{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:42:13Z","timestamp":1787740933783,"version":"build-2784847793"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan","doi-asserted-by":"crossref","award":["242300421019"],"award-info":[{"award-number":["242300421019"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henan Province Youth Health Science and Technology Innovation Project","award":["LJRC2023014"],"award-info":[{"award-number":["LJRC2023014"]}]},{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["QNCXTD2023012"],"award-info":[{"award-number":["QNCXTD2023012"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070209"],"award-info":[{"award-number":["82070209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170183"],"award-info":[{"award-number":["82170183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970184"],"award-info":[{"award-number":["81970184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1904139"],"award-info":[{"award-number":["U1904139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06456-9","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T13:00:56Z","timestamp":1745067656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spatial transcriptomics study of Castleman disease"],"prefix":"10.1186","volume":"23","author":[{"given":"Yanfang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-2864","authenticated-orcid":false,"given":"Zhaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"6456_CR1","first-page":"119","volume":"12","author":"JA Flendrig","year":"1969","unstructured":"Flendrig JA, Schillings PHM. Benign giant lymphoma: the clinical signs and symptoms. Folia Med Neerl. 1969;12:119\u201320.","journal-title":"Folia Med Neerl"},{"key":"6456_CR2","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/1097-0142(197203)29:3<670::AID-CNCR2820290321>3.0.CO;2-#","volume":"29","author":"AR Keller","year":"1972","unstructured":"Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972;29:670\u201383.","journal-title":"Cancer"},{"key":"6456_CR3","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1182\/blood-2004-12-4602","volume":"106","author":"N Nishimoto","year":"2005","unstructured":"Nishimoto N, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric castleman disease. Blood. 2005;106:2627\u201332. https:\/\/doi.org\/10.1182\/blood-2004-12-4602.","journal-title":"Blood"},{"key":"6456_CR4","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1200\/jco.2009.27.2377","volume":"28","author":"F van Rhee","year":"2010","unstructured":"van Rhee F, et al. Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman\u2019s disease. J Clin Oncol. 2010;28:3701\u20138. https:\/\/doi.org\/10.1200\/jco.2009.27.2377.","journal-title":"J Clin Oncol"},{"key":"6456_CR5","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/s1470-2045(14)70319-5","volume":"15","author":"F van Rhee","year":"2014","unstructured":"van Rhee F, et al. Siltuximab for multicentric Castleman\u2019s disease: a randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2014;15:966\u201374. https:\/\/doi.org\/10.1016\/s1470-2045(14)70319-5.","journal-title":"Lancet Oncol"},{"key":"6456_CR6","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1038\/s41375-023-01908-x","volume":"37","author":"Y Xia","year":"2023","unstructured":"Xia Y, et al. Spatial single cell analysis of tumor microenvironment remodeling pattern in primary central nervous system lymphoma. Leukemia. 2023;37:1499\u2013510. https:\/\/doi.org\/10.1038\/s41375-023-01908-x.","journal-title":"Leukemia"},{"key":"6456_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","volume":"181","author":"L Zhang","year":"2020","unstructured":"Zhang L, et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell. 2020;181:442-459.e429. https:\/\/doi.org\/10.1016\/j.cell.2020.03.048.","journal-title":"Cell"},{"key":"6456_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13045-021-01105-2","volume":"14","author":"Y Lei","year":"2021","unstructured":"Lei Y, et al. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol Oncol. 2021;14:91. https:\/\/doi.org\/10.1186\/s13045-021-01105-2.","journal-title":"J Hematol Oncol"},{"key":"6456_CR9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/cac2.12078","volume":"40","author":"S Ding","year":"2020","unstructured":"Ding S, Chen X, Shen K. Single-cell RNA sequencing in breast cancer: understanding tumor heterogeneity and paving roads to individualized therapy. Cancer Commun. 2020;40:329\u201344. https:\/\/doi.org\/10.1002\/cac2.12078.","journal-title":"Cancer Commun"},{"key":"6456_CR10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1126\/science.aaf2403","volume":"353","author":"PL St\u00e5hl","year":"2016","unstructured":"St\u00e5hl PL, et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science. 2016;353:78\u201382. https:\/\/doi.org\/10.1126\/science.aaf2403.","journal-title":"Science"},{"key":"6456_CR11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","volume":"596","author":"A Rao","year":"2021","unstructured":"Rao A, Barkley D, Fran\u00e7a GS, Yanai I. Exploring tissue architecture using spatial transcriptomics. Nature. 2021;596:211\u201320. https:\/\/doi.org\/10.1038\/s41586-021-03634-9.","journal-title":"Nature"},{"key":"6456_CR12","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-022-01448-2","volume":"41","author":"L Tian","year":"2023","unstructured":"Tian L, Chen F, Macosko EZ. The expanding vistas of spatial transcriptomics. Nat Biotechnol. 2023;41:773\u201382. https:\/\/doi.org\/10.1038\/s41587-022-01448-2.","journal-title":"Nat Biotechnol"},{"key":"6456_CR13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41379-021-00950-3","volume":"35","author":"A Wing","year":"2022","unstructured":"Wing A, et al. Transcriptome and unique cytokine microenvironment of Castleman disease. Modern Pathol. 2022;35:451\u201361. https:\/\/doi.org\/10.1038\/s41379-021-00950-3.","journal-title":"Modern Pathol"},{"key":"6456_CR14","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/bjh.15019","volume":"180","author":"E Oksenhendler","year":"2018","unstructured":"Oksenhendler E, et al. The full spectrum of Castleman disease: 273 patients studied over 20 years. Br J Haematol. 2018;180:206\u201316. https:\/\/doi.org\/10.1111\/bjh.15019.","journal-title":"Br J Haematol"},{"key":"6456_CR15","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1200\/jco.1985.3.9.1202","volume":"3","author":"G Frizzera","year":"1985","unstructured":"Frizzera G, Peterson BA, Bayrd ED, Goldman A. A systemic lymphoproliferative disorder with morphologic features of Castleman\u2019s disease: clinical findings and clinicopathologic correlations in 15 patients. J Clin Oncol. 1985;3:1202\u201316. https:\/\/doi.org\/10.1200\/jco.1985.3.9.1202.","journal-title":"J Clin Oncol"},{"key":"6456_CR16","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1016\/s2352-3026(16)00006-5","volume":"3","author":"AY Liu","year":"2016","unstructured":"Liu AY, et al. Idiopathic multicentric Castleman\u2019s disease: a systematic literature review. Lancet Haematol. 2016;3:e163-175. https:\/\/doi.org\/10.1016\/s2352-3026(16)00006-5.","journal-title":"Lancet Haematol"},{"key":"6456_CR17","first-page":"1013","volume":"109","author":"D Dickson","year":"1985","unstructured":"Dickson D, Ben-Ezra JM, Reed J, Flax H, Janis R. Multicentric giant lymph node hyperplasia, Kaposi\u2019s sarcoma, and lymphoma. Arch Pathol Lab Med. 1985;109:1013\u20138.","journal-title":"Arch Pathol Lab Med"},{"key":"6456_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/ajh.10022","volume":"69","author":"C Larroche","year":"2002","unstructured":"Larroche C, et al. Castleman\u2019s disease and lymphoma: report of eight cases in HIV-negative patients and literature review. Am J Hematol. 2002;69:119\u201326. https:\/\/doi.org\/10.1002\/ajh.10022.","journal-title":"Am J Hematol"},{"key":"6456_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616.","journal-title":"Bioinformatics"},{"key":"6456_CR20","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"key":"6456_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 2013;14:7. https:\/\/doi.org\/10.1186\/1471-2105-14-7.","journal-title":"BMC Bioinform"},{"key":"6456_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, et al. Inference and analysis of cell-cell communication using cell chat. Nat Commun. 2021;12:1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9.","journal-title":"Nat Commun"},{"key":"6456_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010391","author":"DJA Oketch","year":"2023","unstructured":"Oketch DJA, Giulietti M, Piva F. Copy number variations in pancreatic cancer: from biological significance to clinical utility. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms25010391.","journal-title":"Int J Mol Sci"},{"key":"6456_CR24","doi-asserted-by":"publisher","first-page":"112804","DOI":"10.1016\/j.intimp.2024.112804","volume":"140","author":"Y Xiao","year":"2024","unstructured":"Xiao Y, Hu F, Chi Q. Single-cell RNA sequencing and spatial transcriptome reveal potential molecular mechanisms of lung cancer brain metastasis. Int Immunopharmacol. 2024;140:112804. https:\/\/doi.org\/10.1016\/j.intimp.2024.112804.","journal-title":"Int Immunopharmacol"},{"key":"6456_CR25","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/s41375-018-0323-6","volume":"33","author":"Z Li","year":"2019","unstructured":"Li Z, et al. Recurrent PDGFRB mutations in unicentric Castleman disease. Leukemia. 2019;33:1035\u20138. https:\/\/doi.org\/10.1038\/s41375-018-0323-6.","journal-title":"Leukemia"},{"key":"6456_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3960\/jslrt.22010","volume":"62","author":"R Sumiyoshi","year":"2022","unstructured":"Sumiyoshi R, Koga T, Kawakami A. Candidate biomarkers for idiopathic multicentric Castleman disease. J Clin Exp Hematopathol: JCEH. 2022;62:85\u201390. https:\/\/doi.org\/10.3960\/jslrt.22010.","journal-title":"J Clin Exp Hematopathol: JCEH"},{"key":"6456_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3109\/10428190009087030","volume":"38","author":"J Nishi","year":"2000","unstructured":"Nishi J, Maruyama I. Increased expression of vascular endothelial growth factor (VEGF) in Castleman\u2019s disease: proposed pathomechanism of vascular proliferation in the affected lymph node. Leuk Lymphoma. 2000;38:387\u201394. https:\/\/doi.org\/10.3109\/10428190009087030.","journal-title":"Leuk Lymphoma"},{"key":"6456_CR28","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1182\/blood.2023021992","volume":"143","author":"JY Chan","year":"2024","unstructured":"Chan JY, et al. Single-cell landscape of idiopathic multicentric Castleman disease in identical twins. Blood. 2024;143:1837\u201344. https:\/\/doi.org\/10.1182\/blood.2023021992.","journal-title":"Blood"},{"key":"6456_CR29","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/path.5856","volume":"256","author":"Q Yuan","year":"2022","unstructured":"Yuan Q, et al. MyD88 in myofibroblasts regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation. J Pathol. 2022;256:414\u201326. https:\/\/doi.org\/10.1002\/path.5856.","journal-title":"J Pathol"},{"key":"6456_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ccell.2023.12.002","volume":"42","author":"G Mucciolo","year":"2024","unstructured":"Mucciolo G, et al. EGFR-activated myofibroblasts promote metastasis of pancreatic cancer. Cancer Cell. 2024;42:101-118.e111. https:\/\/doi.org\/10.1016\/j.ccell.2023.12.002.","journal-title":"Cancer Cell"},{"key":"6456_CR31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ccell.2021.02.007","volume":"39","author":"Y Chen","year":"2021","unstructured":"Chen Y, et al. Type I collagen deletion in \u03b1SMA(+) myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021;39:548-565.e546. https:\/\/doi.org\/10.1016\/j.ccell.2021.02.007.","journal-title":"Cancer Cell"},{"key":"6456_CR32","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41586-022-05272-1","volume":"611","author":"AT Krishnamurty","year":"2022","unstructured":"Krishnamurty AT, et al. LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature. 2022;611:148\u201354. https:\/\/doi.org\/10.1038\/s41586-022-05272-1.","journal-title":"Nature"},{"key":"6456_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.addr.2017.07.010","volume":"121","author":"S Yazdani","year":"2017","unstructured":"Yazdani S, Bansal R, Prakash J. Drug targeting to myofibroblasts: Implications for fibrosis and cancer. Adv Drug Deliv Rev. 2017;121:101\u201316. https:\/\/doi.org\/10.1016\/j.addr.2017.07.010.","journal-title":"Adv Drug Deliv Rev"},{"key":"6456_CR34","unstructured":"GeneCards. https:\/\/www.genecards.org\/. Accessed 20 July 2023."},{"key":"6456_CR35","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s00432-018-2647-z","volume":"144","author":"X Lan","year":"2018","unstructured":"Lan X, Li Z, Zhang M. Analysis of clinical characteristics and prognosis factors of 71 cases with HIV-negative Castleman\u2019s disease: hypoproteinemia is an unfavorable prognostic factor which should be treated appropriately. J Cancer Res Clin Oncol. 2018;144:1265\u201377. https:\/\/doi.org\/10.1007\/s00432-018-2647-z.","journal-title":"J Cancer Res Clin Oncol"},{"key":"6456_CR36","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ajh.23291","volume":"87","author":"A Dispenzieri","year":"2012","unstructured":"Dispenzieri A, et al. The clinical spectrum of Castleman\u2019s disease. Am J Hematol. 2012;87:997\u20131002. https:\/\/doi.org\/10.1002\/ajh.23291.","journal-title":"Am J Hematol"},{"key":"6456_CR37","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1182\/blood.v99.7.2331","volume":"99","author":"E Oksenhendler","year":"2002","unstructured":"Oksenhendler E, et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood. 2002;99:2331\u20136. https:\/\/doi.org\/10.1182\/blood.v99.7.2331.","journal-title":"Blood"},{"key":"6456_CR38","doi-asserted-by":"publisher","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","volume":"25","author":"TD Gilmore","year":"2006","unstructured":"Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene. 2006;25:6680\u20134. https:\/\/doi.org\/10.1038\/sj.onc.1209954.","journal-title":"Oncogene"},{"key":"6456_CR39","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.gendis.2020.06.005","volume":"8","author":"MR Zinatizadeh","year":"2021","unstructured":"Zinatizadeh MR, et al. The nuclear factor kappa B (NF-kB) signaling in cancer development and immune diseases. Genes Dis. 2021;8:287\u201397. https:\/\/doi.org\/10.1016\/j.gendis.2020.06.005.","journal-title":"Genes Dis"},{"key":"6456_CR40","doi-asserted-by":"publisher","first-page":"52437","DOI":"10.1074\/jbc.M304199200","volume":"278","author":"Q Sun","year":"2003","unstructured":"Sun Q, Zachariah S, Chaudhary PM. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003;278:52437\u201345. https:\/\/doi.org\/10.1074\/jbc.M304199200.","journal-title":"J Biol Chem"},{"key":"6456_CR41","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1182\/blood-2008-12-197053","volume":"113","author":"M Bower","year":"2009","unstructured":"Bower M, et al. Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease. Blood. 2009;113:4521\u20134. https:\/\/doi.org\/10.1182\/blood-2008-12-197053.","journal-title":"Blood"},{"key":"6456_CR42","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nri2711","volume":"10","author":"M Saraiva","year":"2010","unstructured":"Saraiva M, O\u2019Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10:170\u201381. https:\/\/doi.org\/10.1038\/nri2711.","journal-title":"Nat Rev Immunol"},{"key":"6456_CR43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","volume":"29","author":"W Ouyang","year":"2011","unstructured":"Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;29:71\u2013109. https:\/\/doi.org\/10.1146\/annurev-immunol-031210-101312.","journal-title":"Annu Rev Immunol"},{"key":"6456_CR44","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028548","author":"X Wang","year":"2019","unstructured":"Wang X, Wong K, Ouyang W, Rutz S. Targeting IL-10 family cytokines for the treatment of human diseases. Cold Spring Harb Perspect Biol. 2019. https:\/\/doi.org\/10.1101\/cshperspect.a028548.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"6456_CR45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.canlet.2015.07.009","volume":"367","author":"MH Mannino","year":"2015","unstructured":"Mannino MH, et al. The paradoxical role of IL-10 in immunity and cancer. Cancer Lett. 2015;367:103\u20137. https:\/\/doi.org\/10.1016\/j.canlet.2015.07.009.","journal-title":"Cancer Lett"},{"key":"6456_CR46","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1189\/jlb.0610351","volume":"89","author":"J Denoeud","year":"2011","unstructured":"Denoeud J, Moser M. Role of CD27\/CD70 pathway of activation in immunity and tolerance. J Leukoc Biol. 2011;89:195\u2013203. https:\/\/doi.org\/10.1189\/jlb.0610351.","journal-title":"J Leukoc Biol"},{"key":"6456_CR47","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1158\/1535-7163.Mct-20-0591","volume":"20","author":"T Fujiwara","year":"2021","unstructured":"Fujiwara T, et al. CSF1\/CSF1R signaling inhibitor pexidartinib (PLX3397) reprograms tumor-associated macrophages and stimulates t-cell infiltration in the sarcoma microenvironment. Mol Cancer Ther. 2021;20:1388\u201399. https:\/\/doi.org\/10.1158\/1535-7163.Mct-20-0591.","journal-title":"Mol Cancer Ther"},{"key":"6456_CR48","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1158\/1078-0432.Ccr-09-2329","volume":"16","author":"BA Teicher","year":"2010","unstructured":"Teicher BA, Fricker SP. CXCL12 (SDF-1)\/CXCR4 pathway in cancer. Clin Cancer Res. 2010;16:2927\u201331. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-09-2329.","journal-title":"Clin Cancer Res"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06456-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06456-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06456-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T13:00:58Z","timestamp":1745067658000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06456-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,19]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6456"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06456-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,19]]},"assertion":[{"value":"21 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University (2023-KY-0764).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"459"}}