{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:32:52Z","timestamp":1792899172771,"version":"4.5.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation Youth Science Fund Project","award":["QN25H310018"],"award-info":[{"award-number":["QN25H310018"]}]},{"name":"Basic Research Program of Guizhou Province","award":["QianKeHe Basics-ZK [2023] General 583"],"award-info":[{"award-number":["QianKeHe Basics-ZK [2023] General 583"]}]},{"name":"Basic Research Program of Guizhou Province","award":["QianKeHe Basics-ZK [2023] General 326"],"award-info":[{"award-number":["QianKeHe Basics-ZK [2023] General 326"]}]},{"name":"Basic Research Project of Zunyi City","award":["Zunshi Kehe HZ Zi (2023) No.259"],"award-info":[{"award-number":["Zunshi Kehe HZ Zi (2023) No.259"]}]},{"name":"Project of Development Center for Medical Science & Technology, National Health Commission of the PRC","award":["WKZX2022JG0105"],"award-info":[{"award-number":["WKZX2022JG0105"]}]},{"name":"Elderly Health Research Project of Health Commission of Jiangsu Province","award":["LKM2022062"],"award-info":[{"award-number":["LKM2022062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Microglia-evoked neuroinflammation contributes to neurodegenerative diseases such as multiple sclerosis (MS). Metabolic reprogramming, including changes in polyunsaturated fatty acids (PUFAs), plays a critical role in MS pathophysiology. Previous studies identified reduced plasma \u03b1-dimorphecolic acid (\u03b1-DIPA), a linoleic acid derivative, in MS patients. This study investigated the anti-inflammatory effects of \u03b1-DIPA on microglia and the underlying pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lipopolysaccharide (LPS)-induced BV-2 microglial inflammation was used as an in vitro model. \u03b1-DIPA effects were assessed via ELISA for nitric oxide (NO) release, flow cytometry was used to examine cell proliferation, activation and polarization, and transcriptomic analysis was applied to identify key signaling pathways regulated by \u03b1-DIPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ELISA results showed that exogenous \u03b1-DIPA treatment significantly inhibited LPS-induced NO release from BV-2 cells in a concentration-dependent manner. Moreover, flow cytometry analysis suggested that 40 \u00b5M \u03b1-DIPA treatment significantly repressed LPS-induced BV-2 cell proliferation, activation, as well as M1 and M2 type polarization. Furthermore, transcriptome analysis revealed that exogenous \u03b1-DIPA extensively and drastically decreased the transcriptional level of numerous genes that are involved in the regulation of inflammatory responses, for instance, proinflammatory genes such as\n                      <jats:italic>Tnf<\/jats:italic>\n                      and\n                      <jats:italic>Ccl3<\/jats:italic>\n                      related to IL-17 and TNF-\u03b1 signaling. In addition, we also observed that the expression of multiple genes in NF-\u03baB signaling were also inhibited greatly by \u03b1-DIPA, such as\n                      <jats:italic>Nfkb2<\/jats:italic>\n                      and\n                      <jats:italic>Nfkbia<\/jats:italic>\n                      . Notably, \u03b1-DIPA robustly suppressed LPS-induced mRNA expression of abundant genes participating in the ferroptosis pathway, including\n                      <jats:italic>Acsl4<\/jats:italic>\n                      ,\n                      <jats:italic>Slc7a11<\/jats:italic>\n                      ,\n                      <jats:italic>Me1<\/jats:italic>\n                      , and\n                      <jats:italic>Hmox1<\/jats:italic>\n                      . Interestingly, the expressions of multiple ferroptosis-related genes were regulated specifically by \u03b1-DIPA but not LPS, such as\n                      <jats:italic>Acsl5<\/jats:italic>\n                      ,\n                      <jats:italic>Acsl6<\/jats:italic>\n                      ,\n                      <jats:italic>Alox5<\/jats:italic>\n                      ,\n                      <jats:italic>Cars<\/jats:italic>\n                      ,\n                      <jats:italic>Dpp3<\/jats:italic>\n                      ,\n                      <jats:italic>Dpp10<\/jats:italic>\n                      ,\n                      <jats:italic>Slc2a5<\/jats:italic>\n                      , and\n                      <jats:italic>Slc7a1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03b1-DIPA inhibits microglial inflammation likely through regulating the pathways of the ferroptosis and NF-\u03baB signaling. These results provided preliminary evidence for \u03b1-DIPA as a potential therapeutic candidate for neurodegenerative diseases like MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12967-025-06296-7","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:31:07Z","timestamp":1741066267000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Transcriptomic profiling identifies ferroptosis and NF-\u03baB signaling involved in \u03b1-dimorphecolic acid regulation of microglial inflammation"],"prefix":"10.1186","volume":"23","author":[{"given":"Xiao-Xi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-You","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Mei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-956X","authenticated-orcid":false,"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"issue":"2","key":"6296_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMra1401483","volume":"378","author":"DS Reich","year":"2018","unstructured":"Reich DS, Lucchinetti CF, Calabresi PA. Multiple Scler N Engl J Med. 2018;378(2):169\u201380.","journal-title":"Multiple Scler N Engl J Med"},{"issue":"6","key":"6296_CR2","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jnr.24090","volume":"96","author":"H Yong","year":"2018","unstructured":"Yong H, Chartier G, Quandt J. Modulating inflammation and neuroprotection in multiple sclerosis. J Neurosci Res. 2018;96(6):927\u201350.","journal-title":"J Neurosci Res"},{"issue":"10422","key":"6296_CR3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","volume":"403","author":"D Jakimovski","year":"2024","unstructured":"Jakimovski D, et al. Multiple sclerosis. Lancet. 2024;403(10422):183\u2013202.","journal-title":"Lancet"},{"issue":"14","key":"6296_CR4","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","volume":"26","author":"C Walton","year":"2020","unstructured":"Walton C, et al. Rising prevalence of multiple sclerosis worldwide: insights from the atlas of MS, third edition. Mult Scler. 2020;26(14):1816\u201321.","journal-title":"Mult Scler"},{"issue":"11","key":"6296_CR5","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1212\/WNL.0000000000000768","volume":"83","author":"P Browne","year":"2014","unstructured":"Browne P, et al. Atlas of multiple sclerosis 2013: A growing global problem with widespread inequity. Neurology. 2014;83(11):1022\u20134.","journal-title":"Neurology"},{"issue":"8","key":"6296_CR6","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1177\/1352458517694432","volume":"23","author":"G Kobelt","year":"2017","unstructured":"Kobelt G, et al. New insights into the burden and costs of multiple sclerosis in Europe. Mult Scler. 2017;23(8):1123\u201336.","journal-title":"Mult Scler"},{"issue":"5","key":"6296_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.molmed.2013.03.004","volume":"19","author":"A Haghikia","year":"2013","unstructured":"Haghikia A, et al. Therapies for multiple sclerosis: translational achievements and outstanding needs. Trends Mol Med. 2013;19(5):309\u201319.","journal-title":"Trends Mol Med"},{"key":"6296_CR8","doi-asserted-by":"publisher","first-page":"724718","DOI":"10.3389\/fphar.2021.724718","volume":"12","author":"W Wei","year":"2021","unstructured":"Wei W, et al. Progress in the application of drugs for the treatment of multiple sclerosis. Front Pharmacol. 2021;12:724718.","journal-title":"Front Pharmacol"},{"issue":"10","key":"6296_CR9","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1212\/WNL.0000000000004330","volume":"89","author":"J Lorscheider","year":"2017","unstructured":"Lorscheider J, et al. Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS. Neurology. 2017;89(10):1050\u20139.","journal-title":"Neurology"},{"issue":"10130","key":"6296_CR10","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","volume":"391","author":"AJ Thompson","year":"2018","unstructured":"Thompson AJ, et al. Multiple sclerosis. Lancet. 2018;391(10130):1622\u201336.","journal-title":"Lancet"},{"issue":"3","key":"6296_CR11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S1474-4422(24)00027-9","volume":"23","author":"J Chataway","year":"2024","unstructured":"Chataway J, et al. Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges. Lancet Neurol. 2024;23(3):277\u2013301.","journal-title":"Lancet Neurol"},{"issue":"7","key":"6296_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41583-024-00823-z","volume":"25","author":"MS Woo","year":"2024","unstructured":"Woo MS, Engler JB, Friese MA. The neuropathobiology of multiple sclerosis. Nat Rev Neurosci. 2024;25(7):493\u2013513.","journal-title":"Nat Rev Neurosci"},{"issue":"7878","key":"6296_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","volume":"597","author":"M Absinta","year":"2021","unstructured":"Absinta M, et al. A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis. Nature. 2021;597(7878):709\u201314.","journal-title":"Nature"},{"issue":"3","key":"6296_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41593-020-00780-7","volume":"24","author":"M Jafari","year":"2021","unstructured":"Jafari M, et al. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 2021;24(3):355\u201367.","journal-title":"Nat Neurosci"},{"issue":"1","key":"6296_CR15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.immuni.2019.12.004","volume":"52","author":"S Werneburg","year":"2020","unstructured":"Werneburg S, et al. Targeted complement Inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease. Immunity. 2020;52(1):167\u2013e1827.","journal-title":"Immunity"},{"issue":"6","key":"6296_CR16","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00401-021-02293-4","volume":"141","author":"L van Olst","year":"2021","unstructured":"van Olst L, et al. Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration. Acta Neuropathol. 2021;141(6):881\u201399.","journal-title":"Acta Neuropathol"},{"issue":"40","key":"6296_CR17","doi-asserted-by":"publisher","first-page":"10714","DOI":"10.1523\/JNEUROSCI.1922-07.2007","volume":"27","author":"ED Ponomarev","year":"2007","unstructured":"Ponomarev ED, et al. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci. 2007;27(40):10714\u201321.","journal-title":"J Neurosci"},{"issue":"6","key":"6296_CR18","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1002\/glia.23940","volume":"69","author":"SP das Neves","year":"2021","unstructured":"das Neves SP, et al. Altered astrocytic function in experimental neuroinflammation and multiple sclerosis. Glia. 2021;69(6):1341\u201368.","journal-title":"Glia"},{"issue":"7796","key":"6296_CR19","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41586-020-1999-0","volume":"578","author":"MA Wheeler","year":"2020","unstructured":"Wheeler MA, et al. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020;578(7796):593\u20139.","journal-title":"Nature"},{"issue":"6","key":"6296_CR20","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","volume":"177","author":"MS Ioannou","year":"2019","unstructured":"Ioannou MS, et al. Neuron-Astrocyte metabolic coupling protects against Activity-Induced fatty acid toxicity. Cell. 2019;177(6):1522\u2013e153514.","journal-title":"Cell"},{"issue":"7846","key":"6296_CR21","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","volume":"590","author":"LM Sanmarco","year":"2021","unstructured":"Sanmarco LM, et al. Gut-licensed IFNgamma(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes. Nature. 2021;590(7846):473\u20139.","journal-title":"Nature"},{"issue":"7883","key":"6296_CR22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","volume":"599","author":"KA Guttenplan","year":"2021","unstructured":"Guttenplan KA, et al. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021;599(7883):102\u20137.","journal-title":"Nature"},{"key":"6296_CR23","doi-asserted-by":"crossref","unstructured":"Kerkering J et al. iPSC-derived reactive astrocytes from patients with multiple sclerosis protect cocultured neurons in inflammatory conditions. J Clin Invest. 2023. 133(13).","DOI":"10.1172\/JCI164637"},{"key":"6296_CR24","doi-asserted-by":"crossref","unstructured":"Kapell H et al. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J Clin Invest. 2023. 133(7).","DOI":"10.1172\/JCI164223"},{"issue":"2","key":"6296_CR25","doi-asserted-by":"publisher","first-page":"eaax5936","DOI":"10.1126\/sciadv.aax5936","volume":"6","author":"KS Evonuk","year":"2020","unstructured":"Evonuk KS, et al. Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Sci Adv. 2020;6(2):eaax5936.","journal-title":"Sci Adv"},{"issue":"1","key":"6296_CR26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41420-022-00929-2","volume":"8","author":"XR Ma","year":"2022","unstructured":"Ma XR, et al. Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-kappaB pathway. Cell Death Discov. 2022;8(1):147.","journal-title":"Cell Death Discov"},{"issue":"3","key":"6296_CR27","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/ana.21581","volume":"65","author":"S Mi","year":"2009","unstructured":"Mi S, et al. Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann Neurol. 2009;65(3):304\u201315.","journal-title":"Ann Neurol"},{"issue":"12","key":"6296_CR28","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","volume":"15","author":"RP Bazinet","year":"2014","unstructured":"Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15(12):771\u201385.","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"6296_CR29","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1093\/brain\/awab040","volume":"144","author":"AK Fleck","year":"2021","unstructured":"Fleck AK, et al. Dietary conjugated Linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity. Brain. 2021;144(4):1152\u201366.","journal-title":"Brain"},{"issue":"1","key":"6296_CR30","doi-asserted-by":"publisher","first-page":"e2209990120","DOI":"10.1073\/pnas.2209990120","volume":"120","author":"LQ Zhou","year":"2023","unstructured":"Zhou LQ, et al. Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of Linoleic acid. Proc Natl Acad Sci U S A. 2023;120(1):e2209990120.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6296_CR31","doi-asserted-by":"publisher","first-page":"103569","DOI":"10.1016\/j.mcn.2020.103569","volume":"109","author":"JR Lowry","year":"2020","unstructured":"Lowry JR, et al. The dietary fatty acids alpha-linolenic acid (ALA) and Linoleic acid (LA) selectively inhibit microglial nitric oxide production. Mol Cell Neurosci. 2020;109:103569.","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"6296_CR32","doi-asserted-by":"publisher","first-page":"6644","DOI":"10.1038\/s41598-024-56959-6","volume":"14","author":"L Jantzen","year":"2024","unstructured":"Jantzen L, et al. Dietary Linoleic acid supplementation protects against obesity-induced microglial reactivity in mice. Sci Rep. 2024;14(1):6644.","journal-title":"Sci Rep"},{"issue":"1","key":"6296_CR33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10753-019-01113-y","volume":"43","author":"AN Carey","year":"2020","unstructured":"Carey AN, et al. Walnut-Associated fatty acids inhibit LPS-Induced activation of BV-2 microglia. Inflammation. 2020;43(1):241\u201350.","journal-title":"Inflammation"},{"issue":"1","key":"6296_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jphs.2018.06.015","volume":"138","author":"S Ikeguchi","year":"2018","unstructured":"Ikeguchi S, et al. Inhibitory effect of the gut microbial Linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation. J Pharmacol Sci. 2018;138(1):9\u201315.","journal-title":"J Pharmacol Sci"},{"key":"6296_CR35","doi-asserted-by":"crossref","unstructured":"Ali W et al. Oral Administration of Alpha Linoleic Acid Rescues Abeta-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL\/6\u00a0N Mice. Cells. 2020. 9(3).","DOI":"10.3390\/cells9030667"},{"issue":"5","key":"6296_CR36","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10753-010-9189-0","volume":"33","author":"LM Willis","year":"2010","unstructured":"Willis LM, et al. Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2. Inflammation. 2010;33(5):325\u201333.","journal-title":"Inflammation"},{"issue":"18","key":"6296_CR37","first-page":"4688","volume":"59","author":"LA Sauer","year":"1999","unstructured":"Sauer LA, et al. 13-Hydroxyoctadecadienoic acid is the mitogenic signal for Linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo. Cancer Res. 1999;59(18):4688\u201392.","journal-title":"Cancer Res"},{"issue":"44","key":"6296_CR38","doi-asserted-by":"publisher","first-page":"18820","DOI":"10.1073\/pnas.0905415106","volume":"106","author":"AM Patwardhan","year":"2009","unstructured":"Patwardhan AM, et al. Activation of TRPV1 in the spinal cord by oxidized Linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A. 2009;106(44):18820\u20134.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"6296_CR39","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/bph.12092","volume":"168","author":"M Alsalem","year":"2013","unstructured":"Alsalem M, et al. The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms. Br J Pharmacol. 2013;168(8):1961\u201374.","journal-title":"Br J Pharmacol"},{"key":"6296_CR40","doi-asserted-by":"publisher","first-page":"114953","DOI":"10.1016\/j.bcp.2022.114953","volume":"198","author":"S Wedel","year":"2022","unstructured":"Wedel S, et al. Oxidized Linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain. Biochem Pharmacol. 2022;198:114953.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"6296_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0009-3084(97)00095-9","volume":"91","author":"W Jira","year":"1998","unstructured":"Jira W, et al. Strong increase in hydroxy fatty acids derived from Linoleic acid in human low density lipoproteins of atherosclerotic patients. Chem Phys Lipids. 1998;91(1):1\u201311.","journal-title":"Chem Phys Lipids"},{"issue":"1","key":"6296_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1006\/bbrc.1997.6048","volume":"231","author":"N Reddy","year":"1997","unstructured":"Reddy N, et al. Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF Alpha\/EGF. Biochem Biophys Res Commun. 1997;231(1):111\u20136.","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"6296_CR43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0891-5849(94)00108-V","volume":"18","author":"K Metzger","year":"1995","unstructured":"Metzger K, et al. Lipoxygenase products in human saliva: patients with oral cancer compared to controls. Free Radic Biol Med. 1995;18(2):185\u201394.","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"6296_CR44","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.jid.2018.02.003","volume":"138","author":"AV Sorokin","year":"2018","unstructured":"Sorokin AV, et al. Bioactive lipid mediator profiles in human psoriasis skin and blood. J Invest Dermatol. 2018;138(7):1518\u201328.","journal-title":"J Invest Dermatol"},{"key":"6296_CR45","doi-asserted-by":"crossref","unstructured":"Mastrogiovanni M et al. HPLC-MS\/MS Oxylipin analysis of plasma from amyotrophic lateral sclerosis patients. Biomedicines. 2022. 10(3).","DOI":"10.3390\/biomedicines10030674"},{"issue":"6","key":"6296_CR46","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1194\/jlr.P042176","volume":"55","author":"J Klawitter","year":"2014","unstructured":"Klawitter J, et al. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014;55(6):1139\u201349.","journal-title":"J Lipid Res"},{"issue":"20","key":"6296_CR47","doi-asserted-by":"publisher","first-page":"14183","DOI":"10.1016\/S0021-9258(19)49695-6","volume":"267","author":"G Ku","year":"1992","unstructured":"Ku G, et al. Induction of Interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem. 1992;267(20):14183\u20138.","journal-title":"J Biol Chem"},{"issue":"12","key":"6296_CR48","doi-asserted-by":"publisher","first-page":"107972","DOI":"10.1016\/j.jbc.2024.107972","volume":"300","author":"ME Ertunc","year":"2024","unstructured":"Ertunc ME, et al. Acute inflammation upregulates FAHFAs in adipose tissue and in differentiated adipocytes. J Biol Chem. 2024;300(12):107972.","journal-title":"J Biol Chem"},{"key":"6296_CR49","doi-asserted-by":"publisher","first-page":"792711","DOI":"10.3389\/fimmu.2021.792711","volume":"12","author":"F Yang","year":"2021","unstructured":"Yang F, et al. Altered plasma metabolic profiles in Chinese patients with multiple sclerosis. Front Immunol. 2021;12:792711.","journal-title":"Front Immunol"},{"issue":"1","key":"6296_CR50","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12883-024-03926-3","volume":"24","author":"F Yang","year":"2024","unstructured":"Yang F, et al. Quantitative proteomics and multi-omics analysis identifies potential biomarkers and the underlying pathological molecular networks in Chinese patients with multiple sclerosis. BMC Neurol. 2024;24(1):423.","journal-title":"BMC Neurol"},{"issue":"5","key":"6296_CR51","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, et al. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137.","journal-title":"OMICS"},{"issue":"D1","key":"6296_CR52","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 2021;49(D1):D605\u201312.","journal-title":"Nucleic Acids Res"},{"key":"6296_CR53","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.","journal-title":"BMC Bioinformatics"},{"issue":"11","key":"6296_CR54","doi-asserted-by":"publisher","first-page":"e1005752","DOI":"10.1371\/journal.pcbi.1005752","volume":"13","author":"F Rohart","year":"2017","unstructured":"Rohart F, et al. MixOmics: an R package for \u2018omics feature selection and multiple data integration. PLoS Comput Biol. 2017;13(11):e1005752.","journal-title":"PLoS Comput Biol"},{"key":"6296_CR55","doi-asserted-by":"publisher","first-page":"104789","DOI":"10.1016\/j.ebiom.2023.104789","volume":"96","author":"H Touil","year":"2023","unstructured":"Touil H, et al. Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis. EBioMedicine. 2023;96:104789.","journal-title":"EBioMedicine"},{"key":"6296_CR56","doi-asserted-by":"crossref","unstructured":"Jansen MI, Thomas Broome S, Castorina A. Exploring the Pro-Phagocytic and Anti-Inflammatory functions of PACAP and VIP in microglia: implications for multiple sclerosis. Int J Mol Sci. 2022. 23(9).","DOI":"10.3390\/ijms23094788"},{"issue":"8","key":"6296_CR57","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S1474-4422(23)00254-5","volume":"22","author":"P Hautecoeur","year":"2023","unstructured":"Hautecoeur P, Kwiatkowski A, Drouin E. The microglial hypothesis of multiple sclerosis. Lancet Neurol. 2023;22(8):655.","journal-title":"Lancet Neurol"},{"issue":"9","key":"6296_CR58","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1136\/jnnp-2023-331051","volume":"94","author":"M Saraste","year":"2023","unstructured":"Saraste M, et al. Association of serum neurofilament light with microglial activation in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2023;94(9):698\u2013706.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"6296_CR59","first-page":"262","volume":"17","author":"H Wood","year":"2021","unstructured":"Wood H. Microglial changes associated with meningeal inflammation in multiple sclerosis. Nat Rev Neurol. 2021;17(5):262.","journal-title":"Nat Rev Neurol"},{"issue":"19","key":"6296_CR60","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1016\/j.neuron.2024.05.025","volume":"112","author":"T Garton","year":"2024","unstructured":"Garton T, et al. Neurodegeneration and demyelination in multiple sclerosis. Neuron. 2024;112(19):3231\u201351.","journal-title":"Neuron"},{"issue":"1","key":"6296_CR61","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00401-024-02730-0","volume":"147","author":"A Geladaris","year":"2024","unstructured":"Geladaris A, et al. BTK Inhibition limits microglia-perpetuated CNS inflammation and promotes Myelin repair. Acta Neuropathol. 2024;147(1):75.","journal-title":"Acta Neuropathol"},{"issue":"7","key":"6296_CR62","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.cell.2023.03.008","volume":"186","author":"M Charabati","year":"2023","unstructured":"Charabati M, et al. Multiple sclerosis: neuroimmune crosstalk and therapeutic targeting. Cell. 2023;186(7):1309\u201327.","journal-title":"Cell"},{"issue":"1","key":"6296_CR63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","volume":"8","author":"C Gao","year":"2023","unstructured":"Gao C, et al. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduct Target Ther. 2023;8(1):359.","journal-title":"Signal Transduct Target Ther"},{"issue":"7942","key":"6296_CR64","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41586-022-05534-y","volume":"613","author":"NB McNamara","year":"2023","unstructured":"McNamara NB, et al. Microglia regulate central nervous system Myelin growth and integrity. Nature. 2023;613(7942):120\u20139.","journal-title":"Nature"},{"issue":"1","key":"6296_CR65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","volume":"87","author":"JA Smith","year":"2012","unstructured":"Smith JA, et al. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull. 2012;87(1):10\u201320.","journal-title":"Brain Res Bull"},{"key":"6296_CR66","doi-asserted-by":"publisher","first-page":"102160","DOI":"10.1016\/j.arr.2023.102160","volume":"93","author":"Y Long","year":"2024","unstructured":"Long Y, et al. Modulating the polarization phenotype of microglia - A valuable strategy for central nervous system diseases. Ageing Res Rev. 2024;93:102160.","journal-title":"Ageing Res Rev"},{"issue":"8","key":"6296_CR67","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","volume":"19","author":"RM Ransohoff","year":"2016","unstructured":"Ransohoff RM. A polarizing question: do M1 and M2 microglia exist? Nat Neurosci. 2016;19(8):987\u201391.","journal-title":"Nat Neurosci"},{"issue":"4","key":"6296_CR68","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ. Microglial M1\/M2 polarization and metabolic States. Br J Pharmacol. 2016;173(4):649\u201365.","journal-title":"Br J Pharmacol"},{"key":"6296_CR69","doi-asserted-by":"crossref","unstructured":"O\u2019Loughlin E et al. Microglial phenotypes and functions in multiple sclerosis. Cold Spring Harb Perspect Med. 2018. 8(2).","DOI":"10.1101\/cshperspect.a028993"},{"key":"6296_CR70","doi-asserted-by":"publisher","first-page":"116884","DOI":"10.1016\/j.biopha.2024.116884","volume":"177","author":"CP Vieira","year":"2024","unstructured":"Vieira CP, et al. Estimating the therapeutic potential of NSAIDs and Linoleic acid-isomers supplementation against neuroinflammation. Biomed Pharmacother. 2024;177:116884.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"6296_CR71","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3109\/14756360903514156","volume":"25","author":"KH Kim","year":"2010","unstructured":"Kim KH, et al. Constituents of Limonia acidissima inhibit LPS-induced nitric oxide production in BV-2 microglia. J Enzyme Inhib Med Chem. 2010;25(6):887\u201392.","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"43","key":"6296_CR72","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4103\/0973-1296.160454","volume":"11","author":"JY Yoon","year":"2015","unstructured":"Yoon JY, et al. A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of cordyceps militaris. Pharmacogn Mag. 2015;11(43):477\u201385.","journal-title":"Pharmacogn Mag"},{"key":"6296_CR73","doi-asserted-by":"publisher","first-page":"146589","DOI":"10.1016\/j.brainres.2019.146589","volume":"1732","author":"DA Sylvestre","year":"2020","unstructured":"Sylvestre DA, et al. Untargeted metabolomic analysis of plasma from relapsing-remitting multiple sclerosis patients reveals changes in metabolites associated with structural changes in brain. Brain Res. 2020;1732:146589.","journal-title":"Brain Res"},{"key":"6296_CR74","first-page":"p9010937","volume":"2020","author":"MF Kasakin","year":"2020","unstructured":"Kasakin MF, et al. Changes in amino acid and acylcarnitine plasma profiles for distinguishing patients with multiple sclerosis from healthy controls. Mult Scler Int. 2020;2020:p9010937.","journal-title":"Mult Scler Int"},{"key":"6296_CR75","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fimmu.2020.00157","volume":"11","author":"L Gaetani","year":"2020","unstructured":"Gaetani L, et al. Host and microbial Tryptophan metabolic profiling in multiple sclerosis. Front Immunol. 2020;11:157.","journal-title":"Front Immunol"},{"issue":"2","key":"6296_CR76","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11306-020-1648-5","volume":"16","author":"H Carlsson","year":"2020","unstructured":"Carlsson H, et al. Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry. Metabolomics. 2020;16(2):26.","journal-title":"Metabolomics"},{"issue":"10","key":"6296_CR77","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1039\/C9MD00253G","volume":"10","author":"MF Kasakin","year":"2019","unstructured":"Kasakin MF, et al. Targeted metabolomics approach for identification of relapsing-remitting multiple sclerosis markers and evaluation of diagnostic models. Medchemcomm. 2019;10(10):1803\u20139.","journal-title":"Medchemcomm"},{"key":"6296_CR78","doi-asserted-by":"crossref","unstructured":"Cicalini I et al. Integrated lipidomics and metabolomics analysis of tears in multiple sclerosis: an insight into diagnostic potential of lacrimal fluid. Int J Mol Sci. 2019. 20(6).","DOI":"10.3390\/ijms20061265"},{"issue":"2","key":"6296_CR79","doi-asserted-by":"publisher","first-page":"e321","DOI":"10.1212\/NXI.0000000000000321","volume":"4","author":"P Villoslada","year":"2017","unstructured":"Villoslada P, et al. Metabolomic signatures associated with disease severity in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2017;4(2):e321.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"6296_CR80","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.biocel.2017.07.004","volume":"93","author":"S Poddighe","year":"2017","unstructured":"Poddighe S, et al. Metabolomic analysis identifies altered metabolic pathways in multiple sclerosis. Int J Biochem Cell Biol. 2017;93:148\u201355.","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"6296_CR81","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1177\/1352458515586086","volume":"22","author":"EL MacMillan","year":"2016","unstructured":"MacMillan EL, et al. Progressive multiple sclerosis exhibits decreasing glutamate and glutamine over two years. Mult Scler. 2016;22(1):112\u20136.","journal-title":"Mult Scler"},{"issue":"1","key":"6296_CR82","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1212\/NXI.0000000000000185","volume":"3","author":"E Cocco","year":"2016","unstructured":"Cocco E, et al. (1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016;3(1):e185.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"10","key":"6296_CR83","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1177\/1352458513516528","volume":"20","author":"SN Reinke","year":"2014","unstructured":"Reinke SN, et al. Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis. Mult Scler. 2014;20(10):1396\u2013400.","journal-title":"Mult Scler"},{"issue":"8","key":"6296_CR84","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s41423-022-00883-0","volume":"19","author":"J Luoqian","year":"2022","unstructured":"Luoqian J, et al. Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis. Cell Mol Immunol. 2022;19(8):913\u201324.","journal-title":"Cell Mol Immunol"},{"key":"6296_CR85","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.3389\/fimmu.2017.01810","volume":"8","author":"DAE Hendrickx","year":"2017","unstructured":"Hendrickx DAE, et al. Gene expression profiling of multiple sclerosis pathology identifies early patterns of demyelination surrounding chronic active lesions. Front Immunol. 2017;8:1810.","journal-title":"Front Immunol"},{"issue":"7","key":"6296_CR86","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1084\/jem.20101974","volume":"209","author":"MH Han","year":"2012","unstructured":"Han MH, et al. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012;209(7):1325\u201334.","journal-title":"J Exp Med"},{"issue":"10","key":"6296_CR87","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","volume":"27","author":"PR Angelova","year":"2020","unstructured":"Angelova PR, et al. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death Differ. 2020;27(10):2781\u201396.","journal-title":"Cell Death Differ"},{"issue":"3","key":"6296_CR88","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/s41418-021-00883-z","volume":"29","author":"S Xin","year":"2022","unstructured":"Xin S, et al. MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Cell Death Differ. 2022;29(3):670\u201386.","journal-title":"Cell Death Differ"},{"key":"6296_CR89","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","volume":"41","author":"S Wang","year":"2022","unstructured":"Wang S, et al. Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx. J Adv Res. 2022;41:63\u201375.","journal-title":"J Adv Res"},{"issue":"1","key":"6296_CR90","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","volume":"5","author":"P Chen","year":"2020","unstructured":"Chen P, et al. Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020;5(1):51.","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"6296_CR91","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1182\/blood-2006-07-037960","volume":"109","author":"K Sochorova","year":"2007","unstructured":"Sochorova K, et al. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood. 2007;109(6):2553\u20136.","journal-title":"Blood"},{"issue":"8","key":"6296_CR92","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1177\/0022034510366898","volume":"89","author":"PP Souza","year":"2010","unstructured":"Souza PP, et al. Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2. J Dent Res. 2010;89(8):802\u20137.","journal-title":"J Dent Res"},{"key":"6296_CR93","doi-asserted-by":"publisher","first-page":"824027","DOI":"10.3389\/fcimb.2022.824027","volume":"12","author":"M Chen","year":"2022","unstructured":"Chen M, et al. Toll-Like receptor 2 modulates pulmonary inflammation and TNF-alpha release mediated by Mycoplasma pneumoniae. Front Cell Infect Microbiol. 2022;12:824027.","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"6296_CR94","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1182\/bloodadvances.2018026450","volume":"3","author":"HY Lai","year":"2019","unstructured":"Lai HY, et al. Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-alpha in myeloproliferative neoplasm. Blood Adv. 2019;3(2):122\u201331.","journal-title":"Blood Adv"},{"issue":"10111","key":"6296_CR95","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1016\/S0140-6736(17)32346-2","volume":"390","author":"AJ Green","year":"2017","unstructured":"Green AJ, et al. Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. Lancet. 2017;390(10111):2481\u20139.","journal-title":"Lancet"},{"issue":"12","key":"6296_CR96","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1007\/s00415-019-09395-w","volume":"267","author":"H Li","year":"2020","unstructured":"Li H, et al. Comparative efficacy and acceptability of disease-modifying therapies in patients with relapsing-remitting multiple sclerosis: a systematic review and network meta-analysis. J Neurol. 2020;267(12):3489\u201398.","journal-title":"J Neurol"},{"issue":"1","key":"6296_CR97","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s13311-015-0409-z","volume":"13","author":"A Shirani","year":"2016","unstructured":"Shirani A, Okuda DT, Stuve O. Therapeutic advances and future prospects in progressive forms of multiple sclerosis. Neurotherapeutics. 2016;13(1):58\u201369.","journal-title":"Neurotherapeutics"},{"issue":"7","key":"6296_CR98","doi-asserted-by":"publisher","first-page":"2002944","DOI":"10.1002\/advs.202002944","volume":"8","author":"A Andrzejewska","year":"2021","unstructured":"Andrzejewska A, et al. Mesenchymal stem cells for neurological disorders. Adv Sci (Weinh). 2021;8(7):2002944.","journal-title":"Adv Sci (Weinh)"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06296-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06296-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:32:43Z","timestamp":1741066363000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06296-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6296"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06296-7","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"6 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The studies involving human participants were reviewed and approved by the Ethics Committee of Lishui Second People\u2019s Hospital (approval number 20171116-3), and the Ethics Committee of Affiliated Hospital of Zunyi Medical University (approval number KLL-2022-305). All subjects provided their written informed consents to participate in this study and for future publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"260"}}