{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:22Z","timestamp":1792099822964,"version":"4.4.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX202126"],"award-info":[{"award-number":["ZYLX202126"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371565"],"award-info":[{"award-number":["82371565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals\u2019 Ascent Plan","doi-asserted-by":"crossref","award":["DFL20241802"],"award-info":[{"award-number":["DFL20241802"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"crossref"}]},{"name":"High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission","award":["2022-02-27"],"award-info":[{"award-number":["2022-02-27"]}]},{"name":"Capital health development scientific research project","award":["2024-2-2175"],"award-info":[{"award-number":["2024-2-2175"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"DOI":"10.1186\/s12967-025-06591-3","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:02:13Z","timestamp":1748235733000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Over-activation and dysfunction of platelet-NK cell aggregates in HIV-infected individuals"],"prefix":"10.1186","volume":"23","author":[{"given":"Meiju","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruojia","family":"Biao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"6591_CR1","doi-asserted-by":"publisher","first-page":"7316456","DOI":"10.1155\/2021\/7316456","volume":"2021","author":"T Lv","year":"2021","unstructured":"Lv T, Cao W, Li T. HIV-related immune activation and inflammation: current understanding and strategies. J Immunol Res. 2021;2021:7316456.","journal-title":"J Immunol Res"},{"issue":"1","key":"6591_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/imr.12079","volume":"254","author":"M Paiardini","year":"2013","unstructured":"Paiardini M, M\u00fcller-Trutwin M. HIV-associated chronic immune activation. Immunol Rev. 2013;254(1):78\u2013101.","journal-title":"Immunol Rev"},{"issue":"1","key":"6591_CR3","doi-asserted-by":"publisher","first-page":"14999","DOI":"10.1038\/s41598-018-33403-0","volume":"8","author":"EC Mesquita","year":"2018","unstructured":"Mesquita EC, Hottz ED, Amancio RT, et al. Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals. Sci Rep. 2018;8(1):14999.","journal-title":"Sci Rep"},{"issue":"5","key":"6591_CR4","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1172\/JCI117921","volume":"95","author":"AS Weyrich","year":"1995","unstructured":"Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion Signal integration and NF-kappa B translocation. J Clin Invest. 1995;95(5):2297\u2013303.","journal-title":"J Clin Invest"},{"issue":"4","key":"6591_CR5","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.4049\/jimmunol.1400091","volume":"193","author":"ED Hottz","year":"2014","unstructured":"Hottz ED, Medeiros-de-Moraes IM, Vieira-de-Abreu A, et al. Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue. J Immunol. 2014;193(4):1864\u201372.","journal-title":"J Immunol"},{"issue":"1","key":"6591_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00281-011-0286-4","volume":"34","author":"A Vieira-de-Abreu","year":"2012","unstructured":"Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA. Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Semin Immunopathol. 2012;34(1):5\u201330.","journal-title":"Semin Immunopathol"},{"key":"6591_CR7","doi-asserted-by":"publisher","first-page":"799124","DOI":"10.3389\/fimmu.2021.799124","volume":"12","author":"XP Dai","year":"2021","unstructured":"Dai XP, Wu FY, Cui C, et al. Increased platelet-CD4(+) T Cell aggregates are correlated with HIV-1 permissiveness and CD4(+) T cell loss. Front Immunol. 2021;12:799124.","journal-title":"Front Immunol"},{"issue":"1","key":"6591_CR8","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/jleuko\/qiae048","volume":"116","author":"F Wu","year":"2024","unstructured":"Wu F, Li Y, Jiang N, et al. Increased platelet-CD8+ T-cell aggregates displaying high activation, exhaustion, and tendency to death correlate with disease progression in people with HIV-1. J Leukoc Biol. 2024;116(1):166\u201376.","journal-title":"J Leukoc Biol"},{"issue":"10","key":"6591_CR9","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.4049\/jimmunol.1302318","volume":"192","author":"MV Singh","year":"2014","unstructured":"Singh MV, Davidson DC, Jackson JW, et al. Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol. 2014;192(10):4674\u201384.","journal-title":"J Immunol"},{"issue":"4","key":"6591_CR10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s11239-015-1212-8","volume":"40","author":"BB Nkambule","year":"2015","unstructured":"Nkambule BB, Davison G, Ipp H. Platelet leukocyte aggregates and markers of platelet aggregation, immune activation and disease progression in HIV infected treatment naive asymptomatic individuals. J Thromb Thrombolysis. 2015;40(4):458\u201367.","journal-title":"J Thromb Thrombolysis"},{"issue":"4","key":"6591_CR11","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/cmi.2014.66","volume":"12","author":"H Liang","year":"2015","unstructured":"Liang H, Duan Z, Li D, et al. Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection. Cell Mol Immunol. 2015;12(4):435\u201343.","journal-title":"Cell Mol Immunol"},{"issue":"19","key":"6591_CR12","doi-asserted-by":"publisher","first-page":"8767","DOI":"10.1073\/pnas.91.19.8767","volume":"91","author":"A Celi","year":"1994","unstructured":"Celi A, Pellegrini G, Lorenzet R, et al. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A. 1994;91(19):8767\u201371.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"6591_CR13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1189\/jlb.0605318","volume":"79","author":"PA da Costa Martins","year":"2006","unstructured":"da Costa Martins PA, van Gils JM, Mol A, Hordijk PL, Zwaginga JJ. Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol. 2006;79(3):499\u2013507.","journal-title":"J Leukoc Biol"},{"key":"6591_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.coi.2015.11.003","volume":"38","author":"N Wu","year":"2016","unstructured":"Wu N, Veillette A. SLAM family receptors in normal immunity and immune pathologies. Curr Opin Immunol. 2016;38:45\u201351.","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"6591_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41423-019-0222-4","volume":"16","author":"S Chen","year":"2019","unstructured":"Chen S, Dong Z. NK cell recognition of hematopoietic cells by SLAM-SAP families. Cell Mol Immunol. 2019;16(5):452\u20139.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"6591_CR16","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1080\/22221751.2020.1826361","volume":"9","author":"S Wang","year":"2020","unstructured":"Wang S, Zhang Q, Hui H, Agrawal K, Karris M, Rana TM. An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics. Emerg Microbes Infect. 2020;9(1):2333\u201347.","journal-title":"Emerg Microbes Infect"},{"issue":"2","key":"6591_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41577-021-00558-3","volume":"22","author":"NK Bj\u00f6rkstr\u00f6m","year":"2022","unstructured":"Bj\u00f6rkstr\u00f6m NK, Strunz B, Ljunggren HG. Natural killer cells in antiviral immunity. Nat Rev Immunol. 2022;22(2):112\u201323.","journal-title":"Nat Rev Immunol"},{"key":"6591_CR18","doi-asserted-by":"publisher","first-page":"861251","DOI":"10.3389\/fimmu.2022.861251","volume":"13","author":"B Malengier-Devlies","year":"2022","unstructured":"Malengier-Devlies B, Filtjens J, Ahmadzadeh K, et al. Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates. Front Immunol. 2022;13:861251.","journal-title":"Front Immunol"},{"issue":"5","key":"6591_CR19","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1189\/jlb.0907615","volume":"83","author":"N Li","year":"2008","unstructured":"Li N. Platelet-lymphocyte cross-talk. J Leukoc Biol. 2008;83(5):1069\u201378.","journal-title":"J Leukoc Biol"},{"key":"6591_CR20","doi-asserted-by":"publisher","first-page":"608849","DOI":"10.3389\/fimmu.2020.608849","volume":"11","author":"S Maurer","year":"2020","unstructured":"Maurer S, Ferrari de Andrade L. NK cell interaction with platelets and myeloid cells in the tumor Milieu. Front Immunol. 2020;11:608849.","journal-title":"Front Immunol"},{"issue":"10","key":"6591_CR21","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1007\/s00262-022-03186-5","volume":"71","author":"LM Gockel","year":"2022","unstructured":"Gockel LM, Nekipelov K, Ferro V, Bendas G, Schlesinger M. Tumour cell-activated platelets modulate the immunological activity of CD4(+), CD8(+), and NK cells, which is efficiently antagonized by heparin. Cancer Immunol Immunother. 2022;71(10):2523\u201333.","journal-title":"Cancer Immunol Immunother"},{"issue":"4","key":"6591_CR22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3390\/cells9040855","volume":"9","author":"D Stoiber","year":"2020","unstructured":"Stoiber D, Assinger A. Platelet-leukocyte interplay in cancer development and progression. Cells. 2020;9(4):855.","journal-title":"Cells"},{"issue":"5","key":"6591_CR23","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4049\/jimmunol.1502658","volume":"197","author":"S Sadallah","year":"2016","unstructured":"Sadallah S, Schmied L, Eken C, Charoudeh HN, Amicarella F, Schifferli JA. Platelet-derived ectosomes reduce NK cell function. J Immunol. 2016;197(5):1663\u201371.","journal-title":"J Immunol"},{"issue":"19","key":"6591_CR24","doi-asserted-by":"publisher","first-page":"7775","DOI":"10.1158\/0008-5472.CAN-09-2123","volume":"69","author":"HG Kopp","year":"2009","unstructured":"Kopp HG, Placke T, Salih HR. Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity. Cancer Res. 2009;69(19):7775\u201383.","journal-title":"Cancer Res"},{"issue":"4","key":"6591_CR25","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/humrep\/dex014","volume":"32","author":"Y Du","year":"2017","unstructured":"Du Y, Liu X, Guo SW. Platelets impair natural killer cell reactivity and function in endometriosis through multiple mechanisms. Hum Reprod. 2017;32(4):794\u2013810.","journal-title":"Hum Reprod"},{"issue":"7","key":"6591_CR26","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/humrep\/dew057","volume":"31","author":"SW Guo","year":"2016","unstructured":"Guo SW, Du Y, Liu X. Platelet-derived TGF-\u03b21 mediates the down-modulation of NKG2D expression and may be responsible for impaired natural killer (NK) cytotoxicity in women with endometriosis. Hum Reprod. 2016;31(7):1462\u201374.","journal-title":"Hum Reprod"},{"issue":"3","key":"6591_CR27","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.4049\/jimmunol.1200458","volume":"189","author":"GF Lichtfuss","year":"2012","unstructured":"Lichtfuss GF, Cheng WJ, Farsakoglu Y, et al. Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation. J Immunol. 2012;189(3):1491\u20139.","journal-title":"J Immunol"},{"issue":"25","key":"6591_CR28","doi-asserted-by":"publisher","first-page":"15011","DOI":"10.1073\/pnas.2336091100","volume":"100","author":"D Mavilio","year":"2003","unstructured":"Mavilio D, Benjamin J, Daucher M, et al. Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A. 2003;100(25):15011\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"6591_CR29","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.iliver.2022.02.003","volume":"1","author":"Z Fang","year":"2022","unstructured":"Fang Z, Yang H, Mao Y. Tumor-immune Co-evolution in hepatocellular carcinoma and its implication for immunotherapy resistance. iLiver. 2022;1(1):78\u201380.","journal-title":"iLiver"},{"issue":"18","key":"6591_CR30","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1128\/JVI.00136-06","volume":"80","author":"C Chaipan","year":"2006","unstructured":"Chaipan C, Soilleux EJ, Simpson P, et al. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 2006;80(18):8951\u201360.","journal-title":"J Virol"},{"issue":"5","key":"6591_CR31","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.immuni.2014.10.008","volume":"41","author":"S Nourshargh","year":"2014","unstructured":"Nourshargh S, Alon R. Leukocyte migration into inflamed tissues. Immunity. 2014;41(5):694\u2013707.","journal-title":"Immunity"},{"issue":"9","key":"6591_CR32","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/ni.f.212","volume":"9","author":"P Friedl","year":"2008","unstructured":"Friedl P, Weigelin B. Interstitial leukocyte migration and immune function. Nat Immunol. 2008;9(9):960\u20139.","journal-title":"Nat Immunol"},{"issue":"1","key":"6591_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1600-065X.2009.00797.x","volume":"230","author":"DA Carlow","year":"2009","unstructured":"Carlow DA, Gossens K, Naus S, Veerman KM, Seo W, Ziltener HJ. PSGL-1 function in immunity and steady state homeostasis. Immunol Rev. 2009;230(1):75\u201396.","journal-title":"Immunol Rev"},{"issue":"3","key":"6591_CR34","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1096\/fj.08-118760","volume":"23","author":"L Almulki","year":"2009","unstructured":"Almulki L, Noda K, Amini R, et al. Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis. FASEB J. 2009;23(3):929\u201339.","journal-title":"FASEB J"},{"key":"6591_CR35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.clim.2018.10.017","volume":"204","author":"M Cuenca","year":"2019","unstructured":"Cuenca M, Sintes J, L\u00e1nyi \u00c1, Engel P. CD84 cell surface signaling molecule: an emerging biomarker and target for cancer and autoimmune disorders. Clin Immunol. 2019;204:43\u20139.","journal-title":"Clin Immunol"},{"issue":"1","key":"6591_CR36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ni0103-19","volume":"4","author":"SP Sidorenko","year":"2003","unstructured":"Sidorenko SP, Clark EA. The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 2003;4(1):19\u201324.","journal-title":"Nat Immunol"},{"issue":"4","key":"6591_CR37","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1084\/jem.20132038","volume":"211","author":"LA P\u00e9rez-Quintero","year":"2014","unstructured":"P\u00e9rez-Quintero LA, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C\u03b3, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014;211(4):727\u201342.","journal-title":"J Exp Med"},{"issue":"3","key":"6591_CR38","doi-asserted-by":"publisher","first-page":"e92184","DOI":"10.1371\/journal.pone.0092184","volume":"9","author":"TJ Wilson","year":"2014","unstructured":"Wilson TJ, Garner LI, Metcalfe C, King E, Margraf S, Brown MH. Fine specificity and molecular competition in SLAM family receptor signalling. PLoS ONE. 2014;9(3):e92184.","journal-title":"PLoS ONE"},{"issue":"3","key":"6591_CR39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ni.1693","volume":"10","author":"ME Cruz-Munoz","year":"2009","unstructured":"Cruz-Munoz ME, Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009;10(3):297\u2013305.","journal-title":"Nat Immunol"}],"container-title":["Journal of Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06591-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12967-025-06591-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12967-025-06591-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T14:43:06Z","timestamp":1749566586000},"score":1,"resource":{"primary":{"URL":"https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-025-06591-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6591"],"URL":"https:\/\/doi.org\/10.1186\/s12967-025-06591-3","relation":{},"ISSN":["1479-5876"],"issn-type":[{"value":"1479-5876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Affiliations have been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Committee of Ethics at Beijing Ditan Hospital, Capital Medical University in Beijing with informed consent acquired from all participants (No. 2021-22-01). Confidentiality and privacy were assured. The study complied with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All listed authors consented to the submission, and all data were used with the consent of the person generating the data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"584"}}