{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:09:51Z","timestamp":1789434591419,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["CTU\/PM-ABHIM\/17\/10\/34\/2023-ECD-II"],"award-info":[{"award-number":["CTU\/PM-ABHIM\/17\/10\/34\/2023-ECD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06286-9","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:57:29Z","timestamp":1741863449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MiR-451a attenuates hepatic steatosis and hepatitis C virus replication by targeting glycerol kinase"],"prefix":"10.1186","volume":"23","author":[{"given":"Swagata","family":"Majumdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeya Roy","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidhan Chandra","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simanti","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1828-9810","authenticated-orcid":false,"given":"Soma","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"issue":"1","key":"6286_CR1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3390\/ijms23010500","volume":"23","author":"FP Russo","year":"2022","unstructured":"Russo FP, Zanetto A, Pinto E, Battistella S, Penzo B, Burra P, Farinati F. Hepatocellular carcinoma in chronic viral hepatitis: where do we stand?? Int J Mol Sci. 2022;23(1):500.","journal-title":"Int J Mol Sci"},{"issue":"18","key":"6286_CR2","doi-asserted-by":"publisher","first-page":"14404","DOI":"10.3390\/ijms241814404","volume":"24","author":"JV Lazarus","year":"2023","unstructured":"Lazarus JV, Picchio CA, Colombo M. Hepatocellular carcinoma prevention in the era of hepatitis C elimination. Int J Mol Sci. 2023;24(18):14404.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"6286_CR3","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/s41575-023-00760-9","volume":"20","author":"YC Hsu","year":"2023","unstructured":"Hsu YC, Huang DQ, Nguyen MH. Global burden of hepatitis B virus: current status, missed opportunities and a call for action. Nat Rev Gastroenterol Hepatol. 2023;20(8):524\u201337.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"6286_CR4","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/cbin.11565","volume":"45","author":"ST Strumillo","year":"2021","unstructured":"Strumillo ST, Kartavykh D, de Carvalho FF Jr, Cruz NC, de Souza Teodoro AC, Sobhie Diaz R, Curcio MF. Host-virus interaction and viral evasion. Cell Biol Int. 2021;45(6):1124\u201347.","journal-title":"Cell Biol Int"},{"key":"6286_CR5","doi-asserted-by":"crossref","unstructured":"Schneider M, Johnson JR, Krogan NJ, Chanda SK. The Virus\u2013Host interactome: knowing the players to understand the game. Viral Pathogenesis. 2016:157\u201367.","DOI":"10.1016\/B978-0-12-800964-2.00012-4"},{"issue":"6","key":"6286_CR6","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3945\/an.113.004648","volume":"4","author":"DG Mashek","year":"2013","unstructured":"Mashek DG. Hepatic fatty acid trafficking: multiple forks in the road. Adv Nutr. 2013;4(6):697\u2013710.","journal-title":"Adv Nutr"},{"issue":"4","key":"6286_CR7","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.3748\/wjg.v22.i4.1664","volume":"22","author":"C Ress","year":"2016","unstructured":"Ress C, Kaser S. Mechanisms of intrahepatic triglyceride accumulation. World J Gastroenterol. 2016;22(4):1664\u201373.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"6286_CR8","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1053\/j.gastro.2003.11.020","volume":"126","author":"A Lonardo","year":"2004","unstructured":"Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology. 2004;126(2):586\u201397.","journal-title":"Gastroenterology"},{"key":"6286_CR9","doi-asserted-by":"publisher","first-page":"636897","DOI":"10.3389\/fmicb.2021.636897","volume":"12","author":"J Zhang","year":"2021","unstructured":"Zhang J, Ling N, Lei Y, Peng M, Hu P, Chen M. Multifaceted interaction between hepatitis B virus infection and lipid metabolism in hepatocytes: A potential target of antiviral therapy for chronic hepatitis B. Front Microbiol. 2021;12:636897.","journal-title":"Front Microbiol"},{"issue":"8","key":"6286_CR10","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.meegid.2012.07.010","volume":"12","author":"B Samreen","year":"2012","unstructured":"Samreen B, Khaliq S, Ashfaq UA, Khan M, Afzal N, Shahzad MA, Riaz S, Jahan S. Hepatitis C virus entry: role of host and viral factors. Infect Genet Evol. 2012;12(8):1699\u2013709.","journal-title":"Infect Genet Evol"},{"issue":"8","key":"6286_CR11","doi-asserted-by":"publisher","first-page":"e0270273","DOI":"10.1371\/journal.pone.0270273","volume":"17","author":"A Hyrina","year":"2022","unstructured":"Hyrina A, Burdette D, Song Z, Ramirez R, Okesli-Armlovich A, Vijayakumar A, Bates J, Trevaskis JL, Fletcher SP, Lee WA, Holdorf MM. Targeting lipid biosynthesis pathways for hepatitis B virus cure. PLoS ONE. 2022;17(8):e0270273.","journal-title":"PLoS ONE"},{"key":"6286_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1146\/annurev-nutr-081810-160756","volume":"31","author":"KJ Moore","year":"2011","unstructured":"Moore KJ, Rayner KJ, Su\u00e1rez Y, Fern\u00e1ndez-Hernando C. The role of MicroRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr. 2011;31:49\u201363.","journal-title":"Annu Rev Nutr"},{"issue":"9","key":"6286_CR13","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1128\/JVI.03022-12","volume":"87","author":"T Shirasaki","year":"2013","unstructured":"Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, Sakai A, Okada H, Watanabe R, Murakami S, Yi M, Lemon SM, Kaneko S. MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells. J Virol. 2013;87(9):5270\u201386.","journal-title":"J Virol"},{"key":"6286_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.isci.2018.11.028","volume":"10","author":"TA Shaw","year":"2018","unstructured":"Shaw TA, Singaravelu R, Powdrill MH, Nhan J, Ahmed N, \u00d6zcelik D, Pezacki JP. MicroRNA-124 regulates fatty acid and triglyceride homeostasis. iScience. 2018;10:149\u201357.","journal-title":"iScience"},{"issue":"8","key":"6286_CR15","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.3390\/v14081776","volume":"14","author":"HC Li","year":"2022","unstructured":"Li HC, Yang CH, Lo SY. Roles of MicroRNAs in hepatitis C virus replication and pathogenesis. Viruses. 2022;14(8):1776.","journal-title":"Viruses"},{"issue":"9","key":"6286_CR16","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1080\/15476286.2020.1768353","volume":"17","author":"S Ghosh","year":"2020","unstructured":"Ghosh S, Chakraborty J, Goswami A, Bhowmik S, Roy S, Ghosh A, Dokania S, Kumari P, Datta S, Chowdhury A, Bhattacharyya SN, Chatterjee R, Banerjee S. A novel MicroRNA boosts hyper-\u03b2-oxidation of fatty acids in liver by impeding CEP350-mediated sequestration of PPAR\u03b1 and thus restricts chronic hepatitis C. RNA Biol. 2020;17(9):1352\u201363.","journal-title":"RNA Biol"},{"issue":"5","key":"6286_CR17","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1053\/j.gastro.2007.08.005","volume":"133","author":"JM Gottwein","year":"2007","unstructured":"Gottwein JM, Scheel TK, Hoegh AM, Lademann JB, Eugen-Olsen J, Lisby G, Bukh J. Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a\/2a (S52\/JFH1) viruses. Gastroenterology. 2007;133(5):1614\u201326.","journal-title":"Gastroenterology"},{"key":"6286_CR18","doi-asserted-by":"crossref","unstructured":"Shih CH, Li LS, Roychoudhury S. In vitro propagation of human hepatitis B virus in a rat hepatoma cell Line.August 15, 1989. 86 (16) 6323\u20137.","DOI":"10.1073\/pnas.86.16.6323"},{"issue":"2","key":"6286_CR19","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1371\/journal.pmed.1000031","volume":"6","author":"JF Drexler","year":"2009","unstructured":"Drexler JF, Kupfer B, Petersen N, Grotto RM, Rodrigues SM, Grywna K, Panning M, Annan A, Silva GF, Douglas J, Koay ES, Smuts H, Netto EM, Simmonds P, Pardini MI, Roth WK, Drosten C. A novel diagnostic target in the hepatitis C virus genome. PLoS Med. 2009;6(2):e31.","journal-title":"PLoS Med"},{"issue":"10","key":"6286_CR20","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1002\/ijc.33111","volume":"147","author":"S Ghosh","year":"2020","unstructured":"Ghosh S, Bhowmik S, Majumdar S, Goswami A, Chakraborty J, Gupta S, Aggarwal S, Ray S, Chatterjee R, Bhattacharyya S, Dutta M, Datta S, Chowdhury A, Dhali GK, Banerjee S. The exosome encapsulated MicroRNAs as Circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. Int J Cancer. 2020;147(10):2934\u201347.","journal-title":"Int J Cancer"},{"issue":"9","key":"6286_CR21","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109(9):1125\u201331.","journal-title":"J Clin Invest"},{"issue":"15","key":"6286_CR22","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.2174\/13816128113199990486","volume":"20","author":"D Guo","year":"2014","unstructured":"Guo D, Bell EH, Mischel P, Chakravarti A. Targeting SREBP-1-driven lipid metabolism to treat cancer. Curr Pharm Des. 2014;20(15):2619\u201326.","journal-title":"Curr Pharm Des"},{"issue":"5","key":"6286_CR23","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.tibs.2018.01.005","volume":"43","author":"RA DeBose-Boyd","year":"2018","unstructured":"DeBose-Boyd RA, Ye J. SREBPs in lipid metabolism, insulin signaling, and beyond. Trends Biochem Sci. 2018;43(5):358\u201368.","journal-title":"Trends Biochem Sci"},{"key":"6286_CR24","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1038\/s12276-023-01079-w","volume":"55","author":"M Xiao","year":"2023","unstructured":"Xiao M, Xu J, Wang W, et al. Functional significance of cholesterol metabolism in cancer: from threat to treatment. Exp Mol Med. 2023;55:1982\u201395.","journal-title":"Exp Mol Med"},{"issue":"3","key":"6286_CR25","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3892\/mmr.2014.2957","volume":"11","author":"Z Su","year":"2015","unstructured":"Su Z, Ni L, Yu W, Yu Z, Chen D, Zhang E, Li Y, Wang Y, Li X, Yang S, Gui Y, Lai Y, Ye J. MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma. Mol Med Rep. 2015;11(3):2248\u201354.","journal-title":"Mol Med Rep"},{"issue":"1","key":"6286_CR26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12943-021-01343-5","volume":"20","author":"J Zhao","year":"2021","unstructured":"Zhao J, Li H, Zhao S, Wang E, Zhu J, Feng D, Zhu Y, Dou W, Fan Q, Hu J, Jia L, Liu L. Epigenetic Silencing of miR-144\/451a cluster contributes to HCC progression via paracrine HGF\/MIF-mediated TAM remodeling. Mol Cancer. 2021;20(1):46.","journal-title":"Mol Cancer"},{"issue":"12","key":"6286_CR27","first-page":"5158","volume":"23","author":"GY Wei","year":"2019","unstructured":"Wei GY, Hu M, Zhao L, Guo WS. MiR-451a suppresses cell proliferation, metastasis and EMT via targeting YWHAZ in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2019;23(12):5158\u201367.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"6286_CR28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1161\/CIRCRESAHA.116.304707","volume":"116","author":"Y Kuwabara","year":"2015","unstructured":"Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1\/AMPK pathway. Circ Res. 2015;116(2):279\u201388. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.304707. Epub 2014 Oct 31.","journal-title":"Circ Res"},{"key":"6286_CR29","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.mce.2018.03.016","volume":"474","author":"N Zeng","year":"2018","unstructured":"Zeng N, Huang R, Li N, Jiang H, Li R, Wang F, Chen W, Xia M, Wang Q. MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. Mol Cell Endocrinol. 2018;474:260\u201371.","journal-title":"Mol Cell Endocrinol"},{"key":"6286_CR30","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.canlet.2020.12.019","volume":"502","author":"J Chen","year":"2021","unstructured":"Chen J, Ding C, Chen Y, Hu W, Yu C, Peng C, Feng X, Cheng Q, Wu W, Lu Y, Xie H, Zhou L, Wu J, Zheng S. ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc\/SREBP1 pathway. Cancer Lett. 2021;502:154\u201365.","journal-title":"Cancer Lett"},{"issue":"1","key":"6286_CR31","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13046-022-02449-4","volume":"41","author":"Y Jia","year":"2022","unstructured":"Jia Y, Yan Q, Zheng Y, Li L, Zhang B, Chang Z, Wang Z, Tang H, Qin Y, Guan XY. Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun\/c-Fos\/SREBP1 axis in gastric cancer. J Exp Clin Cancer Res. 2022;41(1):287.","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"6286_CR32","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.21873\/anticanres.14944","volume":"41","author":"M Fukuda","year":"2021","unstructured":"Fukuda M, Ogasawara Y, Hayashi H, Okuyama A, Shiono J, Inoue K, Sakashita H. Down-regulation of glutathione peroxidase 4 in oral Cancer inhibits tumor growth through SREBP1 signaling. Anticancer Res. 2021;41(4):1785\u201392.","journal-title":"Anticancer Res"},{"issue":"7","key":"6286_CR33","doi-asserted-by":"publisher","first-page":"112790","DOI":"10.1016\/j.celrep.2023.112790","volume":"42","author":"F Geng","year":"2023","unstructured":"Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy TF, Yong WH, Chakravarti A, Guo D. SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells. Cell Rep. 2023;42(7):112790.","journal-title":"Cell Rep"},{"issue":"1","key":"6286_CR34","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13046-019-1288-7","volume":"38","author":"C Zhou","year":"2019","unstructured":"Zhou C, Qian W, Li J, Ma J, Chen X, Jiang Z, Cheng L, Duan W, Wang Z, Wu Z, Ma Q, Li X. High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer. J Exp Clin Cancer Res. 2019;38(1):302.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"6286_CR35","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10555-023-10156-5","volume":"43","author":"F Su","year":"2024","unstructured":"Su F, Koeberle A. Regulation and targeting of SREBP-1 in hepatocellular carcinoma. Cancer Metastasis Rev. 2024;43(2):673\u2013708.","journal-title":"Cancer Metastasis Rev"},{"issue":"Suppl 1","key":"6286_CR36","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1038\/sj.cdd.4401163","volume":"10","author":"D Schuppan","year":"2003","unstructured":"Schuppan D, Krebs A, Bauer M, Hahn EG. Hepatitis C and liver fibrosis. Cell Death Differ. 2003;10(Suppl 1):S59\u201367.","journal-title":"Cell Death Differ"},{"issue":"6","key":"6286_CR37","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.jhep.2008.06.022","volume":"49","author":"S McPherson","year":"2008","unstructured":"McPherson S, Jonsson JR, Barrie HD, O\u2019Rourke P, Clouston AD, Powell EE. Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis. J Hepatol. 2008;49(6):1046\u201354.","journal-title":"J Hepatol"},{"issue":"7","key":"6286_CR38","doi-asserted-by":"publisher","first-page":"e539","DOI":"10.1016\/j.ijid.2013.01.027","volume":"17","author":"JW Yu","year":"2013","unstructured":"Yu JW, Sun LJ, Liu W, Zhao YH, Kang P, Yan BZ. Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway. Int J Infect Dis. 2013;17(7):e539\u201345.","journal-title":"Int J Infect Dis"},{"issue":"1","key":"6286_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12944-017-0437-2","volume":"16","author":"SQ Arain","year":"2017","unstructured":"Arain SQ, Talpur FN, Channa NA, Ali MS, Afridi HI. Serum lipid profile as a marker of liver impairment in hepatitis B cirrhosis patients. Lipids Health Dis. 2017;16(1):51.","journal-title":"Lipids Health Dis"}],"updated-by":[{"DOI":"10.1186\/s12967-026-07996-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000}}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06286-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:02:55Z","timestamp":1774436575000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12967-025-06286-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6286"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06286-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"11 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Article updated for correcting Figures 3 and 4.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12967-026-07996-4","URL":"https:\/\/doi.org\/10.1186\/s12967-026-07996-4","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of the Institute of Postgraduate Medical Education & Research (IPGME&R), Kolkata has approved the study [Approval ID: Inst\/IEC\/2015\/108; dated 07 July 2015]. Patient\u2019s specimen was collected following the declaration of Helsinki and Istanbul. Written informed consent was obtained from all the participants or legal guardians. The study was conducted with archived specimens.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors disclosed to have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"322"}}