{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:14:10Z","timestamp":1790154850498,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06379-5","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:07:24Z","timestamp":1742515644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Do cancer survivors have an increased risk of developing subsequent cancer? A population-based study"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-0225","authenticated-orcid":false,"given":"Yubo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"6379_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"6379_CR2","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1093\/jnci\/djac158","volume":"114","author":"L Gallicchio","year":"2022","unstructured":"Gallicchio L, Devasia TP, Tonorezos E, Mollica MA, Mariotto A. Estimation of the number of individuals living with metastatic cancer in the United States. J Natl Cancer Inst. 2022;114:1476\u201383.","journal-title":"J Natl Cancer Inst"},{"key":"6379_CR3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1056\/NEJMp2007839","volume":"383","author":"RL Schilsky","year":"2020","unstructured":"Schilsky RL, Nass S, Le Beau MM, Benz EJ Jr. Progress in cancer research, prevention, and care. N Engl J Med. 2020;383:897\u2013900.","journal-title":"N Engl J Med"},{"key":"6379_CR4","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/jnci\/djae135","volume":"116","author":"E Tonorezos","year":"2024","unstructured":"Tonorezos E, Devasia T, Mariotto AB, Mollica MA, Gallicchio L, Green P, Doose M, Brick R, Streck B, Reed C, de Moor JS. Prevalence of cancer survivors in the United States. J Natl Cancer Inst. 2024;116:1784\u201390.","journal-title":"J Natl Cancer Inst"},{"key":"6379_CR5","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1001\/jamaoncol.2017.3605","volume":"4","author":"CC Murphy","year":"2018","unstructured":"Murphy CC, Gerber DE, Pruitt SL. Prevalence of prior cancer among persons newly diagnosed with cancer: an initial report from the surveillance, epidemiology, and end results program. JAMA Oncol. 2018;4:832\u20136.","journal-title":"JAMA Oncol"},{"key":"6379_CR6","unstructured":"Overview of the SEER Program [https:\/\/seer.cancer.gov\/about\/overview.html], Access date: Mar.5th, 2025."},{"key":"6379_CR7","unstructured":"Multiple Primary - Standardized Incidence\/Mortality Ratios (MP-SIR\/SMR) [https:\/\/seer.cancer.gov\/seerstat\/mp-sir.html]. Access date: Jan 10th, 2025."},{"key":"6379_CR8","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, Initiative S. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370:1453\u20137.","journal-title":"Lancet"},{"key":"6379_CR9","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence\u2014SEER Research Data, 17 Registries (excl AK), Nov 2023 Sub (2000\u20132021), National Cancer Institute, DCCPS, Surveillance Research Program, released April 2024, based on the November 2023 submission."},{"key":"6379_CR10","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1200\/JCO.2014.55.8361","volume":"32","author":"JH Rowland","year":"2014","unstructured":"Rowland JH, Bellizzi KM. Cancer survivorship issues: life after treatment and implications for an aging population. J Clin Oncol. 2014;32:2662\u20138.","journal-title":"J Clin Oncol"},{"key":"6379_CR11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1001\/archdermatol.2010.2","volume":"146","author":"PT Bradford","year":"2010","unstructured":"Bradford PT, Freedman DM, Goldstein AM, Tucker MA. Increased risk of second primary cancers after a diagnosis of melanoma. Arch Dermatol. 2010;146:265\u201372.","journal-title":"Arch Dermatol"},{"key":"6379_CR12","doi-asserted-by":"crossref","unstructured":"Metayer C, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, Joensuu T, van Leeuwen FE, van't Veer MB, Curtis RE, et al: Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence. J Clin Oncol 2000,18:2435\u201343.","DOI":"10.1200\/JCO.2000.18.12.2435"},{"key":"6379_CR13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1159\/000527437","volume":"56","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wang Z, Hua C, Xu Y, Li Y, Zhao G. Primary malignant brain tumors following systemic malignancies: a population-based analysis. Neuroepidemiology. 2022;56:452\u20139.","journal-title":"Neuroepidemiology"},{"key":"6379_CR14","doi-asserted-by":"publisher","first-page":"20180390","DOI":"10.1259\/bjr.20180390","volume":"92","author":"C Demoor-Goldschmidt","year":"2019","unstructured":"Demoor-Goldschmidt C, de Vathaire F. Review of risk factors of secondary cancers among cancer survivors. Br J Radiol. 2019;92:20180390.","journal-title":"Br J Radiol"},{"key":"6379_CR15","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/pbc.24861","volume":"61","author":"MV Maraldo","year":"2014","unstructured":"Maraldo MV, Jorgensen M, Brodin NP, Aznar MC, Vogelius IR, Petersen PM, Berthelsen AK, Christensen CB, Hjalgrim LL, Specht L. The impact of involved node, involved field and mantle field radiotherapy on estimated radiation doses and risk of late effects for pediatric patients with Hodgkin lymphoma. Pediatr Blood Cancer. 2014;61:717\u201322.","journal-title":"Pediatr Blood Cancer"},{"key":"6379_CR16","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1200\/JCO.2015.62.3314","volume":"34","author":"TO Henderson","year":"2016","unstructured":"Henderson TO, Moskowitz CS, Chou JF, Bradbury AR, Neglia JP, Dang CT, Onel K, Novetsky Friedman D, Bhatia S, Strong LC, et al. Breast cancer risk in childhood cancer survivors without a history of chest radiotherapy: a report from the childhood cancer survivor study. J Clin Oncol. 2016;34:910\u20138.","journal-title":"J Clin Oncol"},{"key":"6379_CR17","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1200\/JCO.2016.71.6902","volume":"35","author":"JC Teepen","year":"2017","unstructured":"Teepen JC, van Leeuwen FE, Tissing WJ, van Dulmen-den BE, van den Heuvel-Eibrink MM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, Neggers S, et al. Long-term risk of subsequent malignant neoplasms after treatment of childhood cancer in the DCOG LATER Study Cohort: role of chemotherapy. J Clin Oncol. 2017;35:2288\u201398.","journal-title":"J Clin Oncol"},{"key":"6379_CR18","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.ebiom.2015.05.022","volume":"2","author":"DS Wishart","year":"2015","unstructured":"Wishart DS. Is cancer a genetic disease or a metabolic disease? EBioMedicine. 2015;2:478\u20139.","journal-title":"EBioMedicine"},{"key":"6379_CR19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/14728222.2021.1951226","volume":"25","author":"S Boussios","year":"2021","unstructured":"Boussios S, Rassy E, Shah S, Ioannidou E, Sheriff M, Pavlidis N. Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology. Expert Opin Ther Targets. 2021;25:329\u201333.","journal-title":"Expert Opin Ther Targets"},{"key":"6379_CR20","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.semcancer.2021.09.007","volume":"86","author":"A Rizzo","year":"2022","unstructured":"Rizzo A, Santoni M, Mollica V, Fiorentino M, Brandi G, Massari F. Microbiota and prostate cancer. Semin Cancer Biol. 2022;86:1058\u201365.","journal-title":"Semin Cancer Biol"},{"key":"6379_CR21","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.23025","volume":"5","author":"HP Bagshaw","year":"2022","unstructured":"Bagshaw HP, Arnow KD, Trickey AW, Leppert JT, Wren SM, Morris AM. Assessment of second primary cancer risk among men receiving primary radiotherapy vs surgery for the treatment of prostate cancer. JAMA Netw Open. 2022;5: e2223025.","journal-title":"JAMA Netw Open"},{"key":"6379_CR22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i851","volume":"352","author":"CJ Wallis","year":"2016","unstructured":"Wallis CJ, Mahar AL, Choo R, Herschorn S, Kodama RT, Shah PS, Danjoux C, Narod SA, Nam RK. Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis. BMJ. 2016;352: i851.","journal-title":"BMJ"},{"key":"6379_CR23","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ygyno.2020.06.492","volume":"158","author":"E Adjei Boakye","year":"2020","unstructured":"Adjei Boakye E, Grubb L, Peterson CE, Osazuwa-Peters N, Grabosch S, Ladage HD, Huh WK. Risk of second primary cancers among survivors of gynecological cancers. Gynecol Oncol. 2020;158:719\u201326.","journal-title":"Gynecol Oncol"},{"key":"6379_CR24","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/cam4.1437","volume":"7","author":"X He","year":"2018","unstructured":"He X, Wu W, Ding Y, Li Y, Si J, Sun L. Excessive risk of second primary cancers in young-onset colorectal cancer survivors. Cancer Med. 2018;7:1201\u201310.","journal-title":"Cancer Med"},{"key":"6379_CR25","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1001\/jama.2020.23130","volume":"324","author":"H Sung","year":"2020","unstructured":"Sung H, Hyun N, Leach CR, Yabroff KR, Jemal A. Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in the United States. JAMA. 2020;324:2521\u201335.","journal-title":"JAMA"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06379-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06379-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06379-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:07:27Z","timestamp":1742515647000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06379-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6379"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06379-5","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"13 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"355"}}