{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:54:39Z","timestamp":1793663679384,"version":"4.5.1"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Key R & Program of China","award":["2022YFC2010101"],"award-info":[{"award-number":["2022YFC2010101"]}]},{"name":"R&D Program of Zhejiang","award":["2022C03138"],"award-info":[{"award-number":["2022C03138"]}]},{"name":"the State Key Laboratory","award":["2021DG700024\u2013KF202209"],"award-info":[{"award-number":["2021DG700024\u2013KF202209"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06426-1","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:18:38Z","timestamp":1744204718000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-1948","authenticated-orcid":false,"given":"Zhiqi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"6426_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","volume":"94","author":"P Wa","year":"1993","unstructured":"Wa P. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646\u201350.","journal-title":"Am J Med"},{"key":"6426_CR2","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.3390\/nu13051609","volume":"13","author":"W S\u0142upski","year":"2021","unstructured":"S\u0142upski W, Jawie\u0144 P, Nowak B. Botanicals in postmenopausal osteoporosis. Nutrients. 2021;13:1609.","journal-title":"Nutrients"},{"key":"6426_CR3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","volume":"5","author":"HG Bone","year":"2017","unstructured":"Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwi\u0144ski E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 2017;5:513\u201323.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"6426_CR4","doi-asserted-by":"publisher","first-page":"16069","DOI":"10.1038\/nrdp.2016.69","volume":"2","author":"R Eastell","year":"2016","unstructured":"Eastell R, O\u2019Neill TW, Hofbauer LC, Langdahl B, Reid IR, Gold DT, Cummings SR. Postmenopausal osteoporosis. Nat Rev Dis Primers. 2016;2:16069.","journal-title":"Nat Rev Dis Primers"},{"key":"6426_CR5","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.3390\/nu11123004","volume":"11","author":"AK Hamm","year":"2019","unstructured":"Hamm AK, Manter DK, Kirkwood JS, Wolfe LM, Cox-York K, Weir TL. The effect of Hops (Humulus lupulus L.) extract supplementation on weight gain, adiposity and intestinal function in ovariectomized mice. Nutrients. 2019;11:3004.","journal-title":"Nutrients"},{"key":"6426_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2022.102258","volume":"68","author":"M Nakano","year":"2022","unstructured":"Nakano M, Omae N, Tsuda K. Inter-organismal phytohormone networks in plant-microbe interactions. Curr Opin Plant Biol. 2022;68: 102258.","journal-title":"Curr Opin Plant Biol"},{"key":"6426_CR7","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jocd.2013.08.011","volume":"16","author":"VS Lagari","year":"2013","unstructured":"Lagari VS, Levis S. Phytoestrogens in the prevention of postmenopausal bone loss. J Clin Densitom. 2013;16:445\u20139.","journal-title":"J Clin Densitom"},{"key":"6426_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.779638","volume":"12","author":"P Ramesh","year":"2021","unstructured":"Ramesh P, Jagadeesan R, Sekaran S, Dhanasekaran A, Vimalraj S. Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling. Front Endocrinol. 2021;12: 779638.","journal-title":"Front Endocrinol"},{"key":"6426_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tem.2020.11.007","volume":"32","author":"D Bellavia","year":"2021","unstructured":"Bellavia D, Dimarco E, Costa V, Carina V, De Luca A, Raimondi L, Fini M, Gentile C, Caradonna F, Giavaresi G. Flavonoids in bone erosive diseases: perspectives in osteoporosis treatment. Trends Endocrinol Metab. 2021;32:76\u201394.","journal-title":"Trends Endocrinol Metab"},{"key":"6426_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/GME.0000000000000102","volume":"21","author":"ZM Liu","year":"2014","unstructured":"Liu ZM, Ho SC, Woo J, Chen YM, Wong C. Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women. Menopause. 2014;21:653\u201360.","journal-title":"Menopause"},{"key":"6426_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3109\/07853899709113696","volume":"29","author":"H Adlercreutz","year":"1997","unstructured":"Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med. 1997;29:95\u2013120.","journal-title":"Ann Med"},{"key":"6426_CR12","first-page":"1","volume":"64","author":"X Wang","year":"2022","unstructured":"Wang X, Chen B, Fang X, Zhong Q, Liao Z, Wang J, Wu X, Ma Y, Li P, Feng X, Wang L. Soy isoflavone-specific biotransformation product S-equol in the colon: physiological functions, transformation mechanisms, and metabolic regulatory pathways. Crit Rev Food Sci Nutr. 2022;64:1\u201329.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"6426_CR13","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1039\/C9FO01081E","volume":"11","author":"KS George","year":"2020","unstructured":"George KS, Mu\u00f1oz J, Akhavan NS, Foley EM, Siebert SC, Tenenbaum G, Khalil DA, Chai SC, Arjmandi BH. Is soy protein effective in reducing cholesterol and improving bone health? Food Funct. 2020;11:544\u201351.","journal-title":"Food Funct"},{"key":"6426_CR14","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.3390\/ijms23063168","volume":"23","author":"R Pohjanvirta","year":"2022","unstructured":"Pohjanvirta R, Nasri A. The potent phytoestrogen 8-prenylnaringenin: a friend or a foe? Int J Mol Sci. 2022;23:3168.","journal-title":"Int J Mol Sci"},{"key":"6426_CR15","first-page":"1073","volume":"73","author":"I Kaczmarczyk-Sedlak","year":"2016","unstructured":"Kaczmarczyk-Sedlak I, Wojnar W, Zych M, Ozimina-Kami\u0144ska E, Bo\u0144ka A. Effect of dietary flavonoid naringenin on bones in rats with ovariectomy-induced osteoporosiS. Acta Pol Pharm. 2016;73:1073\u201381.","journal-title":"Acta Pol Pharm"},{"key":"6426_CR16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3945\/ajcn.114.104646","volume":"102","author":"V Habauzit","year":"2015","unstructured":"Habauzit V, Verny MA, Milenkovic D, Barber-Chamoux N, Mazur A, Dubray C, Morand C. Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: a randomized, controlled, crossover trial. Am J Clin Nutr. 2015;102:66\u201374.","journal-title":"Am J Clin Nutr"},{"key":"6426_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14852","volume":"75","author":"Z Namkhah","year":"2021","unstructured":"Namkhah Z, Naeini F, Mahdi Rezayat S, Mehdi Y, Mansouri S, Javad Hosseinzadeh-Attar M. Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight\/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial. Int J Clin Pract. 2021;75: e14852.","journal-title":"Int J Clin Pract"},{"key":"6426_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/JLB.3MR0321-755R","volume":"110","author":"Y Tu","year":"2021","unstructured":"Tu Y, Yang R, Xu X, Zhou X. The microbiota-gut-bone axis and bone health. J Leukoc Biol. 2021;110:525\u201337.","journal-title":"J Leukoc Biol"},{"key":"6426_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2021.101065","volume":"14","author":"M Castaneda","year":"2021","unstructured":"Castaneda M, Smith KM, Nixon JC, Hernandez CJ, Rowan S. Alterations to the gut microbiome impair bone tissue strength in aged mice. Bone Rep. 2021;14: 101065.","journal-title":"Bone Rep"},{"key":"6426_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S8756-3282(00)00404-X","volume":"28","author":"JT Heiskanen","year":"2001","unstructured":"Heiskanen JT, Kr\u00f6ger H, P\u00e4\u00e4kk\u00f6nen M, Parviainen MT, Lamberg-Allardt C, Alhava E. Bone mineral metabolism after total gastrectomy. Bone. 2001;28:123\u20137.","journal-title":"Bone"},{"key":"6426_CR21","doi-asserted-by":"publisher","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","volume":"113","author":"J Yan","year":"2016","unstructured":"Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci USA. 2016;113:E7554-e7563.","journal-title":"Proc Natl Acad Sci USA"},{"key":"6426_CR22","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/nu13020525","volume":"13","author":"AE Ratajczak","year":"2021","unstructured":"Ratajczak AE, Rychter AM, Zawada A, Dobrowolska A, Krela-Ka\u017amierczak I. Do only calcium and vitamin D Matter? Micronutrients in the diet of inflammatory bowel diseases patients and the risk of osteoporosis. Nutrients. 2021;13:525.","journal-title":"Nutrients"},{"key":"6426_CR23","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/nu11071464","volume":"11","author":"Y Stevens","year":"2019","unstructured":"Stevens Y, Rymenant EV, Grootaert C, Camp JV, Possemiers S, Masclee A, Jonkers D. The intestinal fate of citrus flavanones and their effects on gastrointestinal health. Nutrients. 2019;11:1464.","journal-title":"Nutrients"},{"key":"6426_CR24","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3390\/nu14030553","volume":"14","author":"LM Leonard","year":"2022","unstructured":"Leonard LM, Choi MS, Cross TL. Maximizing the estrogenic potential of soy isoflavones through the gut microbiome: implication for cardiometabolic health in postmenopausal women. Nutrients. 2022;14:553.","journal-title":"Nutrients"},{"key":"6426_CR25","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1093\/ajcn\/nqac252","volume":"116","author":"YY Wu","year":"2022","unstructured":"Wu YY, Gou W, Yan Y, Liu CY, Yang Y, Chen D, Xie K, Jiang Z, Fu Y, Zhu HL, et al. Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study. Am J Clin Nutr. 2022;116:1831\u201341.","journal-title":"Am J Clin Nutr"},{"key":"6426_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","volume":"759","author":"T Komori","year":"2015","unstructured":"Komori T. Animal models for osteoporosis. Eur J Pharmacol. 2015;759:287\u201394.","journal-title":"Eur J Pharmacol"},{"key":"6426_CR27","first-page":"250","volume":"14","author":"L Zheng","year":"2022","unstructured":"Zheng L, Zhuang Z, Li Y, Shi T, Fu K, Yan W, Zhang L, Wang P, Li L, Jiang Q. Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis. Bioact Mater. 2022;14:250\u201361.","journal-title":"Bioact Mater"},{"key":"6426_CR28","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3177\/jnsv.69.220","volume":"69","author":"X Liu","year":"2023","unstructured":"Liu X, He C, Koyama T. D-Pinitol ameliorated osteoporosis via elevating D-chiro-inositol level in ovariectomized mice. J Nutr Sci Vitaminol (Tokyo). 2023;69:220\u20138.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"6426_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154399","volume":"106","author":"J Liu","year":"2022","unstructured":"Liu J, Ding S, Yang L, Zhao X, Ren R, Wang Y, Su C, Chen J, Ma X. Integration of pharmacodynamics and metabolomics reveals the therapeutic effects of 6-acetylacteoside on ovariectomy-induced osteoporosis mice. Phytomedicine. 2022;106: 154399.","journal-title":"Phytomedicine"},{"key":"6426_CR30","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3390\/nu14081568","volume":"14","author":"X Pi","year":"2022","unstructured":"Pi X, Hua H, Wu Q, Wang X, Wang X, Li J. Effects of different feeding methods on the structure, metabolism, and gas production of infant and toddler intestinal flora and their mechanisms. Nutrients. 2022;14:1568.","journal-title":"Nutrients"},{"key":"6426_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","volume":"26","author":"PM Camacho","year":"2020","unstructured":"Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, et al. American association of clinical endocrinologists\/American college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update. Endocr Pract. 2020;26:1\u201346.","journal-title":"Endocr Pract"},{"key":"6426_CR32","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.3390\/ijms23169465","volume":"23","author":"A Aibar-Almaz\u00e1n","year":"2022","unstructured":"Aibar-Almaz\u00e1n A, Voltes-Mart\u00ednez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcel\u00e9n-Fraile MDC, L\u00f3pez-Ruiz E. Current status of the diagnosis and management of osteoporosis. Int J Mol Sci. 2022;23:9465.","journal-title":"Int J Mol Sci"},{"key":"6426_CR33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12887-022-03317-y","volume":"22","author":"S L\u00f3pez-Peralta","year":"2022","unstructured":"L\u00f3pez-Peralta S, Romero-Velarde E, V\u00e1squez-Garibay EM, Gonz\u00e1lez-Hita M, Robles-Robles LC, Ruiz-Gonz\u00e1lez FJ, P\u00e9rez-Romero MA. Bone mineral density and body composition in normal weight, overweight and obese children. BMC Pediatr. 2022;22:249.","journal-title":"BMC Pediatr"},{"key":"6426_CR34","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.clnu.2017.10.008","volume":"37","author":"C Mart\u00edn-Gonz\u00e1lez","year":"2018","unstructured":"Mart\u00edn-Gonz\u00e1lez C, Gonz\u00e1lez-Reimers E, Quintero-Platt G, Cabrera-Garc\u00eda P, Romero-Acevedo L, G\u00f3mez-Rodr\u00edguez M, Rodr\u00edguez Gaspar M, Mart\u00ednez-Mart\u00ednez D, Santolaria-Fern\u00e1ndez F. Lipid profile and bone mineral density in heavy alcoholics. Clin Nutr. 2018;37:2137\u201343.","journal-title":"Clin Nutr"},{"key":"6426_CR35","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.3390\/ijms23031639","volume":"23","author":"P Anagnostis","year":"2022","unstructured":"Anagnostis P, Florentin M, Livadas S, Lambrinoudaki I, Goulis DG. Bone health in patients with dyslipidemias: an underestimated aspect. Int J Mol Sci. 2022;23:1639.","journal-title":"Int J Mol Sci"},{"key":"6426_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/cells10010089","volume":"10","author":"H Kim","year":"2021","unstructured":"Kim H, Oh B, Park-Min KH. Regulation of osteoclast differentiation and activity by lipid metabolism. Cells. 2021;10:89.","journal-title":"Cells"},{"key":"6426_CR37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12944-021-01497-7","volume":"20","author":"Y Tang","year":"2021","unstructured":"Tang Y, Wang S, Yi Q, Xia Y, Geng B. High-density lipoprotein cholesterol is negatively correlated with bone mineral density and has potential predictive value for bone loss. Lipids Health Dis. 2021;20:75.","journal-title":"Lipids Health Dis"},{"key":"6426_CR38","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13018-022-02986-w","volume":"17","author":"R Xie","year":"2022","unstructured":"Xie R, Huang X, Liu Q, Liu M. Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011\u20132018. J Orthop Surg Res. 2022;17:92.","journal-title":"J Orthop Surg Res"},{"key":"6426_CR39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41522-022-00348-2","volume":"8","author":"P Li","year":"2022","unstructured":"Li P, Ji B, Luo H, Sundh D, Lorentzon M, Nielsen J. One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density. NPJ Biofilms Microbiomes. 2022;8:84.","journal-title":"NPJ Biofilms Microbiomes"},{"key":"6426_CR40","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.3390\/ijms22115805","volume":"22","author":"Y Kwon","year":"2021","unstructured":"Kwon Y, Park C, Lee J, Park DH, Jeong S, Yun CH, Park OJ, Han SH. Regulation of bone cell differentiation and activation by microbe-associated molecular patterns. Int J Mol Sci. 2021;22:5805.","journal-title":"Int J Mol Sci"},{"key":"6426_CR41","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1111\/os.13419","volume":"14","author":"J Zhou","year":"2022","unstructured":"Zhou J, Wang R, Zhao R, Guo X, Gou P, Bai H, Lei P, Xue Y. Intermittent parathyroid hormone alters gut microbiota in ovariectomized osteoporotic rats. Orthop Surg. 2022;14:2330\u20138.","journal-title":"Orthop Surg"},{"key":"6426_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.clnu.2015.11.011","volume":"36","author":"LB Tonucci","year":"2017","unstructured":"Tonucci LB, Olbrich Dos Santos KM, Licursi de Oliveira L, Rocha Ribeiro SM, Duarte Martino HS. Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Clin Nutr. 2017;36:85\u201392.","journal-title":"Clin Nutr"},{"key":"6426_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.792793","volume":"8","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Liu S, Mei F, Zhao M, Xia G, Shen X. Tilapia nilotica head lipids improved bone loss by regulating inflammation and serum metabolism through gut microbiota in ovariectomized rats. Front Nutr. 2021;8: 792793.","journal-title":"Front Nutr"},{"key":"6426_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111890","volume":"41","author":"Z Wang","year":"2022","unstructured":"Wang Z, Qin X, Hu D, Huang J, Guo E, Xiao R, Li W, Sun C, Chen G. Akkermansia supplementation reverses the tumor-promoting effect of the fecal microbiota transplantation in ovarian cancer. Cell Rep. 2022;41: 111890.","journal-title":"Cell Rep"},{"key":"6426_CR45","first-page":"917","volume":"26","author":"K \u0141agowska","year":"2022","unstructured":"\u0141agowska K, Drzyma\u0142a-Czy\u017c S. A low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome. Eur Rev Med Pharmacol Sci. 2022;26:917\u201326.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"6426_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136084","volume":"420","author":"Z Guo","year":"2023","unstructured":"Guo Z, Liu Y, Xiang J, Liang X. Mechanochemical preparation of red clover extract\/\u03b2-cyclodextrin dispersion: enhanced water solubility and activities in alleviating high-fat diet-induced lipid accumulation and gut microbiota dysbiosis in mice. Food Chem. 2023;420: 136084.","journal-title":"Food Chem"},{"key":"6426_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113286","volume":"153","author":"YX Wu","year":"2022","unstructured":"Wu YX, Yang XY, Han BS, Hu YY, An T, Lv BH, Lian J, Wang TY, Bao XL, Gao L, Jiang GJ. Naringenin regulates gut microbiota and SIRT1\/ PGC-1\u0251 signaling pathway in rats with letrozole-induced polycystic ovary syndrome. Biomed Pharmacother. 2022;153: 113286.","journal-title":"Biomed Pharmacother"},{"key":"6426_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.870422","volume":"13","author":"S Qin","year":"2022","unstructured":"Qin S, Wang Y, Wang S, Ning B, Huai J, Yang H. Gut microbiota in women with gestational diabetes mellitus has potential impact on metabolism in pregnant mice and their offspring. Front Microbiol. 2022;13: 870422.","journal-title":"Front Microbiol"},{"key":"6426_CR49","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.1039\/D0FO03254A","volume":"12","author":"L Wang","year":"2021","unstructured":"Wang L, Wu X, Ma Y, Li X, Zhang J, Zhao L. Supplementation with soy isoflavones alleviates depression-like behaviour via reshaping the gut microbiota structure. Food Funct. 2021;12:4995\u20135006.","journal-title":"Food Funct"},{"key":"6426_CR50","doi-asserted-by":"crossref","unstructured":"Keshavarz Azizi Raftar S, Hoseini Tavassol Z, Amiri M, Ejtahed HS, Zangeneh M, Sadeghi S, Ashrafian F, Kariman A, Khatami S, Siadat SD. Assessment of fecal Akkermansia muciniphila in patients with osteoporosis and osteopenia: a pilot study. J Diabetes Metab Disord. 2021;20:279\u2013284.","DOI":"10.1007\/s40200-021-00742-1"},{"key":"6426_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mBio.00478-21","volume":"12","author":"B Becken","year":"2021","unstructured":"Becken B, Davey L, Middleton DR, Mueller KD, Sharma A, Holmes ZC, Dallow E, Remick B, Barton GM, David LA, et al. Genotypic and phenotypic diversity among human isolates of akkermansia muciniphila. MBio. 2021;12:10\u2013128.","journal-title":"MBio"},{"key":"6426_CR52","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.cmet.2020.08.012","volume":"32","author":"C Chevalier","year":"2020","unstructured":"Chevalier C, Kieser S, \u00c7olako\u011flu M, Hadadi N, Brun J, Rigo D, Su\u00e1rez-Zamorano N, Spiljar M, Fabbiano S, Busse B, et al. Warmth prevents bone loss through the gut microbiota. Cell Metab. 2020;32:575-590.e577.","journal-title":"Cell Metab"},{"key":"6426_CR53","doi-asserted-by":"crossref","unstructured":"Qin Q, Yan S, Yang Y, Chen J, Yan H, Li T, Gao X, Wang Y, Li A, Wang S, Ding S: The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China. Front Cell Dev Biol. 2021;9:752990.","DOI":"10.3389\/fcell.2021.752990"},{"key":"6426_CR54","doi-asserted-by":"publisher","first-page":"2004831","DOI":"10.1002\/advs.202004831","volume":"8","author":"JH Liu","year":"2021","unstructured":"Liu JH, Chen CY, Liu ZZ, Luo ZW, Rao SS, Jin L, Wan TF, Yue T, Tan YJ, Yin H, et al. Extracellular vesicles from child gut microbiota enter into bone to preserve bone mass and strength. Adv Sci (Weinh). 2021;8:2004831.","journal-title":"Adv Sci (Weinh)"},{"key":"6426_CR55","doi-asserted-by":"crossref","unstructured":"Liu JH, Yue T, Luo ZW, Cao J, Yan ZQ, Jin L, Wan TF, Shuai CJ, Wang ZG, Zhou Y, et al. Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation. Dis Model Mech. 2020;13.","DOI":"10.1242\/dmm.043620"},{"key":"6426_CR56","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00730-21","volume":"9","author":"S Qu","year":"2021","unstructured":"Qu S, Fan L, Qi Y, Xu C, Hu Y, Chen S, Liu W, Liu W, Si J. Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation. Microbiol Spectr. 2021;9: e0073021.","journal-title":"Microbiol Spectr"},{"key":"6426_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1927633","volume":"13","author":"Y Rao","year":"2021","unstructured":"Rao Y, Kuang Z, Li C, Guo S, Xu Y, Zhao D, Hu Y, Song B, Jiang Z, Ge Z, et al. Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis. Gut Microbes. 2021;13:1\u201319.","journal-title":"Gut Microbes"},{"key":"6426_CR58","doi-asserted-by":"publisher","first-page":"242","DOI":"10.23736\/S2724-6507.22.03752-6","volume":"47","author":"N Kobyliak","year":"2022","unstructured":"Kobyliak N, Falalyeyeva T, Kyriachenko Y, Tseyslyer Y, Kovalchuk O, Hadiliia O, Eslami M, Yousefi B, Abenavoli L, Fagoonee S, Pellicano R. Akkermansia muciniphila as a novel powerful bacterial player in the treatment of metabolic disorders. Minerva Endocrino. 2022;47:242\u201352.","journal-title":"Minerva Endocrino"},{"key":"6426_CR59","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/jcpe.13214","volume":"47","author":"O Huck","year":"2020","unstructured":"Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, de Vos WM, Amar S. Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020;47:202\u201312.","journal-title":"J Clin Periodontol"},{"key":"6426_CR60","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez MAG, Canfora EE, Jocken JWE, Blaak EE. The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients. 2019;11.","DOI":"10.3390\/nu11081943"},{"key":"6426_CR61","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","volume":"165","author":"A Koh","year":"2016","unstructured":"Koh A, De Vadder F, Kovatcheva-Datchary P, B\u00e4ckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 2016;165:1332\u201345.","journal-title":"Cell"},{"key":"6426_CR62","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12917-014-0235-2","volume":"10","author":"S Tao","year":"2014","unstructured":"Tao S, Duanmu Y, Dong H, Tian J, Ni Y, Zhao R. A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats. BMC Vet Res. 2014;10:235.","journal-title":"BMC Vet Res"},{"key":"6426_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1892441","volume":"13","author":"S Kim","year":"2021","unstructured":"Kim S, Shin YC, Kim TY, Kim Y, Lee YS, Lee SH, Kim MN, Eunju O, Kim KS, Kweon MN. Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development. Gut Microbes. 2021;13:1\u201320.","journal-title":"Gut Microbes"},{"key":"6426_CR64","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/codi.13720","volume":"19","author":"R Garfinkle","year":"2017","unstructured":"Garfinkle R, Trabulsi N, Morin N, Phang T, Liberman S, Feldman L, Fried G, Boutros M. Study protocol evaluating the use of bowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter randomized controlled trial. Colorectal Dis. 2017;19:1024\u20139.","journal-title":"Colorectal Dis"},{"key":"6426_CR65","doi-asserted-by":"publisher","first-page":"9798","DOI":"10.3390\/ijms22189798","volume":"22","author":"X Wu","year":"2021","unstructured":"Wu X, Hong L. Calmodulin interactions with voltage-gated sodium channels. Int J Mol Sci. 2021;22:9798.","journal-title":"Int J Mol Sci"},{"key":"6426_CR66","doi-asserted-by":"publisher","first-page":"159","DOI":"10.11622\/smedj.2021036","volume":"62","author":"EL Yong","year":"2021","unstructured":"Yong EL, Logan S. Menopausal osteoporosis: screening, prevention and treatment. Singapore Med J. 2021;62:159\u201366.","journal-title":"Singapore Med J"},{"key":"6426_CR67","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jprot.2018.07.008","volume":"192","author":"MF Stokman","year":"2019","unstructured":"Stokman MF, Bijnsdorp IV, Schelfhorst T, Pham TV, Piersma SR, Knol JC, Giles RH, Bongers E, Knoers N, Lilien MR, et al. Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. J Proteomics. 2019;192:27\u201336.","journal-title":"J Proteomics"},{"key":"6426_CR68","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/acps.13038","volume":"140","author":"D Mehta","year":"2019","unstructured":"Mehta D, Rex-Haffner M, S\u00f8ndergaard HB, Pinborg A, Binder EB, Frokjaer VG. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms. Acta Psychiatr Scand. 2019;140:77\u201384.","journal-title":"Acta Psychiatr Scand"},{"key":"6426_CR69","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/bcp.15010","volume":"88","author":"D Fernando","year":"2022","unstructured":"Fernando D, Dimelow R, Gorey C, Zhu X, Muya C, Parker C, Wright W, Soleman S, Walsh S, Crause M, et al. Assessment of the safety, pharmacokinetics and pharmacodynamics of GSK3335065, an inhibitor of kynurenine monooxygenase, in a randomised placebo-controlled first-in-human study in healthy volunteers. Br J Clin Pharmacol. 2022;88:865\u201370.","journal-title":"Br J Clin Pharmacol"},{"key":"6426_CR70","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s40168-021-01050-9","volume":"9","author":"SA Barretto","year":"2021","unstructured":"Barretto SA, Lasserre F, Huillet M, R\u00e9gnier M, Polizzi A, Lippi Y, Fougerat A, Person E, Bruel S, B\u00e9touli\u00e8res C, et al. The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice. Microbiome. 2021;9:93.","journal-title":"Microbiome"},{"key":"6426_CR71","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mSystems.00721-20","volume":"5","author":"T Lian","year":"2020","unstructured":"Lian T, Huang Y, Xie X, Huo X, Shahid MQ, Tian L, Lan T, Jin J. Rice SST variation shapes the rhizosphere bacterial community, conferring tolerance to salt stress through regulating soil metabolites. MSystems. 2020;5:10\u2013128.","journal-title":"MSystems"},{"key":"6426_CR72","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1194\/jlr.S091793","volume":"60","author":"KJ Prentice","year":"2019","unstructured":"Prentice KJ, Saksi J, Hotamisligil GS. Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. J Lipid Res. 2019;60:734\u201340.","journal-title":"J Lipid Res"},{"key":"6426_CR73","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bbalip.2017.03.007","volume":"1862","author":"X Su","year":"2017","unstructured":"Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, et al. Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:692\u2013705.","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"6426_CR74","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2022.01.002","volume":"344","author":"N Villa-Roel","year":"2022","unstructured":"Villa-Roel N, Ryu K, Gu L, Fernandez Esmerats J, Kang DW, Kumar S, Jo H. Hypoxia inducible factor 1\u03b1 inhibitor PX-478 reduces atherosclerosis in mice. Atherosclerosis. 2022;344:20\u201330.","journal-title":"Atherosclerosis"},{"key":"6426_CR75","doi-asserted-by":"crossref","unstructured":"Yang S, Zeng Q, Huang X, Liang Z, Hu H. Effect of isoflavones on blood lipid alterations in postmenopausal females: a systematic review and meta-analysis of randomized trials. Adv Nutr. 2023;14:1633\u20131643.","DOI":"10.1016\/j.advnut.2023.09.008"},{"key":"6426_CR76","doi-asserted-by":"crossref","unstructured":"Akhlaghi M, Ghasemi Nasab M, Riasatian M, Sadeghi F. Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60:2327\u20132341.","DOI":"10.1080\/10408398.2019.1635078"},{"key":"6426_CR77","doi-asserted-by":"crossref","unstructured":"Gholami A, Baradaran HR, Hariri M. Can soy isoflavones plus soy protein change serum levels of interlukin-6? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35:1147\u20131162.","DOI":"10.1002\/ptr.6881"},{"key":"6426_CR78","doi-asserted-by":"crossref","unstructured":"Rotimi SO, Adelani IB, Bankole GE, Rotimi OA. Naringin enhances reverse cholesterol transport in high fat\/low streptozocin induced diabetic rats. Biomed Pharmacother. 2018;101:430\u2013437.","DOI":"10.1016\/j.biopha.2018.02.116"},{"key":"6426_CR79","doi-asserted-by":"crossref","unstructured":"Pari L, Chandramohan R. Modulatory effects of naringin on hepatic key enzymes of carbohydrate metabolism in high-fat diet\/low-dose streptozotocin-induced diabetes in rats. Gen Physiol Biophys. 2017;36:343\u2013352.","DOI":"10.4149\/gpb_2016055"},{"key":"6426_CR80","doi-asserted-by":"crossref","unstructured":"Xiao Q, Luo L, Zhu X, Yan Y, Li S, Chen L, Wang X, Zhang J, Liu D, Liu R, Zhong Y. Formononetin alleviates ulcerative colitis via reshaping the balance of M1\/M2 macrophage polarization in a gut microbiota-dependent manner. Phytomedicine. 2024;135:156153.","DOI":"10.1016\/j.phymed.2024.156153"},{"key":"6426_CR81","doi-asserted-by":"crossref","unstructured":"Liu Y, Zhong X, Lin S, Xu H, Liang X, Wang Y, Xu J, Wang K, Guo X, Wang J, et al. Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders. Microbiome. 2022;10:226.","DOI":"10.1186\/s40168-022-01430-9"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06426-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06426-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06426-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T23:03:39Z","timestamp":1744239819000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06426-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6426"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06426-1","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"9 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was funded by the Ethics Committee of Zhejiang Province, and the animal experiments were conducted at the Zhejiang Academy of Agricultural Sciences (License No. 2021ZAASLA50).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Jinjun Li, Zhiqhi Zhao, Yixuan Deng, Lili, Liying Zhu, XinWang, Haibiao Sun, Xiaoqiong Li, and Xiaoqiang Han confirm that we have reviewed and agree with the contents of the submitted manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"410"}}