2010","unstructured":"Peranzoni E, Zilio S, Marigo I, et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol. 2010;22:238\u201344.","journal-title":"Curr Opin Immunol"},{"key":"6214_CR7","doi-asserted-by":"publisher","first-page":"12150","DOI":"10.1038\/ncomms12150","volume":"7","author":"V Bronte","year":"2016","unstructured":"Bronte V, Brandau S, Chen SH, et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016;7:12150.","journal-title":"Nat Commun"},{"key":"6214_CR8","doi-asserted-by":"crossref","unstructured":"Ma T, Renz BW, Ilmer M et al. Myeloid-derived suppressor cells in solid tumors. Cells. 2022;11.","DOI":"10.3390\/cells11020310"},{"key":"6214_CR9","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1038\/s41388-019-1084-z","volume":"39","author":"R Cheng","year":"2020","unstructured":"Cheng R, Billet S, Liu C, et al. Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Oncogene. 2020;39:1543\u201356.","journal-title":"Oncogene"},{"key":"6214_CR10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/00220345211040729","volume":"101","author":"KH Kwack","year":"2022","unstructured":"Kwack KH, Zhang L, Sohn J, et al. Novel preosteoclast populations in obesity-associated periodontal disease. J Dent Res. 2022;101:348\u201356.","journal-title":"J Dent Res"},{"key":"6214_CR11","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/ni.3771","volume":"18","author":"YG Chen","year":"2017","unstructured":"Chen YG, Satpathy AT, Chang HY. Gene regulation in the immune system by long noncoding rnas. Nat Immunol. 2017;18:962\u201372.","journal-title":"Nat Immunol"},{"key":"6214_CR12","first-page":"2903","volume":"42","author":"R Liu","year":"2018","unstructured":"Liu R, Tang A, Wang X, et al. Inhibition of lncrna neat1 suppresses the inflammatory response in ibd by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages. Int J Mol Med. 2018;42:2903\u201313.","journal-title":"Int J Mol Med"},{"key":"6214_CR13","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1080\/21655979.2021.2018387","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Lv H, Cui Y, et al. The role of long non-coding rna (lncrna) nuclear paraspeckle assembly transcript 1 (neat1) in chronic periodontitis progression. Bioengineered. 2022;13:2336\u201345.","journal-title":"Bioengineered"},{"key":"6214_CR14","doi-asserted-by":"crossref","unstructured":"Murakami T, Nakaminami Y, Takahata Y et al. Activation and function of nlrp3 inflammasome in bone and joint-related diseases. Int J Mol Sci. 2022;23.","DOI":"10.3390\/ijms23105365"},{"key":"6214_CR15","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/s41467-019-09482-6","volume":"10","author":"P Zhang","year":"2019","unstructured":"Zhang P, Cao L, Zhou R, et al. The lncrna neat1 promotes activation of inflammasomes in macrophages. Nat Commun. 2019;10:1495.","journal-title":"Nat Commun"},{"key":"6214_CR16","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1016\/j.cell.2021.05.013","volume":"184","author":"DW Williams","year":"2021","unstructured":"Williams DW, Greenwell-Wild T, Brenchley L, et al. Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell. 2021;184:4090\u2013e41044015.","journal-title":"Cell"},{"key":"6214_CR17","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.7150\/thno.65694","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen Y, Wang H, Yang Q, et al. Single-cell rna landscape of the osteoimmunology microenvironment in periodontitis. Theranostics. 2022;12:1074\u201396.","journal-title":"Theranostics"},{"key":"6214_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","volume":"19","author":"FA Wolf","year":"2018","unstructured":"Wolf FA, Angerer P, Theis FJ, Scanpy. Large-scale single-cell gene expression data analysis. Genome Biol. 2018;19:15.","journal-title":"Genome Biol"},{"key":"6214_CR19","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41592-018-0229-2","volume":"15","author":"R Lopez","year":"2018","unstructured":"Lopez R, Regier J, Cole MB, et al. Deep generative modeling for single-cell transcriptomics. Nat Methods. 2018;15:1053\u20138.","journal-title":"Nat Methods"},{"key":"6214_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cels.2020.05.010","volume":"11","author":"NJ Bernstein","year":"2020","unstructured":"Bernstein NJ, Fong NL, Lam I, et al. Solo: doublet identification in single-cell rna-seq via semi-supervised deep learning. Cell Syst. 2020;11:95\u2013e101105.","journal-title":"Cell Syst"},{"key":"6214_CR21","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","volume":"181","author":"L Zhang","year":"2020","unstructured":"Zhang L, Li Z, Skrzypczynska KM, et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell. 2020;181:442\u2013e459429.","journal-title":"Cell"},{"key":"6214_CR22","doi-asserted-by":"crossref","unstructured":"Alshetaiwi H, Pervolarakis N, McIntyre LL et al. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Sci Immunol. 2020;5.","DOI":"10.1126\/sciimmunol.aay6017"},{"key":"6214_CR23","doi-asserted-by":"publisher","first-page":"vbac016","DOI":"10.1093\/bioadv\/vbac016","volume":"2","author":"IMP Badia","year":"2022","unstructured":"Badia IMP, V\u00e9lez Santiago J, Braunger J, et al. Decoupler: ensemble of computational methods to infer biological activities from omics data. Bioinform Adv. 2022;2:vbac016.","journal-title":"Bioinform Adv"},{"key":"6214_CR24","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","volume":"13","author":"J Marchesan","year":"2018","unstructured":"Marchesan J, Girnary MS, Jing L, et al. An experimental murine model to study periodontitis. Nat Protoc. 2018;13:2247\u201367.","journal-title":"Nat Protoc"},{"key":"6214_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12943-021-01460-1","volume":"20","author":"B Cai","year":"2021","unstructured":"Cai B, Liu Y, Chong Y, et al. Irak1-regulated ifn-\u03b3 signaling induces mdsc to facilitate immune evasion in fgfr1-driven hematological malignancies. Mol Cancer. 2021;20:165.","journal-title":"Mol Cancer"},{"key":"6214_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41368-021-00150-4","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Chen J, Fu H, et al. Exosomes derived from 3d-cultured mscs improve therapeutic effects in periodontitis and experimental colitis and restore the th17 cell\/treg balance in inflamed periodontium. Int J Oral Sci. 2021;13:43.","journal-title":"Int J Oral Sci"},{"key":"6214_CR27","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1158\/0008-5472.CAN-13-0305","volume":"73","author":"A Sawant","year":"2013","unstructured":"Sawant A, Ponnazhagan S. Myeloid-derived suppressor cells as osteoclast progenitors: a novel target for controlling osteolytic bone metastasis. Cancer Res. 2013;73:4606\u201310.","journal-title":"Cancer Res"},{"key":"6214_CR28","doi-asserted-by":"publisher","first-page":"567783","DOI":"10.3389\/fimmu.2020.567783","volume":"11","author":"L Zhong","year":"2020","unstructured":"Zhong L, Li S, Wen Y, et al. Expansion of polymorphonuclear myeloid-derived suppressor cells in patients with gout. Front Immunol. 2020;11:567783.","journal-title":"Front Immunol"},{"key":"6214_CR29","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jaut.2015.08.010","volume":"65","author":"H Zhang","year":"2015","unstructured":"Zhang H, Huang Y, Wang S, et al. Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts. J Autoimmun. 2015;65:82\u20139.","journal-title":"J Autoimmun"},{"key":"6214_CR30","doi-asserted-by":"publisher","first-page":"14979","DOI":"10.1038\/ncomms14979","volume":"8","author":"M Ouzounova","year":"2017","unstructured":"Ouzounova M, Lee E, Piranlioglu R, et al. Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade. Nat Commun. 2017;8:14979.","journal-title":"Nat Commun"},{"key":"6214_CR31","doi-asserted-by":"publisher","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.","journal-title":"Nat Rev Dis Primers"},{"key":"6214_CR32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.actbio.2022.02.007","volume":"142","author":"S Lin","year":"2022","unstructured":"Lin S, Wen Z, Li S, et al. Lncrna neat1 promotes the macrophage inflammatory response and acts as a therapeutic target in titanium particle-induced osteolysis. Acta Biomater. 2022;142:345\u201360.","journal-title":"Acta Biomater"},{"key":"6214_CR33","first-page":"1174","volume":"12","author":"J Ma","year":"2019","unstructured":"Ma J, Zhao N, Du L, et al. Downregulation of lncrna neat1 inhibits mouse mesangial cell proliferation, fibrosis, and inflammation but promotes apoptosis in diabetic nephropathy. Int J Clin Exp Pathol. 2019;12:1174\u201383.","journal-title":"Int J Clin Exp Pathol"},{"key":"6214_CR34","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.tibs.2017.12.001","volume":"43","author":"AH Fox","year":"2018","unstructured":"Fox AH, Nakagawa S, Hirose T, et al. Paraspeckles: where long noncoding rna meets phase separation. Trends Biochem Sci. 2018;43:124\u201335.","journal-title":"Trends Biochem Sci"},{"key":"6214_CR35","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","volume":"164","author":"Z Zhong","year":"2016","unstructured":"Zhong Z, Umemura A, Sanchez-Lopez E, et al. Nf-\u03bab restricts inflammasome activation via elimination of damaged mitochondria. Cell. 2016;164:896\u2013910.","journal-title":"Cell"},{"key":"6214_CR36","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1093\/rheumatology\/keaa625","volume":"60","author":"S Chen","year":"2021","unstructured":"Chen S, Guo C, Wang R, et al. Monocytic mdscs skew th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2021;60:2409\u201320.","journal-title":"Rheumatology (Oxford)"},{"key":"6214_CR37","doi-asserted-by":"publisher","first-page":"331ra340","DOI":"10.1126\/scitranslmed.aae0482","volume":"8","author":"H Wu","year":"2016","unstructured":"Wu H, Zhen Y, Ma Z, et al. Arginase-1-dependent promotion of th17 differentiation and disease progression by mdscs in systemic lupus erythematosus. Sci Transl Med. 2016;8:331ra340.","journal-title":"Sci Transl Med"},{"key":"6214_CR38","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/annrheumdis-2014-205508","volume":"75","author":"C Guo","year":"2016","unstructured":"Guo C, Hu F, Yi H, et al. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. Ann Rheum Dis. 2016;75:278\u201385.","journal-title":"Ann Rheum Dis"},{"key":"6214_CR39","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/JLB.3MA0121-045R","volume":"110","author":"N Zhou","year":"2021","unstructured":"Zhou N, Zou F, Cheng X, et al. Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis. J Leukoc Biol. 2021;110:461\u201373.","journal-title":"J Leukoc Biol"},{"key":"6214_CR40","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41423-023-01004-1","volume":"20","author":"K Rui","year":"2023","unstructured":"Rui K, Peng N, Xiao F, et al. New insights into the functions of mdscs in autoimmune pathogenesis. Cell Mol Immunol. 2023;20:548\u201350.","journal-title":"Cell Mol Immunol"},{"key":"6214_CR41","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41571-023-00846-y","volume":"21","author":"SA Lasser","year":"2024","unstructured":"Lasser SA, Ozbay Kurt FG, Arkhypov I, et al. Myeloid-derived suppressor cells in cancer and cancer therapy. Nat Rev Clin Oncol. 2024;21:147\u201364.","journal-title":"Nat Rev Clin Oncol"},{"key":"6214_CR42","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1038\/s41423-020-0500-1","volume":"18","author":"Z Shen","year":"2021","unstructured":"Shen Z, Kuang S, Zhang M, et al. Inhibition of ccl2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties. Cell Mol Immunol. 2021;18:2224\u201335.","journal-title":"Cell Mol Immunol"},{"key":"6214_CR43","doi-asserted-by":"publisher","first-page":"e2400528121","DOI":"10.1073\/pnas.2400528121","volume":"121","author":"M Shehabeldin","year":"2024","unstructured":"Shehabeldin M, Gao J, Cho Y, et al. Therapeutic delivery of ccl2 modulates immune response and restores host-microbe homeostasis. Proc Natl Acad Sci U S A. 2024;121:e2400528121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6214_CR44","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41590-018-0249-1","volume":"20","author":"I Kourtzelis","year":"2019","unstructured":"Kourtzelis I, Li X, Mitroulis I, et al. Del-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 2019;20:40\u20139.","journal-title":"Nat Immunol"},{"key":"6214_CR45","doi-asserted-by":"publisher","first-page":"e2308587","DOI":"10.1002\/advs.202308587","volume":"11","author":"Y Wang","year":"2024","unstructured":"Wang Y, Chu T, Jin T, et al. Cascade reactions catalyzed by gold hybrid nanoparticles generate co gas against periodontitis in diabetes. Adv Sci (Weinh). 2024;11:e2308587.","journal-title":"Adv Sci (Weinh)"},{"key":"6214_CR46","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.clim.2015.02.001","volume":"157","author":"H Zhang","year":"2015","unstructured":"Zhang H, Wang S, Huang Y, et al. Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating th17 cell differentiation. Clin Immunol. 2015;157:175\u201386.","journal-title":"Clin Immunol"},{"key":"6214_CR47","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41419-023-06132-0","volume":"14","author":"S Chen","year":"2023","unstructured":"Chen S, Wang J, Zhang K, et al. Lncrna neat1 targets nono and mir-128-3p to promote antigen-specific th17 cell responses and autoimmune inflammation. Cell Death Dis. 2023;14:610.","journal-title":"Cell Death Dis"},{"key":"6214_CR48","doi-asserted-by":"publisher","first-page":"165554","DOI":"10.1016\/j.bbadis.2019.165554","volume":"1866","author":"G Dong","year":"2020","unstructured":"Dong G, Yang Y, Li X, et al. Granulocytic myeloid-derived suppressor cells contribute to ifn-i signaling activation of b cells and disease progression through the lncrna neat1-baff axis in systemic lupus erythematosus. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165554.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"6214_CR49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/jre.13069","volume":"58","author":"T Zhang","year":"2023","unstructured":"Zhang T, Yang K, Chen Y, et al. Impaired autophagy flux by lncrna neat1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment. J Periodontal Res. 2023;58:70\u201382.","journal-title":"J Periodontal Res"},{"key":"6214_CR50","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1530\/JME-18-0098","volume":"61","author":"YH Bai","year":"2018","unstructured":"Bai YH, Lv Y, Wang WQ, et al. Lncrna neat1 promotes inflammatory response and induces corneal neovascularization. J Mol Endocrinol. 2018;61:231\u20139.","journal-title":"J Mol Endocrinol"},{"key":"6214_CR51","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, et al. Nf-\u03bab signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023.","journal-title":"Signal Transduct Target Ther"},{"key":"6214_CR52","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.4049\/jimmunol.0800909","volume":"182","author":"MT Huang","year":"2009","unstructured":"Huang MT, Taxman DJ, Holley-Guthrie EA, et al. Critical role of apoptotic speck protein containing a caspase recruitment domain (asc) and nlrp3 in causing necrosis and asc speck formation induced by porphyromonas gingivalis in human cells. J Immunol. 2009;182:2395\u2013404.","journal-title":"J Immunol"},{"key":"6214_CR53","doi-asserted-by":"publisher","first-page":"100889","DOI":"10.1016\/j.mam.2020.100889","volume":"76","author":"L Wang","year":"2020","unstructured":"Wang L, Hauenstein AV. The nlrp3 inflammasome: mechanism of action, role in disease and therapies. Mol Aspects Med. 2020;76:100889.","journal-title":"Mol Aspects Med"},{"key":"6214_CR54","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","volume":"117","author":"CA Dinarello","year":"2011","unstructured":"Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011;117:3720\u201332.","journal-title":"Blood"},{"key":"6214_CR55","doi-asserted-by":"publisher","first-page":"e12973","DOI":"10.1111\/cpr.12973","volume":"54","author":"Y Chen","year":"2021","unstructured":"Chen Y, Yang Q, Lv C, et al. Nlrp3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. Cell Prolif. 2021;54:e12973.","journal-title":"Cell Prolif"},{"key":"6214_CR56","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1158\/1078-0432.CCR-16-1784","volume":"23","author":"GA Dominguez","year":"2017","unstructured":"Dominguez GA, Condamine T, Mony S, et al. Selective targeting of myeloid-derived suppressor cells in cancer patients using ds-8273a, an agonistic trail-r2 antibody. Clin Cancer Res. 2017;23:2942\u201350.","journal-title":"Clin Cancer Res"},{"key":"6214_CR57","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/ard-2023-224762","volume":"83","author":"A Fanouriakis","year":"2024","unstructured":"Fanouriakis A, Kostopoulou M, Andersen J, et al. Eular recommendations for the management of systemic lupus erythematosus: 2023 update. Ann Rheum Dis. 2024;83:15\u201329.","journal-title":"Ann Rheum Dis"},{"key":"6214_CR58","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1136\/annrheumdis-2021-220920","volume":"81","author":"RA Furie","year":"2022","unstructured":"Furie RA, Aroca G, Cascino MD, et al. B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2022;81:100\u20137.","journal-title":"Ann Rheum Dis"},{"key":"6214_CR59","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.4049\/jimmunol.2400332","volume":"213","author":"M Shehabeldin","year":"2024","unstructured":"Shehabeldin M, Kobyra J, Cho Y, et al. Local controlled delivery of il-4 decreases inflammatory bone loss in a murine model of periodontal disease. J Immunol. 2024;213:1635\u201343.","journal-title":"J Immunol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06214-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:50:58Z","timestamp":1740131458000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06214-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6214"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06214-x","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"20 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal study protocol was approved by the Ethics Committee of the Animal Care and Use Committee of Sun Yat-sen University (No. 2024001340). The human subject protocol was approved by the Medical Ethics Committee of Hospital of Stomatology, Sun Yat-sen University (KQEC-2022-06), and all participants had informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have reviewed the final version of the manuscript and approved it for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"217"}}