{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:11:18Z","timestamp":1793729478615,"version":"4.6.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation","award":["2023GXNSFAA026001"],"award-info":[{"award-number":["2023GXNSFAA026001"]}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["YCBZ2024131"],"award-info":[{"award-number":["YCBZ2024131"]}]},{"name":"The 111 Project","award":["D17011"],"award-info":[{"award-number":["D17011"]}]},{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSF202414"],"award-info":[{"award-number":["GXMUYSF202414"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06537-9","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T05:58:22Z","timestamp":1747720702000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K\/Akt\/mTOR pathway"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1079-5666","authenticated-orcid":false,"given":"Zhipeng","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-8119","authenticated-orcid":false,"given":"Zeyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"6537_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7\u201334.","journal-title":"CA Cancer J Clin"},{"key":"6537_CR2","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/hep.29498","volume":"67","author":"PC Valery","year":"2018","unstructured":"Valery PC, Laversanne M, Clark PJ, Petrick JL, McGlynn KA, Bray F. Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology. 2018;67:600\u201311.","journal-title":"Hepatology"},{"key":"6537_CR3","doi-asserted-by":"publisher","first-page":"101942","DOI":"10.1016\/j.redox.2021.101942","volume":"41","author":"J Sun","year":"2021","unstructured":"Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, et al. Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation. Redox Biol. 2021;41:101942.","journal-title":"Redox Biol"},{"key":"6537_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12943-022-01575-z","volume":"21","author":"A Du","year":"2022","unstructured":"Du A, Li S, Zhou Y, Disoma C, Liao Y, Zhang Y, Chen Z, Yang Q, Liu P, Liu S, et al. M6A-mediated upregulation of circmdk promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. Mol Cancer. 2022;21:109.","journal-title":"Mol Cancer"},{"key":"6537_CR5","doi-asserted-by":"publisher","first-page":"102971","DOI":"10.1016\/j.redox.2023.102971","volume":"69","author":"Y Li","year":"2024","unstructured":"Li Y, Guo M, Qiu Y, Li M, Wu Y, Shen M, Wang Y, Zhang F, Shao J, Xu X, et al. Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma. Redox Biol. 2024;69:102971.","journal-title":"Redox Biol"},{"key":"6537_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.61186\/ijbc.16.2.84","volume":"16","author":"SA Aghapour","year":"2024","unstructured":"Aghapour SA, Torabizadeh M, Bahreiny SS, Saki N, Jalali Far MA, Yousefi-Avarvand A, Dost Mohammad Ghasemi K, Aghaei M, Abolhasani MM, Sharifani MS, et al. Investigating the dynamic interplay between cellular immunity and tumor cells in the fight against cancer: an updated comprehensive review %J. Iran J Blood Cancer. 2024;16:84\u2013101.","journal-title":"Iran J Blood Cancer"},{"key":"6537_CR7","doi-asserted-by":"crossref","unstructured":"Sanger A, Hirst J, Davies AK, Robinson MS. Adaptor protein complexes and disease at a glance. J Cell Sci. 2019;132.","DOI":"10.1242\/jcs.222992"},{"key":"6537_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.tcb.2004.02.002","volume":"14","author":"MS Robinson","year":"2004","unstructured":"Robinson MS. Adaptable adaptors for coated vesicles. Trends Cell Biol. 2004;14:167\u201374.","journal-title":"Trends Cell Biol"},{"key":"6537_CR9","doi-asserted-by":"publisher","first-page":"e2004411","DOI":"10.1371\/journal.pbio.2004411","volume":"16","author":"J Hirst","year":"2018","unstructured":"Hirst J, Itzhak DN, Antrobus R, Borner GHH, Robinson MS. Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval. PLoS Biol. 2018;16:e2004411.","journal-title":"PLoS Biol"},{"key":"6537_CR10","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12282-023-01539-1","volume":"31","author":"N Hoshi","year":"2024","unstructured":"Hoshi N, Uemura T, Tachibana K, Abe S, Murakami-Nishimagi Y, Okano M, Noda M, Saito K, Kono K, Ohtake T, Waguri S. Endosomal protein expression of gamma1-adaptin is associated with tumor growth activity and relapse-free survival in breast cancer. Breast Cancer. 2024;31:305\u201316.","journal-title":"Breast Cancer"},{"key":"6537_CR11","doi-asserted-by":"publisher","first-page":"930933","DOI":"10.3389\/fcell.2022.930933","volume":"10","author":"G Wu","year":"2022","unstructured":"Wu G, Chen M, Ren H, Sha X, He M, Ren K, Qi J, Lin F. AP3S1 is a novel prognostic biomarker and correlated with an immunosuppressive tumor microenvironment in Pan-Cancer. Front Cell Dev Biol. 2022;10:930933.","journal-title":"Front Cell Dev Biol"},{"key":"6537_CR12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s40001-024-01814-7","volume":"29","author":"D Kong","year":"2024","unstructured":"Kong D, Wu Y, Liu Q, Huang C, Wang T, Huang Z, Gao Y, Li Y, Guo H. Functional analysis and validation of Oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing. Eur J Med Res. 2024;29:231.","journal-title":"Eur J Med Res"},{"key":"6537_CR13","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1002\/jcb.27699","volume":"120","author":"SH Cho","year":"2019","unstructured":"Cho SH, Pak K, Jeong DC, Han ME, Oh SO, Kim YH. The AP2M1 gene expression is a promising biomarker for predicting survival of patients with hepatocellular carcinoma. J Cell Biochem. 2019;120:4140\u20136.","journal-title":"J Cell Biochem"},{"key":"6537_CR14","doi-asserted-by":"publisher","first-page":"e46228","DOI":"10.1371\/journal.pone.0046228","volume":"7","author":"J Pignatelli","year":"2012","unstructured":"Pignatelli J, Jones MC, LaLonde DP, Turner CE. Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation. PLoS ONE. 2012;7:e46228.","journal-title":"PLoS ONE"},{"key":"6537_CR15","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1212\/NXG.0000000000000098","volume":"2","author":"J Hirst","year":"2016","unstructured":"Hirst J, Madeo M, Smets K, Edgar JR, Schols L, Li J, Yarrow A, Deconinck T, Baets J, Van Aken E, et al. Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48). Neurol Genet. 2016;2:e98.","journal-title":"Neurol Genet"},{"key":"6537_CR16","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/mds.28487","volume":"36","author":"M Breza","year":"2021","unstructured":"Breza M, Hirst J, Chelban V, Banneau G, Tissier L, Kol B, Bourinaris T, Said SA, P\u00e9r\u00e9on Y, Heinzmann A, et al. Expanding the spectrum of AP5Z1-Related hereditary spastic paraplegia (HSP-SPG48): A multicenter study on a rare disease. Mov Disord. 2021;36:1034\u20138.","journal-title":"Mov Disord"},{"key":"6537_CR17","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/s41556-019-0384-4","volume":"21","author":"L Liu","year":"2019","unstructured":"Liu L, Michowski W, Kolodziejczyk A, Sicinski P. The cell cycle in stem cell proliferation, pluripotency and differentiation. Nat Cell Biol. 2019;21:1060\u20137.","journal-title":"Nat Cell Biol"},{"key":"6537_CR18","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","volume":"23","author":"HK Matthews","year":"2022","unstructured":"Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer. Nat Rev Mol Cell Biol. 2022;23:74\u201388.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6537_CR19","doi-asserted-by":"publisher","first-page":"12483","DOI":"10.1093\/nar\/gkaa1002","volume":"48","author":"S Hume","year":"2020","unstructured":"Hume S, Dianov GL, Ramadan K. A unified model for the G1\/S cell cycle transition. Nucleic Acids Res. 2020;48:12483\u2013501.","journal-title":"Nucleic Acids Res"},{"key":"6537_CR20","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.tcb.2021.05.001","volume":"31","author":"C Chu","year":"2021","unstructured":"Chu C, Geng Y, Zhou Y, Sicinski P. Cyclin E in normal physiology and disease States. Trends Cell Biol. 2021;31:732\u201346.","journal-title":"Trends Cell Biol"},{"key":"6537_CR21","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1038\/sj.onc.1208613","volume":"24","author":"HC Hwang","year":"2005","unstructured":"Hwang HC, Clurman BE. Cyclin E in normal and neoplastic cell cycles. Oncogene. 2005;24:2776\u201386.","journal-title":"Oncogene"},{"key":"6537_CR22","doi-asserted-by":"publisher","first-page":"118688","DOI":"10.1016\/j.bbamcr.2020.118688","volume":"1867","author":"A Boice","year":"2020","unstructured":"Boice A, Bouchier-Hayes L. Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020;1867:118688.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"6537_CR23","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.1093\/hmg\/ddv220","volume":"24","author":"J Hirst","year":"2015","unstructured":"Hirst J, Edgar JR, Esteves T, Darios F, Madeo M, Chang J, Roda RH, D\u00fcrr A, Anheim M, Gellera C, et al. Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease. Hum Mol Genet. 2015;24:4984\u201396.","journal-title":"Hum Mol Genet"},{"key":"6537_CR24","doi-asserted-by":"crossref","unstructured":"Dossou AS, Basu A. The emerging roles of mTORC1 in macromanaging autophagy. Cancers (Basel). 2019;11.","DOI":"10.3390\/cancers11101422"},{"key":"6537_CR25","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1093\/emboj\/20.9.2140","volume":"20","author":"A Reymond","year":"2001","unstructured":"Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, et al. The tripartite motif family identifies cell compartments. Embo J. 2001;20:2140\u201351.","journal-title":"Embo J"},{"key":"6537_CR26","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1083\/jcb.97.5.1339","volume":"97","author":"S Zaremba","year":"1983","unstructured":"Zaremba S, Keen JH. Assembly polypeptides from coated vesicles mediate reassembly of unique clathrin coats. J Cell Biol. 1983;97:1339\u201347.","journal-title":"J Cell Biol"},{"key":"6537_CR27","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1002\/j.1460-2075.1984.tb02075.x","volume":"3","author":"BM Pearse","year":"1984","unstructured":"Pearse BM, Robinson MS. Purification and properties of 100-kd proteins from coated vesicles and their reconstitution with clathrin. EMBO J. 1984;3:1951\u20137.","journal-title":"EMBO J"},{"key":"6537_CR28","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/S0955-0674(00)00235-0","volume":"13","author":"MS Robinson","year":"2001","unstructured":"Robinson MS, Bonifacino JS. Adaptor-related proteins. Curr Opin Cell Biol. 2001;13:444\u201353.","journal-title":"Curr Opin Cell Biol"},{"key":"6537_CR29","doi-asserted-by":"publisher","first-page":"e1001170","DOI":"10.1371\/journal.pbio.1001170","volume":"9","author":"J Hirst","year":"2011","unstructured":"Hirst J, Barlow LD, Francisco GC, Sahlender DA, Seaman MN, Dacks JB, Robinson MS. The fifth adaptor protein complex. PLoS Biol. 2011;9:e1001170.","journal-title":"PLoS Biol"},{"key":"6537_CR30","doi-asserted-by":"crossref","unstructured":"Hirst J, Hesketh GG, Gingras AC, Robinson MS. Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5\/SPG11\/SPG15 complex. J Cell Biol. 2021;220.","DOI":"10.1083\/jcb.202002075"},{"key":"6537_CR31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41418-019-0295-8","volume":"26","author":"N Germic","year":"2019","unstructured":"Germic N, Frangez Z, Yousefi S, Simon HU. Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells. Cell Death Differ. 2019;26:703\u201314.","journal-title":"Cell Death Differ"},{"key":"6537_CR32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41568-021-00344-2","volume":"21","author":"H Xia","year":"2021","unstructured":"Xia H, Green DR, Zou W. Autophagy in tumour immunity and therapy. Nat Rev Cancer. 2021;21:281\u201397.","journal-title":"Nat Rev Cancer"},{"key":"6537_CR33","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","volume":"24","author":"J Debnath","year":"2023","unstructured":"Debnath J, Gammoh N, Ryan KM. Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023;24:560\u201375.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6537_CR34","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1002\/cncr.31335","volume":"124","author":"AV Onorati","year":"2018","unstructured":"Onorati AV, Dyczynski M, Ojha R, Amaravadi RK. Targeting autophagy in cancer. Cancer. 2018;124:3307\u201318.","journal-title":"Cancer"},{"key":"6537_CR35","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1158\/2159-8290.CD-19-0292","volume":"9","author":"RK Amaravadi","year":"2019","unstructured":"Amaravadi RK, Kimmelman AC, Debnath J. Targeting autophagy in cancer: recent advances and future directions. Cancer Discov. 2019;9:1167\u201381.","journal-title":"Cancer Discov"},{"key":"6537_CR36","doi-asserted-by":"publisher","first-page":"12002","DOI":"10.18632\/aging.102529","volume":"11","author":"C Diling","year":"2019","unstructured":"Diling C, Yinrui G, Longkai Q, Xiaocui T, Yadi L, Xin Y, Guoyan H, Ou S, Tianqiao Y, Dongdong W, et al. Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and adaptor protein 2 B1 in AD-like mice. Aging. 2019;11:12002\u201331.","journal-title":"Aging"},{"key":"6537_CR37","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","volume":"17","author":"BA Carneiro","year":"2020","unstructured":"Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020;17:395\u2013417.","journal-title":"Nat Rev Clin Oncol"},{"key":"6537_CR38","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1006\/excr.2000.4838","volume":"256","author":"SH Kaufmann","year":"2000","unstructured":"Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res. 2000;256:42\u20139.","journal-title":"Exp Cell Res"},{"key":"6537_CR39","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s11033-024-10200-9","volume":"52","author":"L Rajabi","year":"2025","unstructured":"Rajabi L, Ebrahimdoost M, Mohammadi SA, Soleimani Samarkhazan H, Khamisipour G, Aghaei M. Aqueous and ethanolic extracts of Moringa oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53. Mol Biol Rep. 2025;52:102.","journal-title":"Mol Biol Rep"},{"key":"6537_CR40","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/cdd.2009.33","volume":"16","author":"A Eisenberg-Lerner","year":"2009","unstructured":"Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009;16:966\u201375.","journal-title":"Cell Death Differ"},{"key":"6537_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cub.2006.10.053","volume":"17","author":"RC Scott","year":"2007","unstructured":"Scott RC, Juh\u00e1sz G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007;17:1\u201311.","journal-title":"Curr Biol"},{"key":"6537_CR42","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ebiom.2019.03.045","volume":"42","author":"Y Bai","year":"2019","unstructured":"Bai Y, Liu X, Qi X, Liu X, Peng F, Li H, Fu H, Pei S, Chen L, Chi X, et al. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1\/JNK signaling pathway. EBioMedicine. 2019;42:311\u201325.","journal-title":"EBioMedicine"},{"key":"6537_CR43","doi-asserted-by":"publisher","first-page":"18453","DOI":"10.1074\/jbc.M116.729285","volume":"291","author":"TH Smith","year":"2016","unstructured":"Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. Protease-activated Receptor-4 signaling and trafficking is regulated by the clathrin adaptor protein Complex-2 independent of beta-Arrestins. J Biol Chem. 2016;291:18453\u201364.","journal-title":"J Biol Chem"},{"key":"6537_CR44","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1038\/onc.2008.247","volume":"27","author":"A Carracedo","year":"2008","unstructured":"Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene. 2008;27:5527\u201341.","journal-title":"Oncogene"},{"key":"6537_CR45","doi-asserted-by":"publisher","first-page":"107610","DOI":"10.1016\/j.pharmthera.2020.107610","volume":"214","author":"S Kumar","year":"2020","unstructured":"Kumar S, Fairmichael C, Longley DB, Turkington RC. The multiple roles of the IAP Super-family in cancer. Pharmacol Ther. 2020;214:107610.","journal-title":"Pharmacol Ther"},{"key":"6537_CR46","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41418-020-00696-6","volume":"28","author":"LM Humphreys","year":"2021","unstructured":"Humphreys LM, Smith P, Chen Z, Fouad S, D\u2019Angiolella V. The role of E3 ubiquitin ligases in the development and progression of glioblastoma. Cell Death Differ. 2021;28:522\u201337.","journal-title":"Cell Death Differ"},{"key":"6537_CR47","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1021\/acs.chemrev.6b00737","volume":"118","author":"L Cappadocia","year":"2018","unstructured":"Cappadocia L, Lima CD. Ubiquitin-like protein conjugation: structures, chemistry, and mechanism. Chem Rev. 2018;118:889\u2013918.","journal-title":"Chem Rev"},{"key":"6537_CR48","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/s41418-020-0495-2","volume":"27","author":"M Di Rienzo","year":"2020","unstructured":"Di Rienzo M, Romagnoli A, Antonioli M, Piacentini M, Fimia GM. TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses. Cell Death Differ. 2020;27:887\u2013902.","journal-title":"Cell Death Differ"},{"key":"6537_CR49","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tibs.2017.01.002","volume":"42","author":"S Hatakeyama","year":"2017","unstructured":"Hatakeyama S. TRIM family proteins: roles in autophagy, immunity, and carcinogenesis. Trends Biochem Sci. 2017;42:297\u2013311.","journal-title":"Trends Biochem Sci"},{"key":"6537_CR50","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1093\/nar\/gkac011","volume":"50","author":"X Zhu","year":"2022","unstructured":"Zhu X, Xue J, Jiang X, Gong Y, Gao C, Cao T, Li Q, Bai L, Li Y, Xu G, et al. TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination. Nucleic Acids Res. 2022;50:1517\u201330.","journal-title":"Nucleic Acids Res"},{"key":"6537_CR51","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41419-024-06897-y","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Sandrine IK, Ma L, Chen K, Chen X, Yu Y, Wang S, Xiao L, Li C, Liu Y, et al. TNKS1BP1 facilitates ubiquitination of CNOT4 by TRIM21 to promote hepatocellular carcinoma progression and immune evasion. Cell Death Dis. 2024;15:511.","journal-title":"Cell Death Dis"},{"key":"6537_CR52","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.jcmgh.2021.01.007","volume":"11","author":"F Wang","year":"2021","unstructured":"Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, et al. The ubiquitin E3 ligase TRIM21 promotes hepatocarcinogenesis by suppressing the p62-Keap1-Nrf2 antioxidant pathway. Cell Mol Gastroenterol Hepatol. 2021;11:1369\u201385.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6537_CR53","doi-asserted-by":"publisher","first-page":"e70008","DOI":"10.1002\/hsr2.70008","volume":"7","author":"M Aghaei","year":"2024","unstructured":"Aghaei M, Khademi R, Bahreiny SS, Saki N. The need to Establish and recognize the field of clinical laboratory science (CLS) as an essential field in advancing clinical goals. Health Sci Rep. 2024;7:e70008.","journal-title":"Health Sci Rep"},{"key":"6537_CR54","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1186\/s12967-023-04383-1","volume":"21","author":"N Saki","year":"2023","unstructured":"Saki N, Haybar H, Aghaei M. Subject: motivation can be suppressed, but scientific ability cannot and should not be ignored. J Transl Med. 2023;21:520.","journal-title":"J Transl Med"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06537-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06537-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06537-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:06:38Z","timestamp":1747724798000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06537-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6537"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06537-9","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Committee on the Ethics of the First Affiliated Hospital of Guangxi Medical University (Approval number: 2024-E754-01) on October 24, 2024. Additionally, the animal experiments were approved by the Laboratory Animal Ethics Committee of Guangxi Medical University, with the ethics number: No. 202405005.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declared no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Completing interest"}}],"article-number":"564"}}